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Protein

Exocyst complex component 3

Gene

Exoc3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • SNARE binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-264876 Insulin processing
R-RNO-5620916 VxPx cargo-targeting to cilium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exocyst complex component 3
Alternative name(s):
Exocyst complex component Sec6
Short name:
rSec6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Exoc3
Synonyms:Sec6, Sec6l1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Rat genome database

More...
RGDi
621790 Exoc3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Golgi apparatus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001189271 – 755Exocyst complex component 3Add BLAST755

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei38N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q62825

PRoteomics IDEntifications database

More...
PRIDEi
Q62825

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q62825

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q62825

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with highest levels in kidney, followed by brain (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000039776 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q62825 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (PubMed:9405631). Interacts with EXOC3L1 (By similarity). Interacts with BIRC6/bruce (By similarity). Interacts with MYRIP.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
251644, 1 interactor

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q62825

Database of interacting proteins

More...
DIPi
DIP-60432N

Protein interaction database and analysis system

More...
IntActi
Q62825, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000020251

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q62825

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q62825

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili34 – 62Sequence analysisAdd BLAST29
Coiled coili618 – 649Sequence analysisAdd BLAST32

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SEC6 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2286 Eukaryota
COG5173 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153785

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000043095

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG034187

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q62825

KEGG Orthology (KO)

More...
KOi
K06110

Identification of Orthologs from Complete Genome Data

More...
OMAi
GRPKRWK

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q62825

TreeFam database of animal gene trees

More...
TreeFami
TF314979

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010326 EXOC3/Sec6

The PANTHER Classification System

More...
PANTHERi
PTHR21292 PTHR21292, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06046 Sec6, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q62825-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCKDSACFST MKETDLEAVA TAVQRVAGML QRPDQLDKVE QYRRREARKK
60 70 80 90 100
ASVEARLKAA IQSQLDGVRT GLSQLHNALN DVKDIQQSLA DVSKDWRQSI
110 120 130 140 150
NTIESLKDVK DAVVQHSQLA AAVENLKNIF SVPEIVRETQ DLIEQGALLQ
160 170 180 190 200
AHRKLMDLEC SRDGLMCEQY RMDSGNKRDM TLIHGYFGST QGLSDELAKQ
210 220 230 240 250
LWMVLQRSLV TVRRDPTLLV SVVRIIEREE KIDRRILDRK KQTGFVPPGR
260 270 280 290 300
PKNWKEKMFA VLDRTVTTRI EGTQADTRES DKMWLVRHLE IIRKYVLDDL
310 320 330 340 350
VIAKNLLVQC FPPHYDIFKN LLSMYHQALS IRMQDLASED LEANEIVSLL
360 370 380 390 400
TWVLNTYTSA EMMGNVELAP EVDVNALEPL LSPNVVSELL DTYMSTLTSN
410 420 430 440 450
IIAWLRKALE TDKKDWSKET EPEADQDGYY QTTLPAIVFQ MFEQNLQVAA
460 470 480 490 500
QISEDLKTKV LVLCLQQMNS FLSRYKEEAQ LYKEEHLRNR QHPHCYVQYM
510 520 530 540 550
VAIINNCQTF KESIISLKRK YLKPETEESL CQSQPSMDGI LDAIAKEGCS
560 570 580 590 600
SLLEEVFLDL EQHLNELMTK KWMLGSNAVD IICVTVEDYF NDFAKIKKPY
610 620 630 640 650
KKRMTAEAHR RVVVEYLRAV MQKRISFRSA EERKEGAEKM VREAEQLRFL
660 670 680 690 700
FRKLASGFGE DADGHCDTIV AVAEVIKLTD PSLLYLEVST LVSKYPDIRD
710 720 730 740 750
DHIGALLALR GDASRDMKQT IMETLEQGPM QASPNYVPIF QEIVVPSLNV

AKLLK
Length:755
Mass (Da):86,497
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i67A9C71A4C0860F9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U32575 mRNA Translation: AAA85505.1
BC097993 mRNA Translation: AAH97993.1

NCBI Reference Sequences

More...
RefSeqi
NP_001020135.1, NM_001024964.1
XP_006227829.1, XM_006227767.3
XP_006227830.1, XM_006227768.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Rn.6753

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000020251; ENSRNOP00000020251; ENSRNOG00000039776
ENSRNOT00000077740; ENSRNOP00000072705; ENSRNOG00000039776

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
252881

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:252881

UCSC genome browser

More...
UCSCi
RGD:621790 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32575 mRNA Translation: AAA85505.1
BC097993 mRNA Translation: AAH97993.1
RefSeqiNP_001020135.1, NM_001024964.1
XP_006227829.1, XM_006227767.3
XP_006227830.1, XM_006227768.3
UniGeneiRn.6753

3D structure databases

ProteinModelPortaliQ62825
SMRiQ62825
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi251644, 1 interactor
CORUMiQ62825
DIPiDIP-60432N
IntActiQ62825, 1 interactor
STRINGi10116.ENSRNOP00000020251

PTM databases

iPTMnetiQ62825
PhosphoSitePlusiQ62825

Proteomic databases

PaxDbiQ62825
PRIDEiQ62825

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020251; ENSRNOP00000020251; ENSRNOG00000039776
ENSRNOT00000077740; ENSRNOP00000072705; ENSRNOG00000039776
GeneIDi252881
KEGGirno:252881
UCSCiRGD:621790 rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11336
RGDi621790 Exoc3

Phylogenomic databases

eggNOGiKOG2286 Eukaryota
COG5173 LUCA
GeneTreeiENSGT00940000153785
HOGENOMiHOG000043095
HOVERGENiHBG034187
InParanoidiQ62825
KOiK06110
OMAiGRPKRWK
PhylomeDBiQ62825
TreeFamiTF314979

Enzyme and pathway databases

ReactomeiR-RNO-264876 Insulin processing
R-RNO-5620916 VxPx cargo-targeting to cilium

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q62825

Gene expression databases

BgeeiENSRNOG00000039776 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiQ62825 RN

Family and domain databases

InterProiView protein in InterPro
IPR010326 EXOC3/Sec6
PANTHERiPTHR21292 PTHR21292, 1 hit
PfamiView protein in Pfam
PF06046 Sec6, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEXOC3_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q62825
Secondary accession number(s): Q4QQU2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: November 1, 1996
Last modified: December 5, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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