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Protein

Arginine-glutamic acid dipeptide repeats protein

Gene

Rere

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival (By similarity). Interacts with FAT1 (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri507 – 532GATA-typeAdd BLAST26

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine-glutamic acid dipeptide repeats protein
Alternative name(s):
Atrophin-1-related protein
Gene namesi
Name:Rere
Synonyms:Arp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi629475 Rere

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000835061 – 1559Arginine-glutamic acid dipeptide repeats proteinAdd BLAST1559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei53PhosphoserineCombined sources1
Modified residuei56PhosphoserineCombined sources1
Modified residuei119PhosphothreonineBy similarity1
Modified residuei141PhosphoserineBy similarity1
Modified residuei303PhosphoserineBy similarity1
Cross-linki559Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei593PhosphoserineCombined sources1
Modified residuei599PhosphoserineCombined sources1
Modified residuei612PhosphoserineBy similarity1
Cross-linki636Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei641PhosphoserineCombined sources1
Modified residuei655PhosphoserineCombined sources1
Modified residuei674PhosphoserineCombined sources1
Modified residuei678PhosphoserineCombined sources1
Modified residuei1098PhosphoserineBy similarity1
Modified residuei1105PhosphoserineBy similarity1
Modified residuei1107PhosphoserineBy similarity1
Modified residuei1111PhosphothreonineBy similarity1
Modified residuei1150N6-acetyllysineBy similarity1
Modified residuei1252PhosphotyrosineBy similarity1
Modified residuei1259PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ62901
PRIDEiQ62901

PTM databases

iPTMnetiQ62901
PhosphoSitePlusiQ62901

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSRNOG00000017940 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiQ62901 RN

Interactioni

Subunit structurei

Interacts with HDAC1 and ATN1. Interaction with ATN1 is improved when the poly-Gln region of ATN1 is extended (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024443

Structurei

3D structure databases

ProteinModelPortaliQ62901
SMRiQ62901
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini102 – 282BAHPROSITE-ProRule annotationAdd BLAST181
Domaini283 – 386ELM2PROSITE-ProRule annotationAdd BLAST104
Domaini390 – 442SANTPROSITE-ProRule annotationAdd BLAST53

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1148 – 1205Sequence analysisAdd BLAST58

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi737 – 1110Pro-richAdd BLAST374
Compositional biasi1180 – 1191Arg/Glu-rich (mixed charge)Add BLAST12
Compositional biasi1292 – 1309Arg/Glu-rich (mixed charge)Add BLAST18
Compositional biasi1418 – 1438His-richAdd BLAST21
Compositional biasi1444 – 1503Pro-richAdd BLAST60

Domaini

The interaction with ATN1 is mediated by the coiled domain.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri507 – 532GATA-typeAdd BLAST26

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2133 Eukaryota
ENOG410ZIND LUCA
GeneTreeiENSGT00580000081398
HOGENOMiHOG000231091
HOVERGENiHBG079774
InParanoidiQ62901
KOiK05628
OMAiFMPLAGS
OrthoDBiEOG091G0O1H
PhylomeDBiQ62901
TreeFamiTF328554

Family and domain databases

CDDicd00202 ZnF_GATA, 1 hit
InterProiView protein in InterPro
IPR002951 Atrophin-like
IPR001025 BAH_dom
IPR000949 ELM2_dom
IPR009057 Homeobox-like_sf
IPR001005 SANT/Myb
IPR017884 SANT_dom
IPR000679 Znf_GATA
PfamiView protein in Pfam
PF03154 Atrophin-1, 1 hit
PF01426 BAH, 1 hit
PF01448 ELM2, 1 hit
PF00320 GATA, 1 hit
SMARTiView protein in SMART
SM00439 BAH, 1 hit
SM01189 ELM2, 1 hit
SM00717 SANT, 1 hit
SM00401 ZnF_GATA, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51038 BAH, 1 hit
PS51156 ELM2, 1 hit
PS51293 SANT, 1 hit

Sequencei

Sequence statusi: Complete.

Q62901-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTADKDKDKD KEKDRDRDRD RERDKRDKAR ESENARPRRS CTLEGGAKNY
60 70 80 90 100
AESDHSEDED NDNGATTEES ARKSRKKPPK KKSRYERTDT GEITSYITED
110 120 130 140 150
DVVYRPGDCV YIESRRPNTP YFICSIQDFK LVHNSQACCR SPAPALCDPP
160 170 180 190 200
ACSLPVASQP PQHLSEAGRG PVGSKRDHLL MNVKWYYRQS EVPDSVYQHL
210 220 230 240 250
VQDRHNENDS GRELVITDPV IKNRELFISD YVDTYHAAAL RGKCNISHFS
260 270 280 290 300
DIFAAREFKA RVDSFFYILG YNPETRRLNS TQGEIRVGPS HQAKLPDLQP
310 320 330 340 350
FPSPDGDTVT QHEELVWMPG VSDCDLLMYL RAARSMAAFA GMCDGGSTED
360 370 380 390 400
GCVAASRDDT TLNALNTLHE SSYDAGKALQ RLVKKPVPKL IEKCWTEDEV
410 420 430 440 450
KRFVKGLRQY GKNFFRIRKE LLPNKETGEL ITFYYYWKKT PEAASSRAHR
460 470 480 490 500
RHRRQAVFRR IKTRTASTPV NTPSRPPSSE FLDLSSASED DFDSEDSEQE
510 520 530 540 550
LKGYACRHCF TTTSKDWHHG GRENILLCTD CRIHFKKYGE LPPIEKPVDP
560 570 580 590 600
PPFMFKPVKE EDDGLSGKHS MRTRRSRGSM STLRSGRKKQ PASPDGRASP
610 620 630 640 650
VNEDVRSSGR NSPSAASTSS NDSKAEAVKK SAKKVKEEAA SPLKNTKRQR
660 670 680 690 700
EKVASDTEDT DRATSKKTKT QEISRPNSPS EGEGESSDSR SVNDEGSSDP
710 720 730 740 750
KDIDQDNRST SPSIPSPQDN ESDSDSSAQQ QMLQTQPPAL QAPSGAASAP
760 770 780 790 800
STAPPGTTQL PTPGPTPSAT TVPPQGSPAT SQPPNQTQST VAPAAHTLIQ
810 820 830 840 850
QTPTLHPPRL PSPHPPLQPM TAPPSQNSAQ PHPQPSLHGQ GPPGPHSLQT
860 870 880 890 900
GPLLQHPGPP QPFGLTPQSS QGQGPLGPSP AAAHPHSTIQ LPASQSALQP
910 920 930 940 950
QQPPREQPLP PAPLAMPHIK PPPTTPIPQL PAPQAHKHPP HLSGPSPFSM
960 970 980 990 1000
NANLPPPPAL KPLSSLSTHH PPSAHPPPLQ LMPQSQPLPS SPAQPPGLTQ
1010 1020 1030 1040 1050
SQSLPPPAAS HPTTGGLHQV PSQSPFPQHP FVPGGPPPIT PPSCPPTSTP
1060 1070 1080 1090 1100
PAGPSSSSQP PCSAAVSSGG NVPGAPSCPL PAVQIKEEAL DEAEEPESPP
1110 1120 1130 1140 1150
PPPRSPSPEP TVVDTPSHAS QSARFYKHLD RGYNSCARTD LYFMPLAGSK
1160 1170 1180 1190 1200
LAKKREEAIE KAKREAEQKA REEREREKEK EKERERERER EREAERAAQK
1210 1220 1230 1240 1250
ASSSAHEGRL SDPQLSGPGH MRPSFEPPPT TIAAVPPYIG PDTPALRTLS
1260 1270 1280 1290 1300
EYARPHVMSP TNRNHPFYMP LNPTDPLLAY HMPGLYNVDP TIRERELRER
1310 1320 1330 1340 1350
EIREREIRER ELRERMKPGF EVKPPELDPL HPATNPMEHF ARHSALTIPP
1360 1370 1380 1390 1400
AAGPHPFASF HPGLNPLERE RLALAGPQLR PEMSYPDRLA AERIHAERMA
1410 1420 1430 1440 1450
SLTSDPLARL QMFNVTPHHH QHSHIHSHLH LHQQDPLHQG SAGPVHPLVD
1460 1470 1480 1490 1500
PLTAGPHLAR FPYPPGTLPN PLLGQPPHEH EMLRHPVFGT PYPRDLPGAI
1510 1520 1530 1540 1550
PPPMSAAHQL QAMHAQSAEL QRLAMEQQWL HGHPHMHGGH LPSQEDYYSR

LKKEGDKQL
Length:1,559
Mass (Da):171,815
Last modified:January 10, 2006 - v2
Checksum:i2BE2A7A93CAE0600
GO

Sequence cautioni

The sequence AAA98970 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti342 – 343MC → IVV in AAA98970 (PubMed:9173919).Curated2
Sequence conflicti355A → G in AAA98970 (PubMed:9173919).Curated1
Sequence conflicti360T → N in AAA98970 (PubMed:9173919).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44091 mRNA Translation: AAA98970.1 Frameshift.
AABR03040456 Genomic DNA No translation available.
AABR03040863 Genomic DNA No translation available.
AABR03040940 Genomic DNA No translation available.
AABR03041203 Genomic DNA No translation available.
PIRiT42731
RefSeqiNP_446337.2, NM_053885.2
UniGeneiRn.10277

Genome annotation databases

EnsembliENSRNOT00000024443; ENSRNOP00000024443; ENSRNOG00000017940
GeneIDi116665
KEGGirno:116665
UCSCiRGD:629475 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44091 mRNA Translation: AAA98970.1 Frameshift.
AABR03040456 Genomic DNA No translation available.
AABR03040863 Genomic DNA No translation available.
AABR03040940 Genomic DNA No translation available.
AABR03041203 Genomic DNA No translation available.
PIRiT42731
RefSeqiNP_446337.2, NM_053885.2
UniGeneiRn.10277

3D structure databases

ProteinModelPortaliQ62901
SMRiQ62901
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024443

PTM databases

iPTMnetiQ62901
PhosphoSitePlusiQ62901

Proteomic databases

PaxDbiQ62901
PRIDEiQ62901

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024443; ENSRNOP00000024443; ENSRNOG00000017940
GeneIDi116665
KEGGirno:116665
UCSCiRGD:629475 rat

Organism-specific databases

CTDi473
RGDi629475 Rere

Phylogenomic databases

eggNOGiKOG2133 Eukaryota
ENOG410ZIND LUCA
GeneTreeiENSGT00580000081398
HOGENOMiHOG000231091
HOVERGENiHBG079774
InParanoidiQ62901
KOiK05628
OMAiFMPLAGS
OrthoDBiEOG091G0O1H
PhylomeDBiQ62901
TreeFamiTF328554

Miscellaneous databases

PROiPR:Q62901

Gene expression databases

BgeeiENSRNOG00000017940 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiQ62901 RN

Family and domain databases

CDDicd00202 ZnF_GATA, 1 hit
InterProiView protein in InterPro
IPR002951 Atrophin-like
IPR001025 BAH_dom
IPR000949 ELM2_dom
IPR009057 Homeobox-like_sf
IPR001005 SANT/Myb
IPR017884 SANT_dom
IPR000679 Znf_GATA
PfamiView protein in Pfam
PF03154 Atrophin-1, 1 hit
PF01426 BAH, 1 hit
PF01448 ELM2, 1 hit
PF00320 GATA, 1 hit
SMARTiView protein in SMART
SM00439 BAH, 1 hit
SM01189 ELM2, 1 hit
SM00717 SANT, 1 hit
SM00401 ZnF_GATA, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51038 BAH, 1 hit
PS51156 ELM2, 1 hit
PS51293 SANT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRERE_RAT
AccessioniPrimary (citable) accession number: Q62901
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: September 12, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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