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UniProtKB - Q62818 (EI2BB_RAT)
Protein
Translation initiation factor eIF-2B subunit beta
Gene
Eif2b2
Organism
Rattus norvegicus (Rat)
Status
Functioni
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
GO - Molecular functioni
- ATP binding Source: UniProtKB
- GTP binding Source: UniProtKB
- translation initiation factor activity Source: GO_Central
GO - Biological processi
- central nervous system development Source: UniProtKB
- hippocampus development Source: RGD
- myelination Source: UniProtKB
- oligodendrocyte development Source: UniProtKB
- ovarian follicle development Source: UniProtKB
- positive regulation of axon extension Source: RGD
- regulation of catalytic activity Source: GOC
- response to glucose Source: UniProtKB
- response to heat Source: UniProtKB
- response to peptide hormone Source: UniProtKB
- T cell receptor signaling pathway Source: UniProtKB
- translational initiation Source: UniProtKB
Keywordsi
Molecular function | Initiation factor |
Biological process | Protein biosynthesis |
Enzyme and pathway databases
Reactomei | R-RNO-72731, Recycling of eIF2:GDP |
Names & Taxonomyi
Protein namesi | Recommended name: Translation initiation factor eIF-2B subunit betaAlternative name(s): eIF-2B GDP-GTP exchange factor subunit beta |
Gene namesi | Name:Eif2b2 Synonyms:Eif2bb |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620820, Eif2b2 |
Subcellular locationi
Other locations
- axon Source: RGD
- cytoplasm Source: UniProtKB
- eukaryotic translation initiation factor 2B complex Source: RGD
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000156064 | 1 – 351 | Translation initiation factor eIF-2B subunit betaAdd BLAST | 351 |
Proteomic databases
jPOSTi | Q62818 |
PaxDbi | Q62818 |
PRIDEi | Q62818 |
PTM databases
iPTMneti | Q62818 |
PhosphoSitePlusi | Q62818 |
Interactioni
Subunit structurei
Complex of five different subunits; alpha, beta, gamma, delta and epsilon.
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000008730 |
Family & Domainsi
Sequence similaritiesi
Belongs to the eIF-2B alpha/beta/delta subunits family.Curated
Phylogenomic databases
eggNOGi | KOG1465, Eukaryota |
InParanoidi | Q62818 |
PhylomeDBi | Q62818 |
Family and domain databases
Gene3Di | 3.40.50.10470, 1 hit |
InterProi | View protein in InterPro IPR000649, IF-2B-related IPR042529, IF_2B-like_C IPR037171, NagB/RpiA_transferase-like |
Pfami | View protein in Pfam PF01008, IF-2B, 1 hit |
SUPFAMi | SSF100950, SSF100950, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q62818-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPGAAAKGSE LSERIESFVE TLKRGGGRRT SEDMARETLG LLRRLITDHH
60 70 80 90 100
WNNAGDLMDL IRREGRRMTA AHPPETTVGN MVRRVLKIIR EEYGRLHGRS
110 120 130 140 150
DESDQQESLH KLLTSGGLSE DFSFHYAPLK SNIIEAINEL LVELEGTTEN
160 170 180 190 200
IAAQALEHIH SNEVIMTIGF SRTVEAFLRE AAQKRKFHVI AAECAPFCQG
210 220 230 240 250
HEMAVNLSEA GIETTVMTDA AIFAVMSRVN KVIIGTKTIL ANGSLRAVAG
260 270 280 290 300
THTLALAAKH HSTPLIVCAP MFKLSPQFPS EEDSFHKFVA PEEVLPFTEG
310 320 330 340 350
DILEKVSVHC PVFDYVPPDL ITLFISNIGG NAPSYVYRLM SELYHPDDHV
L
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF7EVX2 | F7EVX2_RAT | Translation initiation factor eIF-2... | Eif2b2 | 382 | Annotation score: | ||
A0A8I6GEG4 | A0A8I6GEG4_RAT | Translation initiation factor eIF-2... | Eif2b2 | 363 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 30 | T → S in AAB58527 (PubMed:9139680).Curated | 1 | |
Sequence conflicti | 72 – 74 | HPP → QPS in AAB58527 (PubMed:9139680).Curated | 3 | |
Sequence conflicti | 93 – 95 | Missing in AAB58527 (PubMed:9139680).Curated | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U31880 mRNA Translation: AAB38753.1 U83914 mRNA Translation: AAB58527.1 |
PIRi | S71960 |
Genome annotation databases
UCSCi | RGD:620820, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U31880 mRNA Translation: AAB38753.1 U83914 mRNA Translation: AAB58527.1 |
PIRi | S71960 |
3D structure databases
AlphaFoldDBi | Q62818 |
SMRi | Q62818 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000008730 |
PTM databases
iPTMneti | Q62818 |
PhosphoSitePlusi | Q62818 |
Proteomic databases
jPOSTi | Q62818 |
PaxDbi | Q62818 |
PRIDEi | Q62818 |
Genome annotation databases
UCSCi | RGD:620820, rat |
Organism-specific databases
RGDi | 620820, Eif2b2 |
Phylogenomic databases
eggNOGi | KOG1465, Eukaryota |
InParanoidi | Q62818 |
PhylomeDBi | Q62818 |
Enzyme and pathway databases
Reactomei | R-RNO-72731, Recycling of eIF2:GDP |
Miscellaneous databases
PROi | PR:Q62818 |
Family and domain databases
Gene3Di | 3.40.50.10470, 1 hit |
InterProi | View protein in InterPro IPR000649, IF-2B-related IPR042529, IF_2B-like_C IPR037171, NagB/RpiA_transferase-like |
Pfami | View protein in Pfam PF01008, IF-2B, 1 hit |
SUPFAMi | SSF100950, SSF100950, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | EI2BB_RAT | |
Accessioni | Q62818Primary (citable) accession number: Q62818 Secondary accession number(s): O08956 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | May 25, 2022 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families