DNA damage-inducible transcript 3 protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cAMP response element binding protein binding Source: UniProtKB
• DNA binding Source: UniProtKB
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
• DNA-binding transcription factor activity Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Bidirectional regulation of monocyte chemoattractant protein-1 gene at distinct sites of its promoter by nitric oxide in vascular smooth muscle cells."
    Kodama K., Nishio Y., Sekine O., Sato Y., Egawa K., Maegawa H., Kashiwagi A.
    Am J Physiol Cell Physiol 289:C582-90(2005) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor inhibitor activity Source: RGD
• leucine zipper domain binding Source: RGD
• protein heterodimerization activity Source: ParkinsonsUK-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element."
    Ubeda M., Wang X.Z., Zinszner H., Wu I., Habener J.F., Ron D.
    Mol Cell Biol 16:1479-1489(1996) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: RGD
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
• transcription coactivator activity Source: RGD
• transcription factor binding Source: RGD
• transcription regulatory region sequence-specific DNA binding Source: RGD

GO - Biological processⁱ

• aging Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Expression of the pro-apoptotic gene gadd153/chop is elevated in liver with aging and sensitizes cells to oxidant injury."
    Ikeyama S., Wang X.T., Li J., Podlutsky A., Martindale J.L., Kokkonen G., van Huizen R., Gorospe M., Holbrook N.J.
    J Biol Chem 278:16726-16731(2003) [PubMed] [Europe PMC] [Abstract]
• apoptotic process Source: UniProtKB
• blood vessel maturation Source: UniProtKB
• cell cycle arrest Source: RGD
• cell redox homeostasis Source: RGD
• cellular response to manganese ion Source: ParkinsonsUK-UCLInferred from expression patternⁱ
  • "alpha-Synuclein is involved in manganese-induced ER stress via PERK signal pathway in organotypic brain slice cultures."
    Xu B., Wang F., Wu S.W., Deng Y., Liu W., Feng S., Yang T.Y., Xu Z.F.
    Mol Neurobiol 49:399-412(2014) [PubMed] [Europe PMC] [Abstract]
• embryonic organ development Source: RGDInferred from expression patternⁱ
  • "Expression of the growth arrest genes (GAS and GADD) changes during organogenesis in the rat fetus."
    Rees W.D., Hay S.M., Fontanier-Razzaq N.C., Antipatis C., Harries D.N.
    J Nutr 129:1532-1536(1999) [PubMed] [Europe PMC] [Abstract]
• endoplasmic reticulum unfolded protein response Source: UniProtKB
• ER overload response Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state."
    McCullough K.D., Martindale J.L., Klotz L.O., Aw T.Y., Holbrook N.J.
    Mol Cell Biol 21:1249-1259(2001) [PubMed] [Europe PMC] [Abstract]
• establishment of protein localization to mitochondrion Source: RGD
• intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: UniProtKB
• intrinsic apoptotic signaling pathway in response to nitrosative stress Source: RGD
• luteolysis Source: RGDInferred from expression patternⁱ
  • "Endoplasmic reticulum stress-mediated apoptotic pathway is involved in corpus luteum regression in rats."
    Yang Y., Sun M., Shan Y., Zheng X., Ma H., Ma W., Wang Z., Pei X., Wang Y.
    Reprod Sci 22:572-584(2015) [PubMed] [Europe PMC] [Abstract]
• negative regulation of canonical Wnt signaling pathway Source: RGD
• negative regulation of cold-induced thermogenesis Source: YuBioLab <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • "Activation of Toll-like receptor 4 (TLR4) attenuates adaptive thermogenesis via endoplasmic reticulum stress."
    Okla M., Wang W., Kang I., Pashaj A., Carr T., Chung S.
    J Biol Chem 290:26476-26490(2015) [PubMed] [Europe PMC] [Abstract]
• negative regulation of CREB transcription factor activity Source: RGDInferred from direct assayⁱ
  • "Bidirectional regulation of monocyte chemoattractant protein-1 gene at distinct sites of its promoter by nitric oxide in vascular smooth muscle cells."
    Kodama K., Nishio Y., Sekine O., Sato Y., Egawa K., Maegawa H., Kashiwagi A.
    Am J Physiol Cell Physiol 289:C582-90(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of determination of dorsal identity Source: RGD
• negative regulation of DNA binding Source: RGD
• negative regulation of DNA-binding transcription factor activity Source: RGD
• negative regulation of fat cell differentiation Source: RGD
• negative regulation of interferon-gamma production Source: RGD
• negative regulation of interleukin-17 production Source: RGD
• negative regulation of interleukin-4 production Source: RGD
• negative regulation of myoblast differentiation Source: UniProtKB
• negative regulation of NF-kappaB transcription factor activity Source: RGD
• negative regulation of protein kinase B signaling Source: RGD
• negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding Source: RGD
• negative regulation of transcription, DNA-templated Source: UniProtKB
• negative regulation of transcription by RNA polymerase II Source: ParkinsonsUK-UCLInferred from direct assayⁱ
  • "Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element."
    Ubeda M., Wang X.Z., Zinszner H., Wu I., Habener J.F., Ron D.
    Mol Cell Biol 16:1479-1489(1996) [PubMed] [Europe PMC] [Abstract]
• positive regulation of apoptotic process Source: RGDInferred from mutant phenotypeⁱ
  • "Involvement of GADD153 and cardiac ankyrin repeat protein in hypoxia-induced apoptosis of H9c2 cells."
    Han X.J., Chae J.K., Lee M.J., You K.R., Lee B.H., Kim D.G.
    J Biol Chem 280:23122-23129(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of autophagy in response to ER overload Source: RGDInferred from mutant phenotypeⁱ
  • "Hepatocyte autophagy is linked to C/EBP-homologous protein, Bcl2-interacting mediator of cell death, and BH3-interacting domain death agonist gene expression."
    Zhang J., Singh N., Robinson-Taylor K.S., Dorsett-Martin W.A., Morris M.W. Jr., Earl T.M., Anderson C.D.
    J Surg Res 195:588-595(2015) [PubMed] [Europe PMC] [Abstract]
• positive regulation of DNA-binding transcription factor activity Source: RGD
• positive regulation of interleukin-8 production Source: UniProtKB
• positive regulation of intrinsic apoptotic signaling pathway Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine."
    Cai D., Huang E., Luo B., Yang Y., Zhang F., Liu C., Lin Z., Xie W.B., Wang H.
    Cell Death Dis. 7:E2161-E2161(2016) [PubMed] [Europe PMC] [Abstract]
• positive regulation of neuron apoptotic process Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Nupr1 Modulates Methamphetamine-Induced Dopaminergic Neuronal Apoptosis and Autophagy through CHOP-Trib3-Mediated Endoplasmic Reticulum Stress Signaling Pathway."
    Xu X., Huang E., Tai Y., Zhao X., Chen X., Chen C., Chen R., Liu C., Lin Z., Wang H., Xie W.B.
    Front. Mol. Neurosci. 10:203-203(2017) [PubMed] [Europe PMC] [Abstract]
• positive regulation of neuron death Source: RGD
• positive regulation of transcription, DNA-templated Source: RGDInferred from direct assayⁱ
  • "Bidirectional regulation of monocyte chemoattractant protein-1 gene at distinct sites of its promoter by nitric oxide in vascular smooth muscle cells."
    Kodama K., Nishio Y., Sekine O., Sato Y., Egawa K., Maegawa H., Kashiwagi A.
    Am J Physiol Cell Physiol 289:C582-90(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: RGD
• positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress Source: ParkinsonsUK-UCLInferred from direct assayⁱ
  • "Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element."
    Ubeda M., Wang X.Z., Zinszner H., Wu I., Habener J.F., Ron D.
    Mol Cell Biol 16:1479-1489(1996) [PubMed] [Europe PMC] [Abstract]
• proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
• regulation of autophagy Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Nupr1 Modulates Methamphetamine-Induced Dopaminergic Neuronal Apoptosis and Autophagy through CHOP-Trib3-Mediated Endoplasmic Reticulum Stress Signaling Pathway."
    Xu X., Huang E., Tai Y., Zhao X., Chen X., Chen C., Chen R., Liu C., Lin Z., Wang H., Xie W.B.
    Front. Mol. Neurosci. 10:203-203(2017) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription, DNA-templated Source: RGDInferred from direct assayⁱ
  • "Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state."
    McCullough K.D., Martindale J.L., Klotz L.O., Aw T.Y., Holbrook N.J.
    Mol Cell Biol 21:1249-1259(2001) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: RGD
• regulation of transcription involved in anterior/posterior axis specification Source: RGD
• release of sequestered calcium ion into cytosol Source: UniProtKB
• response to amphetamine Source: RGDInferred from expression patternⁱ
  • "Serial analysis of gene expression in the rat striatum following methamphetamine administration."
    Cai N.S., McCoy M.T., Ladenheim B., Lyles J., Ali S.F., Cadet J.L.
    Ann N Y Acad Sci 1074:13-30(2006) [PubMed] [Europe PMC] [Abstract]
• response to drug Source: RGDInferred from expression patternⁱ
  • "The protective effect of dantrolene on ischemic neuronal cell death is associated with reduced expression of endoplasmic reticulum stress markers."
    Li F., Hayashi T., Jin G., Deguchi K., Nagotani S., Nagano I., Shoji M., Chan P.H., Abe K.
    Brain Res 1048:59-68(2005) [PubMed] [Europe PMC] [Abstract]
• response to endoplasmic reticulum stress Source: UniProtKB
• response to hydrogen peroxide Source: RGDInferred from expression patternⁱ
  • "Expression of the pro-apoptotic gene gadd153/chop is elevated in liver with aging and sensitizes cells to oxidant injury."
    Ikeyama S., Wang X.T., Li J., Podlutsky A., Martindale J.L., Kokkonen G., van Huizen R., Gorospe M., Holbrook N.J.
    J Biol Chem 278:16726-16731(2003) [PubMed] [Europe PMC] [Abstract]
• response to nutrient Source: RGDInferred from expression patternⁱ
  • "Expression of the pro-apoptotic gene gadd153/chop is elevated in liver with aging and sensitizes cells to oxidant injury."
    Ikeyama S., Wang X.T., Li J., Podlutsky A., Martindale J.L., Kokkonen G., van Huizen R., Gorospe M., Holbrook N.J.
    J Biol Chem 278:16726-16731(2003) [PubMed] [Europe PMC] [Abstract]
• response to oxidative stress Source: RGDInferred from expression patternⁱ
  • "Mechanism of oxidative stress-induced GADD153 gene expression in vascular smooth muscle cells."
    Tang J.R., Nakamura M., Okura T., Takata Y., Watanabe S., Yang Z.H., Liu J., Kitami Y., Hiwada K.
    Biochem Biophys Res Commun 290:1255-1259(2002) [PubMed] [Europe PMC] [Abstract]
• response to starvation Source: UniProtKB
• response to toxic substance Source: RGDInferred from expression patternⁱ
  • "Enhanced expression of C/EBP homologous protein (CHOP) precedes degeneration of fibrocytes in the lateral wall after acute cochlear mitochondrial dysfunction induced by 3-nitropropionic acid."
    Fujinami Y., Mutai H., Kamiya K., Mizutari K., Fujii M., Matsunaga T.
    Neurochem Int 56:487-494(2010) [PubMed] [Europe PMC] [Abstract]
• response to unfolded protein Source: UniProtKB
• sensory perception of sound Source: RGD
• Wnt signaling pathway Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• cAMP response element binding protein binding Source: UniProtKB
• leucine zipper domain binding Source: RGD
• protein heterodimerization activity Source: ParkinsonsUK-UCLInferred from physical interactionⁱ
  • "Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element."
    Ubeda M., Wang X.Z., Zinszner H., Wu I., Habener J.F., Ron D.
    Mol Cell Biol 16:1479-1489(1996) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: RGD
• transcription factor binding Source: RGD

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MAAESLPFAF ETVSSWELEA WYEDLQEVLS SDEIGGTYIS SPGNEEEESK 
        60         70         80         90        100
TFTTLDPASL AWLTEEPGPA EVTSTSQSPR SPDSSQSSMA QEEEEEDQGR 
       110        120        130        140        150
TRKRKQSGQC AARAGKQRMK EKEQENERKV AQLAEENERL KLEIERLTRE 
       160 
VETTRRALID RMVSLHQA                                    

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families