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UniProtKB - Q63269 (ITPR3_RAT)

Protein

Inositol 1,4,5-trisphosphate receptor type 3

Gene

Itpr3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionCalcium channel, Ion channel, Ligand-gated ion channel, Receptor
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Protein family/group databases

TCDBi1.A.3.2.5 the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol 1,4,5-trisphosphate receptor type 3
Alternative name(s):
IP3 receptor isoform 3
Short name:
IP3R 3
Short name:
InsP3R3
Type 3 inositol 1,4,5-trisphosphate receptor
Short name:
Type 3 InsP3 receptor
Gene namesi
Name:Itpr3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2934 Itpr3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 2201CytoplasmicSequence analysisAdd BLAST2201
Transmembranei2202 – 2222HelicalSequence analysisAdd BLAST21
Topological domaini2223 – 2233ExtracellularSequence analysisAdd BLAST11
Transmembranei2234 – 2254HelicalSequence analysisAdd BLAST21
Topological domaini2255 – 2263CytoplasmicSequence analysis9
Transmembranei2264 – 2284HelicalSequence analysisAdd BLAST21
Topological domaini2285 – 2324ExtracellularSequence analysisAdd BLAST40
Transmembranei2325 – 2345HelicalSequence analysisAdd BLAST21
Topological domaini2346 – 2367CytoplasmicSequence analysisAdd BLAST22
Transmembranei2368 – 2388HelicalSequence analysisAdd BLAST21
Topological domaini2389 – 2495ExtracellularSequence analysisAdd BLAST107
Transmembranei2496 – 2516HelicalSequence analysisAdd BLAST21
Topological domaini2517 – 2670CytoplasmicSequence analysisAdd BLAST154

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2846

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001539301 – 2670Inositol 1,4,5-trisphosphate receptor type 3Add BLAST2670

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei916PhosphoserineBy similarity1
Modified residuei934PhosphoserineCombined sources1
Modified residuei1813PhosphoserineBy similarity1
Modified residuei1832PhosphoserineBy similarity1
Modified residuei1834PhosphoserineBy similarity1
Modified residuei2608PhosphoserineBy similarity1
Modified residuei2669PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on tyrosine residues. Phosphorylated by AKT1 on serine and/or threonine residues (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ63269
PRIDEiQ63269

PTM databases

CarbonylDBiQ63269
iPTMnetiQ63269
PhosphoSitePlusiQ63269

Interactioni

Subunit structurei

Homotetramer. Interacts with TRPC1, TRPC3, TRPC4. Interacts with TRPV4 (By similarity). Interacts with SIGMAR1 (PubMed:11149946). Interacts with AKT1 and PML. Interacts with LRMP (via coiled-coil domain) (By similarity). Interacts with CABP1 (PubMed:12032348). Interacts with TMBIM4/LFG4 (By similarity). Interacts with CEMIP (By similarity). Interacts with TESPA1 (By similarity). Interacts with TMEM203 (By similarity). Interacts with BOK; regulates ITPR3 expression (PubMed:23884412).By similarity3 Publications

Protein-protein interaction databases

BioGridi247708, 2 interactors
CORUMiQ63269
IntActiQ63269, 1 interactor
STRINGi10116.ENSRNOP00000011516

Structurei

3D structure databases

ProteinModelPortaliQ63269
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini113 – 173MIR 1PROSITE-ProRule annotationAdd BLAST61
Domaini174 – 224MIR 2PROSITE-ProRule annotationAdd BLAST51
Domaini232 – 288MIR 3PROSITE-ProRule annotationAdd BLAST57
Domaini295 – 372MIR 4PROSITE-ProRule annotationAdd BLAST78
Domaini378 – 434MIR 5PROSITE-ProRule annotationAdd BLAST57

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni266 – 270Inositol 1,4,5-trisphosphate bindingBy similarity5
Regioni507 – 510Inositol 1,4,5-trisphosphate bindingBy similarity4
Regioni567 – 569Inositol 1,4,5-trisphosphate bindingBy similarity3

Domaini

The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

Sequence similaritiesi

Belongs to the InsP3 receptor family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3533 Eukaryota
ENOG410XR97 LUCA
HOGENOMiHOG000007660
HOVERGENiHBG052158
InParanoidiQ63269
KOiK04960
PhylomeDBiQ63269

Family and domain databases

InterProiView protein in InterPro
IPR014821 Ins145_P3_rcpt
IPR000493 InsP3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR015925 Ryanodine_recept-rel
IPR035910 RyR/IP3R_RIH_dom_sf
PANTHERiPTHR13715 PTHR13715, 1 hit
PfamiView protein in Pfam
PF08709 Ins145_P3_rec, 1 hit
PF00520 Ion_trans, 1 hit
PF02815 MIR, 1 hit
PF08454 RIH_assoc, 1 hit
PF01365 RYDR_ITPR, 2 hits
PRINTSiPR00779 INSP3RECEPTR
SMARTiView protein in SMART
SM00472 MIR, 4 hits
SUPFAMiSSF100909 SSF100909, 2 hits
SSF82109 SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50919 MIR, 5 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q63269-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNEMSSFLHI GDIVSLYAEG SVNGFISTLG LVDDRCVVEP AAGDLDNPPK 
        60         70         80         90        100
KFRDCLFKVC PMNRYSAQKQ YWKAKQTKQD KEKIADVVLL QKLQHAAQME 
       110        120        130        140        150
QKQNDTENKK VHGDVVKYGS VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV 
       160        170        180        190        200
TLDATGNEGS WLFIQPFWKL RSNGDNVVVG DKVILNPVNA GQPLHASNYE 
       210        220        230        240        250
LSDNVGCKEV NSVNCNTSWK INLFMQFRDH LEEVLKGGDV VRLFHAEQEK 
       260        270        280        290        300
FLTCDEYRGK LQVFLRTTLR QSATSATSSN ALWEVEVVHH DPCRGGAGHW 
       310        320        330        340        350
NGLYRFKHLA TGNYLAAEEN PSYKGDVSDP KAAGPGAQSR TGRRNAGEKI 
       360        370        380        390        400
KYRLVAVPHG NDIASLFELD PTTLQKTDSF VPRNSYVRLR HLCTNTWIQS 
       410        420        430        440        450
TNAPIDVEEE RPIRLMLGTC PTKEDKEAFA IVSVPVSEIR DLDFANDASS 
       460        470        480        490        500
MLASAVEKLN EGFISQNDRR FVIQLLEDLV FFVSDVPNNG QNVLDIMVTK 
       510        520        530        540        550
PNRERQKLMR DENILKQIFG ILKAPFRDKG GEGPLVRLEE LSDQKNAPYQ 
       560        570        580        590        600
YMFRLCYRVL RHSQEDYRKN QEHIAKQFGM MQSQIGYDIL AEDTITALLH 
       610        620        630        640        650
NNRKLLEKHI TKTEVETFVS LVRKNREPRF LDYLSDLCVS NRIAIPVTQE 
       660        670        680        690        700
LICKCVLDPK NSDILIQTEL RPVKEMAQSH EYLSIEYSEE EVWLTWTDRN 
       710        720        730        740        750
NEHHEKSVRQ LAQEARAGNA HDENVLSYYR YQLKLFARMC LDRQYLAIDE 
       760        770        780        790        800
ISKQLGVELL FLCMADEMLP FDLRASFCHL MLHVHVDRDP QELVTPVKFA 
       810        820        830        840        850
RLWTEIPTAI TIKDYDSNLN ASRDDKKNKF ASTMEFVEDY LNNVVGEAVP 
       860        870        880        890        900
FANDEKNILT FEVVSLAHNL IYFGFYSFSE LLRLTRTLLG IIDCIQAPAA 
       910        920        930        940        950
VLQAYEEPGG KNVRRSIQGV GHMMSTMVLS RKQSVFGASS LPTGVGVPEQ 
       960        970        980        990       1000
LDRSKFEDNE HTVVMETKLK ILEILQFILN VRLDYRISYL LSVFKKEFVE 
      1010       1020       1030       1040       1050
VFPMQDSGAD GTAPAFDSST ANMNLDRIGE QAEAMFGVGK TSSMLEVDDE 
      1060       1070       1080       1090       1100
GGRMFLRVLL HLTMHDYPPL VSGALQLLFK HFSQRQEAMH TFKQVQLLIS 
      1110       1120       1130       1140       1150
AQDVENYKVI KSELDRLRTM VEKSELWVDK KGSVKGEEGE AGASKDKKER 
      1160       1170       1180       1190       1200
PSDEEGFLQP HGEKSSENYQ IVKGILERLN KMCGVGEQMR KKQQRLLKNM 
      1210       1220       1230       1240       1250
DAHKVMLDLL QIPYDKNDNK MMEILRYTHQ FLQKFCAGNP GNQALLHKHL 
      1260       1270       1280       1290       1300
QLFLTPGLLE AETMQHIFLN NYQLCSEISE PVLQHFVHCW PTHGRHVQYL 
      1310       1320       1330       1340       1350
DFLHTVIKAE GKYVKKCQDM IMTELTNAGD DVVVFYNDKA SLAHLLDMMK 
      1360       1370       1380       1390       1400
AARDGVEDHS PLMYHISLVD LLAACAEGKN VYTEIKCTSL LPLEDVVSVV 
      1410       1420       1430       1440       1450
THEDCITEVK MAYVNFVNHC YVDTEVEMKE IYTSNHIWTL FENFTLDMAL 
      1460       1470       1480       1490       1500
VCNKREKRLS DPTLEKYVLT VVLDTISAFF SSPFSENSTS LQTHQTIVVQ 
      1510       1520       1530       1540       1550
LLQSTTRLLE CPWLQQQHKG SVEACVRTLA MVAKSRAILL PMDLDAHMSA 
      1560       1570       1580       1590       1600
LLSSGGSCSA AAQRSAANYK TATRTFPRVI PTANQWDYKN IIEKLQDIIT 
      1610       1620       1630       1640       1650
ALEERLKPLV QAELSVLVDM LHWPELLFLE GSEAYQRCES GGFLSKLIRH 
      1660       1670       1680       1690       1700
TKGLMESEEK LCVKVLRTLQ QMLQKKSKYG DRGNQLRKML LQNYLQNRKS 
      1710       1720       1730       1740       1750
GPRGELTDPT GSGVDQDWSA IAATQCRLDK EGATKLVCDL ITSTKNEKIF 
      1760       1770       1780       1790       1800
QESIGLAIRL LDGGNTEIQK SFYNLMTSDK KSERFFKVLH DRMKRAQQET 
      1810       1820       1830       1840       1850
KSTVAVNMSD LGSQPREDRE PADPTTKGRV SSFSMPSSSR YSLGPGLHRG 
      1860       1870       1880       1890       1900
HDVSERAQNN EMGTSVLIMR PILRFLQLLC ENHNRDLQNF LRCQNNKTNY 
      1910       1920       1930       1940       1950
NLVCETLQFL DIMCGSTTGG LGLLGLYINE DNVGLVIQTL ETLTEYCQGP 
      1960       1970       1980       1990       2000
CHENQTCIVT HESNGIDIIT ALILNDISPL CKYRMDLVLQ LKDNASKLLL 
      2010       2020       2030       2040       2050
ALMESRHDSE NAERILISLR PQELVDVIKK AYLQEEEREN SEVSPREVGH 
      2060       2070       2080       2090       2100
NIYILALQLS RHNKQLQHLL KPVKRIQEEE AEGISSMLSL NNKQLSQMLK 
      2110       2120       2130       2140       2150
SSAPAQEEEE DPLAYYENHT SQIEIVRQDR SMEQIVFPVP AICQFLTEET 
      2160       2170       2180       2190       2200
KHRLFTTTEQ DEQGSKVSDF FDQSSFLHNE MEWQRRLRSM PLIYWFSRRM 
      2210       2220       2230       2240       2250
TLWGSISFNL AVFINIIIAF FYPYVEGAST GVLGSPLISL LFWILICFSI 
      2260       2270       2280       2290       2300
AALFTKHYSV RPLIVALVLR SIYYLGIGPT LNILGALNLT NKIVFVVSFV 
      2310       2320       2330       2340       2350
GNRGTFIRGY KAMVMDMEFL YHVGYILTSV LGLFAHELFY SILLFDLIYR 
      2360       2370       2380       2390       2400
EETLFNVIKS VTRNGRSILL TALLALILVY LFSIVGFLFL KDDFILEVDR 
      2410       2420       2430       2440       2450
LPGNHSRAST LGMPHGAATF MGTCSGDKMD CVSEVSVPEI LEEDEELDST 
      2460       2470       2480       2490       2500
ERACDTLLMC IVTVMNHGLR NGGGVGDILR KPSKDESLFP ARVVYDLLFF 
      2510       2520       2530       2540       2550
FIVIIIVLNL IFGVIIDTFA DLRSEKQKKE EILKTTCFIC GLERDKFDNK 
      2560       2570       2580       2590       2600
TVSFEEHIKL EHNMWNYLYF IVLVRVKNKT DYTGPESYVA QMIKNKNLDW 
      2610       2620       2630       2640       2650
FPRMRAMSLV SGEGEGEQNE IRILQEKLGS TMKLVSHLTA QLNELKEQMT 
      2660       2670
EQRKRRQRLG FVDVQNCMSR
Length:2,670
Mass (Da):304,286
Last modified:November 1, 1996 - v1
Checksum:i13C787E4C2886E45
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C7E1V1C7E1V1_RAT
Inositol 1,4,5-trisphosphate recept...
Itpr3
2,670Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06096 mRNA Translation: AAA41446.1
PIRiA46719
RefSeqiNP_037270.1, NM_013138.1
UniGeneiRn.11242

Genome annotation databases

GeneIDi25679
KEGGirno:25679
UCSCiRGD:2934 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06096 mRNA Translation: AAA41446.1
PIRiA46719
RefSeqiNP_037270.1, NM_013138.1
UniGeneiRn.11242

3D structure databases

ProteinModelPortaliQ63269
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247708, 2 interactors
CORUMiQ63269
IntActiQ63269, 1 interactor
STRINGi10116.ENSRNOP00000011516

Chemistry databases

ChEMBLiCHEMBL2846

Protein family/group databases

TCDBi1.A.3.2.5 the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

PTM databases

CarbonylDBiQ63269
iPTMnetiQ63269
PhosphoSitePlusiQ63269

Proteomic databases

PaxDbiQ63269
PRIDEiQ63269

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25679
KEGGirno:25679
UCSCiRGD:2934 rat

Organism-specific databases

CTDi3710
RGDi2934 Itpr3

Phylogenomic databases

eggNOGiKOG3533 Eukaryota
ENOG410XR97 LUCA
HOGENOMiHOG000007660
HOVERGENiHBG052158
InParanoidiQ63269
KOiK04960
PhylomeDBiQ63269

Miscellaneous databases

PROiPR:Q63269

Family and domain databases

InterProiView protein in InterPro
IPR014821 Ins145_P3_rcpt
IPR000493 InsP3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR015925 Ryanodine_recept-rel
IPR035910 RyR/IP3R_RIH_dom_sf
PANTHERiPTHR13715 PTHR13715, 1 hit
PfamiView protein in Pfam
PF08709 Ins145_P3_rec, 1 hit
PF00520 Ion_trans, 1 hit
PF02815 MIR, 1 hit
PF08454 RIH_assoc, 1 hit
PF01365 RYDR_ITPR, 2 hits
PRINTSiPR00779 INSP3RECEPTR
SMARTiView protein in SMART
SM00472 MIR, 4 hits
SUPFAMiSSF100909 SSF100909, 2 hits
SSF82109 SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50919 MIR, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiITPR3_RAT
AccessioniPrimary (citable) accession number: Q63269
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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