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UniProtKB - Q62901 (RERE_RAT)

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Protein

Arginine-glutamic acid dipeptide repeats protein

Gene

Rere

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival (By similarity). Interacts with FAT1 (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri507 – 532GATA-typeAdd BLAST26

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionDevelopmental protein, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine-glutamic acid dipeptide repeats protein
Alternative name(s):
Atrophin-1-related protein
Gene namesi
Name:Rere
Synonyms:Arp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi629475 Rere

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000835061 – 1559Arginine-glutamic acid dipeptide repeats proteinAdd BLAST1559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei53PhosphoserineCombined sources1
Modified residuei56PhosphoserineCombined sources1
Modified residuei119PhosphothreonineBy similarity1
Modified residuei141PhosphoserineBy similarity1
Modified residuei303PhosphoserineBy similarity1
Cross-linki559Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei593PhosphoserineCombined sources1
Modified residuei599PhosphoserineCombined sources1
Modified residuei612PhosphoserineBy similarity1
Cross-linki636Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei641PhosphoserineCombined sources1
Modified residuei655PhosphoserineCombined sources1
Modified residuei674PhosphoserineCombined sources1
Modified residuei678PhosphoserineCombined sources1
Modified residuei1098PhosphoserineBy similarity1
Modified residuei1105PhosphoserineBy similarity1
Modified residuei1107PhosphoserineBy similarity1
Modified residuei1111PhosphothreonineBy similarity1
Modified residuei1150N6-acetyllysineBy similarity1
Modified residuei1252PhosphotyrosineBy similarity1
Modified residuei1259PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ62901
PRIDEiQ62901

PTM databases

iPTMnetiQ62901
PhosphoSitePlusiQ62901

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSRNOG00000017940
GenevisibleiQ62901 RN

Interactioni

Subunit structurei

Interacts with HDAC1 and ATN1. Interaction with ATN1 is improved when the poly-Gln region of ATN1 is extended (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024443

Structurei

3D structure databases

ProteinModelPortaliQ62901
SMRiQ62901
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini102 – 282BAHPROSITE-ProRule annotationAdd BLAST181
Domaini283 – 386ELM2PROSITE-ProRule annotationAdd BLAST104
Domaini390 – 442SANTPROSITE-ProRule annotationAdd BLAST53

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1148 – 1205Sequence analysisAdd BLAST58

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi737 – 1110Pro-richAdd BLAST374
Compositional biasi1180 – 1191Arg/Glu-rich (mixed charge)Add BLAST12
Compositional biasi1292 – 1309Arg/Glu-rich (mixed charge)Add BLAST18
Compositional biasi1418 – 1438His-richAdd BLAST21
Compositional biasi1444 – 1503Pro-richAdd BLAST60

Domaini

The interaction with ATN1 is mediated by the coiled domain.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri507 – 532GATA-typeAdd BLAST26

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2133 Eukaryota
ENOG410ZIND LUCA
GeneTreeiENSGT00580000081398
HOGENOMiHOG000231091
HOVERGENiHBG079774
InParanoidiQ62901
KOiK05628
OMAiFMPLAGS
OrthoDBiEOG091G0O1H
PhylomeDBiQ62901
TreeFamiTF328554

Family and domain databases

InterProiView protein in InterPro
IPR002951 Atrophin-like
IPR001025 BAH_dom
IPR000949 ELM2_dom
IPR009057 Homeobox-like_sf
IPR001005 SANT/Myb
IPR017884 SANT_dom
IPR000679 Znf_GATA
PfamiView protein in Pfam
PF03154 Atrophin-1, 1 hit
PF01426 BAH, 1 hit
PF01448 ELM2, 1 hit
PF00320 GATA, 1 hit
SMARTiView protein in SMART
SM00439 BAH, 1 hit
SM01189 ELM2, 1 hit
SM00717 SANT, 1 hit
SM00401 ZnF_GATA, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51038 BAH, 1 hit
PS51156 ELM2, 1 hit
PS51293 SANT, 1 hit

Sequencei

Sequence statusi: Complete.

Q62901-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTADKDKDKD KEKDRDRDRD RERDKRDKAR ESENARPRRS CTLEGGAKNY 
        60         70         80         90        100
AESDHSEDED NDNGATTEES ARKSRKKPPK KKSRYERTDT GEITSYITED 
       110        120        130        140        150
DVVYRPGDCV YIESRRPNTP YFICSIQDFK LVHNSQACCR SPAPALCDPP 
       160        170        180        190        200
ACSLPVASQP PQHLSEAGRG PVGSKRDHLL MNVKWYYRQS EVPDSVYQHL 
       210        220        230        240        250
VQDRHNENDS GRELVITDPV IKNRELFISD YVDTYHAAAL RGKCNISHFS 
       260        270        280        290        300
DIFAAREFKA RVDSFFYILG YNPETRRLNS TQGEIRVGPS HQAKLPDLQP 
       310        320        330        340        350
FPSPDGDTVT QHEELVWMPG VSDCDLLMYL RAARSMAAFA GMCDGGSTED 
       360        370        380        390        400
GCVAASRDDT TLNALNTLHE SSYDAGKALQ RLVKKPVPKL IEKCWTEDEV 
       410        420        430        440        450
KRFVKGLRQY GKNFFRIRKE LLPNKETGEL ITFYYYWKKT PEAASSRAHR 
       460        470        480        490        500
RHRRQAVFRR IKTRTASTPV NTPSRPPSSE FLDLSSASED DFDSEDSEQE 
       510        520        530        540        550
LKGYACRHCF TTTSKDWHHG GRENILLCTD CRIHFKKYGE LPPIEKPVDP 
       560        570        580        590        600
PPFMFKPVKE EDDGLSGKHS MRTRRSRGSM STLRSGRKKQ PASPDGRASP 
       610        620        630        640        650
VNEDVRSSGR NSPSAASTSS NDSKAEAVKK SAKKVKEEAA SPLKNTKRQR 
       660        670        680        690        700
EKVASDTEDT DRATSKKTKT QEISRPNSPS EGEGESSDSR SVNDEGSSDP 
       710        720        730        740        750
KDIDQDNRST SPSIPSPQDN ESDSDSSAQQ QMLQTQPPAL QAPSGAASAP 
       760        770        780        790        800
STAPPGTTQL PTPGPTPSAT TVPPQGSPAT SQPPNQTQST VAPAAHTLIQ 
       810        820        830        840        850
QTPTLHPPRL PSPHPPLQPM TAPPSQNSAQ PHPQPSLHGQ GPPGPHSLQT 
       860        870        880        890        900
GPLLQHPGPP QPFGLTPQSS QGQGPLGPSP AAAHPHSTIQ LPASQSALQP 
       910        920        930        940        950
QQPPREQPLP PAPLAMPHIK PPPTTPIPQL PAPQAHKHPP HLSGPSPFSM 
       960        970        980        990       1000
NANLPPPPAL KPLSSLSTHH PPSAHPPPLQ LMPQSQPLPS SPAQPPGLTQ 
      1010       1020       1030       1040       1050
SQSLPPPAAS HPTTGGLHQV PSQSPFPQHP FVPGGPPPIT PPSCPPTSTP 
      1060       1070       1080       1090       1100
PAGPSSSSQP PCSAAVSSGG NVPGAPSCPL PAVQIKEEAL DEAEEPESPP 
      1110       1120       1130       1140       1150
PPPRSPSPEP TVVDTPSHAS QSARFYKHLD RGYNSCARTD LYFMPLAGSK 
      1160       1170       1180       1190       1200
LAKKREEAIE KAKREAEQKA REEREREKEK EKERERERER EREAERAAQK 
      1210       1220       1230       1240       1250
ASSSAHEGRL SDPQLSGPGH MRPSFEPPPT TIAAVPPYIG PDTPALRTLS 
      1260       1270       1280       1290       1300
EYARPHVMSP TNRNHPFYMP LNPTDPLLAY HMPGLYNVDP TIRERELRER 
      1310       1320       1330       1340       1350
EIREREIRER ELRERMKPGF EVKPPELDPL HPATNPMEHF ARHSALTIPP 
      1360       1370       1380       1390       1400
AAGPHPFASF HPGLNPLERE RLALAGPQLR PEMSYPDRLA AERIHAERMA 
      1410       1420       1430       1440       1450
SLTSDPLARL QMFNVTPHHH QHSHIHSHLH LHQQDPLHQG SAGPVHPLVD 
      1460       1470       1480       1490       1500
PLTAGPHLAR FPYPPGTLPN PLLGQPPHEH EMLRHPVFGT PYPRDLPGAI 
      1510       1520       1530       1540       1550
PPPMSAAHQL QAMHAQSAEL QRLAMEQQWL HGHPHMHGGH LPSQEDYYSR 

LKKEGDKQL
Length:1,559
Mass (Da):171,815
Last modified:January 10, 2006 - v2
Checksum:i2BE2A7A93CAE0600
GO

Sequence cautioni

The sequence AAA98970 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti342 – 343MC → IVV in AAA98970 (PubMed:9173919).Curated2
Sequence conflicti355A → G in AAA98970 (PubMed:9173919).Curated1
Sequence conflicti360T → N in AAA98970 (PubMed:9173919).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44091 mRNA Translation: AAA98970.1 Frameshift.
AABR03040456 Genomic DNA No translation available.
AABR03040863 Genomic DNA No translation available.
AABR03040940 Genomic DNA No translation available.
AABR03041203 Genomic DNA No translation available.
PIRiT42731
RefSeqiNP_446337.2, NM_053885.2
UniGeneiRn.10277

Genome annotation databases

EnsembliENSRNOT00000024443; ENSRNOP00000024443; ENSRNOG00000017940
GeneIDi116665
KEGGirno:116665
UCSCiRGD:629475 rat

Similar proteinsi

Entry informationi

Entry nameiRERE_RAT
AccessioniPrimary (citable) accession number: Q62901
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: July 18, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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