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Protein

Mast/stem cell growth factor receptor

Gene

Kit

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi570MagnesiumUniRule annotation1
Binding sitei625ATPUniRule annotation1
Binding sitei797ATPUniRule annotation1
Metal bindingi798MagnesiumUniRule annotation1
Metal bindingi811MagnesiumUniRule annotation1
Sitei937Important for interaction with phosphotyrosine-binding proteinsUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi598 – 605ATPUniRule annotation8
Nucleotide bindingi673 – 679ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton reorganization Source: Ensembl
  • activation of MAPK activity Source: Ensembl
  • cellular response to thyroid hormone stimulus Source: Ensembl
  • dendritic cell cytokine production Source: Ensembl
  • detection of mechanical stimulus involved in sensory perception of sound Source: Ensembl
  • digestive tract development Source: Ensembl
  • ectopic germ cell programmed cell death Source: Ensembl
  • embryonic hemopoiesis Source: Ensembl
  • epithelial cell proliferation Source: RGD
  • erythrocyte differentiation Source: Ensembl
  • erythropoietin-mediated signaling pathway Source: Ensembl
  • Fc receptor signaling pathway Source: UniProtKB-UniRule
  • germ cell migration Source: RGD
  • glycosphingolipid metabolic process Source: Ensembl
  • hematopoietic stem cell migration Source: Ensembl
  • immature B cell differentiation Source: Ensembl
  • inflammatory response Source: Ensembl
  • intracellular signal transduction Source: Ensembl
  • lamellipodium assembly Source: Ensembl
  • lymphoid progenitor cell differentiation Source: Ensembl
  • male gonad development Source: Ensembl
  • mast cell chemotaxis Source: Ensembl
  • mast cell cytokine production Source: Ensembl
  • mast cell degranulation Source: Ensembl
  • mast cell differentiation Source: Ensembl
  • megakaryocyte development Source: Ensembl
  • melanocyte adhesion Source: Ensembl
  • melanocyte differentiation Source: Ensembl
  • melanocyte migration Source: Ensembl
  • myeloid progenitor cell differentiation Source: Ensembl
  • negative regulation of programmed cell death Source: Ensembl
  • ovarian follicle development Source: Ensembl
  • peptidyl-tyrosine phosphorylation Source: RGD
  • positive regulation of cell migration Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of colon smooth muscle contraction Source: RGD
  • positive regulation of DNA binding transcription factor activity Source: Ensembl
  • positive regulation of gene expression Source: Ensembl
  • positive regulation of long-term neuronal synaptic plasticity Source: RGD
  • positive regulation of Notch signaling pathway Source: RGD
  • positive regulation of pseudopodium assembly Source: RGD
  • positive regulation of pyloric antrum smooth muscle contraction Source: RGD
  • positive regulation of small intestine smooth muscle contraction Source: RGD
  • positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
  • positive regulation of vascular smooth muscle cell differentiation Source: Ensembl
  • protein autophosphorylation Source: RGD
  • regulation of bile acid metabolic process Source: RGD
  • regulation of cell shape Source: Ensembl
  • regulation of developmental pigmentation Source: Ensembl
  • response to cadmium ion Source: RGD
  • response to radiation Source: RGD
  • somatic stem cell division Source: RGD
  • somatic stem cell population maintenance Source: RGD
  • spermatid development Source: Ensembl
  • spermatogenesis Source: RGD
  • stem cell differentiation Source: Ensembl
  • T cell differentiation Source: Ensembl
  • tongue development Source: RGD
  • visual learning Source: RGD

Keywordsi

Molecular functionKinase, ReceptorUniRule annotationSAAS annotationImported, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-1257604 PIP3 activates AKT signaling
R-RNO-1433557 Signaling by SCF-KIT
R-RNO-1433559 Regulation of KIT signaling
R-RNO-5673001 RAF/MAP kinase cascade
R-RNO-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Mast/stem cell growth factor receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
Gene namesi
Name:KitImported
Synonyms:KITImported
ORF Names:rCG_56893Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi620568 Kit

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei523 – 550HelicalUniRule annotationAdd BLAST28

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25UniRule annotationAdd BLAST25
ChainiPRO_501521895926 – 978Mast/stem cell growth factor receptorUniRule annotationAdd BLAST953

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000002227

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003050

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 97Ig-likeInterPro annotationAdd BLAST61
Domaini212 – 310Ig-likeInterPro annotationAdd BLAST99
Domaini591 – 938Protein kinaseInterPro annotationAdd BLAST348

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.UniRule annotation

Keywords - Domaini

Immunoglobulin domainUniRule annotationSAAS annotation, RepeatSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0200 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118923
HOGENOMiHOG000112008
HOVERGENiHBG004335
KOiK05091
OMAiPTFKQIV
OrthoDBiEOG091G01TL
TreeFamiTF325768

Family and domain databases

Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR027263 SCGF_receptor
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR001824 Tyr_kinase_rcpt_3_CS
PfamiView protein in Pfam
PF00047 ig, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PIRSFiPIRSF500951 SCGF_recepter, 1 hit
SMARTiView protein in SMART
SM00409 IG, 4 hits
SM00408 IGc2, 3 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 4 hits
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00240 RECEPTOR_TYR_KIN_III, 1 hit

Sequencei

Sequence statusi: Complete.

Q63116-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGARGAWDL LCVLLVLLRG QTGTSQPSAS PGEPSPPSIQ PAQSELIVEA
60 70 80 90 100
GDTIRLTCTD PAFVKWTFEI LDVRIENKQS EWIREKAEAT HTGKYTCVSG
110 120 130 140 150
SGLRSSIYVF VRDPAVLFLV GLPLFGKEDN DALVRCPLTD PQVSNYSLIE
160 170 180 190 200
CDGKSLPTDL KFVPNPKAGI TIKNVKRAYH RLCIRCAAQR EGKWMRSDKF
210 220 230 240 250
TLKVRAAIKA IPVVSVPETS HLLKEGDTFT VICTIKDVST SVDSMWIKLN
260 270 280 290 300
PQPQSKAQVK RNSWHQGDFN YERQETLTIS SARVNDSGVF MCYANNTFGS
310 320 330 340 350
ANVTTTLKVV EKGFINIFPV KNTTVFVTDG ENVDLVVEFE AYPKPEHQQW
360 370 380 390 400
IYMNRTPTNR GEDYVKSDNQ SNIRYVNELR LTRLKGTEGG TYTFLVSNSD
410 420 430 440 450
VSASVTFDVY VNTKPEILTY DRLMNGRLQC VAAGFPEPTI DWYFCTGAEQ
460 470 480 490 500
RCTVPVPPVD VQIQNASVSP FGKLVVQSSI DSSVFRHNGT VECKASNAVG
510 520 530 540 550
KSSAFFNFAF KGNSKEQIQP HTLFTPLLIG FVVTAGLMGI IVMVLAYKYL
560 570 580 590 600
QKPMYEVQWK VVEEINGNNY VYIDPTQLPY DHKWEFPRNR LSFGKTLGAG
610 620 630 640 650
AFGKVVEATA YGLIKSDAAM TVAVKMLKPS AHLTEREALM SELKVLSYLG
660 670 680 690 700
NHMNIVNLLG ACTVGGPTLV ITEYCCYGDL LNFLRRKRDS FIFSKQEEQA
710 720 730 740 750
DAALYKNLLH SKESSCDSSN EYMDMKPGVS YVVPTKTDKR RSARIDSYIE
760 770 780 790 800
RDVTPAIMED DELALDLEDL LSFSYQVAKG MAFLASKNCI HRDLAARNIL
810 820 830 840 850
LTHGRITKIC DFGLARDIRN DSNYVVKGNA RLPVKWMAPE SIFNCVYTFE
860 870 880 890 900
SDVWSYGIFL WELFSLGSSP YPGMPVDSKF YKMIKEGFRM LSPEHAPAAM
910 920 930 940 950
YEVMKTCWDA DPLKRPTFKQ VVQLIEKQIS DSSKHIYSNL ANCNPNPENP
960 970
VVVDHSVRVN SVGSSTSSTQ PLLVHEDA
Length:978
Mass (Da):109,342
Last modified:November 1, 1996 - v1
Checksum:i0958C33F19889051
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07014877 Genomic DNA No translation available.
AABR07014878 Genomic DNA No translation available.
AABR07014879 Genomic DNA No translation available.
EU247827 mRNA Translation: ABX45067.1
EU247828 mRNA Translation: ABX45068.1
D12524 mRNA Translation: BAA02094.1
CH473981 Genomic DNA Translation: EDL89921.1
PIRiA49814
RefSeqiNP_071600.1, NM_022264.1
UniGeneiRn.54004

Genome annotation databases

EnsembliENSRNOT00000003050; ENSRNOP00000003050; ENSRNOG00000002227
GeneIDi64030
KEGGirno:64030

Similar proteinsi

Entry informationi

Entry nameiQ63116_RAT
AccessioniPrimary (citable) accession number: Q63116
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 18, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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