Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 113 (29 Sep 2021)
Sequence version 2 (31 Jul 2019)
Previous versions | rss
Add a publicationFeedback
Protein

Reduced folate transporter

Gene

Slc19a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transporter that mediates the import of reduced folates (PubMed:11600421, PubMed:19243012).

Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate (By similarity).

Also able to mediate the import of antifolate drug methotrexate (PubMed:10827155, PubMed:11600421).

Mechanistically, acts as an antiporter, which export of intracellular organic anions to facilitate uptake of its substrates (By similarity).

5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity (By similarity).

By similarity3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.42 µM for folate1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiport, Transport
LigandFolate-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-196757, Metabolism of folate and pterines

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Reduced folate transporterCurated
Alternative name(s):
Methotrexate carrier 11 Publication
Short name:
MTX-11 Publication
Short name:
MTX11 Publication
Reduced folate carrier 11 Publication
Short name:
RFC-11 Publication
Short name:
RFC11 Publication
Solute carrier family 19 member 1Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc19a1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20
  • UP000234681 Componentsi: Chromosome 20, Unassembled WGS sequence

Organism-specific databases

Rat genome database

More...
RGDi
3695, Slc19a1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 27CytoplasmicBy similarityAdd BLAST27
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 64ExtracellularBy similarityAdd BLAST16
Transmembranei65 – 85Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini86 – 91CytoplasmicBy similarity6
Transmembranei92 – 112Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini113 – 121ExtracellularBy similarity9
Transmembranei122 – 142Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini143 – 155CytoplasmicBy similarityAdd BLAST13
Transmembranei156 – 176Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini177 – 180ExtracellularBy similarity4
Transmembranei181 – 201Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini202 – 271CytoplasmicBy similarityAdd BLAST70
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 304ExtracellularBy similarityAdd BLAST12
Transmembranei305 – 325Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini326 – 329CytoplasmicBy similarity4
Transmembranei330 – 350Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini351 – 354ExtracellularBy similarity4
Transmembranei355 – 375Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini376 – 390CytoplasmicBy similarityAdd BLAST15
Transmembranei391 – 411Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini412 – 426ExtracellularBy similarityAdd BLAST15
Transmembranei427 – 447Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini448 – 512CytoplasmicBy similarityAdd BLAST65

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001786621 – 512Reduced folate transporterAdd BLAST512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei466PhosphoserineBy similarity1
Modified residuei471PhosphoserineBy similarity1
Modified residuei476PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q62866

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q62866, 1 site

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in liver, heart, brain, spleen, lung and skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000001232, Expressed in adult mammalian kidney and 20 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000041562

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni400 – 412Required for substrate-bindingBy similarityAdd BLAST13
Regioni479 – 512DisorderedSequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi498 – 512Basic and acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3810, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183022

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_036909_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q62866

Identification of Orthologs from Complete Genome Data

More...
OMAi
YVYFGYF

Database of Orthologous Groups

More...
OrthoDBi
795242at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q62866

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1250.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002666, Folate_carrier
IPR036259, MFS_trans_sf
IPR028339, SLC19A1

The PANTHER Classification System

More...
PANTHERi
PTHR10686, PTHR10686, 1 hit
PTHR10686:SF12, PTHR10686:SF12, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01770, Folate_carrier, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF028739, Folate_carrier, 1 hit
PIRSF500793, Folate_transporter_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473, SSF103473, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00806, rfc, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q62866-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVPTGQVAEK QACEEPRQDR ELKSWRWLVF YLCFFGFMAQ LRPGESFITP
60 70 80 90 100
YLLERNFTKE QVTNEIIPML PYSHLAVLVP IFLLTDYLRY KPVLVLQCLS
110 120 130 140 150
FVCVWLLLLL GTSVVHMQLM EVFYSITMAA RIAYSSYIFS LVQPSRYQRM
160 170 180 190 200
ASYSRAAVLL GVFISSVLGQ VLVTLGGIST YMLNCISLGF ILFSLSLSLF
210 220 230 240 250
LKRPKRSLFF NRSALVQGAL PCELDQMHPG PGRPEPRKLE RMLGTCRDSF
260 270 280 290 300
LVRMLSELVK NVRQPQLRLW CLWWVFNSAG YYLITYYVHV LWKITDSRLN
310 320 330 340 350
YNGAVDAAST LLSAITAFTA GFVNIRWALW SKLVIASVIA IQAGLVFCMF
360 370 380 390 400
QIPDIWVCYV TFVLFRGAYQ FLVPIATFQI ASSLSKELCA LVFGINTFLA
410 420 430 440 450
TALKTSITLV VSDKRGLGLQ VHQQFRIYFM YFLTLSIICL AWAGLDGLRY
460 470 480 490 500
YRRGRHQPLA QAQALSPLED SVQAISLQDG DLRRPQPSAP QLLPEDGSVE
510
DGRADLRVEA KA
Length:512
Mass (Da):58,108
Last modified:July 31, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i70FAC54F30337B44
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti8A → G in AAC61788 (Ref. 2) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF173642 mRNA Translation: AAD49426.1
AF099009 mRNA Translation: AAF21822.1
U38180 mRNA Translation: AAC61788.1
BC085742 mRNA Translation: AAH85742.1
CH473988 Genomic DNA Translation: EDL97120.1
AABR07044596 Genomic DNA No translation available.
CH473988 Genomic DNA Translation: EDL97117.1
CH473988 Genomic DNA Translation: EDL97118.1
CH473988 Genomic DNA Translation: EDL97119.1

NCBI Reference Sequences

More...
RefSeqi
NP_001030309.1, NM_001035232.1
NP_058995.2, NM_017299.2
XP_006256357.1, XM_006256295.3
XP_006256358.1, XM_006256296.3
XP_006256359.1, XM_006256297.3
XP_006256360.1, XM_006256298.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000044212; ENSRNOP00000041562; ENSRNOG00000001232
ENSRNOT00000065236; ENSRNOP00000060579; ENSRNOG00000001232

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
29723

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:29723

UCSC genome browser

More...
UCSCi
RGD:3695, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173642 mRNA Translation: AAD49426.1
AF099009 mRNA Translation: AAF21822.1
U38180 mRNA Translation: AAC61788.1
BC085742 mRNA Translation: AAH85742.1
CH473988 Genomic DNA Translation: EDL97120.1
AABR07044596 Genomic DNA No translation available.
CH473988 Genomic DNA Translation: EDL97117.1
CH473988 Genomic DNA Translation: EDL97118.1
CH473988 Genomic DNA Translation: EDL97119.1
RefSeqiNP_001030309.1, NM_001035232.1
NP_058995.2, NM_017299.2
XP_006256357.1, XM_006256295.3
XP_006256358.1, XM_006256296.3
XP_006256359.1, XM_006256297.3
XP_006256360.1, XM_006256298.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000041562

PTM databases

GlyGeniQ62866, 1 site

Proteomic databases

PaxDbiQ62866

Genome annotation databases

EnsembliENSRNOT00000044212; ENSRNOP00000041562; ENSRNOG00000001232
ENSRNOT00000065236; ENSRNOP00000060579; ENSRNOG00000001232
GeneIDi29723
KEGGirno:29723
UCSCiRGD:3695, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6573
RGDi3695, Slc19a1

Phylogenomic databases

eggNOGiKOG3810, Eukaryota
GeneTreeiENSGT00950000183022
HOGENOMiCLU_036909_2_0_1
InParanoidiQ62866
OMAiYVYFGYF
OrthoDBi795242at2759
PhylomeDBiQ62866

Enzyme and pathway databases

ReactomeiR-RNO-196757, Metabolism of folate and pterines

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q62866

Gene expression databases

BgeeiENSRNOG00000001232, Expressed in adult mammalian kidney and 20 other tissues

Family and domain databases

Gene3Di1.20.1250.20, 1 hit
InterProiView protein in InterPro
IPR002666, Folate_carrier
IPR036259, MFS_trans_sf
IPR028339, SLC19A1
PANTHERiPTHR10686, PTHR10686, 1 hit
PTHR10686:SF12, PTHR10686:SF12, 1 hit
PfamiView protein in Pfam
PF01770, Folate_carrier, 1 hit
PIRSFiPIRSF028739, Folate_carrier, 1 hit
PIRSF500793, Folate_transporter_1, 1 hit
SUPFAMiSSF103473, SSF103473, 1 hit
TIGRFAMsiTIGR00806, rfc, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS19A1_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q62866
Secondary accession number(s): D3ZQS7, Q9QUM8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 31, 2019
Last modified: September 29, 2021
This is version 113 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again