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Entry version 145 (08 May 2019)
Sequence version 2 (10 Jul 2007)
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Protein

Integrin alpha-7

Gene

Itga7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. Involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells (By similarity). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation.By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi328 – 336Sequence analysis9
Calcium bindingi390 – 398Sequence analysis9
Calcium bindingi448 – 456Sequence analysis9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion, Cell shape
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-3000157 Laminin interactions
R-RNO-3000178 ECM proteoglycans

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integrin alpha-7
Alternative name(s):
H36-alpha7
Cleaved into the following 3 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Itga7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Rat genome database

More...
RGDi
71022 Itga7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini34 – 1036ExtracellularSequence analysisAdd BLAST1003
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1037 – 1057HelicalSequence analysisAdd BLAST21
Topological domaini1058 – 1135CytoplasmicSequence analysisAdd BLAST78

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi603R → G: Abolishes cleavage by urokinase. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 33By similarityAdd BLAST33
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000029312434 – 1135Integrin alpha-7Add BLAST1102
ChainiPRO_000001627334 – 910Integrin alpha-7 heavy chainSequence analysisAdd BLAST877
ChainiPRO_0000398834604 – 1135Integrin alpha-7 70 kDa formAdd BLAST532
ChainiPRO_0000016274914 – 1135Integrin alpha-7 light chainSequence analysisAdd BLAST222

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi94 ↔ 103By similarity
Disulfide bondi140 ↔ 163By similarity
Disulfide bondi184 ↔ 197By similarity
Disulfide bondi495 ↔ 502By similarity
Disulfide bondi508 ↔ 571By similarity
Disulfide bondi637 ↔ 643By similarity
Disulfide bondi736 ↔ 747By similarity
Glycosylationi741N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi894 ↔ 948Interchain (between heavy and light chains)By similarity
Glycosylationi943N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi955 ↔ 960By similarity
Glycosylationi979N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi999N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

ADP-ribosylated on at least two sites of the extracellular domain in skeletal myotubes.By similarity
A 70 kDa form is created by proteolytic cleavage. Cleavage is elevated during myogenic differentiation and the cleaved form enhances cell adhesion and spreading on laminin.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei603 – 604Cleavage; by urokinase2

Keywords - PTMi

ADP-ribosylation, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q63258

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q63258

PRoteomics IDEntifications database

More...
PRIDEi
Q63258

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q63258

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q63258

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in skeletal and cardiac muscle. Expressed in replicating myoblasts. In differentiated muscle fibers localizes between fibers and the surrounding matrix. Isoform Alpha-7X1A and isoform Alpha-7X1B are expressed at myotendinous and neuromuscular junctions; isoform Alpha-7X1C is expressed at neuromuscular junctions and at extrasynaptic sites.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoforms are developmentally regulated during the formation of skeletal muscle. Isoform Alpha-7X1A and isoform Alpha-7X1C are induced upon terminal myogenic differentiation; isoform Alpha-7X1B is present earlier in replicating cells and diminishes upon differentiation.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000007905 Expressed in 10 organ(s), highest expression level in heart

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q63258 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q63258 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via C-terminus intracellular tail region) with CIB1; the interaction is stabilized/increased in a calcium- and magnesium-dependent manner (By similarity). Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-7 associates with beta-1. Interacts with COMP.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q63258

Protein interaction database and analysis system

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IntActi
Q63258, 1 interactor

STRING: functional protein association networks

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STRINGi
10116.ENSRNOP00000058370

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati38 – 103FG-GAP 1PROSITE-ProRule annotationAdd BLAST66
Repeati110 – 165FG-GAP 2PROSITE-ProRule annotationAdd BLAST56
Repeati185 – 238FG-GAP 3PROSITE-ProRule annotationAdd BLAST54
Repeati248 – 305FG-GAP 4PROSITE-ProRule annotationAdd BLAST58
Repeati306 – 367FG-GAP 5PROSITE-ProRule annotationAdd BLAST62
Repeati368 – 423FG-GAP 6PROSITE-ProRule annotationAdd BLAST56
Repeati427 – 486FG-GAP 7PROSITE-ProRule annotationAdd BLAST60
Repeati1111 – 111414
Repeati1119 – 112224
Repeati1127 – 113034

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1111 – 11303 X 4 AA repeats of D-X-H-PAdd BLAST20

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1061 – 1065GFFKR motif5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi908 – 913Poly-Arg6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IPBB Eukaryota
ENOG410XVGZ LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159891

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000015786

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q63258

KEGG Orthology (KO)

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KOi
K06583

Database of Orthologous Groups

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OrthoDBi
743479at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q63258

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.130.10.130, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01839 FG-GAP, 2 hits
PF08441 Integrin_alpha2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01185 INTEGRINA

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00191 Int_alpha, 5 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF69179 SSF69179, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform Alpha-7X1B (identifier: Q63258-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARIPRCDFL GLPGICYLLS FLLAGLLLPR ASAFNLDVMG AIRKEGEPGS
60 70 80 90 100
LFGFSVALHR QLQPRPQSWL LVGAPQALAL PGQQANRTGG LFACPLSLEE
110 120 130 140 150
TDCYRVDIDR GANVQKESKE NQWLGVSVRS QGAGGKVVTC AHRYESRQRV
160 170 180 190 200
DQVLETRDVI GRCFVLSQDL AIRDELDGGE WKFCEGRPQG HEQFGFCQQG
210 220 230 240 250
TAATFSPDSH YLIFGAPGTY NWKGLLFVTN IDSSDPDQLV YKTLDPADRL
260 270 280 290 300
TGPAGDLTLN SYLGFSIDSG KGLMRSEELS FVAGAPRANH KGAVVILRKD
310 320 330 340 350
SASRLIPEVV LSGERLTSGF GYSLAVTDLN SDGWADLIVG APYFFERQEE
360 370 380 390 400
LGGAVYVYMN QGGHWADISP LRLCGSPDSM FGISLAVLGD LNQDGFPDIA
410 420 430 440 450
VGAPFDGDGK VFIYHGSSLG VVTKPSQVLE GEAVGIKSFG YSLSGGLDVD
460 470 480 490 500
GNHYPDLLVG SLADTAALFR ARPVLHVSQE IFIDPRAIDL EQPNCADGRL
510 520 530 540 550
VCVHVKVCFS YVAVPSSYSP IVVLDYVLDG DTDRRLRGQA PRVTFPGRGP
560 570 580 590 600
DDLKHQSSGT VSLKHQHDRV CGDTVFQLQE NVKDKLRAIV VTLSYGLQTP
610 620 630 640 650
RLRRQAPDQG LPLVAPILNA HQPSTQRTEI HFLKQGCGDD KICQSNLQLA
660 670 680 690 700
QAQFCSRISD TEFQALPMDL DGTALFALSG QPFIGLELTV TNLPSDPARP
710 720 730 740 750
QADGDDAHEA QLLATLPASL RYSGVRTLDS VEKPLCLSNE NASHVECELG
760 770 780 790 800
NPMKRGTQVT FYLILSTSGI TIETTELKVE LLLATISEQD LHPVSVRAHV
810 820 830 840 850
FIELPLSISG VATPQQLFFS GKVKGESAMR SERDVGSKVK YEVTVSNQGQ
860 870 880 890 900
SLNTLGSAFL NIMWPHEIAN GKWLLYPMRV ELEGGQGPEK KGICSPRPNI
910 920 930 940 950
LHLDVDSRDR RRRELGQPEP QEPPEKVEPS TSWWPVSSAE KRNVTLDCAQ
960 970 980 990 1000
GTAKCVVFSC PLYSFDRAAV LHVWGRLWNS TFLEEYMSVK SLEVIVRANI
1010 1020 1030 1040 1050
TVKSSIKNLL LRDASTVIPV MVYLDPVAVV AEGVPWWVIL LAVLAGLLVL
1060 1070 1080 1090 1100
ALLVLLLWKL GFFKRAKHPE ATVPQYHAVK ILREDRQQFK EEKTGTIQRS
1110 1120 1130
NWGNSQWEGS DAHPILAADW HPELGPDGHP VSVTA
Length:1,135
Mass (Da):124,194
Last modified:July 10, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEEBA7063537A4AF1
GO
Isoform Alpha-7X1A (identifier: Q63258-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1060-1135: LGFFKRAKHP...PDGHPVSVTA → CGFFRRNSPS...LRPLYPSTTQ

Show »
Length:1,116
Mass (Da):121,678
Checksum:iBBE7FBE7FFEF50A4
GO
Isoform Alpha-7X1C (identifier: Q63258-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1065-1135: RAKHPEATVP...PDGHPVSVTA → CAVPAQRILSIY

Show »
Length:1,076
Mass (Da):117,520
Checksum:i303F816B3547B48E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D4A051D4A051_RAT
Integrin alpha-7
Itga7
1,160Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti79 – 95ALPGQ…LFACP → DSYPDSRQIAHGRPLCLS in CAA46170 (PubMed:1315319).CuratedAdd BLAST17
Sequence conflicti130 – 133SQGA → PRES in CAA46170 (PubMed:1315319).Curated4
Sequence conflicti149R → E in CAA46170 (PubMed:1315319).Curated1
Sequence conflicti225 – 232LLFVTNID → TARVELCAQG in CAA46170 (PubMed:1315319).Curated8
Sequence conflicti236 – 259PDQLV…GDLTL → LAQVDDGPYEAGGEKDQDPR PSPVPA in CAA46170 (PubMed:1315319).CuratedAdd BLAST24
Sequence conflicti378D → H in CAA46170 (PubMed:1315319).Curated1
Sequence conflicti575 – 582VFQLQENV → CVPAAGKR in CAA46170 (PubMed:1315319).Curated8
Sequence conflicti616P → G in CAA46170 (PubMed:1315319).Curated1
Sequence conflicti650A → V in CAA46170 (PubMed:1315319).Curated1
Sequence conflicti678 – 679LS → HG in CAA46170 (PubMed:1315319).Curated2
Sequence conflicti833 – 835RDV → WDE in CAA46170 (PubMed:1315319).Curated3
Sequence conflicti949 – 950AQ → P in CAA46170 (PubMed:1315319).Curated2
Sequence conflicti996V → G in CAA52346 (PubMed:8126096).Curated1
Sequence conflicti996V → G in CAA52347 (PubMed:8126096).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0027341060 – 1135LGFFK…VSVTA → CGFFRRNSPSSSFPANYHRA HLAVQPSAMEAGGPGTVGWD SSSGRSTLRPLYPSTTQ in isoform Alpha-7X1A. 1 PublicationAdd BLAST76
Alternative sequenceiVSP_0027351065 – 1135RAKHP…VSVTA → CAVPAQRILSIY in isoform Alpha-7X1C. 1 PublicationAdd BLAST71

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BC088846 mRNA Translation: AAH88846.1
X65036 mRNA Translation: CAA46170.1
X74293 mRNA Translation: CAA52346.1
X74294 mRNA Translation: CAA52347.1

Protein sequence database of the Protein Information Resource

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PIRi
S38783
S40148
S40149

NCBI Reference Sequences

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RefSeqi
NP_110469.1, NM_030842.1 [Q63258-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSRNOT00000061657; ENSRNOP00000058370; ENSRNOG00000007905 [Q63258-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
81008

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
rno:81008

UCSC genome browser

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UCSCi
RGD:71022 rat [Q63258-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088846 mRNA Translation: AAH88846.1
X65036 mRNA Translation: CAA46170.1
X74293 mRNA Translation: CAA52346.1
X74294 mRNA Translation: CAA52347.1
PIRiS38783
S40148
S40149
RefSeqiNP_110469.1, NM_030842.1 [Q63258-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

CORUMiQ63258
IntActiQ63258, 1 interactor
STRINGi10116.ENSRNOP00000058370

PTM databases

iPTMnetiQ63258
PhosphoSitePlusiQ63258

Proteomic databases

jPOSTiQ63258
PaxDbiQ63258
PRIDEiQ63258

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000061657; ENSRNOP00000058370; ENSRNOG00000007905 [Q63258-1]
GeneIDi81008
KEGGirno:81008
UCSCiRGD:71022 rat [Q63258-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3679
RGDi71022 Itga7

Phylogenomic databases

eggNOGiENOG410IPBB Eukaryota
ENOG410XVGZ LUCA
GeneTreeiENSGT00940000159891
HOGENOMiHOG000015786
InParanoidiQ63258
KOiK06583
OrthoDBi743479at2759
PhylomeDBiQ63258

Enzyme and pathway databases

ReactomeiR-RNO-3000157 Laminin interactions
R-RNO-3000178 ECM proteoglycans

Miscellaneous databases

Protein Ontology

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PROi
PR:Q63258

Gene expression databases

BgeeiENSRNOG00000007905 Expressed in 10 organ(s), highest expression level in heart
ExpressionAtlasiQ63258 baseline and differential
GenevisibleiQ63258 RN

Family and domain databases

Gene3Di2.130.10.130, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 2 hits
PF08441 Integrin_alpha2, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SUPFAMiSSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITA7_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q63258
Secondary accession number(s): Q5HZX9, Q63026, Q63027
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 10, 2007
Last modified: May 8, 2019
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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