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Protein

Translation initiation factor eIF-2B subunit delta

Gene

Eif2b4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.

GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: RGD
  • translation initiation factor activity Source: UniProtKB
  • translation initiation factor binding Source: RGD

GO - Biological processi

  • hippocampus development Source: RGD
  • myelination Source: UniProtKB
  • negative regulation of guanyl-nucleotide exchange factor activity Source: RGD
  • oligodendrocyte development Source: UniProtKB
  • ovarian follicle development Source: UniProtKB
  • response to glucose Source: UniProtKB
  • response to heat Source: UniProtKB
  • response to peptide hormone Source: UniProtKB
  • T cell receptor signaling pathway Source: UniProtKB
  • translational initiation Source: UniProtKB

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor eIF-2B subunit delta
Alternative name(s):
eIF-2B GDP-GTP exchange factor subunit delta
Gene namesi
Name:Eif2b4
Synonyms:Eif2bd
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620208 Eif2b4

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001560702 – 524Translation initiation factor eIF-2B subunit deltaAdd BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei12PhosphoserineBy similarity1
Modified residuei86PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ63186

PTM databases

iPTMnetiQ63186
PhosphoSitePlusiQ63186

Interactioni

Subunit structurei

Complex of five different subunits; alpha, beta, gamma, delta and epsilon.

GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: RGD
  • translation initiation factor binding Source: RGD

Structurei

3D structure databases

ProteinModelPortaliQ63186
SMRiQ63186
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000176924
HOVERGENiHBG051459
InParanoidiQ63186
KOiK03680

Family and domain databases

InterProiView protein in InterPro
IPR000649 IF-2B-related
IPR037171 NagB/RpiA_transferase-like
PfamiView protein in Pfam
PF01008 IF-2B, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63186-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVAVAVRE ESRSEMKTEL SPRPGAAGRE LTQEEKLQLR KEKKQQKKKR
60 70 80 90 100
KEEKGADQEI GSAVSAAQRQ DPVRELQGTG SQLGGTTGEK LPAGRSKAEL
110 120 130 140 150
RAERRAKQEA ERALKQARKG EQGGPSPQAC PSTAGEATSG VKRVPEHTQA
160 170 180 190 200
DDPTLLRRLL RKPDRQQVPT RKDYGSKVSL FSHLPQYSRQ SSLTQYMSIP
210 220 230 240 250
SSVIHPAMVR LGLQYSQGLV SGSNARCIAL LHALQQVIQD YTTPPNEELS
260 270 280 290 300
RDLVNKLKPY ISFLTQCRPM SASMCNAIKF FNKEVTGMSS SKREEEAKSE
310 320 330 340 350
LKEAIDRYVQ EKIVLASQAI SRFASKKISD GDVILVYGCS SLVSRILQEA
360 370 380 390 400
WVEGRRFRVV VVDSRPRLEG RHMLHCLVRA GVPTSYLLIP AASYVLPEVS
410 420 430 440 450
KVLLGAHALL ANGSVMSRVG TAQLALVARA HNVPVLVCCE TYKFCERVQT
460 470 480 490 500
DAFVSNELDD PDDLQCKRGD QVTLANWQNN SSLRLLNLVY DVTPPELVDL
510 520
VITELGMIPC SSVPVVLRVK SSDQ
Length:524
Mass (Da):57,809
Last modified:November 1, 1997 - v1
Checksum:i4B63F2AB10313924
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48225 mRNA Translation: CAA88256.1
PIRiS71961
RefSeqiNP_446402.1, NM_053950.1
UniGeneiRn.11060

Genome annotation databases

GeneIDi117019
KEGGirno:117019

Similar proteinsi

Entry informationi

Entry nameiEI2BD_RAT
AccessioniPrimary (citable) accession number: Q63186
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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