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Entry version 144 (13 Feb 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Proto-oncogene tyrosine-protein kinase ROS

Gene

Ros1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2 (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by dephosphorylation by PTPN6.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1972ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei2071Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1943 – 1951ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Receptor, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proto-oncogene tyrosine-protein kinase ROS (EC:2.7.10.1)
Alternative name(s):
Proto-oncogene c-Ros
Proto-oncogene c-Ros-1
Receptor tyrosine kinase c-ros oncogene 1
c-Ros receptor tyrosine kinase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ros1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Rat genome database

More...
RGDi
3591 Ros1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini28 – 1853ExtracellularSequence analysisAdd BLAST1826
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1854 – 1874HelicalSequence analysisAdd BLAST21
Topological domaini1875 – 2338CytoplasmicSequence analysisAdd BLAST464

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000027811628 – 2338Proto-oncogene tyrosine-protein kinase ROSAdd BLAST2311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi77N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi333N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi361N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi480N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi623N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi934N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1010N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1298N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1675N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2266Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei2325Phosphotyrosine; by autocatalysisBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Probably autophosphorylates. Phosphorylation at Tyr-2266 is required for the interaction with PTPN6 that mediates ROS1 dephosphorylation. Phosphorylation at Tyr-2266 stimulates the kinase activity and the activation of the ERK1 signaling cascade. Phosphorylation at Tyr-2266 and/or Tyr-2325 recruits PTPN11 (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q63132

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q63132

PRoteomics IDEntifications database

More...
PRIDEi
Q63132

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q63132

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart, lung, kidney and testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000000406 Expressed in 7 organ(s), highest expression level in adult mammalian kidney

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q63132 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PTPN11; may activate the PI3 kinase-mTOR signaling pathway. Interacts with VAV3; constitutive interaction mediating VAV3 phosphorylation. Interacts with PTPN6 (via SH2 1 domain); the interaction is direct and promotes ROS1 dephosphorylation (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000000459

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q63132

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q63132

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini110 – 205Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini206 – 294Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST89
Domaini566 – 666Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST101
Domaini942 – 1037Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST96
Domaini1038 – 1145Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST108
Domaini1440 – 1548Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST109
Domaini1549 – 1648Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST100
Domaini1650 – 1743Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST94
Domaini1744 – 1845Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST102
Domaini1937 – 2210Protein kinasePROSITE-ProRule annotationAdd BLAST274

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1095 Eukaryota
ENOG410XPVX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160831

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000137937

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG058631

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q63132

KEGG Orthology (KO)

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KOi
K05088

Identification of Orthologs from Complete Genome Data

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OMAi
ISVDWLY

Database of Orthologous Groups

More...
OrthoDBi
203310at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q63132

TreeFam database of animal gene trees

More...
TreeFami
TF351636

Family and domain databases

Conserved Domains Database

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CDDi
cd00063 FN3, 7 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.120.10.30, 3 hits
2.60.40.10, 8 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000033 LDLR_classB_rpt
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 2 hits
PF07714 Pkinase_Tyr, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00109 TYRKINASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 9 hits
SM00135 LY, 4 hits
SM00219 TyrKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 5 hits
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 9 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q63132-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKRIRWLTPK PATFVVLGCV WISVAQGTIL SSCLTSCVTN LGRQLDSGTR
60 70 80 90 100
YNLSEACIQG CQFWNSIDQE KCALKCNDTY VTICERESCE VGCSNAEGSY
110 120 130 140 150
EEEVLDNTEL PTAPFASSIG SNGVTLRWNP ANISGVKYII QWKYAQLPGS
160 170 180 190 200
WAYTETVSKL SYMVEPLHPF TEYIFRVVWI FTAQLHLYSP PSPSYRTHPY
210 220 230 240 250
GVPETAPFIT NIESSSPDTV EVSWAPPYFP GGPILGYNLR LISKTQKLDS
260 270 280 290 300
GTQRTSFQFY STLPNTTYRF SIAAVNEVGE GPEAESMITT PSPAVQEEEQ
310 320 330 340 350
WLFLSRKTSL RKRSLKYLVD EAHCLWSDAI RHNITGISVN TQQEVVYFSE
360 370 380 390 400
GTIIWMKGAA NMSDVSDLRI FYRGSALVSS ISVDWLYQRM YFIMDNRVHV
410 420 430 440 450
CDLKHCSNLE EITPFSIVAP QKVVVDSYNG YVFYLLRDGI YRVHLPLPSV
460 470 480 490 500
RDTKAVRIVE SGTLKDFAVK PQSKRIIYFN GTMQVFMSTF LDGSAFHRVL
510 520 530 540 550
PWVPLADVKS FACENNDFLI TDGKAIFQQD SLSFNEFIVG CDLSHIEEFG
560 570 580 590 600
FGNLVIFGSS VQSYPLPGHP QEVSVLFGSR EALIQWKPPI LAIGASPSAW
610 620 630 640 650
QNWTYEVKVS SQDILETTQV FLNISRTVLN VPKLQSSTKY MVSVRASSPK
660 670 680 690 700
GPGPWSEPSV GTTLVPATEP PFIMAVKEDG LWSKPLSSFG PGEFLSSDVG
710 720 730 740 750
NVSDMDWYNN SLYYSDTKGN VYVRPLNGMD ISENYHISSI AGACALAFEW
760 770 780 790 800
LGHFLYWAGK TYVIQRQSVL TGHTDIVTHV KLLVNDMAVD PVGGYLYWTT
810 820 830 840 850
LYSVESTRLN GESSLVLQAQ PWLSGKKVIA LTLDLSDGLL YWLVQDNQCI
860 870 880 890 900
HLYTAVLRGW SGADATITEF AAWSTSEISQ NALMYYSGRL FWINGFRIIT
910 920 930 940 950
AQEIGQRTSV SVSEPGKFNQ FTIIQTSLKP LPGNFSSTPT VIPDSVQESS
960 970 980 990 1000
FRIEGHTSSF RILWNEPPAV DWGIVFYSVE FSAHSKFLAI EQQSLPVFTV
1010 1020 1030 1040 1050
EGLEPYALFN LSVTPYTYWG KGQKTSLSFR APESVPSAPE NPRIFILSLG
1060 1070 1080 1090 1100
RYTRKNEVVV EFRWNKPKHE NGVLTKSEIF YHISKQSGTN KSTEDWVSVS
1110 1120 1130 1140 1150
VTPPVMSFQL EAMSPGYIVS FQVRVFTSKG PGPFSDIVMS KTSEIKPCPY
1160 1170 1180 1190 1200
LISLLGNKIE FLDMDQNQVV WTFSLEGAVS TVGYTADDEM GYFAQGDALF
1210 1220 1230 1240 1250
LLNLHNHSSS KLFQDVLASD IAVIAVDWIA RHLYFALKAS QDGTQIFDVD
1260 1270 1280 1290 1300
LEHKVKSPRE VKICKSHTAI ISFSMYPLLS RLYWTEVSDL GYQMFYCNIS
1310 1320 1330 1340 1350
SHTLHHVLQP KASNQHGRRQ CSCNVTESEL SGAMTVDTSD PDRPWIYFTK
1360 1370 1380 1390 1400
QQEIWAMDLE GCQCWKVIMV PATPGKRIIS LTVDGEFIYW ITTMKDDTEI
1410 1420 1430 1440 1450
YQAKKGSGAI LSQVKAPRSK HILAYSSALQ PFPDKAYLSV ASNMVEASIL
1460 1470 1480 1490 1500
NATNTSLILK LPPVKTNLTW HGITTPTSTY LVYYMEANRA NSSDRKHNML
1510 1520 1530 1540 1550
ESQENVARIE GLQPFSTYVI QIAVKNYYSD PLEHLSLGKE IQGKTKSGVP
1560 1570 1580 1590 1600
GAVCHINATV LSDTSLLVFW TESHKPNGPK ELVRYQLVMS YLAPIPETPL
1610 1620 1630 1640 1650
RQDEFPSARL SLLVTKLSGG QQYVLKILAC HSEEMWCTES HPVSVNMFDT
1660 1670 1680 1690 1700
PEKPSALVPE NTSLLLDWKA PSNANLTRFW FELQKWKYSE FYHVKASCSQ
1710 1720 1730 1740 1750
GPVYVCNIAN LQPYTPYNIR VVVVYTTGEN SSSIPESFKT KAGVPSKPGI
1760 1770 1780 1790 1800
PKLLEGSKNS IQWEKAEDNG NRLMYYTLEV RKSISNDSRD QSLRWTAVFN
1810 1820 1830 1840 1850
GSCSSICTWR SKNLKGTFQF RAVASNAIGF GEYSEISEDI TLVEDGFWIT
1860 1870 1880 1890 1900
ETSFILTIIV GIFLVATVPL TFVWHRSLKN HKATKEGLSV LNDNDQELAE
1910 1920 1930 1940 1950
LRGLAAGVGL ANACYAVHTL PTQEEIESLP AFPREKLSLR LLLGSGAFGE
1960 1970 1980 1990 2000
VYEGTAVDIL GRGSGEIKVA VKTLKKGSTD QEKIEFLKEA HLMSKFNHPN
2010 2020 2030 2040 2050
ILKQLGVCLL SEPQYIILEL MEGGDLLSYL RKARGTTLSG PLLTLADLVE
2060 2070 2080 2090 2100
LCVDISKGCV YLEQMHFIHR DLAARNCLVS VKDYTSPRVV KIGDFGLARE
2110 2120 2130 2140 2150
IYKHDYYRKR GEGLLPVRWM APENLMDGIF TSQSDVWSFG ILVWEILTLG
2160 2170 2180 2190 2200
HQPYPAHSNL DVLNYVQAGG RLEPPRNCPD DLWNLMFRCW AQEPDQRPTF
2210 2220 2230 2240 2250
YNIQDQLQLF RNVSLNNVSH CGQAAPAGGV INKGFEGEDN EMATLNSDDT
2260 2270 2280 2290 2300
MPVALMETRN QEGLNYMVLA TKCSQSEDRY EGPLGSKESG LHDLKKDERQ
2310 2320 2330
PADKDFCQQP QVAYGSPGHS EGLNYACLAH SGHGDVSE
Length:2,338
Mass (Da):261,656
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFF45FE561A058453
GO
Isoform 2 (identifier: Q63132-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     431-451: Missing.

Show »
Length:2,317
Mass (Da):259,097
Checksum:i4117901E3B0A6449
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1873 – 1874VW → AC in AAA40967 (PubMed:2139140).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_023127431 – 451Missing in isoform 2. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M35104 mRNA Translation: AAA40966.1
M35105 mRNA Translation: AAA40967.1
M35106 mRNA Translation: AAA40968.1

Protein sequence database of the Protein Information Resource

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PIRi
I73957

NCBI Reference Sequences

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RefSeqi
NP_037006.1, NM_012874.1 [Q63132-1]
XP_008771084.1, XM_008772862.2 [Q63132-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Rn.87436

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSRNOT00000000459; ENSRNOP00000000459; ENSRNOG00000000406 [Q63132-1]
ENSRNOT00000080444; ENSRNOP00000068996; ENSRNOG00000000406 [Q63132-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
25346

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
rno:25346

UCSC genome browser

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UCSCi
RGD:3591 rat [Q63132-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35104 mRNA Translation: AAA40966.1
M35105 mRNA Translation: AAA40967.1
M35106 mRNA Translation: AAA40968.1
PIRiI73957
RefSeqiNP_037006.1, NM_012874.1 [Q63132-1]
XP_008771084.1, XM_008772862.2 [Q63132-2]
UniGeneiRn.87436

3D structure databases

ProteinModelPortaliQ63132
SMRiQ63132
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000459

PTM databases

PhosphoSitePlusiQ63132

Proteomic databases

jPOSTiQ63132
PaxDbiQ63132
PRIDEiQ63132

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000000459; ENSRNOP00000000459; ENSRNOG00000000406 [Q63132-1]
ENSRNOT00000080444; ENSRNOP00000068996; ENSRNOG00000000406 [Q63132-1]
GeneIDi25346
KEGGirno:25346
UCSCiRGD:3591 rat [Q63132-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6098
RGDi3591 Ros1

Phylogenomic databases

eggNOGiKOG1095 Eukaryota
ENOG410XPVX LUCA
GeneTreeiENSGT00940000160831
HOGENOMiHOG000137937
HOVERGENiHBG058631
InParanoidiQ63132
KOiK05088
OMAiISVDWLY
OrthoDBi203310at2759
PhylomeDBiQ63132
TreeFamiTF351636

Miscellaneous databases

Protein Ontology

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PROi
PR:Q63132

Gene expression databases

BgeeiENSRNOG00000000406 Expressed in 7 organ(s), highest expression level in adult mammalian kidney
GenevisibleiQ63132 RN

Family and domain databases

CDDicd00063 FN3, 7 hits
Gene3Di2.120.10.30, 3 hits
2.60.40.10, 8 hits
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000033 LDLR_classB_rpt
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00060 FN3, 9 hits
SM00135 LY, 4 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF49265 SSF49265, 5 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 9 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiROS1_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q63132
Secondary accession number(s): Q63130, Q63131
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: November 1, 1996
Last modified: February 13, 2019
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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