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UniProtKB - Q63269 (ITPR3_RAT)

Entry version 179 (25 May 2022)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
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Protein

Inositol 1,4,5-trisphosphate receptor type 3

Gene

Itpr3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel, Ligand-gated ion channel, Receptor
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-RNO-114508, Effects of PIP2 hydrolysis
R-RNO-139853, Elevation of cytosolic Ca2+ levels
R-RNO-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-RNO-5578775, Ion homeostasis
R-RNO-9717207, Sensory perception of sweet, bitter, and umami (glutamate) taste
R-RNO-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Protein family/group databases

Transport Classification Database

More...TCDBi		1.A.3.2.5, the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inositol 1,4,5-trisphosphate receptor type 3
Alternative name(s):
IP3 receptor isoform 3
Short name:
IP3R 3
Short name:
InsP3R3
Type 3 inositol 1,4,5-trisphosphate receptor
Short name:
Type 3 InsP3 receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Itpr3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...RGDi		2934, Itpr3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 2201CytoplasmicSequence analysisAdd BLAST2201
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2202 – 2222HelicalSequence analysisAdd BLAST21
Topological domaini2223 – 2233ExtracellularSequence analysisAdd BLAST11
Transmembranei2234 – 2254HelicalSequence analysisAdd BLAST21
Topological domaini2255 – 2263CytoplasmicSequence analysis9
Transmembranei2264 – 2284HelicalSequence analysisAdd BLAST21
Topological domaini2285 – 2324ExtracellularSequence analysisAdd BLAST40
Transmembranei2325 – 2345HelicalSequence analysisAdd BLAST21
Topological domaini2346 – 2367CytoplasmicSequence analysisAdd BLAST22
Transmembranei2368 – 2388HelicalSequence analysisAdd BLAST21
Topological domaini2389 – 2495ExtracellularSequence analysisAdd BLAST107
Transmembranei2496 – 2516HelicalSequence analysisAdd BLAST21
Topological domaini2517 – 2670CytoplasmicSequence analysisAdd BLAST154

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2846

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001539301 – 2670Inositol 1,4,5-trisphosphate receptor type 3Add BLAST2670

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei916PhosphoserineBy similarity1
Modified residuei934PhosphoserineCombined sources1
Modified residuei1813PhosphoserineBy similarity1
Modified residuei1832PhosphoserineBy similarity1
Modified residuei1834PhosphoserineBy similarity1
Modified residuei2608PhosphoserineBy similarity1
Modified residuei2669PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues. Phosphorylated by AKT1 on serine and/or threonine residues (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q63269

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q63269

PRoteomics IDEntifications database

More...PRIDEi		Q63269

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		Q63269

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q63269

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q63269

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

Interacts with TRPC1 and TRPC3 (By similarity).

Interacts with TRPC4 (PubMed:11163362).

Interacts with TRPV4 (By similarity).

Interacts with SIGMAR1 (PubMed:11149946).

Interacts with AKT1 and PML.

Interacts with IRAG2 (via coiled-coil domain) (By similarity).

Interacts with CABP1 (PubMed:12032348).

Interacts with TMBIM4/LFG4 (By similarity).

Interacts with CEMIP (By similarity).

Interacts with TESPA1 (By similarity).

Interacts with TMEM203 (By similarity).

Interacts with BOK; regulates ITPR3 expression (PubMed:23884412).

Interacts with BCL2L10 (By similarity).

By similarity4 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		247708, 3 interactors

Protein interaction database and analysis system

More...IntActi		Q63269, 2 interactors

Molecular INTeraction database

More...MINTi		Q63269

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000011516

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q63269

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q63269

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini113 – 173MIR 1PROSITE-ProRule annotationAdd BLAST61
Domaini174 – 224MIR 2PROSITE-ProRule annotationAdd BLAST51
Domaini232 – 288MIR 3PROSITE-ProRule annotationAdd BLAST57
Domaini295 – 372MIR 4PROSITE-ProRule annotationAdd BLAST78
Domaini378 – 434MIR 5PROSITE-ProRule annotationAdd BLAST57

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni266 – 270Inositol 1,4,5-trisphosphate bindingBy similarity5
Regioni321 – 344DisorderedSequence analysisAdd BLAST24
Regioni507 – 510Inositol 1,4,5-trisphosphate bindingBy similarity4
Regioni567 – 569Inositol 1,4,5-trisphosphate bindingBy similarity3
Regioni1132 – 1164DisorderedSequence analysisAdd BLAST33
Regioni1807 – 1849DisorderedSequence analysisAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1132 – 1161Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi1827 – 1841Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the InsP3 receptor family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3533, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q63269

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q63269

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR014821, Ins145_P3_rcpt
IPR000493, InsP3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR035910, RyR/IP3R_RIH_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF01365, RYDR_ITPR, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00779, INSP3RECEPTR

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00472, MIR, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF100909, SSF100909, 2 hits
SSF82109, SSF82109, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50919, MIR, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q63269-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNEMSSFLHI GDIVSLYAEG SVNGFISTLG LVDDRCVVEP AAGDLDNPPK 
        60         70         80         90        100
KFRDCLFKVC PMNRYSAQKQ YWKAKQTKQD KEKIADVVLL QKLQHAAQME 
       110        120        130        140        150
QKQNDTENKK VHGDVVKYGS VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV 
       160        170        180        190        200
TLDATGNEGS WLFIQPFWKL RSNGDNVVVG DKVILNPVNA GQPLHASNYE 
       210        220        230        240        250
LSDNVGCKEV NSVNCNTSWK INLFMQFRDH LEEVLKGGDV VRLFHAEQEK 
       260        270        280        290        300
FLTCDEYRGK LQVFLRTTLR QSATSATSSN ALWEVEVVHH DPCRGGAGHW 
       310        320        330        340        350
NGLYRFKHLA TGNYLAAEEN PSYKGDVSDP KAAGPGAQSR TGRRNAGEKI 
       360        370        380        390        400
KYRLVAVPHG NDIASLFELD PTTLQKTDSF VPRNSYVRLR HLCTNTWIQS 
       410        420        430        440        450
TNAPIDVEEE RPIRLMLGTC PTKEDKEAFA IVSVPVSEIR DLDFANDASS 
       460        470        480        490        500
MLASAVEKLN EGFISQNDRR FVIQLLEDLV FFVSDVPNNG QNVLDIMVTK 
       510        520        530        540        550
PNRERQKLMR DENILKQIFG ILKAPFRDKG GEGPLVRLEE LSDQKNAPYQ 
       560        570        580        590        600
YMFRLCYRVL RHSQEDYRKN QEHIAKQFGM MQSQIGYDIL AEDTITALLH 
       610        620        630        640        650
NNRKLLEKHI TKTEVETFVS LVRKNREPRF LDYLSDLCVS NRIAIPVTQE 
       660        670        680        690        700
LICKCVLDPK NSDILIQTEL RPVKEMAQSH EYLSIEYSEE EVWLTWTDRN 
       710        720        730        740        750
NEHHEKSVRQ LAQEARAGNA HDENVLSYYR YQLKLFARMC LDRQYLAIDE 
       760        770        780        790        800
ISKQLGVELL FLCMADEMLP FDLRASFCHL MLHVHVDRDP QELVTPVKFA 
       810        820        830        840        850
RLWTEIPTAI TIKDYDSNLN ASRDDKKNKF ASTMEFVEDY LNNVVGEAVP 
       860        870        880        890        900
FANDEKNILT FEVVSLAHNL IYFGFYSFSE LLRLTRTLLG IIDCIQAPAA 
       910        920        930        940        950
VLQAYEEPGG KNVRRSIQGV GHMMSTMVLS RKQSVFGASS LPTGVGVPEQ 
       960        970        980        990       1000
LDRSKFEDNE HTVVMETKLK ILEILQFILN VRLDYRISYL LSVFKKEFVE 
      1010       1020       1030       1040       1050
VFPMQDSGAD GTAPAFDSST ANMNLDRIGE QAEAMFGVGK TSSMLEVDDE 
      1060       1070       1080       1090       1100
GGRMFLRVLL HLTMHDYPPL VSGALQLLFK HFSQRQEAMH TFKQVQLLIS 
      1110       1120       1130       1140       1150
AQDVENYKVI KSELDRLRTM VEKSELWVDK KGSVKGEEGE AGASKDKKER 
      1160       1170       1180       1190       1200
PSDEEGFLQP HGEKSSENYQ IVKGILERLN KMCGVGEQMR KKQQRLLKNM 
      1210       1220       1230       1240       1250
DAHKVMLDLL QIPYDKNDNK MMEILRYTHQ FLQKFCAGNP GNQALLHKHL 
      1260       1270       1280       1290       1300
QLFLTPGLLE AETMQHIFLN NYQLCSEISE PVLQHFVHCW PTHGRHVQYL 
      1310       1320       1330       1340       1350
DFLHTVIKAE GKYVKKCQDM IMTELTNAGD DVVVFYNDKA SLAHLLDMMK 
      1360       1370       1380       1390       1400
AARDGVEDHS PLMYHISLVD LLAACAEGKN VYTEIKCTSL LPLEDVVSVV 
      1410       1420       1430       1440       1450
THEDCITEVK MAYVNFVNHC YVDTEVEMKE IYTSNHIWTL FENFTLDMAL 
      1460       1470       1480       1490       1500
VCNKREKRLS DPTLEKYVLT VVLDTISAFF SSPFSENSTS LQTHQTIVVQ 
      1510       1520       1530       1540       1550
LLQSTTRLLE CPWLQQQHKG SVEACVRTLA MVAKSRAILL PMDLDAHMSA 
      1560       1570       1580       1590       1600
LLSSGGSCSA AAQRSAANYK TATRTFPRVI PTANQWDYKN IIEKLQDIIT 
      1610       1620       1630       1640       1650
ALEERLKPLV QAELSVLVDM LHWPELLFLE GSEAYQRCES GGFLSKLIRH 
      1660       1670       1680       1690       1700
TKGLMESEEK LCVKVLRTLQ QMLQKKSKYG DRGNQLRKML LQNYLQNRKS 
      1710       1720       1730       1740       1750
GPRGELTDPT GSGVDQDWSA IAATQCRLDK EGATKLVCDL ITSTKNEKIF 
      1760       1770       1780       1790       1800
QESIGLAIRL LDGGNTEIQK SFYNLMTSDK KSERFFKVLH DRMKRAQQET 
      1810       1820       1830       1840       1850
KSTVAVNMSD LGSQPREDRE PADPTTKGRV SSFSMPSSSR YSLGPGLHRG 
      1860       1870       1880       1890       1900
HDVSERAQNN EMGTSVLIMR PILRFLQLLC ENHNRDLQNF LRCQNNKTNY 
      1910       1920       1930       1940       1950
NLVCETLQFL DIMCGSTTGG LGLLGLYINE DNVGLVIQTL ETLTEYCQGP 
      1960       1970       1980       1990       2000
CHENQTCIVT HESNGIDIIT ALILNDISPL CKYRMDLVLQ LKDNASKLLL 
      2010       2020       2030       2040       2050
ALMESRHDSE NAERILISLR PQELVDVIKK AYLQEEEREN SEVSPREVGH 
      2060       2070       2080       2090       2100
NIYILALQLS RHNKQLQHLL KPVKRIQEEE AEGISSMLSL NNKQLSQMLK 
      2110       2120       2130       2140       2150
SSAPAQEEEE DPLAYYENHT SQIEIVRQDR SMEQIVFPVP AICQFLTEET 
      2160       2170       2180       2190       2200
KHRLFTTTEQ DEQGSKVSDF FDQSSFLHNE MEWQRRLRSM PLIYWFSRRM 
      2210       2220       2230       2240       2250
TLWGSISFNL AVFINIIIAF FYPYVEGAST GVLGSPLISL LFWILICFSI 
      2260       2270       2280       2290       2300
AALFTKHYSV RPLIVALVLR SIYYLGIGPT LNILGALNLT NKIVFVVSFV 
      2310       2320       2330       2340       2350
GNRGTFIRGY KAMVMDMEFL YHVGYILTSV LGLFAHELFY SILLFDLIYR 
      2360       2370       2380       2390       2400
EETLFNVIKS VTRNGRSILL TALLALILVY LFSIVGFLFL KDDFILEVDR 
      2410       2420       2430       2440       2450
LPGNHSRAST LGMPHGAATF MGTCSGDKMD CVSEVSVPEI LEEDEELDST 
      2460       2470       2480       2490       2500
ERACDTLLMC IVTVMNHGLR NGGGVGDILR KPSKDESLFP ARVVYDLLFF 
      2510       2520       2530       2540       2550
FIVIIIVLNL IFGVIIDTFA DLRSEKQKKE EILKTTCFIC GLERDKFDNK 
      2560       2570       2580       2590       2600
TVSFEEHIKL EHNMWNYLYF IVLVRVKNKT DYTGPESYVA QMIKNKNLDW 
      2610       2620       2630       2640       2650
FPRMRAMSLV SGEGEGEQNE IRILQEKLGS TMKLVSHLTA QLNELKEQMT 
      2660       2670
EQRKRRQRLG FVDVQNCMSR
Length:2,670
Mass (Da):304,286
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i13C787E4C2886E45
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2K9N6A0A0G2K9N6_RAT
Inositol 1,4,5-trisphosphate recept...
Itpr3
2,771Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L06096 mRNA Translation: AAA41446.1

Protein sequence database of the Protein Information Resource

More...PIRi		A46719

NCBI Reference Sequences

More...RefSeqi		NP_037270.1, NM_013138.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		25679

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:25679

UCSC genome browser

More...UCSCi		RGD:2934, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06096 mRNA Translation: AAA41446.1
PIRiA46719
RefSeqiNP_037270.1, NM_013138.1

3D structure databases

AlphaFoldDBiQ63269
SMRiQ63269
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi247708, 3 interactors
IntActiQ63269, 2 interactors
MINTiQ63269
STRINGi10116.ENSRNOP00000011516

Chemistry databases

ChEMBLiCHEMBL2846

Protein family/group databases

TCDBi1.A.3.2.5, the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family

PTM databases

CarbonylDBiQ63269
iPTMnetiQ63269
PhosphoSitePlusiQ63269

Proteomic databases

jPOSTiQ63269
PaxDbiQ63269
PRIDEiQ63269

Genome annotation databases

GeneIDi25679
KEGGirno:25679
UCSCiRGD:2934, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3710
RGDi2934, Itpr3

Phylogenomic databases

eggNOGiKOG3533, Eukaryota
InParanoidiQ63269
PhylomeDBiQ63269

Enzyme and pathway databases

ReactomeiR-RNO-114508, Effects of PIP2 hydrolysis
R-RNO-139853, Elevation of cytosolic Ca2+ levels
R-RNO-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-RNO-5578775, Ion homeostasis
R-RNO-9717207, Sensory perception of sweet, bitter, and umami (glutamate) taste
R-RNO-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q63269

Family and domain databases

InterProiView protein in InterPro
IPR014821, Ins145_P3_rcpt
IPR000493, InsP3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR035910, RyR/IP3R_RIH_dom_sf
PfamiView protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF01365, RYDR_ITPR, 2 hits
PRINTSiPR00779, INSP3RECEPTR
SMARTiView protein in SMART
SM00472, MIR, 4 hits
SUPFAMiSSF100909, SSF100909, 2 hits
SSF82109, SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50919, MIR, 5 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITPR3_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q63269
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 1, 1996
Last modified: May 25, 2022
This is version 179 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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