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Entry version 114 (10 Feb 2021)
Sequence version 2 (05 Feb 2008)
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Protein

Dynein heavy chain 7, axonemal

Gene

Dnah7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi165 – 172ATPSequence analysis8
Nucleotide bindingi1361 – 1368ATPSequence analysis8
Nucleotide bindingi1642 – 1649ATPSequence analysis8
Nucleotide bindingi2009 – 2016ATPSequence analysis8
Nucleotide bindingi2374 – 2381ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dynein heavy chain 7, axonemal
Alternative name(s):
Axonemal beta dynein heavy chain 7
Axonemal dynein heavy chain b
Ciliary dynein heavy chain 7
Dynein-like protein 7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dnah7
Synonyms:Axob, Dlp7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
621798, Dnah7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003176671 – 4057Dynein heavy chain 7, axonemalAdd BLAST4057

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q63170

PRoteomics IDEntifications database

More...
PRIDEi
Q63170

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q63170

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated during ciliogenesis.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The dynein complex consists of at least two heavy chains and a number of intermediate and light chains.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000016465

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q63170

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1323 – 1544AAA 1By similarityAdd BLAST222
Regioni1604 – 1835AAA 2By similarityAdd BLAST232
Regioni1971 – 2222AAA 3By similarityAdd BLAST252
Regioni2335 – 2588AAA 4By similarityAdd BLAST254
Regioni2605 – 2906StalkBy similarityAdd BLAST302
Regioni2987 – 3217AAA 5By similarityAdd BLAST231
Regioni3430 – 3653AAA 6By similarityAdd BLAST224

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili716 – 779Sequence analysisAdd BLAST64
Coiled coili2602 – 2646Sequence analysisAdd BLAST45
Coiled coili2860 – 2916Sequence analysisAdd BLAST57

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3595, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q63170

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q63170

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.8.710, 1 hit
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.10.490.20, 1 hit
3.20.180.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR035699, AAA_6
IPR035706, AAA_9
IPR041658, AAA_lid_11
IPR042219, AAA_lid_11_sf
IPR041589, DNAH3_AAA_lid_1
IPR042228, Dynein_2_C
IPR042222, Dynein_2_N
IPR043157, Dynein_AAA1S
IPR041466, Dynein_AAA5_ext
IPR041228, Dynein_C
IPR043160, Dynein_C_barrel
IPR024743, Dynein_HC_stalk
IPR024317, Dynein_heavy_chain_D4_dom
IPR004273, Dynein_heavy_D6_P-loop
IPR013602, Dynein_heavy_dom-2
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12774, AAA_6, 1 hit
PF12780, AAA_8, 1 hit
PF12781, AAA_9, 1 hit
PF17857, AAA_lid_1, 1 hit
PF18198, AAA_lid_11, 1 hit
PF08393, DHC_N2, 1 hit
PF17852, Dynein_AAA_lid, 1 hit
PF18199, Dynein_C, 1 hit
PF03028, Dynein_heavy, 1 hit
PF12777, MT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q63170-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSEQVRAGS PGSRVPGARR TGAVWTAPSE NLDSSTIPAL CVSLLFPSQP
60 70 80 90 100
LDVVVTMGHN TLGMRQLWKL ALQRPQLLSG STGVKPQWQQ TAPSFHLNVK
110 120 130 140 150
QENPIEPYNV KNEQSYAEYM EHFGKKGKLL DQIDDTRSAP STSRSKVKSP
160 170 180 190 200
HKERENFRST LVNVIMQQDS SLEPDVTDES GIPKATTSAI EKDILRYYYY
210 220 230 240 250
IHHGIDTDNV APMEDSWLEH VLQLVPQHLK VLTNSITVLS DEMREDYLLS
260 270 280 290 300
VKKSIVDFVL KDPREKEDDT KITELPPHRA EMEVLPKPWR RSFLSACSYI
310 320 330 340 350
RDHLNAMNPT MLAVLDLWHS TFKKLRLVDI EEFHNRQDAL ELSGFQNIVI
360 370 380 390 400
KHMESAKETL LKTWFPEVQN IYYQGNKKKQ LPTGDSSAKL ESFFNCAATL
410 420 430 440 450
MTLQLQDLIL VSMQDFTDLI AQPPESIRAF EHPGFIMRLV LDKKAVKFEP
460 470 480 490 500
EFTDYIDILV NVYEIMIKAV SFVPRVETKL YSKWESKSKP TTLKPIILDE
510 520 530 540 550
IIDAHKEKIR EVVLRESVAP TEHLKMYDKY QFLITRQAEQ DIEEFLTQSQ
560 570 580 590 600
NYERLIEEIR KYQKLGEEIQ YTSRKTVRLG MFEMHCEELI RSLVKRADII
610 620 630 640 650
CGKLIAKMFR DHQEVNTMLC EEFEKIAEKA LSTPPNTAEL MEMKAHIQKV
660 670 680 690 700
ETTDMLDLGQ RLVDSKNCLA FLIECVNFSP ADIRLNNSVF QWYGRMGEIF
710 720 730 740 750
DEHRKIIKDK TEQYQEGLKL RCERFVEELE SYAKQAEEFY TFGDLQDVQR
760 770 780 790 800
YLKKAQVLNS KLDAAADKIE QFNAEEEAFG WIPSVYPQRK KIQDGLNPYL
810 820 830 840 850
RLYETAVEFS TKHRAWTEGP YHKVNPDQVE ADVGNYWRGL YKLEKAFHDS
860 870 880 890 900
PNALAMTKKV RARVEDFKQY IPLVQVICNP GLRPRHWEAM SAIVGYPLQP
910 920 930 940 950
SDDSTVFSFI DMNLEPFLDR FEGISEAASK EYSLEKSMDK MMTEWEAMEF
960 970 980 990 1000
VIHPYRESGT FILSAVDDIQ MLLDDHIIKT QTMRGSPFIK PYEKQMREWE
1010 1020 1030 1040 1050
GKLLLLQEIL DEWLKVQATW LYLEPIFSSP DIMSQMPEEG RRFTAVDKTW
1060 1070 1080 1090 1100
RDVMKMVVQN KHVLAVVTIE RMLERMKKSN ELLELILKGL NEYLEKKRLF
1110 1120 1130 1140 1150
FPRFFFLSND ELLEILSETK DPTRVQPHLK KCFEGIARVE FTETLDITHM
1160 1170 1180 1190 1200
KSSEGEVVEL VDTISTTKAR GQVEKWLVEL ERIMIKSIHK VIGDAITAYT
1210 1220 1230 1240 1250
KNARINWVRD WPGQTVLCVS QTFWTVEVQV AIPMGHKALE DYLGKCNHQI
1260 1270 1280 1290 1300
DDIVTLVRGK LSKQNRVTLG ALVVLDVHAR DVLANLVKKR ISDDTDFEWL
1310 1320 1330 1340 1350
SQLRYYWHEN NLETKMINAG LRYGYEYLGN SPRMVLAPFC DYCFLTLFGA
1360 1370 1380 1390 1400
LHLHLGGAPE GPAGTGKTET TKDLAKAVAK QCVVFNCSDG LDYLALGKFF
1410 1420 1430 1440 1450
KGLLSCGAWA CFDEFNRIDL EVLSVVAQQI LTIQIGINSG TELLVFEGTE
1460 1470 1480 1490 1500
LKLDPTCAVF ITMNPGYAGR SELPDNLKAL FRTVAMMVPD YAMIAEIVLY
1510 1520 1530 1540 1550
SCGFVTARPL SIKIVATYRL CSEQLSSQHH YDYGMRAVKS VLTAAGNLKL
1560 1570 1580 1590 1600
KYPNENEEIL LLRSIIDVNL PKFLSHDLPL FEGITSDLFP GVKLPKPDYN
1610 1620 1630 1640 1650
DLLAAIRENC HSMNLQMTNF FSEKILQIYE MMIVRHGFMI VGEPFGGKTS
1660 1670 1680 1690 1700
AYRVLAGALG DICEKGLMEE NKVQITVLNP KSVTMGQLYG QFDLVSHEWS
1710 1720 1730 1740 1750
DGILAVSFRA FAASSTPDRK WLIFDGPVDA VWIENMNTVL DDNKKLCLMS
1760 1770 1780 1790 1800
GEIIQMSPQM NLIFEPMDLE VASPATVSRC GMIYMEPQML GWRPLMVSWI
1810 1820 1830 1840 1850
NTLPQSVSII QKEFIEGLFD RMVPLSVEFI RRHTKELSPT SDTNLVRSLM
1860 1870 1880 1890 1900
NLIDCFMDDF ADENKQKERN DRENFSLLEG IFLFSLIWSV GASCTADDRI
1910 1920 1930 1940 1950
KYNKILRELM EGPISDLTRN KFKLLSGTEQ TSSKALTVPF PEKGTIYDYQ
1960 1970 1980 1990 2000
FIPEGLGRWD QWIKKLADTP PIPKDVQFNE IIVPTLDTVR YSALMSLLTT
2010 2020 2030 2040 2050
HQKPSIFVGP TGTGKSVYII NFLLNQLNKD IYKPLIVNFS AQTTAAQTQN
2060 2070 2080 2090 2100
IIMSKLDKRR KGVFGPPLGK RMIVFVDDVN MPAREVYGAQ PPIELLRQWL
2110 2120 2130 2140 2150
DHWNWYDLKD CSMIKLVDIQ IMCAMGPPGG GRNPITPRYM RHFNIITINE
2160 2170 2180 2190 2200
FSDKSMFTIF SRILTWHLRT CYKFPDDFLD LTTQIVNGTM TLYKDAMKNL
2210 2220 2230 2240 2250
LPTPAKSHYL FNLRDFSRVI QGVCLSRPET AENKEAIKRL WVHEVLRVYY
2260 2270 2280 2290 2300
DRLLDNADRS WLVNYIQEIL RNYMQEDFHD LFKNLDFDND GIVEEDDLRS
2310 2320 2330 2340 2350
LMFCDFHDPK REDFGYREIP NVDALRVIVE GHLDEYNNMS KKPMNLVLFR
2360 2370 2380 2390 2400
FAIEHISRIS RILKQPRSHA LLVGVGGSGR QSVTRLAAHM ADYSLFQVEI
2410 2420 2430 2440 2450
SKGYGSHEWH EDLKVILRKC AEGDMQGVFL FTDTQIKRES FLEDVNNLLN
2460 2470 2480 2490 2500
AGEVPNLFAL DEKQEICEKM RQLDRQRDKT KQTDGSPIAL FNMFIDRCRN
2510 2520 2530 2540 2550
QLHVVLAMSP IGDAFRIRLR KFPALVNCCT IDWFQSWPED ALEAVASRFL
2560 2570 2580 2590 2600
EDIEMSEEIR EGCIDMCKSF HTSTINLSTT FHNELQRYNY VTPTSYLELI
2610 2620 2630 2640 2650
STFKLLLEKK RNEVMKMKRR YEVGLDKLDS ASSQVATMQG ELEALHPQLK
2660 2670 2680 2690 2700
VASRQVDDMM IMIEKESIEV AKTEKIVKAD ETVANDQAMA AKAIKDECDA
2710 2720 2730 2740 2750
DLAEALPILE SALAALDTLT AQDITVVKSM KSPPAGVKLV MEAICILKGI
2760 2770 2780 2790 2800
KADKIPDPTG SGKKIEDFWG PAKRLLGDIR FLQSLHEYDK DNIPPAYMNI
2810 2820 2830 2840 2850
IRKSYIPNPD FVPEKIRNAS TAAEGLCKWV IAMDSYDKVA KIVAPKKIKL
2860 2870 2880 2890 2900
AAAEGELRIA MEGLRKKQAA LREVQDKLAK LQDTLELNKQ KKADLENQVD
2910 2920 2930 2940 2950
LCSKKLERAE QLIGGLGGEK TRWSNSALEL GHLYVNLTGD ILISSGVVAY
2960 2970 2980 2990 3000
LGAFTSNYRQ HQTKEWSHSC KERDIPCSDD YSLMGTLGEA VTIRAWNIAG
3010 3020 3030 3040 3050
LPSDLFSIDN GIIIMNARRW PLMIDPQGQA NKWIKNMEKT NSLQLIKLSD
3060 3070 3080 3090 3100
PDYVRTLENC IQFGTPVLLE NVGEELDPIL EPLLLKQTFK QGGSTCIRLG
3110 3120 3130 3140 3150
DSTIEYAPDF RFYITTKLRN PHYLPETSVK VTLLNFMITP EGMQDQLLGI
3160 3170 3180 3190 3200
VVARERPDLE EEKQALILQG AENKRQLKEI EDKILEVLSS SEGNILEDET
3210 3220 3230 3240 3250
AIKILSSSKA LANEISQKQE VAEETEKKID NTRMGYRPIA VHSSILFFSI
3260 3270 3280 3290 3300
ADLANIEPMY QYSLTWFINL FILSIENSEK SDILSQRLHI LRDHFTYSLY
3310 3320 3330 3340 3350
VNICRSLFEK DKMLFSFCLT VNLLIHENAI NKAEWRFLLT GGIGLDNPYT
3360 3370 3380 3390 3400
NPCTWLPQKS WDEICRLDEL HAFKTIRREF MRLKEGWKKV YDSMEPHHEI
3410 3420 3430 3440 3450
FPEEWENKAN DFQRMLIIRC LRPDKVIPML QEFIIKKLGR SFIEPPPFDL
3460 3470 3480 3490 3500
AKAFGDSNCC APLIFVLSPG ADPMNALLKF ADDQGYGGSK LSSLSLGQGQ
3510 3520 3530 3540 3550
GPIAMKMLEK AVKDGTWVVL QNCHLATSWM PTLEKVCEEL SPESTHPDFR
3560 3570 3580 3590 3600
IWLTSYPSPN FPVSVLQNGV KMTNEAPKGL RANIIRSYLM DPISDPEFFG
3610 3620 3630 3640 3650
SCRKPEEFKK LLYGLCFFHA LVQERRKFGP LGWNIPYEFN ETDLRISVQQ
3660 3670 3680 3690 3700
LHMFLNQYEE LPYDALRYMT GECNYGGRVT DDWDRRTLRS ILNKFFCTEL
3710 3720 3730 3740 3750
VENPQYKFDS SGIYFVPPSG DHKSYIEYTK TLPLIPDPEI FGMNANADIT
3760 3770 3780 3790 3800
KDQSETQLLF DNILLTQSRS SGSGAKSSDE VVNEVAGDIL GKLPNNFDIE
3810 3820 3830 3840 3850
SAMRRYPTTY TQSMNTVLVQ EMGRFNKLLI TIRESCINIQ KAIKGLVVMS
3860 3870 3880 3890 3900
TELEEVVSSI LNVKIPGMWM GKSYPSLKPL GSYVNDFLAR LKFLQQWYEV
3910 3920 3930 3940 3950
GPPPVFWLSG FFFTQAFLTG AQQNYARKFT IPIDLLGFDY EVMDDKEYKN
3960 3970 3980 3990 4000
APEDGVYIHG LFLDGASWNR KTKKLAESHP KVLYDTVPVM WLKPCKKSDI
4010 4020 4030 4040 4050
PKRPSYVAPL YKTSERRGTL STTGHSTNFV IAMILPSDQP KEHWIGRGVA

LLCQLNS
Length:4,057
Mass (Da):464,557
Last modified:February 5, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iECFA19724BABCFD4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JYD0A0A0G2JYD0_RAT
Dynein heavy chain 7, axonemal
Dnah7
3,697Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2Q612A0A1W2Q612_RAT
Dynein heavy chain 7, axonemal
Dnah7
2,712Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2Q624A0A1W2Q624_RAT
Dynein heavy chain 7, axonemal
Dnah7
953Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1449 – 1451TEL → NRT in BAA05506 (PubMed:7657712).Curated3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AABR03068169 Genomic DNA No translation available.
AABR03068266 Genomic DNA No translation available.
AABR03068762 Genomic DNA No translation available.
AABR03068958 Genomic DNA No translation available.
AABR03068975 Genomic DNA No translation available.
AABR03069173 Genomic DNA No translation available.
AABR03069339 Genomic DNA No translation available.
AABR03069471 Genomic DNA No translation available.
AABR03070154 Genomic DNA No translation available.
AABR03071231 Genomic DNA No translation available.
AABR03071501 Genomic DNA No translation available.
AABR03071646 Genomic DNA No translation available.
AABR03071706 Genomic DNA No translation available.
AABR03071857 Genomic DNA No translation available.
AABR03072256 Genomic DNA No translation available.
D26498 mRNA Translation: BAA05506.1
U32180 mRNA Translation: AAC52363.1

Protein sequence database of the Protein Information Resource

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PIRi
I70177

Genome annotation databases

UCSC genome browser

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UCSCi
RGD:621798, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03068169 Genomic DNA No translation available.
AABR03068266 Genomic DNA No translation available.
AABR03068762 Genomic DNA No translation available.
AABR03068958 Genomic DNA No translation available.
AABR03068975 Genomic DNA No translation available.
AABR03069173 Genomic DNA No translation available.
AABR03069339 Genomic DNA No translation available.
AABR03069471 Genomic DNA No translation available.
AABR03070154 Genomic DNA No translation available.
AABR03071231 Genomic DNA No translation available.
AABR03071501 Genomic DNA No translation available.
AABR03071646 Genomic DNA No translation available.
AABR03071706 Genomic DNA No translation available.
AABR03071857 Genomic DNA No translation available.
AABR03072256 Genomic DNA No translation available.
D26498 mRNA Translation: BAA05506.1
U32180 mRNA Translation: AAC52363.1
PIRiI70177

3D structure databases

SMRiQ63170
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016465

PTM databases

CarbonylDBiQ63170

Proteomic databases

PaxDbiQ63170
PRIDEiQ63170

Genome annotation databases

UCSCiRGD:621798, rat

Organism-specific databases

RGDi621798, Dnah7

Phylogenomic databases

eggNOGiKOG3595, Eukaryota
InParanoidiQ63170
PhylomeDBiQ63170

Miscellaneous databases

Protein Ontology

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PROi
PR:Q63170

Family and domain databases

Gene3Di1.10.8.710, 1 hit
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.10.490.20, 1 hit
3.20.180.20, 1 hit
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR035699, AAA_6
IPR035706, AAA_9
IPR041658, AAA_lid_11
IPR042219, AAA_lid_11_sf
IPR041589, DNAH3_AAA_lid_1
IPR042228, Dynein_2_C
IPR042222, Dynein_2_N
IPR043157, Dynein_AAA1S
IPR041466, Dynein_AAA5_ext
IPR041228, Dynein_C
IPR043160, Dynein_C_barrel
IPR024743, Dynein_HC_stalk
IPR024317, Dynein_heavy_chain_D4_dom
IPR004273, Dynein_heavy_D6_P-loop
IPR013602, Dynein_heavy_dom-2
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF12774, AAA_6, 1 hit
PF12780, AAA_8, 1 hit
PF12781, AAA_9, 1 hit
PF17857, AAA_lid_1, 1 hit
PF18198, AAA_lid_11, 1 hit
PF08393, DHC_N2, 1 hit
PF17852, Dynein_AAA_lid, 1 hit
PF18199, Dynein_C, 1 hit
PF03028, Dynein_heavy, 1 hit
PF12777, MT, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SUPFAMiSSF52540, SSF52540, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDYH7_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q63170
Secondary accession number(s): Q62821
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: February 10, 2021
This is version 114 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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