UniProtKB - Q63245 (FOXD3_RAT)

BLAST

>sp|Q63245|FOXD3_RAT Forkhead box protein D3 (Fragment) OS=Rattus norvegicus OX=10116 GN=Foxd3 PE=1 SV=1
LVKPPYSYIALITMAILQSPQKKLTLSGICEFISNRFPYYREKFPAWQNSIRHNLSLNDC
FVKIPREPGNPGKGNYWTLDPQSEDMFDNGSFLRRRKRFKR

Align
Format
Add to basket Added to basket
History
Entry version 144 (07 Nov 2018)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Forkhead box protein D3

Gene

Foxd3

Organism

Rattus norvegicus (Rat)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	3 – 97	Fork-headPROSITE-ProRule annotationAdd BLAST		95

GO - Molecular functionⁱ

DNA binding
Source: RGD
Inferred from direct assayⁱ
- 7683413
DNA-binding transcription factor activity Source: UniProtKB
DNA-binding transcription factor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
double-stranded DNA binding
Source: RGD
Inferred from mutant phenotypeⁱ
- 7683413
sequence-specific DNA binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anatomical structure morphogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
in utero embryonic development Source: UniProtKB
negative regulation of transcription by RNA polymerase II Source: UniProtKB
positive regulation of transcription by RNA polymerase II Source: UniProtKB
regulation of transcription, DNA-templated
Source: RGD
Traceable author statementⁱ
- 7683413
regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Developmental protein, DNA-binding, Repressor
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Forkhead box protein D3 Alternative name(s): HNF3/FH transcription factor genesis Hepatocyte nuclear factor 3 forkhead homolog 2 Short name: HFH-2
Gene namesⁱ	Name:Foxd3 Synonyms:Hfh2
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Unplaced

Organism-specific databases

Rat genome database More...RGDⁱ	621715 Foxd3

RGDⁱ

621715 Foxd3

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000091819	‹1 – ›101	Forkhead box protein D3Add BLAST		›101

Proteomic databases

PaxDbⁱ	Q63245
PRIDEⁱ	Q63245

PTM databases

PhosphoSitePlusⁱ	Q63245

PhosphoSitePlusⁱ

Q63245

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000054694

STRINGⁱ

10116.ENSRNOP00000054694

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	8 – 17	Combined sources	10
Turnⁱ	20 – 22	Combined sources	3
Helixⁱ	26 – 36	Combined sources	11
Helixⁱ	38 – 43	Combined sources	6
Helixⁱ	47 – 59	Combined sources	13
Beta strandⁱ	62 – 64	Combined sources	3
Beta strandⁱ	71 – 73	Combined sources	3
Beta strandⁱ	76 – 78	Combined sources	3
Helixⁱ	83 – 89	Combined sources	7
Beta strandⁱ	94 – 96	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q63245
SMRⁱ	Q63245
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q63245

EvolutionaryTraceⁱ

Q63245

Family & Domainsⁱ

Phylogenomic databases

eggNOGⁱ	KOG2294 Eukaryota COG5025 LUCA
HOGENOMⁱ	HOG000231285
HOVERGENⁱ	HBG083674
InParanoidⁱ	Q63245
PhylomeDBⁱ	Q63245

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00059 FH, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR001766 Fork_head_dom IPR018122 TF_fork_head_CS_1 IPR030456 TF_fork_head_CS_2 IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00250 Forkhead, 1 hit
PRINTSⁱ	PR00053 FORKHEAD
SMARTⁱ	View protein in SMART SM00339 FH, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS00657 FORK_HEAD_1, 1 hit PS00658 FORK_HEAD_2, 1 hit PS50039 FORK_HEAD_3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Fragment.

Q63245-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
LVKPPYSYIA LITMAILQSP QKKLTLSGIC EFISNRFPYY REKFPAWQNS 
        60         70         80         90        100
IRHNLSLNDC FVKIPREPGN PGKGNYWTLD PQSEDMFDNG SFLRRRKRFK 

R

Length:101

Mass (Da):11,943

Last modified:November 1, 1996 - v1

Checksum:ⁱDC0ADEC15A1DD143

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	1			1
Non-terminal residueⁱ	101			1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L13202 mRNA Translation: AAA41319.1
PIRⁱ	I60917
UniGeneⁱ	Rn.92964

Genome annotation databases

UCSC genome browser More...UCSCⁱ	RGD:621715 rat

UCSCⁱ

RGD:621715 rat

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q63245	Forkhead box protein D3 (Fragment)		ANAPL		83	UniRef100_Q63245
Forkhead box D3 (Fragment)		CAPHI		85
forkhead box protein D3		TARSY		120
UPI00022577DE		CANLF		495
UPI000940181F		MELGA		83
+2

Protein	Similar proteins		Species	Score	Length	Source
Q63245	Forkhead box protein D3 (Fragment)		ANAPL		83	UniRef90_Q63245
Forkhead box D3 (Fragment)		CAPHI		85
forkhead box protein D3		TARSY		120
Forkhead box D3		CANLF		439
UPI000940181F		MELGA		83
+3

Protein	Similar proteins		Species	Score	Length	Source
Q63245	Forkhead box protein D3		MOUSE		465	UniRef50_Q61060
Forkhead box protein D3		CHICK		394
Forkhead box protein D3		HUMAN		478
Uncharacterized protein		ASTMX		424
Forkhead box D3		CANLF		439
+93

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L13202 mRNA Translation: AAA41319.1
PIRⁱ	I60917
UniGeneⁱ	Rn.92964

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2HDC	NMR	-	A	2-98	[»]
	2HFH	NMR	-	A	2-101	[»]
ProteinModelPortalⁱ	Q63245
SMRⁱ	Q63245
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000054694

STRINGⁱ

10116.ENSRNOP00000054694

PTM databases

PhosphoSitePlusⁱ	Q63245

PhosphoSitePlusⁱ

Q63245

Proteomic databases

PaxDbⁱ	Q63245
PRIDEⁱ	Q63245

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

UCSCⁱ	RGD:621715 rat

UCSCⁱ

RGD:621715 rat

Organism-specific databases

RGDⁱ	621715 Foxd3

Phylogenomic databases

eggNOGⁱ	KOG2294 Eukaryota COG5025 LUCA
HOGENOMⁱ	HOG000231285
HOVERGENⁱ	HBG083674
InParanoidⁱ	Q63245
PhylomeDBⁱ	Q63245

Miscellaneous databases

EvolutionaryTraceⁱ	Q63245

EvolutionaryTraceⁱ

Q63245

Family and domain databases

CDDⁱ	cd00059 FH, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR001766 Fork_head_dom IPR018122 TF_fork_head_CS_1 IPR030456 TF_fork_head_CS_2 IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF00250 Forkhead, 1 hit
PRINTSⁱ	PR00053 FORKHEAD
SMARTⁱ	View protein in SMART SM00339 FH, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS00657 FORK_HEAD_1, 1 hit PS00658 FORK_HEAD_2, 1 hit PS50039 FORK_HEAD_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FOXD3_RAT
Accessionⁱ	Q63245Primary (citable) accession number: Q63245
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	November 1, 1996
	Last modified:	November 7, 2018
	This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q63245 (FOXD3_RAT)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Forkhead box protein D3

Foxd3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ