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Entry version 157 (12 Aug 2020)
Sequence version 2 (19 Jul 2004)
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Protein

Interleukin-4 receptor subunit alpha

Gene

Il4r

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 (By similarity).By similarity
Isoform 2 (soluble form) inhibits IL4-induced spleen cell proliferation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-6785807, Interleukin-4 and Interleukin-13 signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-4 receptor subunit alpha
Short name:
IL-4 receptor subunit alpha
Short name:
IL-4R subunit alpha
Short name:
IL-4R-alpha
Short name:
IL-4RA
Alternative name(s):
CD_antigen: CD124
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Il4r
Synonyms:Il4ra
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Rat genome database

More...
RGDi
2899, Il4r

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 232ExtracellularSequence analysisAdd BLAST207
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei233 – 256HelicalSequence analysisAdd BLAST24
Topological domaini257 – 801CytoplasmicSequence analysisAdd BLAST545

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25By similarityAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001089226 – 801Interleukin-4 receptor subunit alphaAdd BLAST776

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi34 ↔ 44By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi74 ↔ 86By similarity
Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei164PhosphoserineBy similarity1
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei492PhosphotyrosineBy similarity1
Modified residuei566PhosphotyrosineBy similarity1
Modified residuei594PhosphotyrosineBy similarity1
Modified residuei622PhosphotyrosineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

On IL4 binding, phosphorylated on C-terminal tyrosine residues.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q63257

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q63257

PRoteomics IDEntifications database

More...
PRIDEi
Q63257

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q63257, 5 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q63257

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q63257

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 2 is expressed in kidney, spleen, lung and liver.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000015441, Expressed in liver and 20 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q63257, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain, in immune cells, creates a type I receptor and, in non-immune cells, of IL13RA1 forms a type II receptor. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor.

Interacts with PIK3C3.

Interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP.

Interacts with JAK1 through a Box 1-containing region; inhibited by SOCS5.

Interacts with SOCS5; inhibits IL4 signaling.

Interacts with JAK3.

Interacts with CLM1.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000020994

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q63257

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini125 – 223Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST99

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni439 – 549Required for IRS1 activation and IL4-induced cell growthBy similarityAdd BLAST111
Regioni549 – 644Required for IL4-induced gene expressionBy similarityAdd BLAST96

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi212 – 216WSXWS motif5
Motifi262 – 270Box 1 motif9
Motifi698 – 703ITIM motif6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi375 – 380Poly-Glu6

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502S3Y8, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000049182

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_020561_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q63257

KEGG Orthology (KO)

More...
KOi
K05071

Identification of Orthologs from Complete Genome Data

More...
OMAi
WCPVEVS

Database of Orthologous Groups

More...
OrthoDBi
476828at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q63257

TreeFam database of animal gene trees

More...
TreeFami
TF337996

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063, FN3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR003531, Hempt_rcpt_S_F1_CS
IPR013783, Ig-like_fold
IPR015319, IL-4_rcpt-alpha_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09238, IL4Ra_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265, SSF49265, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853, FN3, 1 hit
PS01355, HEMATOPO_REC_S_F1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q63257-1) [UniParc]FASTAAdd to basket
Also known as: Membrane-bound form, mIL4R

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGWLCTKFLS SVSCLILLWV TGSGGIKVLG DPTCFSDYIR TSTCEWQLDS
60 70 80 90 100
TVDCSSQLLL DYRLLFEFSE NLTCTPKNSA DTVCVCQMAI EEPIQADTYW
110 120 130 140 150
LELWSERGQL WQGSFKPSDN VKPPAPDNLT LHTNVSNALL LMWSNPYPSN
160 170 180 190 200
NFLHKGLICM VNISREDNPA EFKVYNVTYT EPKLSFPVNT LTSGVRYRAR
210 220 230 240 250
VRVLSQSFPG IWSEWSPSIT WYNHFQLPLL QRLPLGVSIS CICILLFCLT
260 270 280 290 300
CYFSIIKIKK IWWDQIPTPA RSPLAAIIIQ DTKVSLWEKQ TRSQESTKSR
310 320 330 340 350
HWKTCLTKLL PCLLEHRVKK ERESPKAAKT KPLQSPEKAG WYPAEVSRTV
360 370 380 390 400
LWPENVHVSV VRCMELFEAP VQNVEEEEDE MVKGDLSMSP ENSGGGFQES
410 420 430 440 450
QADIMARLTE NLFSDLLGAE NGGVGQSSMA ESSSLLPSES GQASTSWACF
460 470 480 490 500
PTGPSETTCQ VTGQQPPHPD PERATGTACT QVPLVISDNP AYRSFSDFSS
510 520 530 540 550
PAPNPGELAS EQKQAGHLEE GDLLSPVDPH SSGPPMQQAE SWEQILHMSV
560 570 580 590 600
LQHGTAGSTP APTSGYQEFV QAVKQGASQD AGVPGVGPSG DTGYKAFSSL
610 620 630 640 650
LSSSGVCTDT AAAGTDSGCG GYKPFQNPVP NQSPNSMPLF TFGLDMELPP
660 670 680 690 700
SPLNSAPPNS TPECLGLELG LKGGTWLKAP PPSEQVPKPF GDDLGLGIVY
710 720 730 740 750
SSLTCHLCGH LKQHHSQEED GQIHVVASPG CGCCYDEKSP SLGNLSGTLE
760 770 780 790 800
SCPGEMSQEA NLTLAPRTPS NLSGVGKGPG HSPVPSQTTE VPVGTLGVTV

S
Length:801
Mass (Da):86,719
Last modified:July 19, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i835E98D5E800EC76
GO
Isoform 2 (identifier: Q63257-2) [UniParc]FASTAAdd to basket
Also known as: Soluble form, sIL4R

The sequence of this isoform differs from the canonical sequence as follows:
     224-229: HFQLPL → PNNVNL
     230-801: Missing.

Show »
Length:229
Mass (Da):26,001
Checksum:iF3C6DE348B1A162F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3W → R in CAA49528 (PubMed:7640343).Curated1
Sequence conflicti138A → G in CAA49528 (PubMed:7640343).Curated1
Sequence conflicti285S → L in CAA49528 (PubMed:7640343).Curated1
Sequence conflicti580 – 582DAG → ARW in CAA49528 (PubMed:7640343).Curated3
Sequence conflicti728S → C in CAA49528 (PubMed:7640343).Curated1
Sequence conflicti776 – 777GK → Q in CAA49528 (PubMed:7640343).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_011118224 – 229HFQLPL → PNNVNL in isoform 2. 1 Publication6
Alternative sequenceiVSP_011119230 – 801Missing in isoform 2. 1 PublicationAdd BLAST572

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X69903 mRNA Translation: CAA49528.1
AB015746 mRNA Translation: BAA78337.1
AB015747 mRNA Translation: BAA78338.1

Protein sequence database of the Protein Information Resource

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PIRi
S31575

NCBI Reference Sequences

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RefSeqi
NP_596871.2, NM_133380.2 [Q63257-1]
XP_006230277.1, XM_006230215.3 [Q63257-1]
XP_006230278.1, XM_006230216.2 [Q63257-1]
XP_008758085.1, XM_008759863.2 [Q63257-1]
XP_008758086.1, XM_008759864.2 [Q63257-1]
XP_017444292.1, XM_017588803.1 [Q63257-1]
XP_017444293.1, XM_017588804.1 [Q63257-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000020994; ENSRNOP00000020994; ENSRNOG00000015441 [Q63257-1]
ENSRNOT00000088073; ENSRNOP00000073767; ENSRNOG00000015441 [Q63257-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
25084

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
rno:25084

UCSC genome browser

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UCSCi
RGD:2899, rat [Q63257-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69903 mRNA Translation: CAA49528.1
AB015746 mRNA Translation: BAA78337.1
AB015747 mRNA Translation: BAA78338.1
PIRiS31575
RefSeqiNP_596871.2, NM_133380.2 [Q63257-1]
XP_006230277.1, XM_006230215.3 [Q63257-1]
XP_006230278.1, XM_006230216.2 [Q63257-1]
XP_008758085.1, XM_008759863.2 [Q63257-1]
XP_008758086.1, XM_008759864.2 [Q63257-1]
XP_017444292.1, XM_017588803.1 [Q63257-1]
XP_017444293.1, XM_017588804.1 [Q63257-1]

3D structure databases

SMRiQ63257
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020994

PTM databases

GlyGeniQ63257, 5 sites
iPTMnetiQ63257
PhosphoSitePlusiQ63257

Proteomic databases

jPOSTiQ63257
PaxDbiQ63257
PRIDEiQ63257

Genome annotation databases

EnsembliENSRNOT00000020994; ENSRNOP00000020994; ENSRNOG00000015441 [Q63257-1]
ENSRNOT00000088073; ENSRNOP00000073767; ENSRNOG00000015441 [Q63257-2]
GeneIDi25084
KEGGirno:25084
UCSCiRGD:2899, rat [Q63257-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3566
RGDi2899, Il4r

Phylogenomic databases

eggNOGiENOG502S3Y8, Eukaryota
GeneTreeiENSGT00510000049182
HOGENOMiCLU_020561_0_0_1
InParanoidiQ63257
KOiK05071
OMAiWCPVEVS
OrthoDBi476828at2759
PhylomeDBiQ63257
TreeFamiTF337996

Enzyme and pathway databases

ReactomeiR-RNO-6785807, Interleukin-4 and Interleukin-13 signaling

Miscellaneous databases

Protein Ontology

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PROi
PR:Q63257

Gene expression databases

BgeeiENSRNOG00000015441, Expressed in liver and 20 other tissues
GenevisibleiQ63257, RN

Family and domain databases

CDDicd00063, FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR003531, Hempt_rcpt_S_F1_CS
IPR013783, Ig-like_fold
IPR015319, IL-4_rcpt-alpha_N
PfamiView protein in Pfam
PF09238, IL4Ra_N, 1 hit
SUPFAMiSSF49265, SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853, FN3, 1 hit
PS01355, HEMATOPO_REC_S_F1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIL4RA_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q63257
Secondary accession number(s): Q9R1W8, Q9WTM8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: August 12, 2020
This is version 157 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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