We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q62901 (RERE_RAT)
Protein
Arginine-glutamic acid dipeptide repeats protein
Gene
Rere
Organism
Rattus norvegicus (Rat)
Status
Functioni
Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival (By similarity).
Interacts with FAT1 (By similarity).
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 507 – 532 | GATA-typeAdd BLAST | 26 |
GO - Molecular functioni
- chromatin binding Source: InterPro
- sequence-specific DNA binding Source: InterPro
- transcription coactivator activity Source: RGD
- transcription corepressor activity Source: RGD
- zinc ion binding Source: InterPro
GO - Biological processi
- branching morphogenesis of a nerve Source: RGD
- cerebellar granule cell precursor proliferation Source: RGD
- cerebellar Purkinje cell layer maturation Source: RGD
- cerebellum development Source: RGD
- chromatin remodeling Source: RGD
- dendrite morphogenesis Source: RGD
- radial glia guided migration of Purkinje cell Source: RGD
Keywordsi
Molecular function | Developmental protein, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Arginine-glutamic acid dipeptide repeats proteinAlternative name(s): Atrophin-1-related protein |
Gene namesi | Name:Rere Synonyms:Arp |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 629475, Rere |
Subcellular locationi
Nucleus
- PML body By similarity
Note: Localized in nuclear bodies of variable size. Colocalized with PML and BAX in nuclear PODs (By similarity).By similarity
Nucleus
- histone deacetylase complex Source: RGD
- nucleus Source: RGD
- PML body Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000083506 | 1 – 1559 | Arginine-glutamic acid dipeptide repeats proteinAdd BLAST | 1559 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 53 | PhosphoserineCombined sources | 1 | |
Modified residuei | 56 | PhosphoserineCombined sources | 1 | |
Modified residuei | 119 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 141 | PhosphoserineBy similarity | 1 | |
Modified residuei | 303 | PhosphoserineBy similarity | 1 | |
Cross-linki | 559 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 593 | PhosphoserineCombined sources | 1 | |
Modified residuei | 599 | PhosphoserineCombined sources | 1 | |
Modified residuei | 612 | PhosphoserineBy similarity | 1 | |
Cross-linki | 636 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 641 | PhosphoserineCombined sources | 1 | |
Modified residuei | 655 | PhosphoserineCombined sources | 1 | |
Modified residuei | 674 | PhosphoserineCombined sources | 1 | |
Modified residuei | 678 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1098 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1105 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1107 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1111 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1150 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 1252 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 1259 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | Q62901 |
PRIDEi | Q62901 |
PTM databases
iPTMneti | Q62901 |
PhosphoSitePlusi | Q62901 |
Expressioni
Tissue specificityi
Widely expressed.1 Publication
Gene expression databases
Bgeei | ENSRNOG00000017940, Expressed in skeletal muscle tissue and 20 other tissues |
Genevisiblei | Q62901, RN |
Interactioni
Subunit structurei
Interacts with HDAC1 and ATN1. Interaction with ATN1 is improved when the poly-Gln region of ATN1 is extended (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000024443 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 102 – 282 | BAHPROSITE-ProRule annotationAdd BLAST | 181 | |
Domaini | 283 – 386 | ELM2PROSITE-ProRule annotationAdd BLAST | 104 | |
Domaini | 390 – 442 | SANTPROSITE-ProRule annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 89 | DisorderedSequence analysisAdd BLAST | 89 | |
Regioni | 463 – 494 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 541 – 1125 | DisorderedSequence analysisAdd BLAST | 585 | |
Regioni | 1154 – 1239 | DisorderedSequence analysisAdd BLAST | 86 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1148 – 1205 | Sequence analysisAdd BLAST | 58 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 38 | Basic and acidic residuesSequence analysisAdd BLAST | 38 | |
Compositional biasi | 463 – 485 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 555 – 570 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 604 – 625 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 626 – 669 | Basic and acidic residuesSequence analysisAdd BLAST | 44 | |
Compositional biasi | 670 – 686 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 687 – 706 | Basic and acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 707 – 755 | Polar residuesSequence analysisAdd BLAST | 49 | |
Compositional biasi | 756 – 780 | Pro residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 781 – 805 | Polar residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 806 – 840 | Pro residuesSequence analysisAdd BLAST | 35 | |
Compositional biasi | 888 – 902 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 903 – 940 | Pro residuesSequence analysisAdd BLAST | 38 | |
Compositional biasi | 971 – 1002 | Pro residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 1003 – 1025 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 1026 – 1057 | Pro residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 1154 – 1202 | Basic and acidic residuesSequence analysisAdd BLAST | 49 |
Domaini
The interaction with ATN1 is mediated by the coiled domain.By similarity
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 507 – 532 | GATA-typeAdd BLAST | 26 |
Keywords - Domaini
Coiled coil, Zinc-fingerPhylogenomic databases
eggNOGi | KOG2133, Eukaryota |
GeneTreei | ENSGT00940000153615 |
HOGENOMi | CLU_005292_1_0_1 |
InParanoidi | Q62901 |
OMAi | SARFYKY |
PhylomeDBi | Q62901 |
TreeFami | TF328554 |
Family and domain databases
CDDi | cd00202, ZnF_GATA, 1 hit |
Gene3Di | 2.30.30.490, 1 hit |
InterProi | View protein in InterPro IPR002951, Atrophin-like IPR001025, BAH_dom IPR043151, BAH_sf IPR000949, ELM2_dom IPR009057, Homeobox-like_sf IPR001005, SANT/Myb IPR017884, SANT_dom IPR000679, Znf_GATA |
Pfami | View protein in Pfam PF03154, Atrophin-1, 1 hit PF01426, BAH, 1 hit PF01448, ELM2, 1 hit PF00320, GATA, 1 hit |
SMARTi | View protein in SMART SM00439, BAH, 1 hit SM01189, ELM2, 1 hit SM00717, SANT, 1 hit SM00401, ZnF_GATA, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS51038, BAH, 1 hit PS51156, ELM2, 1 hit PS51293, SANT, 1 hit |
i Sequence
Sequence statusi: Complete.
Q62901-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTADKDKDKD KEKDRDRDRD RERDKRDKAR ESENARPRRS CTLEGGAKNY
60 70 80 90 100
AESDHSEDED NDNGATTEES ARKSRKKPPK KKSRYERTDT GEITSYITED
110 120 130 140 150
DVVYRPGDCV YIESRRPNTP YFICSIQDFK LVHNSQACCR SPAPALCDPP
160 170 180 190 200
ACSLPVASQP PQHLSEAGRG PVGSKRDHLL MNVKWYYRQS EVPDSVYQHL
210 220 230 240 250
VQDRHNENDS GRELVITDPV IKNRELFISD YVDTYHAAAL RGKCNISHFS
260 270 280 290 300
DIFAAREFKA RVDSFFYILG YNPETRRLNS TQGEIRVGPS HQAKLPDLQP
310 320 330 340 350
FPSPDGDTVT QHEELVWMPG VSDCDLLMYL RAARSMAAFA GMCDGGSTED
360 370 380 390 400
GCVAASRDDT TLNALNTLHE SSYDAGKALQ RLVKKPVPKL IEKCWTEDEV
410 420 430 440 450
KRFVKGLRQY GKNFFRIRKE LLPNKETGEL ITFYYYWKKT PEAASSRAHR
460 470 480 490 500
RHRRQAVFRR IKTRTASTPV NTPSRPPSSE FLDLSSASED DFDSEDSEQE
510 520 530 540 550
LKGYACRHCF TTTSKDWHHG GRENILLCTD CRIHFKKYGE LPPIEKPVDP
560 570 580 590 600
PPFMFKPVKE EDDGLSGKHS MRTRRSRGSM STLRSGRKKQ PASPDGRASP
610 620 630 640 650
VNEDVRSSGR NSPSAASTSS NDSKAEAVKK SAKKVKEEAA SPLKNTKRQR
660 670 680 690 700
EKVASDTEDT DRATSKKTKT QEISRPNSPS EGEGESSDSR SVNDEGSSDP
710 720 730 740 750
KDIDQDNRST SPSIPSPQDN ESDSDSSAQQ QMLQTQPPAL QAPSGAASAP
760 770 780 790 800
STAPPGTTQL PTPGPTPSAT TVPPQGSPAT SQPPNQTQST VAPAAHTLIQ
810 820 830 840 850
QTPTLHPPRL PSPHPPLQPM TAPPSQNSAQ PHPQPSLHGQ GPPGPHSLQT
860 870 880 890 900
GPLLQHPGPP QPFGLTPQSS QGQGPLGPSP AAAHPHSTIQ LPASQSALQP
910 920 930 940 950
QQPPREQPLP PAPLAMPHIK PPPTTPIPQL PAPQAHKHPP HLSGPSPFSM
960 970 980 990 1000
NANLPPPPAL KPLSSLSTHH PPSAHPPPLQ LMPQSQPLPS SPAQPPGLTQ
1010 1020 1030 1040 1050
SQSLPPPAAS HPTTGGLHQV PSQSPFPQHP FVPGGPPPIT PPSCPPTSTP
1060 1070 1080 1090 1100
PAGPSSSSQP PCSAAVSSGG NVPGAPSCPL PAVQIKEEAL DEAEEPESPP
1110 1120 1130 1140 1150
PPPRSPSPEP TVVDTPSHAS QSARFYKHLD RGYNSCARTD LYFMPLAGSK
1160 1170 1180 1190 1200
LAKKREEAIE KAKREAEQKA REEREREKEK EKERERERER EREAERAAQK
1210 1220 1230 1240 1250
ASSSAHEGRL SDPQLSGPGH MRPSFEPPPT TIAAVPPYIG PDTPALRTLS
1260 1270 1280 1290 1300
EYARPHVMSP TNRNHPFYMP LNPTDPLLAY HMPGLYNVDP TIRERELRER
1310 1320 1330 1340 1350
EIREREIRER ELRERMKPGF EVKPPELDPL HPATNPMEHF ARHSALTIPP
1360 1370 1380 1390 1400
AAGPHPFASF HPGLNPLERE RLALAGPQLR PEMSYPDRLA AERIHAERMA
1410 1420 1430 1440 1450
SLTSDPLARL QMFNVTPHHH QHSHIHSHLH LHQQDPLHQG SAGPVHPLVD
1460 1470 1480 1490 1500
PLTAGPHLAR FPYPPGTLPN PLLGQPPHEH EMLRHPVFGT PYPRDLPGAI
1510 1520 1530 1540 1550
PPPMSAAHQL QAMHAQSAEL QRLAMEQQWL HGHPHMHGGH LPSQEDYYSR
LKKEGDKQL
Sequence cautioni
The sequence AAA98970 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 342 – 343 | MC → IVV in AAA98970 (PubMed:9173919).Curated | 2 | |
Sequence conflicti | 355 | A → G in AAA98970 (PubMed:9173919).Curated | 1 | |
Sequence conflicti | 360 | T → N in AAA98970 (PubMed:9173919).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U44091 mRNA Translation: AAA98970.1 Frameshift. AABR03040456 Genomic DNA No translation available. AABR03040863 Genomic DNA No translation available. AABR03040940 Genomic DNA No translation available. AABR03041203 Genomic DNA No translation available. |
PIRi | T42731 |
RefSeqi | NP_446337.2, NM_053885.2 |
Genome annotation databases
Ensembli | ENSRNOT00000024443; ENSRNOP00000024443; ENSRNOG00000017940 |
GeneIDi | 116665 |
KEGGi | rno:116665 |
UCSCi | RGD:629475, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U44091 mRNA Translation: AAA98970.1 Frameshift. AABR03040456 Genomic DNA No translation available. AABR03040863 Genomic DNA No translation available. AABR03040940 Genomic DNA No translation available. AABR03041203 Genomic DNA No translation available. |
PIRi | T42731 |
RefSeqi | NP_446337.2, NM_053885.2 |
3D structure databases
SMRi | Q62901 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000024443 |
PTM databases
iPTMneti | Q62901 |
PhosphoSitePlusi | Q62901 |
Proteomic databases
PaxDbi | Q62901 |
PRIDEi | Q62901 |
Genome annotation databases
Ensembli | ENSRNOT00000024443; ENSRNOP00000024443; ENSRNOG00000017940 |
GeneIDi | 116665 |
KEGGi | rno:116665 |
UCSCi | RGD:629475, rat |
Organism-specific databases
CTDi | 473 |
RGDi | 629475, Rere |
Phylogenomic databases
eggNOGi | KOG2133, Eukaryota |
GeneTreei | ENSGT00940000153615 |
HOGENOMi | CLU_005292_1_0_1 |
InParanoidi | Q62901 |
OMAi | SARFYKY |
PhylomeDBi | Q62901 |
TreeFami | TF328554 |
Miscellaneous databases
PROi | PR:Q62901 |
Gene expression databases
Bgeei | ENSRNOG00000017940, Expressed in skeletal muscle tissue and 20 other tissues |
Genevisiblei | Q62901, RN |
Family and domain databases
CDDi | cd00202, ZnF_GATA, 1 hit |
Gene3Di | 2.30.30.490, 1 hit |
InterProi | View protein in InterPro IPR002951, Atrophin-like IPR001025, BAH_dom IPR043151, BAH_sf IPR000949, ELM2_dom IPR009057, Homeobox-like_sf IPR001005, SANT/Myb IPR017884, SANT_dom IPR000679, Znf_GATA |
Pfami | View protein in Pfam PF03154, Atrophin-1, 1 hit PF01426, BAH, 1 hit PF01448, ELM2, 1 hit PF00320, GATA, 1 hit |
SMARTi | View protein in SMART SM00439, BAH, 1 hit SM01189, ELM2, 1 hit SM00717, SANT, 1 hit SM00401, ZnF_GATA, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS51038, BAH, 1 hit PS51156, ELM2, 1 hit PS51293, SANT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RERE_RAT | |
Accessioni | Q62901Primary (citable) accession number: Q62901 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 10, 2006 |
Last sequence update: | January 10, 2006 | |
Last modified: | February 23, 2022 | |
This is version 146 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |