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Protein

Cadherin-4

Gene

Cdh4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-4
Alternative name(s):
Retinal cadherin
Short name:
R-CAD
Short name:
R-cadherin
Gene namesi
Name:Cdh4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621091 Cdh4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini‹1 – ›296ExtracellularSequence analysisAdd BLAST›296

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000126644‹1 – ›296Cadherin-4Add BLAST›296

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi107N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi236N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

PTM databases

iPTMnetiQ63149
PhosphoSitePlusiQ63149

Structurei

3D structure databases

ProteinModelPortaliQ63149
SMRiQ63149
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini‹1 – 101Cadherin 1PROSITE-ProRule annotationAdd BLAST›101
Domaini102 – 216Cadherin 2PROSITE-ProRule annotationAdd BLAST115
Domaini217 – ›296Cadherin 3PROSITE-ProRule annotationAdd BLAST›80

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Transmembrane

Phylogenomic databases

HOVERGENiHBG106438
InParanoidiQ63149
PhylomeDBiQ63149

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR020894 Cadherin_CS
PfamiView protein in Pfam
PF00028 Cadherin, 3 hits
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 2 hits
SUPFAMiSSF49313 SSF49313, 3 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 2 hits
PS50268 CADHERIN_2, 3 hits

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q63149-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
NVPENSRGPF PQQLVRIRSD KDNDIPIRYS ITGVGADQPP MEVFNIDSMS
60 70 80 90 100
GRMYVTRPMD REERASYHLR AHAVDMNGNK VENPIDLYIY VIDMNDNRPE
110 120 130 140 150
FINQVYNGSV DEGSKPGTYV MTVTANDADD STTANGMVRY RIVTQTPQSP
160 170 180 190 200
SQNMFTINSE TGDIVTVAAG LDREKVQQYT VIVQATDMEG NLNYGLSNTA
210 220 230 240 250
TAIITVTDVN DNPPEFTTST FAGEVPENRI ETVVANLTVM DRDQPHSPNW
260 270 280 290
NAVYRIISGD PSGHFSVRTD PVTNEGMVTV VKAVDYELNR AFMLTI
Length:296
Mass (Da):32,912
Last modified:November 1, 1996 - v1
Checksum:i722FBC3C0A463FE8
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2K728A0A0G2K728_RAT
Cadherin-4
Cdh4
861Annotation score:
A0A0G2JZD0A0A0G2JZD0_RAT
Cadherin-4
Cdh4
256Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei2961

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86742 mRNA Translation: BAA13166.1
UniGeneiRn.214089

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86742 mRNA Translation: BAA13166.1
UniGeneiRn.214089

3D structure databases

ProteinModelPortaliQ63149
SMRiQ63149
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ63149
PhosphoSitePlusiQ63149

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi621091 Cdh4

Phylogenomic databases

HOVERGENiHBG106438
InParanoidiQ63149
PhylomeDBiQ63149

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR020894 Cadherin_CS
PfamiView protein in Pfam
PF00028 Cadherin, 3 hits
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 2 hits
SUPFAMiSSF49313 SSF49313, 3 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 2 hits
PS50268 CADHERIN_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCADH4_RAT
AccessioniPrimary (citable) accession number: Q63149
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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