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Protein

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2

Gene

Bst1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.

Catalytic activityi

NAD+ + H2O = ADP-D-ribose + nicotinamide.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Transferase
LigandNAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 (EC:3.2.2.6)
Alternative name(s):
ADP-ribosyl cyclase 2
Bone marrow stromal antigen 1
Short name:
BST-1
Cyclic ADP-ribose hydrolase 2
Short name:
cADPr hydrolase 2
CD_antigen: CD157
Gene namesi
Name:Bst1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620344 Bst1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000000403628 – 294ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2Add BLAST267
PropeptideiPRO_0000004037295 – 319Sequence analysisAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi52 ↔ 68By similarity
Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi84 ↔ 164By similarity
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi145 ↔ 158By similarity
Glycosylationi149N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi239 ↔ 260By similarity
Disulfide bondi272 ↔ 281By similarity
Lipidationi294GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ63072
PRIDEiQ63072

Expressioni

Tissue specificityi

Pancreatic islets, kidney, spleen, heart, thymus, intestine and salivary gland.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004094

Structurei

3D structure databases

ProteinModelPortaliQ63072
SMRiQ63072
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADP-ribosyl cyclase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IP4Q Eukaryota
ENOG4111W33 LUCA
HOGENOMiHOG000293141
HOVERGENiHBG097049
InParanoidiQ63072
KOiK18152
PhylomeDBiQ63072

Family and domain databases

CDDicd04759 Rib_hydrolase, 1 hit
InterProiView protein in InterPro
IPR003193 ADP-ribosyl_cyclase
PANTHERiPTHR10912 PTHR10912, 1 hit
PfamiView protein in Pfam
PF02267 Rib_hydrolayse, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63072-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVQACALSL RLGLWMSLLL PVLPGAGARA AGARWSGEGT TPHLQSIFLG
60 70 80 90 100
RCAEYTTLLS LEPGNKNCTA IWEAFKVVLD KDPCSVLPSD YDLFINLSRH
110 120 130 140 150
AIPRDKSLFW ENNHLLVMSY AENTRRLMPL CDVLYGKVGD FLSWCRQENA
160 170 180 190 200
SGLDYQSCPT AEDCENNAVD AYWKSASMQY SRDSSGVINV MLNGSEPKGA
210 220 230 240 250
YPTKGFFADF EIPYLQKDKI TRIEIWVMHE VGGPHVESCG EGSVKILEDR
260 270 280 290 300
LEALGFQHSC INDYPPVKFL MCVDHSTHPD CAMNSASASM WRESPALHAI
310
GDISLIISLL VALASSSQA
Length:319
Mass (Da):35,131
Last modified:November 1, 1996 - v1
Checksum:i46831685DE2B2472
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49955 mRNA Translation: BAA08710.1
PIRiJC4390
RefSeqiNP_110475.1, NM_030848.1
UniGeneiRn.10728

Genome annotation databases

GeneIDi81506
KEGGirno:81506

Similar proteinsi

Entry informationi

Entry nameiBST1_RAT
AccessioniPrimary (citable) accession number: Q63072
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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