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Entry version 145 (16 Jan 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Leptin receptor

Gene

Lepr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for hormone LEP/leptin (Probable). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (PubMed:8690163). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (By similarity). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T-cells. Leptin increases Th1 and suppresses Th2 cytokine production (By similarity).By similarity1 Publication1 Publication
Isoform A: May transport LEP across the blood-brain barrier. Binds LEP and mediates LEP endocytosis (PubMed:10698121). Does not induce phosphorylation of and activate STAT3 (By similarity).By similarity1 Publication
Isoform E: Antagonizes Isoform A and isoform B-mediated LEP binding and endocytosis.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cytokine binding Source: GO_Central
  • cytokine receptor activity Source: GO_Central
  • leptin receptor activity Source: UniProtKB
  • peptide hormone binding Source: RGD
  • protein-hormone receptor activity Source: RGD

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leptin receptor
Short name:
LEP-R
Alternative name(s):
OB receptor
Short name:
OB-R
CD_antigen: CD295
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lepr
Synonyms:Fa, Obr
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
3001 Lepr

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 839ExtracellularSequence analysisAdd BLAST818
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei840 – 860HelicalSequence analysisAdd BLAST21
Topological domaini861 – 1162CytoplasmicSequence analysisAdd BLAST302

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

The fatty (Fa) mutation produces profound obesity of early onset caused by hyperphagia, defective non-shivering thermogenesis, and preferential deposition of energy into adipose tissue.

Keywords - Diseasei

Disease mutation, Obesity

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001090822 – 1162Leptin receptorAdd BLAST1141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi37 ↔ 90By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi73N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi89 ↔ 99By similarity
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi131 ↔ 142By similarity
Disulfide bondi186 ↔ 195By similarity
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi188 ↔ 193By similarity
Glycosylationi275N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi345N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi350 ↔ 410By similarity
Glycosylationi356N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi411 ↔ 416By similarity
Glycosylationi431N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi434 ↔ 445By similarity
Disulfide bondi471 ↔ 526By similarity
Disulfide bondi486 ↔ 496By similarity
Glycosylationi514N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi622N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi657N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi668N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi686N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi695N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi698N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi726N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei880PhosphoserineBy similarity1
Modified residuei985Phosphotyrosine; by JAK2By similarity1
Modified residuei1077PhosphotyrosineBy similarity1
Modified residuei1138Phosphotyrosine; by JAK2By similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-985 is required for complete binding and activation of PTPN11, ERK/FOS activation,for interaction with SOCS3 and SOCS3 mediated inhibition of leptin signaling. Phosphorylation on Tyr-1138 is required for STAT3 binding/activation. Phosphorylation of Tyr-1077 has a more accessory role.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q62959

PRoteomics IDEntifications database

More...
PRIDEi
Q62959

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q62959

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q62959

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform B is expressed in kidney, liver, lung, ovary, spleen and uterus. Increased level in uterus during gestation (PubMed:8772180). Isoform A and isoform C are predominantly expressed in cerebral microvessels and choroid plexus, with lower levels in cortex, cerebellum and hypothalamus but also liver and lung (PubMed:11861497). Isoform F is expressed at high levels in brain, liver and spleen and less in stomach, kidney, thymus, heart, lung and hypothalamus (PubMed:11861497, PubMed:8772180).2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Present as a mixture of monomers and dimers (Probable). The phosphorylated receptor binds a number of SH2 domain-containing proteins such as JAK2, STAT3, PTPN11, and SOCS3 (By similarity). Interaction with SOCS3 inhibits JAK/STAT signaling and MAPK cascade (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
246689, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000046647

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q62959

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini238 – 331Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST94
Domaini537 – 632Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini637 – 729Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST93
Domaini738 – 831Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni465 – 482Leptin-bindingBy similarityAdd BLAST18
Regioni891 – 896Required for JAK2 activationBy similarity6
Regioni896 – 904Required for STAT3 phosphorylationBy similarity9

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi620 – 624WSXWS motif5
Motifi869 – 877Box 1 motif9

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IKH4 Eukaryota
ENOG4110JZP LUCA

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000140

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q62959

KEGG Orthology (KO)

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KOi
K05062

Database of Orthologous Groups

More...
OrthoDBi
144839at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q62959

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 4 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 7 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003529 Hematopoietin_rcpt_Gp130_CS
IPR003531 Hempt_rcpt_S_F1_CS
IPR013783 Ig-like_fold
IPR010457 IgC2-like_lig-bd
IPR015752 Lep_receptor

The PANTHER Classification System

More...
PANTHERi
PTHR23036:SF109 PTHR23036:SF109, 3 hits

Pfam protein domain database

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Pfami
View protein in Pfam
PF06328 Lep_receptor_Ig, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 3 hits
PS01353 HEMATOPO_REC_L_F2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform B (identifier: Q62959-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTCQKFYVVL LHWEFLYVIT ALNLAYPTSP WRFKLFCAPP STTDDSFLSP
60 70 80 90 100
AGVPNNTSSL KGASEALVEA KFNSTGIYVS ELSKTIFHCC FGNEQGQNCS
110 120 130 140 150
ALTGNTEGKT LASVVKPLVF RQLGVNWDIE CWMKGDLTLF ICHMEPLLKN
160 170 180 190 200
PFKNYDSKVH LLYDLPEVID DLPLPPLKDS FQTVQCNCSV RECECHVPVP
210 220 230 240 250
RAKVNYALLM YLEITSAGVS FQSPLMSLQP MLVVKPDPPL GLRMEVTDDG
260 270 280 290 300
NLKISWDSQT KAPFPLQYQV KYLENSTIVR EAAEIVSDTS LLVDSVLPGS
310 320 330 340 350
SYEVQVRSKR LDGSGVWSDW SLPQLFTTQD VMYFPPKILT SVGSNASFCC
360 370 380 390 400
IYKNENQTIS SKQIVWWMNL AEKIPETQYN TVSDHISKVT FSNLKATRPR
410 420 430 440 450
GKFTYDAVYC CNEQACHHRY AELYVIDVNI NISCETDGYL TKMTCRWSPS
460 470 480 490 500
TIQSLVGSTV QLRYHRRSLY CPDNPSIRPT SELKNCVLQT DGFYECVFQP
510 520 530 540 550
IFLLSGYTMW IRINHSLGSL DSPPTCVLPD SVVKPLPPSN VKAEITINTG
560 570 580 590 600
LLKVSWEKPV FPENNLQFQI RYGLNGKEIQ WKTHEVFDAK SKSASLPVSD
610 620 630 640 650
LCAVYVVQVR CRRLDGLGYW SNWSSPAYTL VMDVKVPMRG PEFWRIMDGD
660 670 680 690 700
ITKKERNVTL LWKPLMKNDS LCSVRRYVVK HRTAHNGTWS QDVGNQTNLT
710 720 730 740 750
FLWAESAHTV TVLAINSIGA SLVNFNLTFS WPMSKVNAVQ SLSAYPLSSS
760 770 780 790 800
CVILSWTLSP NDYSLLYLVI EWKNLNDDDG MKWLRIPSNV NKYYIHDNFI
810 820 830 840 850
PIEKYQFSLY PVFMEGVGKP KIINGFTKDD IAKQQNDAGL YVIVPIIISS
860 870 880 890 900
CVLLLGTLLI SHQRMKKLFW DDVPNPKNCS WAQGLNFQKP ETFEHLFTKH
910 920 930 940 950
AESVIFGPLL LEPEPVSEEI SVDTAWKNKD EMVPAAMVSL LLTTPDSTRG
960 970 980 990 1000
SICISDQCNS ANFSGAQSTQ GTCEDECQSQ PSVKYATLVS NVKTVETDEE
1010 1020 1030 1040 1050
QGAIHSSVSQ CIARKHSPLR QSFSSNSWEI EAQAFFLLSD HPPNVISPQL
1060 1070 1080 1090 1100
SFSGLDELLE LEGNFPEENH GEKSVYYLGV SSGNKRENDM LLTDEAGVLC
1110 1120 1130 1140 1150
PFPAHCLFSD IRILQESCSH FVENNLNLGT SGKNFVPYMP QFQSCSTHSH
1160
KIIENKMCDL TV
Length:1,162
Mass (Da):130,833
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBA7AC2CA2D2E62AF
GO
Isoform A (identifier: Q62959-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     890-894: PETFE → RADTL
     895-1162: Missing.

Show »
Length:894
Mass (Da):101,283
Checksum:iAB30482E47EE11F5
GO
Isoform C (identifier: Q62959-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     890-892: PET → VTV
     893-1162: Missing.

Show »
Length:892
Mass (Da):101,025
Checksum:iD052312E11F59B6C
GO
Isoform D (identifier: Q62959-6)
Sequence is not available
Length:
Mass (Da):
Isoform E (identifier: Q62959-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     797-805: DNFIPIEKY → GMCTVLLLN
     806-1162: Missing.

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Length:805
Mass (Da):91,088
Checksum:iE8E5090C346530E5
GO
Isoform F (identifier: Q62959-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     890-895: PETFEH → IMPGRN
     896-1162: Missing.

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Length:895
Mass (Da):101,395
Checksum:iFAE80985E513BE11
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1M9F2F1M9F2_RAT
Leptin receptor
Lepr
895Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2T → M in AAB06616 (Ref. 4) Curated1
Sequence conflicti12H → P in BAA24899 (Ref. 8) Curated1
Sequence conflicti34K → R in BAA24899 (Ref. 8) Curated1
Sequence conflicti415 – 417ACH → QCQ in AAB03088 (PubMed:8772180).Curated3
Sequence conflicti422E → D in AAB03088 (PubMed:8772180).Curated1
Sequence conflicti493F → L in AAB03088 (PubMed:8772180).Curated1
Sequence conflicti498F → S in AAB03088 (PubMed:8772180).Curated1
Sequence conflicti612R → Q in AAB03088 (PubMed:8772180).Curated1
Sequence conflicti690S → T in AAB03088 (PubMed:8772180).Curated1
Sequence conflicti703 – 704WA → SG in AAB03088 (PubMed:8772180).Curated2
Sequence conflicti714A → D in AAB03088 (PubMed:8772180).Curated1
Sequence conflicti738 – 739AV → GW in AAB03088 (PubMed:8772180).Curated2
Sequence conflicti751 – 752CV → SL in AAB40654 (Ref. 10) Curated2
Sequence conflicti766L → S in AAB63202 (PubMed:9268737).Curated1
Sequence conflicti785R → K in AAB63202 (PubMed:9268737).Curated1
Sequence conflicti794Y → N in AAB63202 (PubMed:9268737).Curated1
Sequence conflicti846I → V in AAB63201 (PubMed:9268737).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti269Q → P in FA. 5 Publications1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001709797 – 805DNFIPIEKY → GMCTVLLLN in isoform E. 2 Publications9
Alternative sequenceiVSP_001710806 – 1162Missing in isoform E. 2 PublicationsAdd BLAST357
Alternative sequenceiVSP_001711890 – 895PETFEH → IMPGRN in isoform F. 1 Publication6
Alternative sequenceiVSP_001705890 – 894PETFE → RADTL in isoform A. 3 Publications5
Alternative sequenceiVSP_001707890 – 892PET → VTV in isoform C. 1 Publication3
Alternative sequenceiVSP_001708893 – 1162Missing in isoform C. 1 PublicationAdd BLAST270
Alternative sequenceiVSP_001706895 – 1162Missing in isoform A. 3 PublicationsAdd BLAST268
Alternative sequenceiVSP_001712896 – 1162Missing in isoform F. 1 PublicationAdd BLAST267

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U52966 mRNA Translation: AAC52587.1
D84550 mRNA Translation: BAA12697.1
D84551 mRNA Translation: BAA12698.1
D85557 mRNA Translation: BAA12830.1
D85558 mRNA Translation: BAA12831.1
D85559 mRNA Translation: BAA12832.1
U60151 mRNA Translation: AAB06616.1
D84125 mRNA Translation: BAA12230.1
D84126 mRNA Translation: BAA12231.1
AF287268 mRNA Translation: AAF89300.1
U53144 mRNA Translation: AAB03088.1
AB011006 Genomic DNA Translation: BAA24899.1
AF007818 mRNA Translation: AAB63201.1
AF007819 mRNA Translation: AAB63202.1
U67207 mRNA Translation: AAB40654.1
AF304191 mRNA Translation: AAG22823.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JC4895 PC4184
S74225

NCBI Reference Sequences

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RefSeqi
NP_036728.1, NM_012596.1 [Q62959-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Rn.9891

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
24536

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:24536

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52966 mRNA Translation: AAC52587.1
D84550 mRNA Translation: BAA12697.1
D84551 mRNA Translation: BAA12698.1
D85557 mRNA Translation: BAA12830.1
D85558 mRNA Translation: BAA12831.1
D85559 mRNA Translation: BAA12832.1
U60151 mRNA Translation: AAB06616.1
D84125 mRNA Translation: BAA12230.1
D84126 mRNA Translation: BAA12231.1
AF287268 mRNA Translation: AAF89300.1
U53144 mRNA Translation: AAB03088.1
AB011006 Genomic DNA Translation: BAA24899.1
AF007818 mRNA Translation: AAB63201.1
AF007819 mRNA Translation: AAB63202.1
U67207 mRNA Translation: AAB40654.1
AF304191 mRNA Translation: AAG22823.1
PIRiJC4895 PC4184
S74225
RefSeqiNP_036728.1, NM_012596.1 [Q62959-1]
UniGeneiRn.9891

3D structure databases

ProteinModelPortaliQ62959
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi246689, 1 interactor
STRINGi10116.ENSRNOP00000046647

PTM databases

iPTMnetiQ62959
PhosphoSitePlusiQ62959

Proteomic databases

PaxDbiQ62959
PRIDEiQ62959

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24536
KEGGirno:24536

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3953
RGDi3001 Lepr

Phylogenomic databases

eggNOGiENOG410IKH4 Eukaryota
ENOG4110JZP LUCA
HOVERGENiHBG000140
InParanoidiQ62959
KOiK05062
OrthoDBi144839at2759
PhylomeDBiQ62959

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q62959

Family and domain databases

CDDicd00063 FN3, 4 hits
Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003529 Hematopoietin_rcpt_Gp130_CS
IPR003531 Hempt_rcpt_S_F1_CS
IPR013783 Ig-like_fold
IPR010457 IgC2-like_lig-bd
IPR015752 Lep_receptor
PANTHERiPTHR23036:SF109 PTHR23036:SF109, 3 hits
PfamiView protein in Pfam
PF06328 Lep_receptor_Ig, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 4 hits
SUPFAMiSSF49265 SSF49265, 4 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits
PS01353 HEMATOPO_REC_L_F2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLEPR_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q62959
Secondary accession number(s): O35772
, O35773, O54805, P70493, P70494, P70495, P97589, Q62960, Q63007, Q63385, Q63386, Q9ERI4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: January 16, 2019
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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