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Protein

Cell division cycle protein 123 homolog

Gene

Cdc123

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for S phase entry of the cell cycle.

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle protein 123 homolog
Short name:
Protein D123
Gene namesi
Name:Cdc123
Synonyms:D123
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi619766 Cdc123

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002286651 – 336Cell division cycle protein 123 homologAdd BLAST336

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated.1 Publication
The Val-109 variant is degraded by the proteasome suggesting that it is polyubiquitinated.

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEiQ62834

Expressioni

Tissue specificityi

Frequently detected in granular vesicles, in the cytoplasm of some epithelial, stromal and sperm cells and in varicosities lining nervous fibers, while it appears to be absent in endothelial and smooth muscle cells (at protein level). Widely expressed. Expressed at high level in testis.1 Publication

Gene expression databases

BgeeiENSRNOG00000017770
GenevisibleiQ62834 RN

Family & Domainsi

Sequence similaritiesi

Belongs to the CDC123 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000003057
HOGENOMiHOG000231938
HOVERGENiHBG080491
InParanoidiQ62834
OMAiALEFRCF
OrthoDBiEOG091G0A9C
PhylomeDBiQ62834
TreeFamiTF323348

Family and domain databases

InterProiView protein in InterPro
IPR009772 CDC123
PANTHERiPTHR15323 PTHR15323, 1 hit
PfamiView protein in Pfam
PF07065 D123, 1 hit
PIRSFiPIRSF007807 Cdc123, 1 hit

Sequencei

Sequence statusi: Complete.

Q62834-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKEHVSHCQ FSAWYPLFRS LTIKSVILPL PQNVKDYLLD DGTLVVSGRE
60 70 80 90 100
DPPTCSQPDS GDEAEETQWS DDESTATLTA PEFPEFNTQV QEAINSLGGS
110 120 130 140 150
VFPKLNWSAP RDAYWIAMNS SLKCKSLSDI FLLFKSSDFI THDFTQPFIH
160 170 180 190 200
CNDDSPDPCI EYELVLRKWC ELIPGAEFRC FVKENKLIGI SQRDYTQYYD
210 220 230 240 250
HISKQKEEIC RCIQDFFKEH LQYKFLDEDF VFDIYRDSRG KVWLIDFNPF
260 270 280 290 300
GEVTDSLLFT WEELTSENNL RGDVSEADAL EQDSPAFRCT NSEVTVQPSP
310 320 330
YLSYGLPKDF VDLSTGEDAH KLIDFLKLKR NQQEDD
Length:336
Mass (Da):38,812
Last modified:November 1, 1996 - v1
Checksum:i6E1D1379A2612934
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti109A → V in 3Y1tsD123 cell line; reversibly arrested in G1 phase of cell cycle at the restrictive temperature of 39.8 degrees Celsius; due to extensive degradation by the proteasome. 3 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34843 mRNA Translation: AAB60521.1
BC061527 mRNA Translation: AAH61527.1
RefSeqiNP_446329.1, NM_053877.3
UniGeneiRn.11096

Genome annotation databases

EnsembliENSRNOT00000024016; ENSRNOP00000024016; ENSRNOG00000017770
GeneIDi116656
KEGGirno:116656

Similar proteinsi

Entry informationi

Entry nameiCD123_RAT
AccessioniPrimary (citable) accession number: Q62834
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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