UniProtKB - Q63132 (ROS1_RAT)
Proto-oncogene tyrosine-protein kinase ROS
Ros1
Functioni
Catalytic activityi
- EC:2.7.10.1PROSITE-ProRule annotation
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 1972 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 2071 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 1943 – 1951 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein phosphatase binding Source: RGD
- protein tyrosine kinase activity Source: UniProtKB
- transmembrane receptor protein tyrosine kinase activity Source: GO_Central
GO - Biological processi
- cell differentiation Source: UniProtKB
- columnar/cuboidal epithelial cell development Source: UniProtKB
- gene expression Source: RGD
- multicellular organism development Source: GO_Central
- negative regulation of gene expression Source: RGD
- peptidyl-tyrosine autophosphorylation Source: RGD
- positive regulation of kinase activity Source: GO_Central
- protein phosphorylation Source: UniProtKB
- regulation of cell growth Source: UniProtKB
- regulation of ERK1 and ERK2 cascade Source: UniProtKB
- regulation of phosphate transport Source: RGD
- regulation of TOR signaling Source: UniProtKB
- signal transduction Source: RGD
- spermatogenesis Source: UniProtKB
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Keywordsi
Molecular function | Kinase, Receptor, Transferase, Tyrosine-protein kinase |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Proto-oncogene tyrosine-protein kinase ROS (EC:2.7.10.1)Alternative name(s): Proto-oncogene c-Ros Proto-oncogene c-Ros-1 Receptor tyrosine kinase c-ros oncogene 1 c-Ros receptor tyrosine kinase |
Gene namesi | Name:Ros1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3591, Ros1 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Single-pass type I membrane protein Curated
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
- cell surface Source: RGD
- perinuclear region of cytoplasm Source: RGD
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 28 – 1853 | ExtracellularSequence analysisAdd BLAST | 1826 | |
Transmembranei | 1854 – 1874 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1875 – 2338 | CytoplasmicSequence analysisAdd BLAST | 464 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Sequence analysisAdd BLAST | 27 | |
ChainiPRO_0000278116 | 28 – 2338 | Proto-oncogene tyrosine-protein kinase ROSAdd BLAST | 2311 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 52 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 77 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 333 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 361 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 480 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 623 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 934 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1010 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1298 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1675 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 2266 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 2325 | Phosphotyrosine; by autocatalysisBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q63132 |
PRIDEi | Q63132 |
PTM databases
GlyGeni | Q63132, 10 sites |
PhosphoSitePlusi | Q63132 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSRNOG00000000406, Expressed in pancreas and 15 other tissues |
Genevisiblei | Q63132, RN |
Interactioni
Subunit structurei
Interacts with PTPN11; may activate the PI3 kinase-mTOR signaling pathway.
Interacts with VAV3; constitutive interaction mediating VAV3 phosphorylation.
Interacts with PTPN6 (via SH2 1 domain); the interaction is direct and promotes ROS1 dephosphorylation (By similarity).
By similarityGO - Molecular functioni
- protein phosphatase binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000000459 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 110 – 205 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 206 – 294 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 89 | |
Domaini | 566 – 666 | Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST | 101 | |
Domaini | 942 – 1037 | Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 1038 – 1145 | Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST | 108 | |
Domaini | 1440 – 1548 | Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST | 109 | |
Domaini | 1549 – 1648 | Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST | 100 | |
Domaini | 1650 – 1743 | Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST | 94 | |
Domaini | 1744 – 1845 | Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST | 102 | |
Domaini | 1937 – 2210 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 274 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1095, Eukaryota |
GeneTreei | ENSGT00940000160831 |
HOGENOMi | CLU_000798_0_0_1 |
InParanoidi | Q63132 |
OMAi | ENIVCLV |
OrthoDBi | 203310at2759 |
PhylomeDBi | Q63132 |
TreeFami | TF351636 |
Family and domain databases
CDDi | cd00063, FN3, 7 hits |
Gene3Di | 2.120.10.30, 3 hits 2.60.40.10, 8 hits |
InterProi | View protein in InterPro IPR011042, 6-blade_b-propeller_TolB-like IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold IPR011009, Kinase-like_dom_sf IPR000033, LDLR_classB_rpt IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF00041, fn3, 2 hits PF07714, PK_Tyr_Ser-Thr, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00060, FN3, 9 hits SM00135, LY, 4 hits SM00219, TyrKc, 1 hit |
SUPFAMi | SSF49265, SSF49265, 5 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50853, FN3, 9 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKRIRWLTPK PATFVVLGCV WISVAQGTIL SSCLTSCVTN LGRQLDSGTR
60 70 80 90 100
YNLSEACIQG CQFWNSIDQE KCALKCNDTY VTICERESCE VGCSNAEGSY
110 120 130 140 150
EEEVLDNTEL PTAPFASSIG SNGVTLRWNP ANISGVKYII QWKYAQLPGS
160 170 180 190 200
WAYTETVSKL SYMVEPLHPF TEYIFRVVWI FTAQLHLYSP PSPSYRTHPY
210 220 230 240 250
GVPETAPFIT NIESSSPDTV EVSWAPPYFP GGPILGYNLR LISKTQKLDS
260 270 280 290 300
GTQRTSFQFY STLPNTTYRF SIAAVNEVGE GPEAESMITT PSPAVQEEEQ
310 320 330 340 350
WLFLSRKTSL RKRSLKYLVD EAHCLWSDAI RHNITGISVN TQQEVVYFSE
360 370 380 390 400
GTIIWMKGAA NMSDVSDLRI FYRGSALVSS ISVDWLYQRM YFIMDNRVHV
410 420 430 440 450
CDLKHCSNLE EITPFSIVAP QKVVVDSYNG YVFYLLRDGI YRVHLPLPSV
460 470 480 490 500
RDTKAVRIVE SGTLKDFAVK PQSKRIIYFN GTMQVFMSTF LDGSAFHRVL
510 520 530 540 550
PWVPLADVKS FACENNDFLI TDGKAIFQQD SLSFNEFIVG CDLSHIEEFG
560 570 580 590 600
FGNLVIFGSS VQSYPLPGHP QEVSVLFGSR EALIQWKPPI LAIGASPSAW
610 620 630 640 650
QNWTYEVKVS SQDILETTQV FLNISRTVLN VPKLQSSTKY MVSVRASSPK
660 670 680 690 700
GPGPWSEPSV GTTLVPATEP PFIMAVKEDG LWSKPLSSFG PGEFLSSDVG
710 720 730 740 750
NVSDMDWYNN SLYYSDTKGN VYVRPLNGMD ISENYHISSI AGACALAFEW
760 770 780 790 800
LGHFLYWAGK TYVIQRQSVL TGHTDIVTHV KLLVNDMAVD PVGGYLYWTT
810 820 830 840 850
LYSVESTRLN GESSLVLQAQ PWLSGKKVIA LTLDLSDGLL YWLVQDNQCI
860 870 880 890 900
HLYTAVLRGW SGADATITEF AAWSTSEISQ NALMYYSGRL FWINGFRIIT
910 920 930 940 950
AQEIGQRTSV SVSEPGKFNQ FTIIQTSLKP LPGNFSSTPT VIPDSVQESS
960 970 980 990 1000
FRIEGHTSSF RILWNEPPAV DWGIVFYSVE FSAHSKFLAI EQQSLPVFTV
1010 1020 1030 1040 1050
EGLEPYALFN LSVTPYTYWG KGQKTSLSFR APESVPSAPE NPRIFILSLG
1060 1070 1080 1090 1100
RYTRKNEVVV EFRWNKPKHE NGVLTKSEIF YHISKQSGTN KSTEDWVSVS
1110 1120 1130 1140 1150
VTPPVMSFQL EAMSPGYIVS FQVRVFTSKG PGPFSDIVMS KTSEIKPCPY
1160 1170 1180 1190 1200
LISLLGNKIE FLDMDQNQVV WTFSLEGAVS TVGYTADDEM GYFAQGDALF
1210 1220 1230 1240 1250
LLNLHNHSSS KLFQDVLASD IAVIAVDWIA RHLYFALKAS QDGTQIFDVD
1260 1270 1280 1290 1300
LEHKVKSPRE VKICKSHTAI ISFSMYPLLS RLYWTEVSDL GYQMFYCNIS
1310 1320 1330 1340 1350
SHTLHHVLQP KASNQHGRRQ CSCNVTESEL SGAMTVDTSD PDRPWIYFTK
1360 1370 1380 1390 1400
QQEIWAMDLE GCQCWKVIMV PATPGKRIIS LTVDGEFIYW ITTMKDDTEI
1410 1420 1430 1440 1450
YQAKKGSGAI LSQVKAPRSK HILAYSSALQ PFPDKAYLSV ASNMVEASIL
1460 1470 1480 1490 1500
NATNTSLILK LPPVKTNLTW HGITTPTSTY LVYYMEANRA NSSDRKHNML
1510 1520 1530 1540 1550
ESQENVARIE GLQPFSTYVI QIAVKNYYSD PLEHLSLGKE IQGKTKSGVP
1560 1570 1580 1590 1600
GAVCHINATV LSDTSLLVFW TESHKPNGPK ELVRYQLVMS YLAPIPETPL
1610 1620 1630 1640 1650
RQDEFPSARL SLLVTKLSGG QQYVLKILAC HSEEMWCTES HPVSVNMFDT
1660 1670 1680 1690 1700
PEKPSALVPE NTSLLLDWKA PSNANLTRFW FELQKWKYSE FYHVKASCSQ
1710 1720 1730 1740 1750
GPVYVCNIAN LQPYTPYNIR VVVVYTTGEN SSSIPESFKT KAGVPSKPGI
1760 1770 1780 1790 1800
PKLLEGSKNS IQWEKAEDNG NRLMYYTLEV RKSISNDSRD QSLRWTAVFN
1810 1820 1830 1840 1850
GSCSSICTWR SKNLKGTFQF RAVASNAIGF GEYSEISEDI TLVEDGFWIT
1860 1870 1880 1890 1900
ETSFILTIIV GIFLVATVPL TFVWHRSLKN HKATKEGLSV LNDNDQELAE
1910 1920 1930 1940 1950
LRGLAAGVGL ANACYAVHTL PTQEEIESLP AFPREKLSLR LLLGSGAFGE
1960 1970 1980 1990 2000
VYEGTAVDIL GRGSGEIKVA VKTLKKGSTD QEKIEFLKEA HLMSKFNHPN
2010 2020 2030 2040 2050
ILKQLGVCLL SEPQYIILEL MEGGDLLSYL RKARGTTLSG PLLTLADLVE
2060 2070 2080 2090 2100
LCVDISKGCV YLEQMHFIHR DLAARNCLVS VKDYTSPRVV KIGDFGLARE
2110 2120 2130 2140 2150
IYKHDYYRKR GEGLLPVRWM APENLMDGIF TSQSDVWSFG ILVWEILTLG
2160 2170 2180 2190 2200
HQPYPAHSNL DVLNYVQAGG RLEPPRNCPD DLWNLMFRCW AQEPDQRPTF
2210 2220 2230 2240 2250
YNIQDQLQLF RNVSLNNVSH CGQAAPAGGV INKGFEGEDN EMATLNSDDT
2260 2270 2280 2290 2300
MPVALMETRN QEGLNYMVLA TKCSQSEDRY EGPLGSKESG LHDLKKDERQ
2310 2320 2330
PADKDFCQQP QVAYGSPGHS EGLNYACLAH SGHGDVSE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1873 – 1874 | VW → AC in AAA40967 (PubMed:2139140).Curated | 2 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_023127 | 431 – 451 | Missing in isoform 2. 1 PublicationAdd BLAST | 21 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M35104 mRNA Translation: AAA40966.1 M35105 mRNA Translation: AAA40967.1 M35106 mRNA Translation: AAA40968.1 |
PIRi | I73957 |
RefSeqi | NP_037006.1, NM_012874.1 [Q63132-1] XP_008771084.1, XM_008772862.2 [Q63132-2] |
Genome annotation databases
Ensembli | ENSRNOT00000000459; ENSRNOP00000000459; ENSRNOG00000000406 [Q63132-1] ENSRNOT00000080444; ENSRNOP00000068996; ENSRNOG00000000406 [Q63132-1] |
GeneIDi | 25346 |
KEGGi | rno:25346 |
UCSCi | RGD:3591, rat [Q63132-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M35104 mRNA Translation: AAA40966.1 M35105 mRNA Translation: AAA40967.1 M35106 mRNA Translation: AAA40968.1 |
PIRi | I73957 |
RefSeqi | NP_037006.1, NM_012874.1 [Q63132-1] XP_008771084.1, XM_008772862.2 [Q63132-2] |
3D structure databases
SMRi | Q63132 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000000459 |
PTM databases
GlyGeni | Q63132, 10 sites |
PhosphoSitePlusi | Q63132 |
Proteomic databases
PaxDbi | Q63132 |
PRIDEi | Q63132 |
Genome annotation databases
Ensembli | ENSRNOT00000000459; ENSRNOP00000000459; ENSRNOG00000000406 [Q63132-1] ENSRNOT00000080444; ENSRNOP00000068996; ENSRNOG00000000406 [Q63132-1] |
GeneIDi | 25346 |
KEGGi | rno:25346 |
UCSCi | RGD:3591, rat [Q63132-1] |
Organism-specific databases
CTDi | 6098 |
RGDi | 3591, Ros1 |
Phylogenomic databases
eggNOGi | KOG1095, Eukaryota |
GeneTreei | ENSGT00940000160831 |
HOGENOMi | CLU_000798_0_0_1 |
InParanoidi | Q63132 |
OMAi | ENIVCLV |
OrthoDBi | 203310at2759 |
PhylomeDBi | Q63132 |
TreeFami | TF351636 |
Miscellaneous databases
PROi | PR:Q63132 |
Gene expression databases
Bgeei | ENSRNOG00000000406, Expressed in pancreas and 15 other tissues |
Genevisiblei | Q63132, RN |
Family and domain databases
CDDi | cd00063, FN3, 7 hits |
Gene3Di | 2.120.10.30, 3 hits 2.60.40.10, 8 hits |
InterProi | View protein in InterPro IPR011042, 6-blade_b-propeller_TolB-like IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold IPR011009, Kinase-like_dom_sf IPR000033, LDLR_classB_rpt IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF00041, fn3, 2 hits PF07714, PK_Tyr_Ser-Thr, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00060, FN3, 9 hits SM00135, LY, 4 hits SM00219, TyrKc, 1 hit |
SUPFAMi | SSF49265, SSF49265, 5 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50853, FN3, 9 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ROS1_RAT | |
Accessioni | Q63132Primary (citable) accession number: Q63132 Secondary accession number(s): Q63130, Q63131 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 20, 2007 |
Last sequence update: | November 1, 1996 | |
Last modified: | April 7, 2021 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families