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Protein

Prostaglandin E2 receptor EP2 subtype

Gene

Ptger2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle (By similarity).By similarity

GO - Molecular functioni

  • prostaglandin E receptor activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-391908 Prostanoid ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin E2 receptor EP2 subtype
Short name:
PGE receptor EP2 subtype
Short name:
PGE2 receptor EP2 subtype
Alternative name(s):
Prostanoid EP2 receptor
Gene namesi
Name:Ptger2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi620020 Ptger2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24ExtracellularSequence analysisAdd BLAST24
Transmembranei25 – 48Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini49 – 66CytoplasmicSequence analysisAdd BLAST18
Transmembranei67 – 92Helical; Name=2Sequence analysisAdd BLAST26
Topological domaini93 – 112ExtracellularSequence analysisAdd BLAST20
Transmembranei113 – 133Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini134 – 152CytoplasmicSequence analysisAdd BLAST19
Transmembranei153 – 177Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini178 – 199ExtracellularSequence analysisAdd BLAST22
Transmembranei200 – 224Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini225 – 262CytoplasmicSequence analysisAdd BLAST38
Transmembranei263 – 286Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini287 – 299ExtracellularSequence analysisAdd BLAST13
Transmembranei300 – 323Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini324 – 357CytoplasmicSequence analysisAdd BLAST34

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4909
GuidetoPHARMACOLOGYi341

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700561 – 357Prostaglandin E2 receptor EP2 subtypeAdd BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi110 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ62928

PTM databases

PhosphoSitePlusiQ62928

Expressioni

Gene expression databases

BgeeiENSRNOG00000050968 Expressed in 8 organ(s), highest expression level in testis
GenevisibleiQ62928 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064907

Chemistry databases

BindingDBiQ62928

Structurei

3D structure databases

ProteinModelPortaliQ62928
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119188
HOGENOMiHOG000115475
HOVERGENiHBG003074
InParanoidiQ62928
KOiK04259
OMAiTWCFIRH
OrthoDBiEOG091G0F07
PhylomeDBiQ62928
TreeFamiTF324982

Family and domain databases

CDDicd15139 7tmA_PGE2_EP2, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR008365 Prostanoid_rcpt
IPR001923 Prostglndn_EP2_rcpt
PANTHERiPTHR11866 PTHR11866, 1 hit
PTHR11866:SF8 PTHR11866:SF8, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01788 PROSTANOIDR
PR00581 PRSTNOIDEP2R
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q62928-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDNSFNDSRR VENCESRQYL LSDESPAISS VMFTAGVLGN LIALALLARR
60 70 80 90 100
WRGDTGCSAG SRTSISLFHV LVTELVLTDL LGTCLISPVV LASYSRNQTL
110 120 130 140 150
VALAPESRAC TYFAFTMTFF SLATMLMLFA MALERYLAIG HPYFYRRRVS
160 170 180 190 200
RRGGLAVLPA IYGVSLLFCS LPLLNYGEYV QYCPGTWCFI QHGRTAYLQL
210 220 230 240 250
YATVLLLLIV AVLGCNISVI LNLIRMQLRS KRSRCGLSGS SLRGPGSRRR
260 270 280 290 300
GERTSMAEET DHLILLAIMT ITFAVCSLPF TIFAYMDETS SRKEKWDLRA
310 320 330 340 350
LRFLSVNSII DPWVFVILRP PVLRLMRSVL CCRTSLRAPE APGASCSTQQ

TDLCGQL
Length:357
Mass (Da):39,772
Last modified:November 1, 1996 - v1
Checksum:iAAB22A8280AFEFB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48858 mRNA Translation: AAA97889.1
U94708 mRNA Translation: AAB53325.1
AF454964 Genomic DNA Translation: AAM73855.1
RefSeqiNP_112350.1, NM_031088.1
UniGeneiRn.10264

Genome annotation databases

EnsembliENSRNOT00000075209; ENSRNOP00000064907; ENSRNOG00000050968
GeneIDi81752
KEGGirno:81752

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48858 mRNA Translation: AAA97889.1
U94708 mRNA Translation: AAB53325.1
AF454964 Genomic DNA Translation: AAM73855.1
RefSeqiNP_112350.1, NM_031088.1
UniGeneiRn.10264

3D structure databases

ProteinModelPortaliQ62928
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064907

Chemistry databases

BindingDBiQ62928
ChEMBLiCHEMBL4909
GuidetoPHARMACOLOGYi341

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ62928

Proteomic databases

PaxDbiQ62928

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000075209; ENSRNOP00000064907; ENSRNOG00000050968
GeneIDi81752
KEGGirno:81752

Organism-specific databases

CTDi5732
RGDi620020 Ptger2

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119188
HOGENOMiHOG000115475
HOVERGENiHBG003074
InParanoidiQ62928
KOiK04259
OMAiTWCFIRH
OrthoDBiEOG091G0F07
PhylomeDBiQ62928
TreeFamiTF324982

Enzyme and pathway databases

ReactomeiR-RNO-391908 Prostanoid ligand receptors

Miscellaneous databases

PROiPR:Q62928

Gene expression databases

BgeeiENSRNOG00000050968 Expressed in 8 organ(s), highest expression level in testis
GenevisibleiQ62928 RN

Family and domain databases

CDDicd15139 7tmA_PGE2_EP2, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR008365 Prostanoid_rcpt
IPR001923 Prostglndn_EP2_rcpt
PANTHERiPTHR11866 PTHR11866, 1 hit
PTHR11866:SF8 PTHR11866:SF8, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01788 PROSTANOIDR
PR00581 PRSTNOIDEP2R
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPE2R2_RAT
AccessioniPrimary (citable) accession number: Q62928
Secondary accession number(s): Q547S0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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