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Protein

Limbic system-associated membrane protein

Gene

Lsamp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hyppocampal mossy fiber projection.

GO - Biological processi

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Limbic system-associated membrane protein
Short name:
LSAMP
Gene namesi
Name:Lsamp
Synonyms:Lamp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi71102 Lsamp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 281 PublicationAdd BLAST28
ChainiPRO_000001510629 – 315Limbic system-associated membrane proteinAdd BLAST287
PropeptideiPRO_0000015107316 – 338Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi40N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi53 ↔ 111PROSITE-ProRule annotation
Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei94PhosphotyrosineBy similarity1
Glycosylationi136N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi153 ↔ 197PROSITE-ProRule annotation
Disulfide bondi239 ↔ 290PROSITE-ProRule annotation
Glycosylationi279N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi287N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi300N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi315GPI-anchor amidated asparagine; alternateSequence analysis1
Glycosylationi315N-linked (GlcNAc...) asparagine; alternateSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ62813

PTM databases

iPTMnetiQ62813
PhosphoSitePlusiQ62813
UniCarbKBiQ62813

Expressioni

Tissue specificityi

Expressed mostly by neurons comprising limbic-associated cortical and subcortical regions that function in cognition, emotion, memory, and learning.

Developmental stagei

First detected at E15-16, at stage E20 it is detected in presumptive cortex, medial limbic areas of the thalamus and hypothalamus. In the adult, it is found in hypothalamus, perirhinal cortex, amygdala and medial thalamic region.

Gene expression databases

GenevisibleiQ62813 RN

Structurei

3D structure databases

ProteinModelPortaliQ62813
SMRiQ62813
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 122Ig-like C2-type 1Add BLAST94
Domaini132 – 214Ig-like C2-type 2Add BLAST83
Domaini219 – 304Ig-like C2-type 3Add BLAST86

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

HOGENOMiHOG000019085
HOVERGENiHBG017341
InParanoidiQ62813
KOiK06772
OrthoDBiEOG091G0B5D
TreeFamiTF325565

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF07679 I-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q62813-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVGRVQPDRK QLPLVLLRLL CLLPTGLPVR SVDFNRGTDN ITVRQGDTAI
60 70 80 90 100
LRCVVEDKNS KVAWLNRSGI IFAGHDKWSL DPRVELEKRH ALEYSLRIQK
110 120 130 140 150
VDVYDEGSYT CSVQTQHEPK TSQVYLIVQV PPKISNISSD VTVNEGSNVT
160 170 180 190 200
LVCMANGRPE PVITWRHLTP LGREFEGEEE YLEILGITRE QSGKYECKAA
210 220 230 240 250
NEVSSADVKQ VKVTVNYPPT ITESKSNEAT TGRQASLKCE ASAVPAPDFE
260 270 280 290 300
WYRDDTRINS ANGLEIKSTE GQSSLTVTNV TEEHYGNYTC VAANKLGVTN
310 320 330
ASLVLFRPGS VRGINGSISL AVPLWLLAAS LFCLLSKC
Note: GPI-anchored form.
Length:338
Mass (Da):37,324
Last modified:November 1, 1996 - v1
Checksum:i0B76AFDD68A39BB6
GO
Isoform 2 (identifier: Q62813-2) [UniParc]FASTAAdd to basket
Also known as: 6C

The sequence of this isoform differs from the canonical sequence as follows:
     307-307: R → KRVLPTVPHPIQEIGTTVHFKQKG

Show »
Length:361
Mass (Da):39,861
Checksum:iCF93DECA78E1EC59
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011601307R → KRVLPTVPHPIQEIGTTVHF KQKG in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31554 mRNA Translation: AAA86120.1
AY326256 mRNA Translation: AAQ91613.1
RefSeqiNP_058938.1, NM_017242.1 [Q62813-1]
XP_006248401.1, XM_006248339.3 [Q62813-2]
UniGeneiRn.10176

Genome annotation databases

GeneIDi29561
KEGGirno:29561
UCSCiRGD:71102 rat [Q62813-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiLSAMP_RAT
AccessioniPrimary (citable) accession number: Q62813
Secondary accession number(s): Q6VUH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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