UniProtKB - Q62912 (MAD3_RAT)
Max dimerization protein 3
Mxd3
Functioni
Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity).
By similarityGO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Max dimerization protein 3Short name: Max dimerizer 3 Alternative name(s): Max-associated protein 3 Max-interacting transcriptional repressor MAD3 Myx |
Gene namesi | Name:Mxd3 Synonyms:Mad3 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 628624, Mxd3 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000253709 | 1 – 206 | Max dimerization protein 3Add BLAST | 206 |
Proteomic databases
PaxDbi | Q62912 |
Interactioni
Subunit structurei
Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX.
Interacts with SIN3A AND SIN3B.
Interacts with RNF17 (By similarity).
By similarityGO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000021946 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 57 – 109 | bHLHPROSITE-ProRule annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 8 – 25 | Interaction with SIN3A and SIN3BBy similarityAdd BLAST | 18 |
Phylogenomic databases
eggNOGi | KOG2483, Eukaryota |
InParanoidi | Q62912 |
OrthoDBi | 1545091at2759 |
PhylomeDBi | Q62912 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MEPVASNIQV LLQAAEFLER REREAEHGYA SLCPHHSPGT VCRRRKAPLQ
60 70 80 90 100
APGALNSGRH VHNELEKRRR AQLKRCLEQL RQQMPLGVDH TRYTTLSLLR
110 120 130 140 150
GARMHIQKLE EQEQQAQRLK EKLRSRQQSL QQQLEQLQGL LGVRERDRLR
160 170 180 190 200
ADSLDSSGLS SERFDSDQED LEVDVESLVF GTETELLQSF SAGQEHSYSH
STGTWL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V831 | G3V831_RAT | Max dimerization protein 3 | Mxd3 rCG_24190 | 206 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U45986 mRNA Translation: AAA91185.1 |
RefSeqi | NP_665716.1, NM_145773.1 |
Genome annotation databases
GeneIDi | 252915 |
KEGGi | rno:252915 |
UCSCi | RGD:628624, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U45986 mRNA Translation: AAA91185.1 |
RefSeqi | NP_665716.1, NM_145773.1 |
3D structure databases
AlphaFoldDBi | Q62912 |
SMRi | Q62912 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000021946 |
Proteomic databases
PaxDbi | Q62912 |
Genome annotation databases
GeneIDi | 252915 |
KEGGi | rno:252915 |
UCSCi | RGD:628624, rat |
Organism-specific databases
CTDi | 83463 |
RGDi | 628624, Mxd3 |
Phylogenomic databases
eggNOGi | KOG2483, Eukaryota |
InParanoidi | Q62912 |
OrthoDBi | 1545091at2759 |
PhylomeDBi | Q62912 |
Miscellaneous databases
PROi | PR:Q62912 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MAD3_RAT | |
Accessioni | Q62912Primary (citable) accession number: Q62912 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 17, 2006 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |