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Protein

Zinc finger protein 260

Gene

Znf260

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA. Also acts as a cofactor with GATA4, a key cardiac regulator.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri23 – 45C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri51 – 73C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri79 – 101C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri131 – 153C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri159 – 181C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri187 – 209C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri215 – 237C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri243 – 265C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 260
Short name:
Zfp-260
Alternative name(s):
Pancreas-only zinc finger protein 1
Short name:
POZF-1
Gene namesi
Name:Znf260
Synonyms:Pex1, Zfp260
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi621205 Zfp260

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473221 – 407Zinc finger protein 260Add BLAST407

Proteomic databases

PaxDbiQ62981
PRIDEiQ62981

Expressioni

Tissue specificityi

Expressed in both embryonic, fetal and adult heart. Also expressed in lung, skeletal muscle and adrenal glands.1 Publication

Developmental stagei

Expressed in cardiomyocytes from E14.1 Publication

Inductioni

Up-regulated by activation of alpha1-adrenergic receptors.1 Publication

Gene expression databases

BgeeiENSRNOG00000020762 Expressed in 9 organ(s), highest expression level in Ammon's horn
GenevisibleiQ62981 RN

Interactioni

Subunit structurei

Binds DNA. Interacts with GATA4.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065656

Structurei

3D structure databases

ProteinModelPortaliQ62981
SMRiQ62981
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri23 – 45C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri51 – 73C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri79 – 101C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri131 – 153C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri159 – 181C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri187 – 209C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri215 – 237C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri243 – 265C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150959
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ62981
OMAiYECGKAS
OrthoDBiEOG091G02KC
PhylomeDBiQ62981
TreeFamiTF341817

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 12 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequencei

Sequence statusi: Complete.

Q62981-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLESLQPESE LLHDEPDPGE KVYECDECRK TFSLEQHFVE HKKTHGGEKS
60 70 80 90 100
PECTGCGEEF SKASSLTRHL RSRSRRESYK CGNCGRTFSQ RGNFLSHQKQ
110 120 130 140 150
HAEERPSESK KTPVPMTTIV RNQRNAGNKP YACKECGKAF NGKSYLKEHE
160 170 180 190 200
KIHTGEKPFE CNQCGRAFSQ KQYLIKHQNV HSGKKPFKCN ECGKAFSQKE
210 220 230 240 250
NLIIHQRIHT GEKPYECKGC GKAFIQKSSL IRHQRSHTGE KPYTCKECGK
260 270 280 290 300
AFSGKSNLTE HEKIHIGEKP YKCNECGTIF RQKQYLIKHH NIHTGEKPYE
310 320 330 340 350
CNKCGKAFSR ITSLIVHVRI HTGDKPYECK VCGKAFCQSS SLTVHMRSHT
360 370 380 390 400
GEKPYGCNEC GKAFSQFSTL ALHMRIHTGE KPYQCSECGK AFSQKSHHIR

HQRIHIH
Length:407
Mass (Da):46,584
Last modified:November 1, 1997 - v1
Checksum:iFA6FB32E67A33BF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U56862 mRNA Translation: AAB01227.1
BC099805 mRNA Translation: AAH99805.1
RefSeqiNP_059060.1, NM_017364.4
UniGeneiRn.98773

Genome annotation databases

EnsembliENSRNOT00000049877; ENSRNOP00000047459; ENSRNOG00000020762
ENSRNOT00000074301; ENSRNOP00000065656; ENSRNOG00000046867
GeneIDi53982
KEGGirno:53982

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U56862 mRNA Translation: AAB01227.1
BC099805 mRNA Translation: AAH99805.1
RefSeqiNP_059060.1, NM_017364.4
UniGeneiRn.98773

3D structure databases

ProteinModelPortaliQ62981
SMRiQ62981
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065656

Proteomic databases

PaxDbiQ62981
PRIDEiQ62981

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000049877; ENSRNOP00000047459; ENSRNOG00000020762
ENSRNOT00000074301; ENSRNOP00000065656; ENSRNOG00000046867
GeneIDi53982
KEGGirno:53982

Organism-specific databases

CTDi26466
RGDi621205 Zfp260

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150959
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ62981
OMAiYECGKAS
OrthoDBiEOG091G02KC
PhylomeDBiQ62981
TreeFamiTF341817

Miscellaneous databases

PROiPR:Q62981

Gene expression databases

BgeeiENSRNOG00000020762 Expressed in 9 organ(s), highest expression level in Ammon's horn
GenevisibleiQ62981 RN

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 12 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN260_RAT
AccessioniPrimary (citable) accession number: Q62981
Secondary accession number(s): Q499Q6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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