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Protein

Protein ERGIC-53

Gene

Lman1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei96CarbohydratePROSITE-ProRule annotation1
Binding sitei129CarbohydratePROSITE-ProRule annotation1
Metal bindingi160Calcium 11
Metal bindingi162Calcium 1; via carbonyl oxygen1
Metal bindingi163Calcium 21
Metal bindingi164Calcium 11
Binding sitei164CarbohydratePROSITE-ProRule annotation1
Metal bindingi165Calcium 21
Metal bindingi169Calcium 21
Metal bindingi170Calcium 21
Binding sitei186CarbohydratePROSITE-ProRule annotation1
Metal bindingi189Calcium 11
Metal bindingi189Calcium 21
Sitei508Required for ER exportBy similarity1

GO - Molecular functioni

  • calcium ion binding Source: RGD
  • identical protein binding Source: RGD
  • mannose binding Source: RGD

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: RGD
  • protein transport Source: UniProtKB-KW

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandLectin, Metal-binding

Protein family/group databases

UniLectiniQ62902

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ERGIC-53
Alternative name(s):
ER-Golgi intermediate compartment 53 kDa protein
Lectin mannose-binding 1
p58
Gene namesi
Name:Lman1
Synonyms:Ergic53
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi71020 Lman1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 484LumenalSequence analysisAdd BLAST454
Transmembranei485 – 505HelicalSequence analysisAdd BLAST21
Topological domaini506 – 517CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000001766231 – 517Protein ERGIC-53Add BLAST487

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi198 ↔ 238PROSITE-ProRule annotation2 Publications
Modified residuei433PhosphoserineBy similarity1
Disulfide bondi473InterchainPROSITE-ProRule annotation
Disulfide bondi482InterchainPROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ62902
PeptideAtlasiQ62902
PRIDEiQ62902

PTM databases

iPTMnetiQ62902
PhosphoSitePlusiQ62902

Interactioni

Subunit structurei

Exists both as a covalent disulfide-linked homohexamer, and a complex of three disulfide-linked dimers non-covalently kept together. Interacts with MCFD2. May interact with TMEM115. Interacts with RAB3GAP1 and RAB3GAP2. Interacts with UBXN6.By similarity

GO - Molecular functioni

  • identical protein binding Source: RGD

Protein-protein interaction databases

BioGridi250550, 1 interactor
IntActiQ62902, 5 interactors
MINTiQ62902
STRINGi10116.ENSRNOP00000035966

Structurei

Secondary structure

1517
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi43 – 46Combined sources4
Beta strandi51 – 54Combined sources4
Helixi56 – 58Combined sources3
Beta strandi60 – 64Combined sources5
Beta strandi75 – 79Combined sources5
Beta strandi88 – 91Combined sources4
Beta strandi98 – 105Combined sources8
Beta strandi110 – 121Combined sources12
Beta strandi123 – 125Combined sources3
Beta strandi130 – 138Combined sources9
Beta strandi153 – 160Combined sources8
Beta strandi172 – 180Combined sources9
Helixi186 – 193Combined sources8
Beta strandi195 – 198Combined sources4
Beta strandi209 – 216Combined sources8
Beta strandi219 – 225Combined sources7
Beta strandi227 – 230Combined sources4
Beta strandi236 – 241Combined sources6
Beta strandi248 – 257Combined sources10
Beta strandi264 – 276Combined sources13

3D structure databases

ProteinModelPortaliQ62902
SMRiQ62902
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ62902

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 275L-type lectin-likePROSITE-ProRule annotationAdd BLAST224

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni259 – 261Carbohydrate bindingPROSITE-ProRule annotation3
Regioni506 – 517Mediates interaction with RAB3GAP1, RAB3GAP2 and UBXN6By similarityAdd BLAST12

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi516 – 517ER export motifBy similarity2

Domaini

The FF ER export motif at the C-terminus is not sufficient to support endoplasmic reticulum exit, and needs assistance of Gln-508 for proper recognition of COPII coat components.By similarity

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3838 Eukaryota
ENOG410ZFRX LUCA
HOGENOMiHOG000017354
HOVERGENiHBG052332
InParanoidiQ62902
KOiK10080
PhylomeDBiQ62902

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR005052 Lectin_leg
IPR033085 LMAN1
PANTHERiPTHR12223:SF32 PTHR12223:SF32, 1 hit
PfamiView protein in Pfam
PF03388 Lectin_leg-like, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51328 L_LECTIN_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62902-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVSRRRGPQ AGAQSFFCAL LLSFSQFVGS DGMGGDAAAP GAAGTQAELP
60 70 80 90 100
HRRFEYKYSF KGPHLVQSDG TVPFWAHAGN AIPSADQIRI APSLKSQRGS
110 120 130 140 150
VWTKTKAAFE NWEVEVTFRV TGRGRIGADG LAIWYTENQG LDGPVFGSAD
160 170 180 190 200
MWNGVGIFFD SFDNDGKKNN PAIVVVGNNG QINYDHQNDG ATQALASCQR
210 220 230 240 250
DFRNKPYPVR AKITYYQKTL TVMINNGFTP DKNDYEFCAK VENMVIPTQG
260 270 280 290 300
HFGISAATGG LADDHDVLSF LTFQLTEPGK EPPTPEKDIS EKEKEKYQEE
310 320 330 340 350
FEHFQQELDK KKEEFQKGHP DLQGQPADDI FESIGDRELR QVFEGQNRIH
360 370 380 390 400
LEIKQLNRQL DMILDEQRRY VSSLTEEISR RGAGTPGQPG QVSQQELDTV
410 420 430 440 450
VRTQLEILRQ VNEMKNSMRE TMRLVSGVQH PGSAGVYETT QHFMDIKEHL
460 470 480 490 500
HIVKRDIDSL AQRSMSSNEK PKCPDLPAFP SCLSTVHFVI FIVVQTVLFI
510
GYIMYRTQQE AAAKKFF
Length:517
Mass (Da):57,957
Last modified:November 1, 1996 - v1
Checksum:iDFD9036C6773F7EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44129 mRNA Translation: AAC52434.1
RefSeqiNP_446338.1, NM_053886.2
UniGeneiRn.25734

Genome annotation databases

GeneIDi116666
KEGGirno:116666
UCSCiRGD:71020 rat

Similar proteinsi

Entry informationi

Entry nameiLMAN1_RAT
AccessioniPrimary (citable) accession number: Q62902
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: November 1, 1996
Last modified: July 18, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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