Ptprn

Functionⁱ

Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Required to maintain normal levels of renin expression and renin release. Seems to lack intrinsic enzyme activity.By similarity

ICA512-transmembrane fragment: ICA512-TMF regulates dynamics and exocytosis of insulin secretory granules (SGs); binding of ICA512-TMF to SNTB2/beta-2-syntrophin is proposed to restrain SGs mobility and exocytosis by tethering them to the actin cytoskeleton depending on UTRN; the function is inhibited by cytoplasmic ICA512-CFF dimerizing with ICA512-TMF and displacing SNTB2 (By similarity).By similarity

ICA512-cleaved cytosolic fragment: ICA512-CCF translocated to the nucleus promotes expression of insulin and other granule-related genes; the function implicates binding to and regulating activity of STAT5B probably by preventing its dephosphorylation and potentially by inducing its sumoylation by recruiting PIAS4 (By similarity). Enhances pancreatic beta-cell proliferation by converging with signaling by STAT5B and STAT3 (PubMed:18178618). ICA512-CCF located in the cytoplasm regulates dynamics and exocytosis of insulin secretory granules (SGs) by dimerizing with ICA512-TMF and displacing SNTB2 thus enhancing SGs mobility and exocytosis (By similarity).By similarity1 Publication

Caution

Does not possess catalytic activity due to replacement of highly conserved residues in tyrosine-protein phosphatase domain.Curated

GO - Molecular functionⁱ

GTPase binding
Source: RGD
Inferred from physical interactionⁱ
- 16413169
spectrin binding Source: Ensembl
transcription factor binding Source: Ensembl
ubiquitin-like protein ligase binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cytokine-mediated signaling pathway
Source: RGD
Inferred from direct assayⁱ
- 12239095
dense core granule maturation Source: Ensembl
insulin secretion involved in cellular response to glucose stimulus Source: UniProtKB
luteinization Source: UniProtKB
peptidyl-tyrosine dephosphorylation Source: GOC
positive regulation of transcription by RNA polymerase II Source: Ensembl
positive regulation of type B pancreatic cell proliferation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18178618
response to cAMP
Source: RGD
Inferred from expression patternⁱ
- 12351437
response to estrogen
Source: RGD
Inferred from expression patternⁱ
- 9607778
response to glucose
Source: RGD
Inferred from expression patternⁱ
- 12351437
response to insulin
Source: RGD
Inferred from expression patternⁱ
- 12351437
response to reactive oxygen species Source: UniProtKB
second-messenger-mediated signaling
Source: RGD
Traceable author statementⁱ
- 12239095
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Receptor-type tyrosine-protein phosphatase-like N Short name: R-PTP-N Alternative name(s): 105 kDa islet cell antigen BEM-3 Brain-enriched membrane-associated protein tyrosine phosphatase ICA1051 Publication ICA5121 Publication PTP IA-21 Publication PTPLP Cleaved into the following 3 chains: ICA512-N-terminal fragment Short name: ICA512-NTF ICA512-transmembrane fragment Short name: ICA512-TMF ICA512-cleaved cytosolic fragment Short name: ICA512-CCF
Gene namesⁱ	Name:Ptprn
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 9

Organism-specific databases

Rat genome database More...RGDⁱ	620777 Ptprn

RGDⁱ

620777 Ptprn

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	41 – 579	LumenalSequence analysisAdd BLAST	539
Transmembraneⁱ	580 – 604	HelicalSequence analysisAdd BLAST	25
Topological domainⁱ	605 – 983	CytoplasmicSequence analysisAdd BLAST	379

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Cell projection, Cytoplasmic vesicle, Endosome, Membrane, Nucleus, Synapse

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 40	By similarityAdd BLAST	40
ChainⁱPRO_0000025453	41 – 983	Receptor-type tyrosine-protein phosphatase-like NAdd BLAST	943
ChainⁱPRO_0000438085	41 – 452	ICA512-N-terminal fragmentBy similarityAdd BLAST	412
ChainⁱPRO_0000438086	453 – 983	ICA512-transmembrane fragmentBy similarityAdd BLAST	531
ChainⁱPRO_0000438087	663 – 983	ICA512-cleaved cytosolic fragmentBy similarityAdd BLAST	321

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	46	Interchain (with C-46 or C-53); in multimeric formBy similarity
Disulfide bondⁱ	53	Interchain (with C-46 or C-53); in multimeric formBy similarity
Disulfide bondⁱ	59 ↔ 68	By similarity
Modified residueⁱ	311	PhosphoserineCombined sources	1
Modified residueⁱ	312	PhosphoserineCombined sources	1
Glycosylationⁱ	510	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	528	N-linked (GlcNAc...) asparagineSequence analysis	1
Cross-linkⁱ	758	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

Post-translational modificationⁱ

Subject to proteolytic cleavage at multiple sites (PubMed:7568143). Subject to cleavage on a pair of basic residues (By similarity). Following exocytosis of secretory granules in pancreatic beta-cells ICA512-TMF located in the plasma-membrane is cleaved by mu-type calpain CPN1 to yield ICA512-CCF (PubMed:15596545).By similarity2 Publications

N-glycosylated.By similarity

O-glycosylated.By similarity

Sumoylated at two sites including Lys-758. Sumoylation decreases interaction with STAT5.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	452 – 453	CleavageBy similarity		2

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q63259
PRIDEⁱ	Q63259

PTM databases

iPTMnetⁱ	Q63259
PhosphoSitePlusⁱ	Q63259

Expressionⁱ

Tissue specificityⁱ

Detected in pancreas islets (PubMed:7657822, PubMed:10457160). Detected in pancreas alpha, beta and delta cells, and in chromaffin cells in the adrenal medulla (PubMed:8641276). Detected in amygdala, hypothalamus, autonomous nerve fibers and ganglia, especially at synaptic contacts (PubMed:8641276). Detected in pituitary (at protein level) (PubMed:8641276, PubMed:10457160). Detected in brain, specifically in cerebral cortex, diencephalon and brain stem (PubMed:7887886).4 Publications

Gene expression databases

Bgeeⁱ	ENSRNOG00000019587 Expressed in 9 organ(s), highest expression level in brain
Genevisibleⁱ	Q63259 RN

Interactionⁱ

Subunit structureⁱ

Homodimer; shown for the unprocessed protein (proICA512) in the endoplasmic reticulum and resolved during protein maturation as ICA512-TMF seems to be predominantly monomeric in secretory granules; however, ICA512-CCF interacts with ICA512-TMF disrupting the ICA512-TMF:SNTB2 complex. The isolated lumenal RESP18 homology domain has been shown to form disulfide-linked homooligomers. Interacts (via cytoplasmic domain) with phosphorylated SNTB2; this protects PTPRN against cleavage by CAPN1 to produce ICA512-CCF. Dephosphorylation of SNTB2 upon insulin stimulation disrupts the interaction and results in PTPRN cleavage. Interacts with SNX19. ICA512-CCF interacts with PIAS4; in the nucleus. Interacts with STAT5B (phosphorylated); down-regulated by ICA512-CCF sumoylation; ICA512-CCF prevents STAT5B dephosphorylation; ICA512-CCF mediates interaction of STAT5B with PIAS4. Interacts (via RESP18 homology domain) with insulin and proinsulin. Interacts with PTPRN2, PTPRA and PTPRE.By similarity

GO - Molecular functionⁱ

GTPase binding
Source: RGD
Inferred from physical interactionⁱ
- 16413169
spectrin binding Source: Ensembl
transcription factor binding Source: Ensembl
ubiquitin-like protein ligase binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	Q63259, 2 interactors
STRINGⁱ	10116.ENSRNOP00000026654

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q63259
SMRⁱ	Q63259
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	713 – 973	Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST		261

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	41 – 137	RESP18 homology domainBy similarityAdd BLAST	97
Regionⁱ	453 – 579	Sufficient for dimerization of proICA512By similarityAdd BLAST	127
Regionⁱ	605 – 736	Sufficient for dimerization of proICA512By similarityAdd BLAST	132

Domainⁱ

The RESP18 homology domain is sufficient for targeting proICA512 to secretory granules.By similarity

Sequence similaritiesⁱ

Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0793 Eukaryota COG5599 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148980
HOGENOMⁱ	HOG000243992
HOVERGENⁱ	HBG053762
InParanoidⁱ	Q63259
KEGG Orthology (KO) More...KOⁱ	K07817
OMAⁱ	FLPYDHA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0LUR
PhylomeDBⁱ	Q63259
TreeFamⁱ	TF351976

Family and domain databases

Gene3Dⁱ	3.30.70.2470, 1 hit 3.90.190.10, 1 hit
InterProⁱ	View protein in InterPro IPR033522 IA-2/IA-2_beta IPR029021 Prot-tyrosine_phosphatase-like IPR000242 PTPase_domain IPR021613 Receptor_IA-2_dom IPR038112 Receptor_IA-2_ectodomain_sf IPR029403 RESP18_dom IPR016130 Tyr_Pase_AS IPR003595 Tyr_Pase_cat IPR000387 TYR_PHOSPHATASE_dom
PANTHERⁱ	PTHR19134:SF2 PTHR19134:SF2, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF11548 Receptor_IA-2, 1 hit PF14948 RESP18, 1 hit PF00102 Y_phosphatase, 1 hit
PRINTSⁱ	PR00700 PRTYPHPHTASE
SMARTⁱ	View protein in SMART SM00194 PTPc, 1 hit SM00404 PTPc_motif, 1 hit
SUPFAMⁱ	SSF52799 SSF52799, 1 hit
PROSITEⁱ	View protein in PROSITE PS00383 TYR_PHOSPHATASE_1, 1 hit PS50056 TYR_PHOSPHATASE_2, 1 hit PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q63259-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRRPRRPGGP AGCGGSEGSG GLRLLVCLLL LSGRPGGCSA ISAHGCLFDR 
        60         70         80         90        100
RLCSHLEVCI QDGLFGQCQA GVGQARPLLQ VTSPVLQRLQ GVLRQLMSQG 
       110        120        130        140        150
LSWHDDLTQY VISQEMERIP RLRPPEPHPR DRSGSVPRRA GPAGELLSQG 
       160        170        180        190        200
NPTGSSPAVQ GLSRPPGDGN GAGVGSPLSS LQAELLPPLL EHLLMPPQPP 
       210        220        230        240        250
HPSLTYEPAL LQPYLFQQFG SRDGSRGSES ASGVVGHLAK AEDPVLFSRS 
       260        270        280        290        300
LSKAILGTHS GHSFGDLTGP SPAQLFQDSG LLYMAQELPV PGRARAPRLP 
       310        320        330        340        350
EEGGSSRAED SSEGHEEEVL GGHGEKSPPQ AVQADVSLQR LAAVLAGYGV 
       360        370        380        390        400
ELRQLTPEQL STLLTLLQLL PKGTGRHLGG AVNGGADVKK TIEEQMQRGD 
       410        420        430        440        450
TADARPPTPL LPGHPTASST SIKVRQVLSP GFPEPPKTSS PLGISAVLLE 
       460        470        480        490        500
KKSPLGQSQP TVVGQPSARP SAEEYGYIVT DQKPLSLVAG VKLLEILAEH 
       510        520        530        540        550
VHMTSGSFIN ISVVGPAVTF RIRHNEQNLS LADVTQQAGL VKSELEAQTG 
       560        570        580        590        600
LQILQTGVGQ REESAAVLPR QAHGISPMRS LLLTLVALAG VAGLLVALAV 
       610        620        630        640        650
ALCMRHHSKQ RDKERLAALG PEGAHGDTTF EYQDLCRQHM ATKSLFNRAE 
       660        670        680        690        700
GQPEPSRVSS VSSQFSDAAQ ASPSSHSSTP SWCEEPAQAN MDISTGHMIL 
       710        720        730        740        750
AYMEDHLRNR DRLAKEWQAL CAYQAEPNTC ATAQGEGNIK KNRHPDFLPY 
       760        770        780        790        800
DHARIKLKVE SSPSRSDYIN ASPIIEHDPR MPAYIATQGP LSHTIADFWQ 
       810        820        830        840        850
MVWESGCTVI VMLTPLVEDG VKQCDRYWPD EGSSLYHVYE VNLVSEHIWC 
       860        870        880        890        900
EDFLVRSFYL KNVQTQETRT LTQFHFLSWP AEGTPASTRP LLDFRRKVNK 
       910        920        930        940        950
CYRGRSCPII VHCSDGAGRT GTYILIDMVL NRMAKGVKEI DIAATLEHVR 
       960        970        980 
DQRPGLVRSK DQFEFALTAV AEEVNAILKA LPQ

Length:983

Mass (Da):106,228

Last modified:July 15, 1998 - v2

Checksum:ⁱBCD567DAFFFE2A2B

GO

Sequence cautionⁱ

The sequence BAA07397 differs from that shown. Reason: Frameshift at positions 33 and 102.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	466	P → T in AAA83235 (PubMed:7657822).Curated	1
Sequence conflictⁱ	507	S → R in AAA83235 (PubMed:7657822).Curated	1
Sequence conflictⁱ	517	A → V in AAA83235 (PubMed:7657822).Curated	1
Sequence conflictⁱ	520	F → S in AAA83235 (PubMed:7657822).Curated	1
Sequence conflictⁱ	564	S → A in AAA83235 (PubMed:7657822).Curated	1
Sequence conflictⁱ	566	A → E in AAA83235 (PubMed:7657822).Curated	1
Sequence conflictⁱ	574	G → R in BAA07397 (PubMed:7887886).Curated	1
Sequence conflictⁱ	581	L → V in AAA83235 (PubMed:7657822).Curated	1
Sequence conflictⁱ	599	A → V in BAA08254 (Ref. 4) Curated	1
Sequence conflictⁱ	609	K → R in AAA83235 (PubMed:7657822).Curated	1
Sequence conflictⁱ	664	Q → K in AAA83235 (PubMed:7657822).Curated	1
Sequence conflictⁱ	672	S → N in AAA83235 (PubMed:7657822).Curated	1
Sequence conflictⁱ	714	A → P in AAA83235 (PubMed:7657822).Curated	1
Sequence conflictⁱ	716	E → K in CAA63313 (PubMed:7568143).Curated	1
Sequence conflictⁱ	731	A → S in AAA83235 (PubMed:7657822).Curated	1
Sequence conflictⁱ	953 – 955	RPG → PTC in AAA83235 (PubMed:7657822).Curated	3
Sequence conflictⁱ	962	Q → K in AAA83235 (PubMed:7657822).Curated	1
Sequence conflictⁱ	966	A → P in AAA83235 (PubMed:7657822).Curated	1
Sequence conflictⁱ	969	A → P in AAA83235 (PubMed:7657822).Curated	1
Sequence conflictⁱ	971	A → G in AAA83235 (PubMed:7657822).Curated	1
Sequence conflictⁱ	976	A → P in AAA83235 (PubMed:7657822).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X92563 mRNA Translation: CAA63313.1 D38222 mRNA Translation: BAA07397.1 Frameshift. U40652 mRNA Translation: AAA83235.1 D45414 mRNA Translation: BAA08254.1
PIRⁱ	S54342
NCBI Reference Sequences More...RefSeqⁱ	NP_446333.1, NM_053881.1
UniGeneⁱ	Rn.11097

Genome annotation databases

Ensemblⁱ	ENSRNOT00000026654; ENSRNOP00000026654; ENSRNOG00000019587
GeneIDⁱ	116660
KEGGⁱ	rno:116660
UCSC genome browser More...UCSCⁱ	RGD:620777 rat

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q63259	Receptor-type tyrosine-protein phosphatase-like N		MOUSE		979	UniRef90_Q63259
UPI0003D0DD89		RAT		1064
UPI000A31B075		MUSCR		985
UPI000A30BD8E		MUSPA		982
Protein tyrosine phosphatase, receptor type, N (Fragment)		MOUSE		985
+6

Protein	Similar proteins		Species	Score	Length	Source
Q63259	Receptor-type tyrosine-protein phosphatase-like N	)	HUMAN		979	UniRef50_Q16849
Receptor-type tyrosine-protein phosphatase-like N		MOUSE		979
Receptor-type tyrosine-protein phosphatase-like N		BOVIN		979
Protein tyrosine phosphatase, receptor type N		CERAT		1043
Protein tyrosine phosphatase, receptor type N		SAIBB		1019
+424

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X92563 mRNA Translation: CAA63313.1 D38222 mRNA Translation: BAA07397.1 Frameshift. U40652 mRNA Translation: AAA83235.1 D45414 mRNA Translation: BAA08254.1
PIRⁱ	S54342
RefSeqⁱ	NP_446333.1, NM_053881.1
UniGeneⁱ	Rn.11097

3D structure databases

ProteinModelPortalⁱ	Q63259
SMRⁱ	Q63259
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q63259, 2 interactors
STRINGⁱ	10116.ENSRNOP00000026654

PTM databases

iPTMnetⁱ	Q63259
PhosphoSitePlusⁱ	Q63259

Proteomic databases

PaxDbⁱ	Q63259
PRIDEⁱ	Q63259

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000026654; ENSRNOP00000026654; ENSRNOG00000019587
GeneIDⁱ	116660
KEGGⁱ	rno:116660
UCSCⁱ	RGD:620777 rat

Organism-specific databases

CTDⁱ	5798
RGDⁱ	620777 Ptprn

Phylogenomic databases

eggNOGⁱ	KOG0793 Eukaryota COG5599 LUCA
GeneTreeⁱ	ENSGT00920000148980
HOGENOMⁱ	HOG000243992
HOVERGENⁱ	HBG053762
InParanoidⁱ	Q63259
KOⁱ	K07817
OMAⁱ	FLPYDHA
OrthoDBⁱ	EOG091G0LUR
PhylomeDBⁱ	Q63259
TreeFamⁱ	TF351976

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q63259

PROⁱ

PR:Q63259

Gene expression databases

Bgeeⁱ	ENSRNOG00000019587 Expressed in 9 organ(s), highest expression level in brain
Genevisibleⁱ	Q63259 RN

Family and domain databases

Gene3Dⁱ	3.30.70.2470, 1 hit 3.90.190.10, 1 hit
InterProⁱ	View protein in InterPro IPR033522 IA-2/IA-2_beta IPR029021 Prot-tyrosine_phosphatase-like IPR000242 PTPase_domain IPR021613 Receptor_IA-2_dom IPR038112 Receptor_IA-2_ectodomain_sf IPR029403 RESP18_dom IPR016130 Tyr_Pase_AS IPR003595 Tyr_Pase_cat IPR000387 TYR_PHOSPHATASE_dom
PANTHERⁱ	PTHR19134:SF2 PTHR19134:SF2, 1 hit
Pfamⁱ	View protein in Pfam PF11548 Receptor_IA-2, 1 hit PF14948 RESP18, 1 hit PF00102 Y_phosphatase, 1 hit
PRINTSⁱ	PR00700 PRTYPHPHTASE
SMARTⁱ	View protein in SMART SM00194 PTPc, 1 hit SM00404 PTPc_motif, 1 hit
SUPFAMⁱ	SSF52799 SSF52799, 1 hit
PROSITEⁱ	View protein in PROSITE PS00383 TYR_PHOSPHATASE_1, 1 hit PS50056 TYR_PHOSPHATASE_2, 1 hit PS50055 TYR_PHOSPHATASE_PTP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PTPRN_RAT
Accessionⁱ	Q63259Primary (citable) accession number: Q63259 Secondary accession number(s): Q62883, Q63795, Q64643
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	July 15, 1998
	Last modified:	September 12, 2018
	This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q63259 (PTPRN_RAT)

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Receptor-type tyrosine-protein phosphatase-like N

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Plasma membrane

Other locations

Other locations

Nucleus

Endosome

Nucleus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ