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Entry version 116 (12 Aug 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Apical endosomal glycoprotein

Gene

Mamdc4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably involved in the sorting and selective transport of receptors and ligands across polarized epithelia.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Apical endosomal glycoprotein
Alternative name(s):
MAM domain-containing protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mamdc4
Synonyms:Aegp
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
708583, Mamdc4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 1155ExtracellularSequence analysisAdd BLAST1134
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1156 – 1176HelicalSequence analysisAdd BLAST21
Topological domaini1177 – 1216CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 211 PublicationAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002063422 – 1216Apical endosomal glycoproteinAdd BLAST1195

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi205N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi231 ↔ 243PROSITE-ProRule annotation
Disulfide bondi238 ↔ 256PROSITE-ProRule annotation
Disulfide bondi250 ↔ 267PROSITE-ProRule annotation
Glycosylationi291N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi341N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi368N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi456 ↔ 467PROSITE-ProRule annotation
Disulfide bondi463 ↔ 480PROSITE-ProRule annotation
Disulfide bondi474 ↔ 489PROSITE-ProRule annotation
Glycosylationi639N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi839N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q63191

PRoteomics IDEntifications database

More...
PRIDEi
Q63191

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q63191, 6 sites

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Apical endosomal tubules of developing rat intestinal epithelial cells.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000022390

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q63191

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 54LDL-receptor class A 1; truncatedPROSITE-ProRule annotationAdd BLAST28
Domaini62 – 224MAM 1PROSITE-ProRule annotationAdd BLAST163
Domaini229 – 269LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST41
Domaini268 – 427MAM 2PROSITE-ProRule annotationAdd BLAST160
Domaini454 – 491LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST38
Domaini492 – 647MAM 3PROSITE-ProRule annotationAdd BLAST156
Domaini654 – 813MAM 4PROSITE-ProRule annotationAdd BLAST160
Domaini812 – 973MAM 5PROSITE-ProRule annotationAdd BLAST162
Domaini972 – 1142MAM 6PROSITE-ProRule annotationAdd BLAST171

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3627, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q63191

Database of Orthologous Groups

More...
OrthoDBi
72691at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q63191

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00112, LDLa, 2 hits
cd06263, MAM, 5 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.400.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320, ConA-like_dom_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR000998, MAM_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00057, Ldl_recept_a, 1 hit
PF00629, MAM, 6 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261, LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00192, LDLa, 2 hits
SM00137, MAM, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899, SSF49899, 6 hits
SSF57424, SSF57424, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01209, LDLRA_1, 2 hits
PS50068, LDLRA_2, 2 hits
PS50060, MAM_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q63191-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCLPSCLLSI WVLFMAAQSL GKTWVPDHCR SPTEATCNFV CDCGDCSDEA
60 70 80 90 100
QCGFHGASTT PNTPFTCNFE QDPCGWQDIS TSGYRWLRDR AGAGLDSSGP
110 120 130 140 150
HSDHTRGTDL GWYMAVGTHS GKEPSTRTLR SPVMREAAPT CELRLWYHTD
160 170 180 190 200
SRDVAELRLD LTHGMETLTL WQSSGPWGPW PGRELAVNTG RIQGDFKVTF
210 220 230 240 250
SATRNATHRG AVALDDMEFW DCGLPIPQAR CPLGHHHCQN KACVEPHQLC
260 270 280 290 300
DGEDNCGDSS DEDPLICSHH MATDFETGLG PWTQLEGWTR NFSAGSMVSP
310 320 330 340 350
AWPHRDHSRN SAYGFFLVSV AKPGTTAVLY SPEFQGSVSY NCSFTFYYYL
360 370 380 390 400
HGSEANQFQL FVQAQGLNTT QPPVLLRSRH GELGTAWVRD RVNIQSAHPF
410 420 430 440 450
RILLAGETGP GGFVGLDDLI MSNHCILVPG MSTLQSSLSG PVPLALYPQT
460 470 480 490 500
SIKRTCDAGH LSCDELCVPP EQLCDFQQHC AEGEDEEKCG TTDFESASAG
510 520 530 540 550
GWEDISIGKL QWQRAEAQES GKPARDTNRN APGHFLSLRK AWGQLRSEAR
560 570 580 590 600
ALTPTLGPSG PHCELHMTYY FHSHPQGFLA LAVVENGFRE LLWQAPSSSS
610 620 630 640 650
GGWTLQKILL GARRWPFQLE FVSLVDLDGP GQQGAGVDNV TLRDCNPMVT
660 670 680 690 700
TESDQEVSCN FERDSCSWHT GHLTDAHWHR VKSHGSQYDH TTGQGFFMFL
710 720 730 740 750
DPMDPPARGQ GALLLTRPQV PVVPKECLSF WYHLHGPQIG TLCLAMRREG
760 770 780 790 800
EEDTLLWSRS GTHGNRWHQA WVTLHHQLQP STKYQLLFEG LRDGYHGTMG
810 820 830 840 850
LDDMAVRPGP CWAAKRCSFE DSDCGFSPGD WGLWTRQNNA SGLGPWGPWI
860 870 880 890 900
DHTTGTAQGH YMVVDTSPNL LPKGHVASLT SEEHPPLSRP ACLSFWYHLS
910 920 930 940 950
FHNPGTLRVF VEESTRRQEL SISGHGGFAW RLGSVNVQAE QAWKVVFEAM
960 970 980 990 1000
ASGVEHSYMA LDDISLQDGP CAQPGSCDFE SGLCGWSHLP WPGLGGYSWD
1010 1020 1030 1040 1050
WSSGATPSRY PRPSVDHTVG TEAGHFAFFE TSVLGPGGQA AWLGSEPLPA
1060 1070 1080 1090 1100
TAVSCLHFWY YMGFPAHFYK GELRVLLSST QGQLAVWHRG GHLRDQWLQV
1110 1120 1130 1140 1150
QIEVSSSEEF QIVFEATLGG QPALGPIALD DVEYLAGQHC KQPTPSQGRV
1160 1170 1180 1190 1200
AAPVSVPVAV GGALLLFLLL LGLGGWHWLQ KQHLPCQSTD AAASGFDNIL
1210
FNADQVTLPE SITSNP
Length:1,216
Mass (Da):133,777
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i64F3B28A7B61BA2E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1LMU6F1LMU6_RAT
Apical endosomal glycoprotein
Mamdc4
1,215Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L37380 mRNA Translation: AAA65200.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A55620

NCBI Reference Sequences

More...
RefSeqi
NP_665711.1, NM_145768.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
252882

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:252882

UCSC genome browser

More...
UCSCi
RGD:708583, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37380 mRNA Translation: AAA65200.1
PIRiA55620
RefSeqiNP_665711.1, NM_145768.1

3D structure databases

SMRiQ63191
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022390

PTM databases

GlyGeniQ63191, 6 sites

Proteomic databases

PaxDbiQ63191
PRIDEiQ63191

Genome annotation databases

GeneIDi252882
KEGGirno:252882
UCSCiRGD:708583, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
158056
RGDi708583, Mamdc4

Phylogenomic databases

eggNOGiKOG3627, Eukaryota
InParanoidiQ63191
OrthoDBi72691at2759
PhylomeDBiQ63191

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q63191

Family and domain databases

CDDicd00112, LDLa, 2 hits
cd06263, MAM, 5 hits
Gene3Di4.10.400.10, 2 hits
InterProiView protein in InterPro
IPR013320, ConA-like_dom_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR000998, MAM_dom
PfamiView protein in Pfam
PF00057, Ldl_recept_a, 1 hit
PF00629, MAM, 6 hits
PRINTSiPR00261, LDLRECEPTOR
SMARTiView protein in SMART
SM00192, LDLa, 2 hits
SM00137, MAM, 5 hits
SUPFAMiSSF49899, SSF49899, 6 hits
SSF57424, SSF57424, 2 hits
PROSITEiView protein in PROSITE
PS01209, LDLRA_1, 2 hits
PS50068, LDLRA_2, 2 hits
PS50060, MAM_2, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAEGP_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q63191
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: August 12, 2020
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome
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