UniProtKB - Q63148 (CHRD_RAT)
Protein
Chordin
Gene
Chrd
Organism
Rattus norvegicus (Rat)
Status
Functioni
Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity).By similarity
GO - Molecular functioni
- heparin binding Source: RGD
- syndecan binding Source: RGD
GO - Biological processi
- BMP signaling pathway involved in spinal cord dorsal/ventral patterning Source: RGD
- central nervous system development Source: RGD
- dorsal/ventral pattern formation Source: RGD
- forebrain development Source: RGD
- gastrulation with mouth forming second Source: RGD
- mesoderm formation Source: RGD
- negative regulation of BMP signaling pathway Source: RGD
- negative regulation of cell migration Source: RGD
- negative regulation of osteoblast differentiation Source: RGD
- osteoblast differentiation Source: RGD
- pattern specification process Source: RGD
- positive regulation of cell adhesion Source: RGD
- positive regulation of mesenchymal cell proliferation Source: RGD
- skeletal system development Source: RGD
Keywordsi
Molecular function | Developmental protein |
Names & Taxonomyi
Protein namesi | Recommended name: Chordin |
Gene namesi | Name:Chrd |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620181, Chrd |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular space Source: RGD
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_0000219088 | 27 – 951 | ChordinAdd BLAST | 925 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 350 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 433 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 880 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Cleaved by tolloid proteases; cleavage participates in dorsoventral patterning during early development.By similarity
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q63148 |
PRIDEi | Q63148 |
PTM databases
GlyGeni | Q63148, 3 sites |
Interactioni
Subunit structurei
Interacts with TWSG1 and/or BMP4.
By similarityGO - Molecular functioni
- syndecan binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000002394 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 49 – 126 | VWFC 1PROSITE-ProRule annotationAdd BLAST | 78 | |
Domaini | 171 – 280 | CHRD 1PROSITE-ProRule annotationAdd BLAST | 110 | |
Domaini | 282 – 401 | CHRD 2PROSITE-ProRule annotationAdd BLAST | 120 | |
Domaini | 402 – 523 | CHRD 3PROSITE-ProRule annotationAdd BLAST | 122 | |
Domaini | 529 – 649 | CHRD 4PROSITE-ProRule annotationAdd BLAST | 121 | |
Domaini | 702 – 762 | VWFC 2PROSITE-ProRule annotationAdd BLAST | 61 | |
Domaini | 782 – 848 | VWFC 3PROSITE-ProRule annotationAdd BLAST | 67 | |
Domaini | 870 – 930 | VWFC 4PROSITE-ProRule annotationAdd BLAST | 61 |
Sequence similaritiesi
Belongs to the chordin family.Curated
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502QR4J, Eukaryota |
HOGENOMi | CLU_008477_0_0_1 |
InParanoidi | Q63148 |
PhylomeDBi | Q63148 |
Family and domain databases
InterProi | View protein in InterPro IPR016353, Chordin IPR010895, CHRD IPR001007, VWF_dom |
Pfami | View protein in Pfam PF07452, CHRD, 2 hits PF00093, VWC, 3 hits |
PIRSFi | PIRSF002496, Chordin, 1 hit |
SMARTi | View protein in SMART SM00754, CHRD, 4 hits SM00214, VWC, 4 hits |
PROSITEi | View protein in PROSITE PS50933, CHRD, 4 hits PS01208, VWFC_1, 2 hits PS50184, VWFC_2, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q63148-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPSLPAPPAP RLLLGLLLLG SRPAGGTGPE APALPIRSEK EPLPVRGAAG
60 70 80 90 100
CSFGGKVYAL DETWHPDLGE PFGVMRCVLC ACEAPQWARR GRGPGRVSCK
110 120 130 140 150
NIKPQCPTLA CRQPRQLPGH CCQTCPQDAE RSNLDPQPAG LVFEYPRDPE
160 170 180 190 200
HRSYSDRGEP GTGERTRGDG HTEDFVALLT GPRTQAVARA RVSLLRSSLR
210 220 230 240 250
FSISYQRLDR PSRVRFTDPT GNILFEHPAA PTQDGLVCGV WRAVPRLSVR
260 270 280 290 300
LLRAEQLRVA LVTPTHPSEE VWGPLIWQGA LTAETFSAIL TLEDPLQRGV
310 320 330 340 350
GGIALLTLSD TEDALHFLLL FRGLLGGLAH VPLKLQILHQ GQLLRELQAN
360 370 380 390 400
ASAQEPGFAE VLPSLTDQEM DWLVLGELQM VLEKMGGPEL RISGYITTRQ
410 420 430 440 450
SCDVLQSVLC GADALIPVQT GAAGSASFIL LGNGSLIYQV QVIGTGSEVV
460 470 480 490 500
AMTLETKPQR KNQRTVLCHM AGLQLGGHMA VGVCSGLGAR GAHMLLQNEL
510 520 530 540 550
FLNIGTKDFP DGELRGHVTA LCYSGHSAHY DRLPVPLAGA LVLPPVRSQA
560 570 580 590 600
AGHAWLSLDT HCHLHYEVLL AGLGGSEQGT VTAHLLGPPG MPGPQRLLKG
610 620 630 640 650
FYGSEAQGVV KDLEPVLLRH LTQGTASLLI TTKSNPRGEL RGQVHIASQC
660 670 680 690 700
EVGGLRLASE GVRMSLAPNG EAATSPMLPA GPGPEAPVPA KHGSSGRPRD
710 720 730 740 750
PNTCFFEGQQ RPHGARWAPN YDPLCSLCTC QRRTVICDPV VCPPPSCPHP
760 770 780 790 800
VQALDQCCPV CPEKQRSRDL PSLPNLEPGE GCYFDGDRSW RAAGTRWHPV
810 820 830 840 850
VPPFGLIKCA VCTCKGATGE VHCEKVQCPR LACAQPVRAN PTDCCKQCPV
860 870 880 890 900
GSGTHAKLGD PMQADGPRGC RFAGQWFPEN QSWHPSVPPF GEMSCITCRC
910 920 930 940 950
GAGVPHCERD DCSPPLSCGS GKESRCCSHC TAQRSSETRT LPELEKEAQR
S
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A140TA94 | A0A140TA94_RAT | Chordin | Chrd rCG_36702 | 948 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 746 – 749 | SCPH → RCSQ in BAA13128 (Ref. 2) Curated | 4 | |
Sequence conflicti | 757 | C → W in BAA13128 (Ref. 2) Curated | 1 | |
Sequence conflicti | 762 | P → S in BAA13128 (Ref. 2) Curated | 1 | |
Sequence conflicti | 771 | P → S in BAA13128 (Ref. 2) Curated | 1 | |
Sequence conflicti | 810 | A → G in BAA13128 (Ref. 2) Curated | 1 | |
Sequence conflicti | 817 – 818 | AT → VN in BAA13128 (Ref. 2) Curated | 2 | |
Sequence conflicti | 823 | C → S in BAA13128 (Ref. 2) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR03079283 Genomic DNA No translation available. D86581 mRNA Translation: BAA13128.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR03079283 Genomic DNA No translation available. D86581 mRNA Translation: BAA13128.1 |
3D structure databases
SMRi | Q63148 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000002394 |
PTM databases
GlyGeni | Q63148, 3 sites |
Proteomic databases
PaxDbi | Q63148 |
PRIDEi | Q63148 |
Organism-specific databases
RGDi | 620181, Chrd |
Phylogenomic databases
eggNOGi | ENOG502QR4J, Eukaryota |
HOGENOMi | CLU_008477_0_0_1 |
InParanoidi | Q63148 |
PhylomeDBi | Q63148 |
Miscellaneous databases
PROi | PR:Q63148 |
Gene expression databases
Genevisiblei | Q63148, RN |
Family and domain databases
InterProi | View protein in InterPro IPR016353, Chordin IPR010895, CHRD IPR001007, VWF_dom |
Pfami | View protein in Pfam PF07452, CHRD, 2 hits PF00093, VWC, 3 hits |
PIRSFi | PIRSF002496, Chordin, 1 hit |
SMARTi | View protein in SMART SM00754, CHRD, 4 hits SM00214, VWC, 4 hits |
PROSITEi | View protein in PROSITE PS50933, CHRD, 4 hits PS01208, VWFC_1, 2 hits PS50184, VWFC_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CHRD_RAT | |
Accessioni | Q63148Primary (citable) accession number: Q63148 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | March 20, 2007 | |
Last modified: | August 12, 2020 | |
This is version 101 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families