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Entry version 149 (11 Dec 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Sodium channel protein type 10 subunit alpha

Gene

Scn10a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Sodium channel, Voltage-gated channel
Biological processIon transport, Sodium transport, Transport
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-RNO-5576892 Phase 0 - rapid depolarisation

Protein family/group databases

Transport Classification Database

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TCDBi
1.A.1.10.6 the voltage-gated ion channel (vic) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium channel protein type 10 subunit alpha
Alternative name(s):
Peripheral nerve sodium channel 3
Short name:
PN3
Sensory neuron sodium channel
Sodium channel protein type X subunit alpha
Voltage-gated sodium channel subunit alpha Nav1.8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Scn10a
Synonyms:Sns
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Rat genome database

More...
RGDi
3629 Scn10a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 125CytoplasmicCuratedAdd BLAST125
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei126 – 149Helical; Name=S1 of repeat ISequence analysisAdd BLAST24
Topological domaini150 – 154ExtracellularCurated5
Transmembranei155 – 174Helical; Name=S2 of repeat ISequence analysisAdd BLAST20
Topological domaini175 – 187CytoplasmicCuratedAdd BLAST13
Transmembranei188 – 206Helical; Name=S3 of repeat ISequence analysisAdd BLAST19
Topological domaini207 – 212ExtracellularCurated6
Transmembranei213 – 232Helical; Voltage-sensor; Name=S4 of repeat ISequence analysisAdd BLAST20
Topological domaini233 – 248CytoplasmicCuratedAdd BLAST16
Transmembranei249 – 272Helical; Name=S5 of repeat ISequence analysisAdd BLAST24
Topological domaini273 – 340ExtracellularCuratedAdd BLAST68
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei341 – 365Pore-formingBy similarityAdd BLAST25
Topological domaini366 – 372ExtracellularCurated7
Transmembranei373 – 398Helical; Name=S6 of repeat ISequence analysisAdd BLAST26
Topological domaini399 – 658CytoplasmicCuratedAdd BLAST260
Transmembranei659 – 683Helical; Name=S1 of repeat IISequence analysisAdd BLAST25
Topological domaini684 – 694ExtracellularCuratedAdd BLAST11
Transmembranei695 – 718Helical; Name=S2 of repeat IISequence analysisAdd BLAST24
Topological domaini719 – 726CytoplasmicCurated8
Transmembranei727 – 746Helical; Name=S3 of repeat IISequence analysisAdd BLAST20
Topological domaini747 – 752ExtracellularCurated6
Transmembranei753 – 772Helical; Voltage-sensor; Name=S4 of repeat IISequence analysisAdd BLAST20
Topological domaini773 – 788CytoplasmicCuratedAdd BLAST16
Transmembranei789 – 809Helical; Name=S5 of repeat IISequence analysisAdd BLAST21
Topological domaini810 – 833ExtracellularCuratedAdd BLAST24
Intramembranei834 – 854Pore-formingBy similarityAdd BLAST21
Topological domaini855 – 863ExtracellularCurated9
Transmembranei864 – 889Helical; Name=S6 of repeat IISequence analysisAdd BLAST26
Topological domaini890 – 1148CytoplasmicCuratedAdd BLAST259
Transmembranei1149 – 1172Helical; Name=S1 of repeat IIISequence analysisAdd BLAST24
Topological domaini1173 – 1185ExtracellularCuratedAdd BLAST13
Transmembranei1186 – 1211Helical; Name=S2 of repeat IIISequence analysisAdd BLAST26
Topological domaini1212 – 1217CytoplasmicCurated6
Transmembranei1218 – 1239Helical; Name=S3 of repeat IIISequence analysisAdd BLAST22
Topological domaini1240 – 1243ExtracellularCurated4
Transmembranei1244 – 1265Helical; Voltage-sensor; Name=S4 of repeat IIISequence analysisAdd BLAST22
Topological domaini1266 – 1284CytoplasmicCuratedAdd BLAST19
Transmembranei1285 – 1312Helical; Name=S5 of repeat IIISequence analysisAdd BLAST28
Topological domaini1313 – 1354ExtracellularCuratedAdd BLAST42
Intramembranei1355 – 1376Pore-formingBy similarityAdd BLAST22
Topological domaini1377 – 1392ExtracellularCuratedAdd BLAST16
Transmembranei1393 – 1419Helical; Name=S6 of repeat IIISequence analysisAdd BLAST27
Topological domaini1420 – 1472CytoplasmicCuratedAdd BLAST53
Transmembranei1473 – 1496Helical; Name=S1 of repeat IVSequence analysisAdd BLAST24
Topological domaini1497 – 1507ExtracellularCuratedAdd BLAST11
Transmembranei1508 – 1531Helical; Name=S2 of repeat IVSequence analysisAdd BLAST24
Topological domaini1532 – 1537CytoplasmicCurated6
Transmembranei1538 – 1561Helical; Name=S3 of repeat IVSequence analysisAdd BLAST24
Topological domaini1562 – 1573ExtracellularCuratedAdd BLAST12
Transmembranei1574 – 1595Helical; Voltage-sensor; Name=S4 of repeat IVSequence analysisAdd BLAST22
Topological domaini1596 – 1610CytoplasmicCuratedAdd BLAST15
Transmembranei1611 – 1633Helical; Name=S5 of repeat IVSequence analysisAdd BLAST23
Topological domaini1634 – 1647ExtracellularCuratedAdd BLAST14
Intramembranei1648 – 1670Pore-formingBy similarityAdd BLAST23
Topological domaini1671 – 1698ExtracellularCuratedAdd BLAST28
Transmembranei1699 – 1723Helical; Name=S6 of repeat IVSequence analysisAdd BLAST25
Topological domaini1724 – 1956CytoplasmicCuratedAdd BLAST233

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4017

DrugCentral

More...
DrugCentrali
Q62968

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
585

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000485091 – 1956Sodium channel protein type 10 subunit alphaAdd BLAST1956

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi276 ↔ 318By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi279N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi288N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi311N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi334N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei440PhosphoserineBy similarity1
Modified residuei443PhosphoserineBy similarity1
Modified residuei466PhosphoserineBy similarity1
Modified residuei478PhosphoserineBy similarity1
Modified residuei611PhosphoserineBy similarity1
Modified residuei614PhosphoserineBy similarity1
Disulfide bondi856 ↔ 865By similarity
Glycosylationi1323N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1329N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1337N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1452Phosphoserine; by PKCBy similarity1
Glycosylationi1687N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by NEDD4L; which promotes its endocytosis.By similarity
Phosphorylation at Ser-1452 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.By similarity
Lacks the cysteine which covalently binds the conotoxin GVIIJ. This cysteine (position 815) is speculated in other sodium channel subunits alpha to be implied in covalent binding with the sodium channel subunit beta-2 or beta-4.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q62968

PRoteomics IDEntifications database

More...
PRIDEi
Q62968

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q62968

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q62968

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in dorsal root ganglia, trigeminal ganglia, nodose ganglia and sciatic nerve.3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in dorsal root ganglia at 15 dpc onwards.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated after axotomy in dorsal root ganglia.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSRNOG00000032473 Expressed in 4 organ(s), highest expression level in testis

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q62968 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The channel consists of an ion conducting pore forming alpha-subunit regulated by one or more associated auxiliary subunits SCN1B, SCN2B and SCN3B; electrophysiological properties may vary depending on the type of the associated beta subunits.

Found in a number of complexes with PRX, DYNLT1 and PDZD2.

Interacts with proteins such as FSTL1, PRX, DYNLT1, PDZD2, S100A10 and many others.

Interacts with NEDD4 and NEDD4L.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q62968

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q62968

Protein interaction database and analysis system

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IntActi
Q62968, 23 interactors

STRING: functional protein association networks

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STRINGi
10116.ENSRNOP00000047944

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q62968

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati116 – 404ICuratedAdd BLAST289
Repeati646 – 910IICuratedAdd BLAST265
Repeati1141 – 1450IIICuratedAdd BLAST310
Repeati1459 – 1758IVCuratedAdd BLAST300
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1852 – 1881IQAdd BLAST30

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.Curated

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2301 Eukaryota
ENOG410XNP6 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154992

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231755

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q62968

KEGG Orthology (KO)

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KOi
K04842

Identification of Orthologs from Complete Genome Data

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OMAi
DYYLDQK

Database of Orthologous Groups

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OrthoDBi
172471at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q62968

TreeFam database of animal gene trees

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TreeFami
TF323985

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005821 Ion_trans_dom
IPR028809 Na_channel_a10su
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR027359 Volt_channel_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR10037:SF208 PTHR10037:SF208, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00170 NACHANNEL

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q62968-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELPFASVGT TNFRRFTPES LAEIEKQIAA HRAAKKARTK HRGQEDKGEK
60 70 80 90 100
PRPQLDLKAC NQLPKFYGEL PAELVGEPLE DLDPFYSTHR TFMVLNKSRT
110 120 130 140 150
ISRFSATWAL WLFSPFNLIR RTAIKVSVHS WFSIFITITI LVNCVCMTRT
160 170 180 190 200
DLPEKVEYVF TVIYTFEALI KILARGFCLN EFTYLRDPWN WLDFSVITLA
210 220 230 240 250
YVGAAIDLRG ISGLRTFRVL RALKTVSVIP GLKVIVGALI HSVRKLADVT
260 270 280 290 300
ILTVFCLSVF ALVGLQLFKG NLKNKCIRNG TDPHKADNLS SEMAEYIFIK
310 320 330 340 350
PGTTDPLLCG NGSDAGHCPG GYVCLKTPDN PDFNYTSFDS FAWAFLSLFR
360 370 380 390 400
LMTQDSWERL YQQTLRASGK MYMVFFVLVI FLGSFYLVNL ILAVVTMAYE
410 420 430 440 450
EQSQATIAEI EAKEKKFQEA LEVLQKEQEV LAALGIDTTS LQSHSGSPLA
460 470 480 490 500
SKNANERRPR VKSRVSEGST DDNRSPQSDP YNQRRMSFLG LSSGRRRASH
510 520 530 540 550
GSVFHFRAPS QDISFPDGIT DDGVFHGDQE SRRGSILLGR GAGQTGPLPR
560 570 580 590 600
SPLPQSPNPG RRHGEEGQLG VPTGELTAGA PEGPALDTTG QKSFLSAGYL
610 620 630 640 650
NEPFRAQRAM SVVSIMTSVI EELEESKLKC PPCLISFAQK YLIWECCPKW
660 670 680 690 700
RKFKMALFEL VTDPFAELTI TLCIVVNTVF MAMEHYPMTD AFDAMLQAGN
710 720 730 740 750
IVFTVFFTME MAFKIIAFDP YYYFQKKWNI FDCVIVTVSL LELSASKKGS
760 770 780 790 800
LSVLRTFRLL RVFKLAKSWP TLNTLIKIIG NSVGALGNLT FILAIIVFIF
810 820 830 840 850
ALVGKQLLSE DYGCRKDGVS VWNGEKLRWH MCDFFHSFLV VFRILCGEWI
860 870 880 890 900
ENMWVCMEVS QKSICLILFL TVMVLGNLVV LNLFIALLLN SFSADNLTAP
910 920 930 940 950
EDDGEVNNLQ LALARIQVLG HRASRAIASY ISSHCRFRWP KVETQLGMKP
960 970 980 990 1000
PLTSSEAKNH IATDAVSAAV GNLTKPALSS PKENHGDFIT DPNVWVSVPI
1010 1020 1030 1040 1050
AEGESDLDEL EEDMEQASQS SWQEEDPKGQ QEQLPQVQKC ENHQAARSPA
1060 1070 1080 1090 1100
SMMSSEDLAP YLGESWKRKD SPQVPAEGVD DTSSSEGSTV DCPDPEEILR
1110 1120 1130 1140 1150
KIPELADDLD EPDDCFTEGC TRRCPCCNVN TSKSPWATGW QVRKTCYRIV
1160 1170 1180 1190 1200
EHSWFESFII FMILLSSGAL AFEDNYLEEK PRVKSVLEYT DRVFTFIFVF
1210 1220 1230 1240 1250
EMLLKWVAYG FKKYFTNAWC WLDFLIVNIS LTSLIAKILE YSDVASIKAL
1260 1270 1280 1290 1300
RTLRALRPLR ALSRFEGMRV VVDALVGAIP SIMNVLLVCL IFWLIFSIMG
1310 1320 1330 1340 1350
VNLFAGKFSK CVDTRNNPFS NVNSTMVNNK SECHNQNSTG HFFWVNVKVN
1360 1370 1380 1390 1400
FDNVAMGYLA LLQVATFKGW MDIMYAAVDS GEINSQPNWE NNLYMYLYFV
1410 1420 1430 1440 1450
VFIIFGGFFT LNLFVGVIID NFNQQKKKLG GQDIFMTEEQ KKYYNAMKKL
1460 1470 1480 1490 1500
GSKKPQKPIP RPLNKYQGFV FDIVTRQAFD IIIMVLICLN MITMMVETDE
1510 1520 1530 1540 1550
QGEEKTKVLG RINQFFVAVF TGECVMKMFA LRQYYFTNGW NVFDFIVVIL
1560 1570 1580 1590 1600
SIGSLLFSAI LKSLENYFSP TLFRVIRLAR IGRILRLIRA AKGIRTLLFA
1610 1620 1630 1640 1650
LMMSLPALFN IGLLLFLVMF IYSIFGMASF ANVVDEAGID DMFNFKTFGN
1660 1670 1680 1690 1700
SMLCLFQITT SAGWDGLLSP ILNTGPPYCD PNLPNSNGSR GNCGSPAVGI
1710 1720 1730 1740 1750
IFFTTYIIIS FLIVVNMYIA VILENFNVAT EESTEPLSED DFDMFYETWE
1760 1770 1780 1790 1800
KFDPEATQFI AFSALSDFAD TLSGPLRIPK PNQNILIQMD LPLVPGDKIH
1810 1820 1830 1840 1850
CLDILFAFTK NVLGESGELD SLKTNMEEKF MATNLSKASY EPIATTLRWK
1860 1870 1880 1890 1900
QEDLSATVIQ KAYRSYMLHR SLTLSNTLHV PRAEEDGVSL PGEGYVTFMA
1910 1920 1930 1940 1950
NSGLPDKSET ASATSFPPSY DSVTRGLSDR ANINPSSSMQ NEDEVAAKEG

NSPGPQ
Length:1,956
Mass (Da):219,733
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8FC58EDAD263AC67
GO
Isoform 2 (identifier: Q62968-2) [UniParc]FASTAAdd to basket
Also known as: Nav1.8c

The sequence of this isoform differs from the canonical sequence as follows:
     1030-1030: Missing.

Show »
Length:1,955
Mass (Da):219,605
Checksum:i4C6677DF46388F43
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti59A → D in CAA63095 (PubMed:8538791).Curated1
Sequence conflicti432A → E in CAA63095 (PubMed:8538791).Curated1
Sequence conflicti520T → TP in CAA63095 (PubMed:8538791).Curated1
Sequence conflicti587D → H in CAA63095 (PubMed:8538791).Curated1
Sequence conflicti757F → L in CAA63095 (PubMed:8538791).Curated1
Sequence conflicti938R → H in CAA63095 (PubMed:8538791).Curated1
Sequence conflicti1896V → I in CAA63095 (PubMed:8538791).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0122581030Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X92184 mRNA Translation: CAA63095.1
U53833 Genomic DNA Translation: AAC52619.1
AJ623271 mRNA Translation: CAF25041.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S68453

NCBI Reference Sequences

More...
RefSeqi
NP_058943.1, NM_017247.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000046864; ENSRNOP00000047944; ENSRNOG00000032473 [Q62968-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
29571

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:29571

UCSC genome browser

More...
UCSCi
RGD:3629 rat [Q62968-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92184 mRNA Translation: CAA63095.1
U53833 Genomic DNA Translation: AAC52619.1
AJ623271 mRNA Translation: CAF25041.1
PIRiS68453
RefSeqiNP_058943.1, NM_017247.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

CORUMiQ62968
ELMiQ62968
IntActiQ62968, 23 interactors
STRINGi10116.ENSRNOP00000047944

Chemistry databases

BindingDBiQ62968
ChEMBLiCHEMBL4017
DrugCentraliQ62968
GuidetoPHARMACOLOGYi585

Protein family/group databases

TCDBi1.A.1.10.6 the voltage-gated ion channel (vic) superfamily

PTM databases

iPTMnetiQ62968
PhosphoSitePlusiQ62968

Proteomic databases

PaxDbiQ62968
PRIDEiQ62968

Genome annotation databases

EnsembliENSRNOT00000046864; ENSRNOP00000047944; ENSRNOG00000032473 [Q62968-1]
GeneIDi29571
KEGGirno:29571
UCSCiRGD:3629 rat [Q62968-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6336
RGDi3629 Scn10a

Phylogenomic databases

eggNOGiKOG2301 Eukaryota
ENOG410XNP6 LUCA
GeneTreeiENSGT00940000154992
HOGENOMiHOG000231755
InParanoidiQ62968
KOiK04842
OMAiDYYLDQK
OrthoDBi172471at2759
PhylomeDBiQ62968
TreeFamiTF323985

Enzyme and pathway databases

ReactomeiR-RNO-5576892 Phase 0 - rapid depolarisation

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q62968

Gene expression databases

BgeeiENSRNOG00000032473 Expressed in 4 organ(s), highest expression level in testis
GenevisibleiQ62968 RN

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR028809 Na_channel_a10su
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10037:SF208 PTHR10037:SF208, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PRINTSiPR00170 NACHANNEL

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCNAA_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q62968
Secondary accession number(s): Q63554, Q6EWG6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: November 1, 1996
Last modified: December 11, 2019
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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