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UniProtKB - Q63132 (ROS1_RAT)

Entry version 145 (08 May 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Proto-oncogene tyrosine-protein kinase ROS

Gene

Ros1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2 (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by dephosphorylation by PTPN6.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1972ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei2071Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1943 – 1951ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Receptor, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proto-oncogene tyrosine-protein kinase ROS (EC:2.7.10.1)
Alternative name(s):
Proto-oncogene c-Ros
Proto-oncogene c-Ros-1
Receptor tyrosine kinase c-ros oncogene 1
c-Ros receptor tyrosine kinase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ros1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Rat genome database

More...RGDi		3591 Ros1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini28 – 1853ExtracellularSequence analysisAdd BLAST1826
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1854 – 1874HelicalSequence analysisAdd BLAST21
Topological domaini1875 – 2338CytoplasmicSequence analysisAdd BLAST464

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000027811628 – 2338Proto-oncogene tyrosine-protein kinase ROSAdd BLAST2311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi77N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi333N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi361N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi480N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi623N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi934N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1010N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1298N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1675N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2266Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei2325Phosphotyrosine; by autocatalysisBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Probably autophosphorylates. Phosphorylation at Tyr-2266 is required for the interaction with PTPN6 that mediates ROS1 dephosphorylation. Phosphorylation at Tyr-2266 stimulates the kinase activity and the activation of the ERK1 signaling cascade. Phosphorylation at Tyr-2266 and/or Tyr-2325 recruits PTPN11 (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q63132

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q63132

PRoteomics IDEntifications database

More...PRIDEi		Q63132

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q63132

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart, lung, kidney and testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000000406 Expressed in 7 organ(s), highest expression level in adult mammalian kidney

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q63132 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PTPN11; may activate the PI3 kinase-mTOR signaling pathway.

Interacts with VAV3; constitutive interaction mediating VAV3 phosphorylation.

Interacts with PTPN6 (via SH2 1 domain); the interaction is direct and promotes ROS1 dephosphorylation (By similarity).

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000000459

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q63132

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini110 – 205Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini206 – 294Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST89
Domaini566 – 666Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST101
Domaini942 – 1037Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST96
Domaini1038 – 1145Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST108
Domaini1440 – 1548Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST109
Domaini1549 – 1648Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST100
Domaini1650 – 1743Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST94
Domaini1744 – 1845Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST102
Domaini1937 – 2210Protein kinasePROSITE-ProRule annotationAdd BLAST274

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1095 Eukaryota
ENOG410XPVX LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160831

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000137937

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q63132

KEGG Orthology (KO)

More...KOi		K05088

Identification of Orthologs from Complete Genome Data

More...OMAi		YVWLLNG

Database of Orthologous Groups

More...OrthoDBi		203310at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q63132

TreeFam database of animal gene trees

More...TreeFami		TF351636

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063 FN3, 7 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.120.10.30, 3 hits
2.60.40.10, 8 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000033 LDLR_classB_rpt
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00041 fn3, 2 hits
PF07714 Pkinase_Tyr, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00109 TYRKINASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00060 FN3, 9 hits
SM00135 LY, 4 hits
SM00219 TyrKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49265 SSF49265, 5 hits
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50853 FN3, 9 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q63132-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKRIRWLTPK PATFVVLGCV WISVAQGTIL SSCLTSCVTN LGRQLDSGTR 
        60         70         80         90        100
YNLSEACIQG CQFWNSIDQE KCALKCNDTY VTICERESCE VGCSNAEGSY 
       110        120        130        140        150
EEEVLDNTEL PTAPFASSIG SNGVTLRWNP ANISGVKYII QWKYAQLPGS 
       160        170        180        190        200
WAYTETVSKL SYMVEPLHPF TEYIFRVVWI FTAQLHLYSP PSPSYRTHPY 
       210        220        230        240        250
GVPETAPFIT NIESSSPDTV EVSWAPPYFP GGPILGYNLR LISKTQKLDS 
       260        270        280        290        300
GTQRTSFQFY STLPNTTYRF SIAAVNEVGE GPEAESMITT PSPAVQEEEQ 
       310        320        330        340        350
WLFLSRKTSL RKRSLKYLVD EAHCLWSDAI RHNITGISVN TQQEVVYFSE 
       360        370        380        390        400
GTIIWMKGAA NMSDVSDLRI FYRGSALVSS ISVDWLYQRM YFIMDNRVHV 
       410        420        430        440        450
CDLKHCSNLE EITPFSIVAP QKVVVDSYNG YVFYLLRDGI YRVHLPLPSV 
       460        470        480        490        500
RDTKAVRIVE SGTLKDFAVK PQSKRIIYFN GTMQVFMSTF LDGSAFHRVL 
       510        520        530        540        550
PWVPLADVKS FACENNDFLI TDGKAIFQQD SLSFNEFIVG CDLSHIEEFG 
       560        570        580        590        600
FGNLVIFGSS VQSYPLPGHP QEVSVLFGSR EALIQWKPPI LAIGASPSAW 
       610        620        630        640        650
QNWTYEVKVS SQDILETTQV FLNISRTVLN VPKLQSSTKY MVSVRASSPK 
       660        670        680        690        700
GPGPWSEPSV GTTLVPATEP PFIMAVKEDG LWSKPLSSFG PGEFLSSDVG 
       710        720        730        740        750
NVSDMDWYNN SLYYSDTKGN VYVRPLNGMD ISENYHISSI AGACALAFEW 
       760        770        780        790        800
LGHFLYWAGK TYVIQRQSVL TGHTDIVTHV KLLVNDMAVD PVGGYLYWTT 
       810        820        830        840        850
LYSVESTRLN GESSLVLQAQ PWLSGKKVIA LTLDLSDGLL YWLVQDNQCI 
       860        870        880        890        900
HLYTAVLRGW SGADATITEF AAWSTSEISQ NALMYYSGRL FWINGFRIIT 
       910        920        930        940        950
AQEIGQRTSV SVSEPGKFNQ FTIIQTSLKP LPGNFSSTPT VIPDSVQESS 
       960        970        980        990       1000
FRIEGHTSSF RILWNEPPAV DWGIVFYSVE FSAHSKFLAI EQQSLPVFTV 
      1010       1020       1030       1040       1050
EGLEPYALFN LSVTPYTYWG KGQKTSLSFR APESVPSAPE NPRIFILSLG 
      1060       1070       1080       1090       1100
RYTRKNEVVV EFRWNKPKHE NGVLTKSEIF YHISKQSGTN KSTEDWVSVS 
      1110       1120       1130       1140       1150
VTPPVMSFQL EAMSPGYIVS FQVRVFTSKG PGPFSDIVMS KTSEIKPCPY 
      1160       1170       1180       1190       1200
LISLLGNKIE FLDMDQNQVV WTFSLEGAVS TVGYTADDEM GYFAQGDALF 
      1210       1220       1230       1240       1250
LLNLHNHSSS KLFQDVLASD IAVIAVDWIA RHLYFALKAS QDGTQIFDVD 
      1260       1270       1280       1290       1300
LEHKVKSPRE VKICKSHTAI ISFSMYPLLS RLYWTEVSDL GYQMFYCNIS 
      1310       1320       1330       1340       1350
SHTLHHVLQP KASNQHGRRQ CSCNVTESEL SGAMTVDTSD PDRPWIYFTK 
      1360       1370       1380       1390       1400
QQEIWAMDLE GCQCWKVIMV PATPGKRIIS LTVDGEFIYW ITTMKDDTEI 
      1410       1420       1430       1440       1450
YQAKKGSGAI LSQVKAPRSK HILAYSSALQ PFPDKAYLSV ASNMVEASIL 
      1460       1470       1480       1490       1500
NATNTSLILK LPPVKTNLTW HGITTPTSTY LVYYMEANRA NSSDRKHNML 
      1510       1520       1530       1540       1550
ESQENVARIE GLQPFSTYVI QIAVKNYYSD PLEHLSLGKE IQGKTKSGVP 
      1560       1570       1580       1590       1600
GAVCHINATV LSDTSLLVFW TESHKPNGPK ELVRYQLVMS YLAPIPETPL 
      1610       1620       1630       1640       1650
RQDEFPSARL SLLVTKLSGG QQYVLKILAC HSEEMWCTES HPVSVNMFDT 
      1660       1670       1680       1690       1700
PEKPSALVPE NTSLLLDWKA PSNANLTRFW FELQKWKYSE FYHVKASCSQ 
      1710       1720       1730       1740       1750
GPVYVCNIAN LQPYTPYNIR VVVVYTTGEN SSSIPESFKT KAGVPSKPGI 
      1760       1770       1780       1790       1800
PKLLEGSKNS IQWEKAEDNG NRLMYYTLEV RKSISNDSRD QSLRWTAVFN 
      1810       1820       1830       1840       1850
GSCSSICTWR SKNLKGTFQF RAVASNAIGF GEYSEISEDI TLVEDGFWIT 
      1860       1870       1880       1890       1900
ETSFILTIIV GIFLVATVPL TFVWHRSLKN HKATKEGLSV LNDNDQELAE 
      1910       1920       1930       1940       1950
LRGLAAGVGL ANACYAVHTL PTQEEIESLP AFPREKLSLR LLLGSGAFGE 
      1960       1970       1980       1990       2000
VYEGTAVDIL GRGSGEIKVA VKTLKKGSTD QEKIEFLKEA HLMSKFNHPN 
      2010       2020       2030       2040       2050
ILKQLGVCLL SEPQYIILEL MEGGDLLSYL RKARGTTLSG PLLTLADLVE 
      2060       2070       2080       2090       2100
LCVDISKGCV YLEQMHFIHR DLAARNCLVS VKDYTSPRVV KIGDFGLARE 
      2110       2120       2130       2140       2150
IYKHDYYRKR GEGLLPVRWM APENLMDGIF TSQSDVWSFG ILVWEILTLG 
      2160       2170       2180       2190       2200
HQPYPAHSNL DVLNYVQAGG RLEPPRNCPD DLWNLMFRCW AQEPDQRPTF 
      2210       2220       2230       2240       2250
YNIQDQLQLF RNVSLNNVSH CGQAAPAGGV INKGFEGEDN EMATLNSDDT 
      2260       2270       2280       2290       2300
MPVALMETRN QEGLNYMVLA TKCSQSEDRY EGPLGSKESG LHDLKKDERQ 
      2310       2320       2330 
PADKDFCQQP QVAYGSPGHS EGLNYACLAH SGHGDVSE
Length:2,338
Mass (Da):261,656
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFF45FE561A058453
GO
Isoform 2 (identifier: Q63132-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     431-451: Missing.

Show »
Length:2,317
Mass (Da):259,097
Checksum:i4117901E3B0A6449
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1873 – 1874VW → AC in AAA40967 (PubMed:2139140).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_023127431 – 451Missing in isoform 2. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M35104 mRNA Translation: AAA40966.1
M35105 mRNA Translation: AAA40967.1
M35106 mRNA Translation: AAA40968.1

Protein sequence database of the Protein Information Resource

More...PIRi		I73957

NCBI Reference Sequences

More...RefSeqi		NP_037006.1, NM_012874.1 [Q63132-1]
XP_008771084.1, XM_008772862.2 [Q63132-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000000459; ENSRNOP00000000459; ENSRNOG00000000406 [Q63132-1]
ENSRNOT00000080444; ENSRNOP00000068996; ENSRNOG00000000406 [Q63132-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		25346

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:25346

UCSC genome browser

More...UCSCi		RGD:3591 rat [Q63132-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35104 mRNA Translation: AAA40966.1
M35105 mRNA Translation: AAA40967.1
M35106 mRNA Translation: AAA40968.1
PIRiI73957
RefSeqiNP_037006.1, NM_012874.1 [Q63132-1]
XP_008771084.1, XM_008772862.2 [Q63132-2]

3D structure databases

SMRiQ63132
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000459

PTM databases

PhosphoSitePlusiQ63132

Proteomic databases

jPOSTiQ63132
PaxDbiQ63132
PRIDEiQ63132

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000000459; ENSRNOP00000000459; ENSRNOG00000000406 [Q63132-1]
ENSRNOT00000080444; ENSRNOP00000068996; ENSRNOG00000000406 [Q63132-1]
GeneIDi25346
KEGGirno:25346
UCSCiRGD:3591 rat [Q63132-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6098
RGDi3591 Ros1

Phylogenomic databases

eggNOGiKOG1095 Eukaryota
ENOG410XPVX LUCA
GeneTreeiENSGT00940000160831
HOGENOMiHOG000137937
InParanoidiQ63132
KOiK05088
OMAiYVWLLNG
OrthoDBi203310at2759
PhylomeDBiQ63132
TreeFamiTF351636

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q63132

Gene expression databases

BgeeiENSRNOG00000000406 Expressed in 7 organ(s), highest expression level in adult mammalian kidney
GenevisibleiQ63132 RN

Family and domain databases

CDDicd00063 FN3, 7 hits
Gene3Di2.120.10.30, 3 hits
2.60.40.10, 8 hits
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000033 LDLR_classB_rpt
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00060 FN3, 9 hits
SM00135 LY, 4 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF49265 SSF49265, 5 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 9 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiROS1_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q63132
Secondary accession number(s): Q63130, Q63131
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: November 1, 1996
Last modified: May 8, 2019
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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