Rere

Functionⁱ

Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival (By similarity). Interacts with FAT1 (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	507 – 532	GATA-typeAdd BLAST		26

GO - Molecular functionⁱ

chromatin binding Source: InterPro
sequence-specific DNA binding Source: InterPro
transcription coactivator activity Source: Ensembl
transcription corepressor activity Source: Ensembl
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

branching morphogenesis of a nerve Source: Ensembl
cerebellar granule cell precursor proliferation Source: Ensembl
cerebellar Purkinje cell layer maturation Source: Ensembl
chromatin remodeling Source: Ensembl
dendrite morphogenesis Source: Ensembl
radial glia guided migration of Purkinje cell Source: Ensembl
regulation of transcription, DNA-templated Source: UniProtKB-KW
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, Repressor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Arginine-glutamic acid dipeptide repeats protein Alternative name(s): Atrophin-1-related protein
Gene namesⁱ	Name:Rere Synonyms:Arp
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 5

Organism-specific databases

Rat genome database More...RGDⁱ	629475 Rere

RGDⁱ

629475 Rere

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000083506	1 – 1559	Arginine-glutamic acid dipeptide repeats proteinAdd BLAST		1559

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	53	PhosphoserineCombined sources	1
Modified residueⁱ	56	PhosphoserineCombined sources	1
Modified residueⁱ	119	PhosphothreonineBy similarity	1
Modified residueⁱ	141	PhosphoserineBy similarity	1
Modified residueⁱ	303	PhosphoserineBy similarity	1
Cross-linkⁱ	559	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	593	PhosphoserineCombined sources	1
Modified residueⁱ	599	PhosphoserineCombined sources	1
Modified residueⁱ	612	PhosphoserineBy similarity	1
Cross-linkⁱ	636	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	641	PhosphoserineCombined sources	1
Modified residueⁱ	655	PhosphoserineCombined sources	1
Modified residueⁱ	674	PhosphoserineCombined sources	1
Modified residueⁱ	678	PhosphoserineCombined sources	1
Modified residueⁱ	1098	PhosphoserineBy similarity	1
Modified residueⁱ	1105	PhosphoserineBy similarity	1
Modified residueⁱ	1107	PhosphoserineBy similarity	1
Modified residueⁱ	1111	PhosphothreonineBy similarity	1
Modified residueⁱ	1150	N6-acetyllysineBy similarity	1
Modified residueⁱ	1252	PhosphotyrosineBy similarity	1
Modified residueⁱ	1259	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q62901
PRIDEⁱ	Q62901

PTM databases

iPTMnetⁱ	Q62901
PhosphoSitePlusⁱ	Q62901

Expressionⁱ

Tissue specificityⁱ

Widely expressed.1 Publication

Gene expression databases

Bgeeⁱ	ENSRNOG00000017940 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
Genevisibleⁱ	Q62901 RN

Interactionⁱ

Subunit structureⁱ

Interacts with HDAC1 and ATN1. Interaction with ATN1 is improved when the poly-Gln region of ATN1 is extended (By similarity).By similarity

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000024443

STRINGⁱ

10116.ENSRNOP00000024443

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q62901
SMRⁱ	Q62901
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	102 – 282	BAHPROSITE-ProRule annotationAdd BLAST	181
Domainⁱ	283 – 386	ELM2PROSITE-ProRule annotationAdd BLAST	104
Domainⁱ	390 – 442	SANTPROSITE-ProRule annotationAdd BLAST	53

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	1148 – 1205	Sequence analysisAdd BLAST		58

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	737 – 1110	Pro-richAdd BLAST	374
Compositional biasⁱ	1180 – 1191	Arg/Glu-rich (mixed charge)Add BLAST	12
Compositional biasⁱ	1292 – 1309	Arg/Glu-rich (mixed charge)Add BLAST	18
Compositional biasⁱ	1418 – 1438	His-richAdd BLAST	21
Compositional biasⁱ	1444 – 1503	Pro-richAdd BLAST	60

Domainⁱ

The interaction with ATN1 is mediated by the coiled domain.By similarity

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	507 – 532	GATA-typeAdd BLAST		26

Keywords - Domainⁱ

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG2133 Eukaryota ENOG410ZIND LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00580000081398
HOGENOMⁱ	HOG000231091
HOVERGENⁱ	HBG079774
InParanoidⁱ	Q62901
KEGG Orthology (KO) More...KOⁱ	K05628
OMAⁱ	FMPLAGS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0O1H
PhylomeDBⁱ	Q62901
TreeFamⁱ	TF328554

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00202 ZnF_GATA, 1 hit
InterProⁱ	View protein in InterPro IPR002951 Atrophin-like IPR001025 BAH_dom IPR000949 ELM2_dom IPR009057 Homeobox-like_sf IPR001005 SANT/Myb IPR017884 SANT_dom IPR000679 Znf_GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03154 Atrophin-1, 1 hit PF01426 BAH, 1 hit PF01448 ELM2, 1 hit PF00320 GATA, 1 hit
SMARTⁱ	View protein in SMART SM00439 BAH, 1 hit SM01189 ELM2, 1 hit SM00717 SANT, 1 hit SM00401 ZnF_GATA, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS51038 BAH, 1 hit PS51156 ELM2, 1 hit PS51293 SANT, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q62901-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTADKDKDKD KEKDRDRDRD RERDKRDKAR ESENARPRRS CTLEGGAKNY 
        60         70         80         90        100
AESDHSEDED NDNGATTEES ARKSRKKPPK KKSRYERTDT GEITSYITED 
       110        120        130        140        150
DVVYRPGDCV YIESRRPNTP YFICSIQDFK LVHNSQACCR SPAPALCDPP 
       160        170        180        190        200
ACSLPVASQP PQHLSEAGRG PVGSKRDHLL MNVKWYYRQS EVPDSVYQHL 
       210        220        230        240        250
VQDRHNENDS GRELVITDPV IKNRELFISD YVDTYHAAAL RGKCNISHFS 
       260        270        280        290        300
DIFAAREFKA RVDSFFYILG YNPETRRLNS TQGEIRVGPS HQAKLPDLQP 
       310        320        330        340        350
FPSPDGDTVT QHEELVWMPG VSDCDLLMYL RAARSMAAFA GMCDGGSTED 
       360        370        380        390        400
GCVAASRDDT TLNALNTLHE SSYDAGKALQ RLVKKPVPKL IEKCWTEDEV 
       410        420        430        440        450
KRFVKGLRQY GKNFFRIRKE LLPNKETGEL ITFYYYWKKT PEAASSRAHR 
       460        470        480        490        500
RHRRQAVFRR IKTRTASTPV NTPSRPPSSE FLDLSSASED DFDSEDSEQE 
       510        520        530        540        550
LKGYACRHCF TTTSKDWHHG GRENILLCTD CRIHFKKYGE LPPIEKPVDP 
       560        570        580        590        600
PPFMFKPVKE EDDGLSGKHS MRTRRSRGSM STLRSGRKKQ PASPDGRASP 
       610        620        630        640        650
VNEDVRSSGR NSPSAASTSS NDSKAEAVKK SAKKVKEEAA SPLKNTKRQR 
       660        670        680        690        700
EKVASDTEDT DRATSKKTKT QEISRPNSPS EGEGESSDSR SVNDEGSSDP 
       710        720        730        740        750
KDIDQDNRST SPSIPSPQDN ESDSDSSAQQ QMLQTQPPAL QAPSGAASAP 
       760        770        780        790        800
STAPPGTTQL PTPGPTPSAT TVPPQGSPAT SQPPNQTQST VAPAAHTLIQ 
       810        820        830        840        850
QTPTLHPPRL PSPHPPLQPM TAPPSQNSAQ PHPQPSLHGQ GPPGPHSLQT 
       860        870        880        890        900
GPLLQHPGPP QPFGLTPQSS QGQGPLGPSP AAAHPHSTIQ LPASQSALQP 
       910        920        930        940        950
QQPPREQPLP PAPLAMPHIK PPPTTPIPQL PAPQAHKHPP HLSGPSPFSM 
       960        970        980        990       1000
NANLPPPPAL KPLSSLSTHH PPSAHPPPLQ LMPQSQPLPS SPAQPPGLTQ 
      1010       1020       1030       1040       1050
SQSLPPPAAS HPTTGGLHQV PSQSPFPQHP FVPGGPPPIT PPSCPPTSTP 
      1060       1070       1080       1090       1100
PAGPSSSSQP PCSAAVSSGG NVPGAPSCPL PAVQIKEEAL DEAEEPESPP 
      1110       1120       1130       1140       1150
PPPRSPSPEP TVVDTPSHAS QSARFYKHLD RGYNSCARTD LYFMPLAGSK 
      1160       1170       1180       1190       1200
LAKKREEAIE KAKREAEQKA REEREREKEK EKERERERER EREAERAAQK 
      1210       1220       1230       1240       1250
ASSSAHEGRL SDPQLSGPGH MRPSFEPPPT TIAAVPPYIG PDTPALRTLS 
      1260       1270       1280       1290       1300
EYARPHVMSP TNRNHPFYMP LNPTDPLLAY HMPGLYNVDP TIRERELRER 
      1310       1320       1330       1340       1350
EIREREIRER ELRERMKPGF EVKPPELDPL HPATNPMEHF ARHSALTIPP 
      1360       1370       1380       1390       1400
AAGPHPFASF HPGLNPLERE RLALAGPQLR PEMSYPDRLA AERIHAERMA 
      1410       1420       1430       1440       1450
SLTSDPLARL QMFNVTPHHH QHSHIHSHLH LHQQDPLHQG SAGPVHPLVD 
      1460       1470       1480       1490       1500
PLTAGPHLAR FPYPPGTLPN PLLGQPPHEH EMLRHPVFGT PYPRDLPGAI 
      1510       1520       1530       1540       1550
PPPMSAAHQL QAMHAQSAEL QRLAMEQQWL HGHPHMHGGH LPSQEDYYSR 

LKKEGDKQL

Length:1,559

Mass (Da):171,815

Last modified:January 10, 2006 - v2

Checksum:ⁱ2BE2A7A93CAE0600

GO

Sequence cautionⁱ

The sequence AAA98970 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	342 – 343	MC → IVV in AAA98970 (PubMed:9173919).Curated	2
Sequence conflictⁱ	355	A → G in AAA98970 (PubMed:9173919).Curated	1
Sequence conflictⁱ	360	T → N in AAA98970 (PubMed:9173919).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U44091 mRNA Translation: AAA98970.1 Frameshift. AABR03040456 Genomic DNA No translation available. AABR03040863 Genomic DNA No translation available. AABR03040940 Genomic DNA No translation available. AABR03041203 Genomic DNA No translation available.
PIRⁱ	T42731
NCBI Reference Sequences More...RefSeqⁱ	NP_446337.2, NM_053885.2
UniGeneⁱ	Rn.10277

Genome annotation databases

Ensemblⁱ	ENSRNOT00000024443; ENSRNOP00000024443; ENSRNOG00000017940
GeneIDⁱ	116665
KEGGⁱ	rno:116665
UCSC genome browser More...UCSCⁱ	RGD:629475 rat

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q62901	Arginine-glutamic acid dipeptide repeats protein		MOUSE		1558	UniRef90_Q80TZ9
Uncharacterized protein		PIG		1617
Arginine-glutamic acid dipeptide repeats protein (Fragment)		HUMAN		35
RERE isoform 18 (Fragment)		PONAB		35
RERE isoform 4 (Fragment)		PANTR		35
+146

Protein	Similar proteins		Species	Score	Length	Source
Q62901	Arginine-glutamic acid dipeptide repeats protein	)	HUMAN		1566	UniRef50_Q9P2R6
Arginine-glutamic acid dipeptide repeats protein		MOUSE		1558
Arginine-glutamic acid dipeptide (RE) repeats		PANTR		1566
Arginine-glutamic acid dipeptide repeats protein isoform a		MACMU		1566
Uncharacterized protein		MACFA		1566
+572

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U44091 mRNA Translation: AAA98970.1 Frameshift. AABR03040456 Genomic DNA No translation available. AABR03040863 Genomic DNA No translation available. AABR03040940 Genomic DNA No translation available. AABR03041203 Genomic DNA No translation available.
PIRⁱ	T42731
RefSeqⁱ	NP_446337.2, NM_053885.2
UniGeneⁱ	Rn.10277

3D structure databases

ProteinModelPortalⁱ	Q62901
SMRⁱ	Q62901
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000024443

STRINGⁱ

10116.ENSRNOP00000024443

PTM databases

iPTMnetⁱ	Q62901
PhosphoSitePlusⁱ	Q62901

Proteomic databases

PaxDbⁱ	Q62901
PRIDEⁱ	Q62901

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000024443; ENSRNOP00000024443; ENSRNOG00000017940
GeneIDⁱ	116665
KEGGⁱ	rno:116665
UCSCⁱ	RGD:629475 rat

Organism-specific databases

CTDⁱ	473
RGDⁱ	629475 Rere

Phylogenomic databases

eggNOGⁱ	KOG2133 Eukaryota ENOG410ZIND LUCA
GeneTreeⁱ	ENSGT00580000081398
HOGENOMⁱ	HOG000231091
HOVERGENⁱ	HBG079774
InParanoidⁱ	Q62901
KOⁱ	K05628
OMAⁱ	FMPLAGS
OrthoDBⁱ	EOG091G0O1H
PhylomeDBⁱ	Q62901
TreeFamⁱ	TF328554

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q62901

PROⁱ

PR:Q62901

Gene expression databases

Bgeeⁱ	ENSRNOG00000017940 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
Genevisibleⁱ	Q62901 RN

Family and domain databases

CDDⁱ	cd00202 ZnF_GATA, 1 hit
InterProⁱ	View protein in InterPro IPR002951 Atrophin-like IPR001025 BAH_dom IPR000949 ELM2_dom IPR009057 Homeobox-like_sf IPR001005 SANT/Myb IPR017884 SANT_dom IPR000679 Znf_GATA
Pfamⁱ	View protein in Pfam PF03154 Atrophin-1, 1 hit PF01426 BAH, 1 hit PF01448 ELM2, 1 hit PF00320 GATA, 1 hit
SMARTⁱ	View protein in SMART SM00439 BAH, 1 hit SM01189 ELM2, 1 hit SM00717 SANT, 1 hit SM00401 ZnF_GATA, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS51038 BAH, 1 hit PS51156 ELM2, 1 hit PS51293 SANT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RERE_RAT
Accessionⁱ	Q62901Primary (citable) accession number: Q62901
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
	Last sequence update:	January 10, 2006
	Last modified:	September 12, 2018
	This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q62901 (RERE_RAT)

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Arginine-glutamic acid dipeptide repeats protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Compositional bias

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ