UniProtKB - Q63269 (ITPR3_RAT)
Inositol 1,4,5-trisphosphate receptor type 3
Itpr3
Functioni
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
GO - Molecular functioni
- calcium ion binding Source: RGD
- calcium ion transmembrane transporter activity Source: RGD
- calcium-release channel activity Source: UniProtKB
- identical protein binding Source: RGD
- inositol 1,3,4,5 tetrakisphosphate binding Source: RGD
- inositol 1,4,5 trisphosphate binding Source: RGD
- inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Source: RGD
- inositol hexakisphosphate binding Source: RGD
- phosphatidylinositol binding Source: RGD
- protein-containing complex binding Source: RGD
GO - Biological processi
- calcium ion transport Source: RGD
- calcium ion transport into cytosol Source: UniProtKB
- cellular response to cAMP Source: RGD
- G protein-coupled receptor signaling pathway Source: RGD
- long-term synaptic potentiation Source: RGD
- memory Source: RGD
- positive regulation of cytosolic calcium ion concentration Source: RGD
- release of sequestered calcium ion into cytosol Source: GO_Central
- response to calcium ion Source: RGD
- sensory perception of bitter taste Source: RGD
- sensory perception of sweet taste Source: RGD
- sensory perception of umami taste Source: RGD
Keywordsi
Molecular function | Calcium channel, Ion channel, Ligand-gated ion channel, Receptor |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | Calcium |
Enzyme and pathway databases
Reactomei | R-RNO-114508, Effects of PIP2 hydrolysis R-RNO-139853, Elevation of cytosolic Ca2+ levels R-RNO-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-RNO-5578775, Ion homeostasis R-RNO-9717207, Sensory perception of sweet, bitter, and umami (glutamate) taste R-RNO-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
Protein family/group databases
TCDBi | 1.A.3.2.5, the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family |
Names & Taxonomyi
Protein namesi | Recommended name: Inositol 1,4,5-trisphosphate receptor type 3Alternative name(s): IP3 receptor isoform 3 Short name: IP3R 3 Short name: InsP3R3 Type 3 inositol 1,4,5-trisphosphate receptor Short name: Type 3 InsP3 receptor |
Gene namesi | Name:Itpr3 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2934, Itpr3 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: BHF-UCL
- endoplasmic reticulum membrane Source: RGD
- integral component of endoplasmic reticulum membrane Source: SynGO
- sarcoplasmic reticulum Source: GO_Central
Nucleus
- nuclear envelope Source: RGD
- nuclear outer membrane Source: RGD
- nucleolus Source: RGD
- nucleoplasm Source: RGD
- nucleus Source: RGD
Plasma Membrane
- integral component of plasma membrane Source: RGD
- plasma membrane Source: RGD
Other locations
- apical part of cell Source: BHF-UCL
- brush border Source: BHF-UCL
- cytoplasm Source: RGD
- cytoplasmic vesicle membrane Source: GO_Central
- dendrite Source: RGD
- myelin sheath Source: RGD
- neuronal cell body Source: RGD
- perinuclear region of cytoplasm Source: RGD
- presynapse Source: SynGO
- receptor complex Source: RGD
- secretory granule membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 2201 | CytoplasmicSequence analysisAdd BLAST | 2201 | |
Transmembranei | 2202 – 2222 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 2223 – 2233 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 2234 – 2254 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 2255 – 2263 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 2264 – 2284 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 2285 – 2324 | ExtracellularSequence analysisAdd BLAST | 40 | |
Transmembranei | 2325 – 2345 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 2346 – 2367 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 2368 – 2388 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 2389 – 2495 | ExtracellularSequence analysisAdd BLAST | 107 | |
Transmembranei | 2496 – 2516 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 2517 – 2670 | CytoplasmicSequence analysisAdd BLAST | 154 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000153930 | 1 – 2670 | Inositol 1,4,5-trisphosphate receptor type 3Add BLAST | 2670 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 916 | PhosphoserineBy similarity | 1 | |
Modified residuei | 934 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1813 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1832 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1834 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2608 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2669 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q63269 |
PaxDbi | Q63269 |
PRIDEi | Q63269 |
PTM databases
CarbonylDBi | Q63269 |
iPTMneti | Q63269 |
PhosphoSitePlusi | Q63269 |
Interactioni
Subunit structurei
Homotetramer.
Interacts with TRPC1 and TRPC3 (By similarity).
Interacts with TRPC4 (PubMed:11163362).
Interacts with TRPV4 (By similarity).
Interacts with SIGMAR1 (PubMed:11149946).
Interacts with AKT1 and PML.
Interacts with IRAG2 (via coiled-coil domain) (By similarity).
Interacts with CABP1 (PubMed:12032348).
Interacts with TMBIM4/LFG4 (By similarity).
Interacts with CEMIP (By similarity).
Interacts with TESPA1 (By similarity).
Interacts with TMEM203 (By similarity).
Interacts with BOK; regulates ITPR3 expression (PubMed:23884412).
Interacts with BCL2L10 (By similarity).
By similarity4 PublicationsGO - Molecular functioni
- identical protein binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 247708, 3 interactors |
IntActi | Q63269, 2 interactors |
MINTi | Q63269 |
STRINGi | 10116.ENSRNOP00000011516 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 113 – 173 | MIR 1PROSITE-ProRule annotationAdd BLAST | 61 | |
Domaini | 174 – 224 | MIR 2PROSITE-ProRule annotationAdd BLAST | 51 | |
Domaini | 232 – 288 | MIR 3PROSITE-ProRule annotationAdd BLAST | 57 | |
Domaini | 295 – 372 | MIR 4PROSITE-ProRule annotationAdd BLAST | 78 | |
Domaini | 378 – 434 | MIR 5PROSITE-ProRule annotationAdd BLAST | 57 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 266 – 270 | Inositol 1,4,5-trisphosphate bindingBy similarity | 5 | |
Regioni | 321 – 344 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 507 – 510 | Inositol 1,4,5-trisphosphate bindingBy similarity | 4 | |
Regioni | 567 – 569 | Inositol 1,4,5-trisphosphate bindingBy similarity | 3 | |
Regioni | 1132 – 1164 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 1807 – 1849 | DisorderedSequence analysisAdd BLAST | 43 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1132 – 1161 | Basic and acidic residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 1827 – 1841 | Polar residuesSequence analysisAdd BLAST | 15 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3533, Eukaryota |
InParanoidi | Q63269 |
PhylomeDBi | Q63269 |
Family and domain databases
InterProi | View protein in InterPro IPR014821, Ins145_P3_rcpt IPR000493, InsP3_rcpt IPR005821, Ion_trans_dom IPR036300, MIR_dom_sf IPR016093, MIR_motif IPR013662, RIH_assoc-dom IPR000699, RIH_dom IPR035910, RyR/IP3R_RIH_dom_sf |
Pfami | View protein in Pfam PF08709, Ins145_P3_rec, 1 hit PF00520, Ion_trans, 1 hit PF02815, MIR, 1 hit PF08454, RIH_assoc, 1 hit PF01365, RYDR_ITPR, 2 hits |
PRINTSi | PR00779, INSP3RECEPTR |
SMARTi | View protein in SMART SM00472, MIR, 4 hits |
SUPFAMi | SSF100909, SSF100909, 2 hits SSF82109, SSF82109, 2 hits |
PROSITEi | View protein in PROSITE PS50919, MIR, 5 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MNEMSSFLHI GDIVSLYAEG SVNGFISTLG LVDDRCVVEP AAGDLDNPPK
60 70 80 90 100
KFRDCLFKVC PMNRYSAQKQ YWKAKQTKQD KEKIADVVLL QKLQHAAQME
110 120 130 140 150
QKQNDTENKK VHGDVVKYGS VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV
160 170 180 190 200
TLDATGNEGS WLFIQPFWKL RSNGDNVVVG DKVILNPVNA GQPLHASNYE
210 220 230 240 250
LSDNVGCKEV NSVNCNTSWK INLFMQFRDH LEEVLKGGDV VRLFHAEQEK
260 270 280 290 300
FLTCDEYRGK LQVFLRTTLR QSATSATSSN ALWEVEVVHH DPCRGGAGHW
310 320 330 340 350
NGLYRFKHLA TGNYLAAEEN PSYKGDVSDP KAAGPGAQSR TGRRNAGEKI
360 370 380 390 400
KYRLVAVPHG NDIASLFELD PTTLQKTDSF VPRNSYVRLR HLCTNTWIQS
410 420 430 440 450
TNAPIDVEEE RPIRLMLGTC PTKEDKEAFA IVSVPVSEIR DLDFANDASS
460 470 480 490 500
MLASAVEKLN EGFISQNDRR FVIQLLEDLV FFVSDVPNNG QNVLDIMVTK
510 520 530 540 550
PNRERQKLMR DENILKQIFG ILKAPFRDKG GEGPLVRLEE LSDQKNAPYQ
560 570 580 590 600
YMFRLCYRVL RHSQEDYRKN QEHIAKQFGM MQSQIGYDIL AEDTITALLH
610 620 630 640 650
NNRKLLEKHI TKTEVETFVS LVRKNREPRF LDYLSDLCVS NRIAIPVTQE
660 670 680 690 700
LICKCVLDPK NSDILIQTEL RPVKEMAQSH EYLSIEYSEE EVWLTWTDRN
710 720 730 740 750
NEHHEKSVRQ LAQEARAGNA HDENVLSYYR YQLKLFARMC LDRQYLAIDE
760 770 780 790 800
ISKQLGVELL FLCMADEMLP FDLRASFCHL MLHVHVDRDP QELVTPVKFA
810 820 830 840 850
RLWTEIPTAI TIKDYDSNLN ASRDDKKNKF ASTMEFVEDY LNNVVGEAVP
860 870 880 890 900
FANDEKNILT FEVVSLAHNL IYFGFYSFSE LLRLTRTLLG IIDCIQAPAA
910 920 930 940 950
VLQAYEEPGG KNVRRSIQGV GHMMSTMVLS RKQSVFGASS LPTGVGVPEQ
960 970 980 990 1000
LDRSKFEDNE HTVVMETKLK ILEILQFILN VRLDYRISYL LSVFKKEFVE
1010 1020 1030 1040 1050
VFPMQDSGAD GTAPAFDSST ANMNLDRIGE QAEAMFGVGK TSSMLEVDDE
1060 1070 1080 1090 1100
GGRMFLRVLL HLTMHDYPPL VSGALQLLFK HFSQRQEAMH TFKQVQLLIS
1110 1120 1130 1140 1150
AQDVENYKVI KSELDRLRTM VEKSELWVDK KGSVKGEEGE AGASKDKKER
1160 1170 1180 1190 1200
PSDEEGFLQP HGEKSSENYQ IVKGILERLN KMCGVGEQMR KKQQRLLKNM
1210 1220 1230 1240 1250
DAHKVMLDLL QIPYDKNDNK MMEILRYTHQ FLQKFCAGNP GNQALLHKHL
1260 1270 1280 1290 1300
QLFLTPGLLE AETMQHIFLN NYQLCSEISE PVLQHFVHCW PTHGRHVQYL
1310 1320 1330 1340 1350
DFLHTVIKAE GKYVKKCQDM IMTELTNAGD DVVVFYNDKA SLAHLLDMMK
1360 1370 1380 1390 1400
AARDGVEDHS PLMYHISLVD LLAACAEGKN VYTEIKCTSL LPLEDVVSVV
1410 1420 1430 1440 1450
THEDCITEVK MAYVNFVNHC YVDTEVEMKE IYTSNHIWTL FENFTLDMAL
1460 1470 1480 1490 1500
VCNKREKRLS DPTLEKYVLT VVLDTISAFF SSPFSENSTS LQTHQTIVVQ
1510 1520 1530 1540 1550
LLQSTTRLLE CPWLQQQHKG SVEACVRTLA MVAKSRAILL PMDLDAHMSA
1560 1570 1580 1590 1600
LLSSGGSCSA AAQRSAANYK TATRTFPRVI PTANQWDYKN IIEKLQDIIT
1610 1620 1630 1640 1650
ALEERLKPLV QAELSVLVDM LHWPELLFLE GSEAYQRCES GGFLSKLIRH
1660 1670 1680 1690 1700
TKGLMESEEK LCVKVLRTLQ QMLQKKSKYG DRGNQLRKML LQNYLQNRKS
1710 1720 1730 1740 1750
GPRGELTDPT GSGVDQDWSA IAATQCRLDK EGATKLVCDL ITSTKNEKIF
1760 1770 1780 1790 1800
QESIGLAIRL LDGGNTEIQK SFYNLMTSDK KSERFFKVLH DRMKRAQQET
1810 1820 1830 1840 1850
KSTVAVNMSD LGSQPREDRE PADPTTKGRV SSFSMPSSSR YSLGPGLHRG
1860 1870 1880 1890 1900
HDVSERAQNN EMGTSVLIMR PILRFLQLLC ENHNRDLQNF LRCQNNKTNY
1910 1920 1930 1940 1950
NLVCETLQFL DIMCGSTTGG LGLLGLYINE DNVGLVIQTL ETLTEYCQGP
1960 1970 1980 1990 2000
CHENQTCIVT HESNGIDIIT ALILNDISPL CKYRMDLVLQ LKDNASKLLL
2010 2020 2030 2040 2050
ALMESRHDSE NAERILISLR PQELVDVIKK AYLQEEEREN SEVSPREVGH
2060 2070 2080 2090 2100
NIYILALQLS RHNKQLQHLL KPVKRIQEEE AEGISSMLSL NNKQLSQMLK
2110 2120 2130 2140 2150
SSAPAQEEEE DPLAYYENHT SQIEIVRQDR SMEQIVFPVP AICQFLTEET
2160 2170 2180 2190 2200
KHRLFTTTEQ DEQGSKVSDF FDQSSFLHNE MEWQRRLRSM PLIYWFSRRM
2210 2220 2230 2240 2250
TLWGSISFNL AVFINIIIAF FYPYVEGAST GVLGSPLISL LFWILICFSI
2260 2270 2280 2290 2300
AALFTKHYSV RPLIVALVLR SIYYLGIGPT LNILGALNLT NKIVFVVSFV
2310 2320 2330 2340 2350
GNRGTFIRGY KAMVMDMEFL YHVGYILTSV LGLFAHELFY SILLFDLIYR
2360 2370 2380 2390 2400
EETLFNVIKS VTRNGRSILL TALLALILVY LFSIVGFLFL KDDFILEVDR
2410 2420 2430 2440 2450
LPGNHSRAST LGMPHGAATF MGTCSGDKMD CVSEVSVPEI LEEDEELDST
2460 2470 2480 2490 2500
ERACDTLLMC IVTVMNHGLR NGGGVGDILR KPSKDESLFP ARVVYDLLFF
2510 2520 2530 2540 2550
FIVIIIVLNL IFGVIIDTFA DLRSEKQKKE EILKTTCFIC GLERDKFDNK
2560 2570 2580 2590 2600
TVSFEEHIKL EHNMWNYLYF IVLVRVKNKT DYTGPESYVA QMIKNKNLDW
2610 2620 2630 2640 2650
FPRMRAMSLV SGEGEGEQNE IRILQEKLGS TMKLVSHLTA QLNELKEQMT
2660 2670
EQRKRRQRLG FVDVQNCMSR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2K9N6 | A0A0G2K9N6_RAT | Inositol 1,4,5-trisphosphate recept... | Itpr3 | 2,771 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L06096 mRNA Translation: AAA41446.1 |
PIRi | A46719 |
RefSeqi | NP_037270.1, NM_013138.1 |
Genome annotation databases
GeneIDi | 25679 |
KEGGi | rno:25679 |
UCSCi | RGD:2934, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L06096 mRNA Translation: AAA41446.1 |
PIRi | A46719 |
RefSeqi | NP_037270.1, NM_013138.1 |
3D structure databases
AlphaFoldDBi | Q63269 |
SMRi | Q63269 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 247708, 3 interactors |
IntActi | Q63269, 2 interactors |
MINTi | Q63269 |
STRINGi | 10116.ENSRNOP00000011516 |
Chemistry databases
ChEMBLi | CHEMBL2846 |
Protein family/group databases
TCDBi | 1.A.3.2.5, the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family |
PTM databases
CarbonylDBi | Q63269 |
iPTMneti | Q63269 |
PhosphoSitePlusi | Q63269 |
Proteomic databases
jPOSTi | Q63269 |
PaxDbi | Q63269 |
PRIDEi | Q63269 |
Genome annotation databases
GeneIDi | 25679 |
KEGGi | rno:25679 |
UCSCi | RGD:2934, rat |
Organism-specific databases
CTDi | 3710 |
RGDi | 2934, Itpr3 |
Phylogenomic databases
eggNOGi | KOG3533, Eukaryota |
InParanoidi | Q63269 |
PhylomeDBi | Q63269 |
Enzyme and pathway databases
Reactomei | R-RNO-114508, Effects of PIP2 hydrolysis R-RNO-139853, Elevation of cytosolic Ca2+ levels R-RNO-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-RNO-5578775, Ion homeostasis R-RNO-9717207, Sensory perception of sweet, bitter, and umami (glutamate) taste R-RNO-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
Miscellaneous databases
PROi | PR:Q63269 |
Family and domain databases
InterProi | View protein in InterPro IPR014821, Ins145_P3_rcpt IPR000493, InsP3_rcpt IPR005821, Ion_trans_dom IPR036300, MIR_dom_sf IPR016093, MIR_motif IPR013662, RIH_assoc-dom IPR000699, RIH_dom IPR035910, RyR/IP3R_RIH_dom_sf |
Pfami | View protein in Pfam PF08709, Ins145_P3_rec, 1 hit PF00520, Ion_trans, 1 hit PF02815, MIR, 1 hit PF08454, RIH_assoc, 1 hit PF01365, RYDR_ITPR, 2 hits |
PRINTSi | PR00779, INSP3RECEPTR |
SMARTi | View protein in SMART SM00472, MIR, 4 hits |
SUPFAMi | SSF100909, SSF100909, 2 hits SSF82109, SSF82109, 2 hits |
PROSITEi | View protein in PROSITE PS50919, MIR, 5 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ITPR3_RAT | |
Accessioni | Q63269Primary (citable) accession number: Q63269 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 2, 2001 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 179 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families