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Protein

Exocyst complex component 3

Gene

Exoc3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-264876 Insulin processing
R-RNO-5620916 VxPx cargo-targeting to cilium

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 3
Alternative name(s):
Exocyst complex component Sec6
Short name:
rSec6
Gene namesi
Name:Exoc3
Synonyms:Sec6, Sec6l1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi621790 Exoc3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001189271 – 755Exocyst complex component 3Add BLAST755

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ62825
PRIDEiQ62825

PTM databases

iPTMnetiQ62825
PhosphoSitePlusiQ62825

Expressioni

Tissue specificityi

Widely expressed, with highest levels in kidney, followed by brain (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000039776 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiQ62825 RN

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (PubMed:9405631). Interacts with EXOC3L1 (By similarity). Interacts with BIRC6/bruce (By similarity). Interacts with MYRIP.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi251644, 1 interactor
CORUMiQ62825
DIPiDIP-60432N
IntActiQ62825, 1 interactor
STRINGi10116.ENSRNOP00000020251

Structurei

3D structure databases

ProteinModelPortaliQ62825
SMRiQ62825
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili34 – 62Sequence analysisAdd BLAST29
Coiled coili618 – 649Sequence analysisAdd BLAST32

Sequence similaritiesi

Belongs to the SEC6 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2286 Eukaryota
COG5173 LUCA
GeneTreeiENSGT00530000062934
HOGENOMiHOG000043095
HOVERGENiHBG034187
InParanoidiQ62825
KOiK06110
OMAiYMIAIIN
PhylomeDBiQ62825
TreeFamiTF314979

Family and domain databases

InterProiView protein in InterPro
IPR010326 EXOC3/Sec6
PANTHERiPTHR21292 PTHR21292, 1 hit
PfamiView protein in Pfam
PF06046 Sec6, 1 hit

Sequencei

Sequence statusi: Complete.

Q62825-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCKDSACFST MKETDLEAVA TAVQRVAGML QRPDQLDKVE QYRRREARKK
60 70 80 90 100
ASVEARLKAA IQSQLDGVRT GLSQLHNALN DVKDIQQSLA DVSKDWRQSI
110 120 130 140 150
NTIESLKDVK DAVVQHSQLA AAVENLKNIF SVPEIVRETQ DLIEQGALLQ
160 170 180 190 200
AHRKLMDLEC SRDGLMCEQY RMDSGNKRDM TLIHGYFGST QGLSDELAKQ
210 220 230 240 250
LWMVLQRSLV TVRRDPTLLV SVVRIIEREE KIDRRILDRK KQTGFVPPGR
260 270 280 290 300
PKNWKEKMFA VLDRTVTTRI EGTQADTRES DKMWLVRHLE IIRKYVLDDL
310 320 330 340 350
VIAKNLLVQC FPPHYDIFKN LLSMYHQALS IRMQDLASED LEANEIVSLL
360 370 380 390 400
TWVLNTYTSA EMMGNVELAP EVDVNALEPL LSPNVVSELL DTYMSTLTSN
410 420 430 440 450
IIAWLRKALE TDKKDWSKET EPEADQDGYY QTTLPAIVFQ MFEQNLQVAA
460 470 480 490 500
QISEDLKTKV LVLCLQQMNS FLSRYKEEAQ LYKEEHLRNR QHPHCYVQYM
510 520 530 540 550
VAIINNCQTF KESIISLKRK YLKPETEESL CQSQPSMDGI LDAIAKEGCS
560 570 580 590 600
SLLEEVFLDL EQHLNELMTK KWMLGSNAVD IICVTVEDYF NDFAKIKKPY
610 620 630 640 650
KKRMTAEAHR RVVVEYLRAV MQKRISFRSA EERKEGAEKM VREAEQLRFL
660 670 680 690 700
FRKLASGFGE DADGHCDTIV AVAEVIKLTD PSLLYLEVST LVSKYPDIRD
710 720 730 740 750
DHIGALLALR GDASRDMKQT IMETLEQGPM QASPNYVPIF QEIVVPSLNV

AKLLK
Length:755
Mass (Da):86,497
Last modified:November 1, 1996 - v1
Checksum:i67A9C71A4C0860F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32575 mRNA Translation: AAA85505.1
BC097993 mRNA Translation: AAH97993.1
RefSeqiNP_001020135.1, NM_001024964.1
XP_006227829.1, XM_006227767.3
XP_006227830.1, XM_006227768.3
UniGeneiRn.6753

Genome annotation databases

EnsembliENSRNOT00000020251; ENSRNOP00000020251; ENSRNOG00000039776
ENSRNOT00000077740; ENSRNOP00000072705; ENSRNOG00000039776
GeneIDi252881
KEGGirno:252881
UCSCiRGD:621790 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32575 mRNA Translation: AAA85505.1
BC097993 mRNA Translation: AAH97993.1
RefSeqiNP_001020135.1, NM_001024964.1
XP_006227829.1, XM_006227767.3
XP_006227830.1, XM_006227768.3
UniGeneiRn.6753

3D structure databases

ProteinModelPortaliQ62825
SMRiQ62825
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi251644, 1 interactor
CORUMiQ62825
DIPiDIP-60432N
IntActiQ62825, 1 interactor
STRINGi10116.ENSRNOP00000020251

PTM databases

iPTMnetiQ62825
PhosphoSitePlusiQ62825

Proteomic databases

PaxDbiQ62825
PRIDEiQ62825

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020251; ENSRNOP00000020251; ENSRNOG00000039776
ENSRNOT00000077740; ENSRNOP00000072705; ENSRNOG00000039776
GeneIDi252881
KEGGirno:252881
UCSCiRGD:621790 rat

Organism-specific databases

CTDi11336
RGDi621790 Exoc3

Phylogenomic databases

eggNOGiKOG2286 Eukaryota
COG5173 LUCA
GeneTreeiENSGT00530000062934
HOGENOMiHOG000043095
HOVERGENiHBG034187
InParanoidiQ62825
KOiK06110
OMAiYMIAIIN
PhylomeDBiQ62825
TreeFamiTF314979

Enzyme and pathway databases

ReactomeiR-RNO-264876 Insulin processing
R-RNO-5620916 VxPx cargo-targeting to cilium

Miscellaneous databases

PROiPR:Q62825

Gene expression databases

BgeeiENSRNOG00000039776 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiQ62825 RN

Family and domain databases

InterProiView protein in InterPro
IPR010326 EXOC3/Sec6
PANTHERiPTHR21292 PTHR21292, 1 hit
PfamiView protein in Pfam
PF06046 Sec6, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEXOC3_RAT
AccessioniPrimary (citable) accession number: Q62825
Secondary accession number(s): Q4QQU2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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