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Protein

Exocyst complex component 4

Gene

Exoc4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

GO - Molecular functioni

  • PDZ domain binding Source: RGD
  • protein-containing complex binding Source: RGD

GO - Biological processi

Keywordsi

Biological processExocytosis, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 4
Alternative name(s):
Exocyst complex component Sec8
Short name:
rSec8
Gene namesi
Name:Exoc4
Synonyms:Sec8, Sec8l1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621791 Exoc4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001189362 – 975Exocyst complex component 4Add BLAST974

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei9N6-acetyllysineBy similarity1
Modified residuei32PhosphoserineCombined sources1
Modified residuei226PhosphoserineCombined sources1
Modified residuei238PhosphothreonineBy similarity1
Modified residuei469PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ62824

PTM databases

iPTMnetiQ62824
PhosphoSitePlusiQ62824

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with BIRC6/bruce (By similarity). Interacts with MYRIP. Interacts with SH3BP1; required for the localization of both SH3BP1 and the exocyst to the leading edge of migrating cells (By similarity).By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi250539, 2 interactors
CORUMiQ62824
DIPiDIP-40985N
IntActiQ62824, 7 interactors
MINTiQ62824

Structurei

3D structure databases

SMRiQ62824
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili32 – 114Sequence analysisAdd BLAST83

Sequence similaritiesi

Belongs to the SEC8 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000044203
HOVERGENiHBG036151
InParanoidiQ62824
KOiK06111
PhylomeDBiQ62824

Family and domain databases

InterProiView protein in InterPro
IPR007191 Sec8_exocyst
PfamiView protein in Pfam
PF04048 Sec8_exocyst, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q62824-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAEAAGGKY RSTVSKSKDP SGLLISVIRT LSTSDDVEDR ENEKGRLEEA
60 70 80 90 100
YEKCDRDLDE LIVQHYTELT TAIRTYQSIT ERITNSRNKI KQVKENLLSC
110 120 130 140 150
KMLLHCKRDE LRKLWIEGIE HKHVLNLLDE IENIKQVPQK LEQCMASKHY
160 170 180 190 200
LSATDMLVSA VESLEGPLLQ VEGLSDLRLE LHSKKMNLHL VLIEELHRHL
210 220 230 240 250
YIKSTSRVVQ RNKEKGKMSS HGKDASPGPL IDVSNISTPR KFLDATQYSA
260 270 280 290 300
AGSSSVREMN LQDIKEDLDC DPEENSTLFM GILIQGLARL KKIPETVKAI
310 320 330 340 350
KERLEQELKQ IVKRSTTQVA DSAYQRGESL TVDNQPRLLL ELLELLFDKF
360 370 380 390 400
NAVASAHSIV LGYLQDSVGT QPTQQEEIKL YDMADVWVKI QDVLQMLLTE
410 420 430 440 450
YLDMKNTRTA SEPSAQLSYA STGREFAAFF AKKKPQRPKN SLFKFESSSH
460 470 480 490 500
AISMSAYLRE QRRELYSRSG ELQGGPDDNL IEGGGTKFVC KPGARNITVI
510 520 530 540 550
FHPLLRFIQE IEHALGLGPA KQCLLREFLT IYIKNIFLNQ VLTEINKEIE
560 570 580 590 600
GVTKTSDPLK ILANADTMKV LGVQRPLLQS TIIVEKTVQD LMNLMHDLSA
610 620 630 640 650
YSDQFLNMVC VKLQEYKDTC STAYRGIVQS EEKLVISASW AKDDDISRLL
660 670 680 690 700
KSLPNWTNMA QPKQLRPKRE EEEDFIRAAF GKESEVLIGN LGDKLIPPQD
710 720 730 740 750
ILRDVSDLKA LANMHESLEW LAGRTKSAFS SLSASQMLSP AQESHVNMDL
760 770 780 790 800
PPVSEQIMQT LSELAKSFQD MADRCLLVLH LEVRVHCFHY LIPLAKEGNY
810 820 830 840 850
AIVANVESMD YDPLVVKLNK DISAMEEAMS ASLQQHKFQY IFEGLGHLIS
860 870 880 890 900
CILINGAQYF RRISESGIKK MCRNIFVLQQ NLTNITMSRE ADLDFARQYY
910 920 930 940 950
EMLYNTADEL LNLVVDQGVK YTELEYIHAL TLLHRSQTGV GDQTTQNTRL
960 970
QRLKEIICEQ AAIKQATKDK KITTV
Length:975
Mass (Da):110,553
Last modified:November 1, 1996 - v1
Checksum:iC52FD3553BE75858
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0RBF8M0RBF8_RAT
Exocyst complex component 4
Exoc4
974Annotation score:
M0R649M0R649_RAT
Exocyst complex component 4
Exoc4
973Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32498 mRNA Translation: AAC52265.1
PIRiI59422
RefSeqiNP_446327.1, NM_053875.1
UniGeneiRn.51841

Genome annotation databases

GeneIDi116654
KEGGirno:116654
UCSCiRGD:621791 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32498 mRNA Translation: AAC52265.1
PIRiI59422
RefSeqiNP_446327.1, NM_053875.1
UniGeneiRn.51841

3D structure databases

SMRiQ62824
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250539, 2 interactors
CORUMiQ62824
DIPiDIP-40985N
IntActiQ62824, 7 interactors
MINTiQ62824

PTM databases

iPTMnetiQ62824
PhosphoSitePlusiQ62824

Proteomic databases

PRIDEiQ62824

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi116654
KEGGirno:116654
UCSCiRGD:621791 rat

Organism-specific databases

CTDi60412
RGDi621791 Exoc4

Phylogenomic databases

HOGENOMiHOG000044203
HOVERGENiHBG036151
InParanoidiQ62824
KOiK06111
PhylomeDBiQ62824

Miscellaneous databases

PROiPR:Q62824

Family and domain databases

InterProiView protein in InterPro
IPR007191 Sec8_exocyst
PfamiView protein in Pfam
PF04048 Sec8_exocyst, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEXOC4_RAT
AccessioniPrimary (citable) accession number: Q62824
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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