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Protein

Forkhead box protein D3

Gene

Foxd3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi3 – 97Fork-headPROSITE-ProRule annotationAdd BLAST95

GO - Molecular functioni

  • DNA binding Source: RGD
  • DNA binding transcription factor activity Source: UniProtKB
  • double-stranded DNA binding Source: RGD
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: GO_Central
  • sequence-specific DNA binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein D3
Alternative name(s):
HNF3/FH transcription factor genesis
Hepatocyte nuclear factor 3 forkhead homolog 2
Short name:
HFH-2
Gene namesi
Name:Foxd3
Synonyms:Hfh2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621715 Foxd3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000091819‹1 – ›101Forkhead box protein D3Add BLAST›101

Proteomic databases

PaxDbiQ63245

PTM databases

PhosphoSitePlusiQ63245

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054694

Structurei

Secondary structure

1101
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 17Combined sources10
Turni20 – 22Combined sources3
Helixi26 – 36Combined sources11
Helixi38 – 43Combined sources6
Helixi47 – 59Combined sources13
Beta strandi62 – 64Combined sources3
Beta strandi71 – 73Combined sources3
Beta strandi76 – 78Combined sources3
Helixi83 – 89Combined sources7
Beta strandi94 – 96Combined sources3

3D structure databases

ProteinModelPortaliQ63245
SMRiQ63245
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ63245

Family & Domainsi

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
HOGENOMiHOG000231285
HOVERGENiHBG083674
InParanoidiQ63245
PhylomeDBiQ63245

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequencei

Sequence statusi: Fragment.

Q63245-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LVKPPYSYIA LITMAILQSP QKKLTLSGIC EFISNRFPYY REKFPAWQNS
60 70 80 90 100
IRHNLSLNDC FVKIPREPGN PGKGNYWTLD PQSEDMFDNG SFLRRRKRFK

R
Length:101
Mass (Da):11,943
Last modified:November 1, 1996 - v1
Checksum:iDC0ADEC15A1DD143
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei1011

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13202 mRNA Translation: AAA41319.1
PIRiI60917
UniGeneiRn.92964

Genome annotation databases

UCSCiRGD:621715 rat

Similar proteinsi

Entry informationi

Entry nameiFOXD3_RAT
AccessioniPrimary (citable) accession number: Q63245
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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