Znf148

Functionⁱ

Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	171 – 193	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	199 – 221	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	227 – 249	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	255 – 278	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	24

GO - Molecular functionⁱ

DNA-binding transcription factor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
double-stranded DNA binding
Source: RGD
Inferred from direct assayⁱ
- 8943318
metal ion binding Source: UniProtKB-KW
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific Source: Ensembl
RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
transcription regulatory region DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription regulatory region sequence-specific DNA binding
Source: RGD
Inferred from direct assayⁱ
- 8943318

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

gamete generation Source: Ensembl
negative regulation of transcription by RNA polymerase II
Source: RGD
Inferred from direct assayⁱ
- 8943318
positive regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein-containing complex assembly
Source: RGD
Inferred from mutant phenotypeⁱ
- 8943318

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Repressor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 148 Alternative name(s): Transcription factor ZBP-89 Zinc finger DNA-binding protein 89
Gene namesⁱ	Name:Znf148 Synonyms:Zbp89, Zfp148
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 11

Organism-specific databases

Rat genome database More...RGDⁱ	62063 Zfp148

RGDⁱ

62063 Zfp148

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047429	1 – 794	Zinc finger protein 148Add BLAST		794

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	6	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	51	PhosphoserineBy similarity	1
Cross-linkⁱ	88	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	115	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	132	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	194	PhosphothreonineBy similarity	1
Modified residueⁱ	250	PhosphoserineBy similarity	1
Cross-linkⁱ	291	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	301	PhosphoserineBy similarity	1
Modified residueⁱ	306	PhosphoserineCombined sources	1
Cross-linkⁱ	308	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	356	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linkⁱ	356	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linkⁱ	402	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	412	PhosphoserineCombined sources	1
Cross-linkⁱ	421	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	424	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	607	N6-acetyllysineBy similarity	1
Modified residueⁱ	665	PhosphoserineBy similarity	1
Modified residueⁱ	784	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Sumoylated with SUMO2. Desumoylated by SENP3, resulting in the stimulation of transcription of its target genes (By similarity).By similarity

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q62806
PRIDEⁱ	Q62806

PTM databases

CarbonylDBⁱ	Q62806
iPTMnetⁱ	Q62806
PhosphoSitePlusⁱ	Q62806

Expressionⁱ

Tissue specificityⁱ

Expressed in heart, lung, kidney, skeletal muscle, liver, brain and spleen.1 Publication

Gene expression databases

Bgeeⁱ	ENSRNOG00000001789 Expressed in 9 organ(s), highest expression level in Ammon's horn
Genevisibleⁱ	Q62806 RN

Interactionⁱ

Subunit structureⁱ

Interacts with HNRNPDL. Interacts with the 5FMC complex; the interaction requires association with CHTOP. Interacts with CAVIN1.By similarity

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000002435

STRINGⁱ

10116.ENSRNOP00000002435

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q62806
SMRⁱ	Q62806
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	171 – 193	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	199 – 221	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	227 – 249	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	255 – 278	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063238
HOGENOMⁱ	HOG000293204
HOVERGENⁱ	HBG054247
InParanoidⁱ	Q62806
OMAⁱ	EMISHDE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02EU
PhylomeDBⁱ	Q62806
TreeFamⁱ	TF331779

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q62806-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNIDDKLEGL FLKCGGIDEM QSSRAMVVMG GVSGQSAVSG ELQESVLQDR 
        60         70         80         90        100
SLPHQEILAA DEVLQESEMR QQDMISHDEL MVHEETVKND EEQTDTHERL 
       110        120        130        140        150
PQGLQYALNV PISVKQEITF TDVSEQLMRD KKQVREPVDL QKKKKRKQRS 
       160        170        180        190        200
PAKILTINED GSLGLKTPKS HVCEHCNAAF RTNYHLQRHV FIHTGEKPFQ 
       210        220        230        240        250
CSQCDMRFIQ KYLLQRHEKI HTGEKPFRCD ECGMRFIQKY HMERHKRTHS 
       260        270        280        290        300
GEKPYQCEYC LQYFSRTDRV LKHKRMCHEN HDKKLNRCAI KGGLLTSEED 
       310        320        330        340        350
SGFSTSPKDN SLPKKKRQKP EKKSSGMDKE SVLDKSDTKK DRNDYLPLYS 
       360        370        380        390        400
SSTKVKDEYM VAEYAVEMPH SSVGGSHLED ASGEIHPPKL VLKKINSKRS 
       410        420        430        440        450
LKQPLEQSQT ISPLSTYEDS KVSKYAFELV DKQALLDSEG SADIDQVDNL 
       460        470        480        490        500
QEGPSKPVHS STNYDDAMQF LKKKRYLQAA SNNSREYALN VGTIASQPSV 
       510        520        530        540        550
TQAAVASVID ENTTASILDS QALNVEIKSN HDKNVIPDEV LQTLLDHYSH 
       560        570        580        590        600
KANGQHEISF SVADTEVTSS ISINSSDVPE VTQSENVGSS SQASSSDKAN 
       610        620        630        640        650
MLQEYSKFLQ QALDRTSQND AYLNSPSLNF VTDNQTLPNP PAFSSIDKQV 
       660        670        680        690        700
YAAMPINSFR SGMNSPLRTT PDKSHFGLIV GDSQHPFPFS GDETNHASAT 
       710        720        730        740        750
STADFLDQVT SQKKAEAQPV HQAYQMSSFE QPFRAPYHGS RAGIATQFST 
       760        770        780        790 
ANGQVNLRGP GTSAEFSEFP LVNVNDNRAG MTSSPDATTG QTFG

Length:794

Mass (Da):88,748

Last modified:November 1, 1996 - v1

Checksum:ⁱ7CAED0E3E79EA756

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U30381 mRNA Translation: AAC52958.1
NCBI Reference Sequences More...RefSeqⁱ	NP_113803.1, NM_031615.2
UniGeneⁱ	Rn.64671

Genome annotation databases

Ensemblⁱ	ENSRNOT00000002435; ENSRNOP00000002435; ENSRNOG00000001789 ENSRNOT00000086955; ENSRNOP00000071067; ENSRNOG00000001789
GeneIDⁱ	58820
KEGGⁱ	rno:58820
UCSC genome browser More...UCSCⁱ	RGD:62063 rat

Protein	Similar proteins		Species	Score	Length	Source
Q62806	Zinc finger protein 148		HUMAN		794	UniRef90_Q9UQR1
Zinc finger protein 148		BOVIN		794
Zinc finger protein 148		MOUSE		794
Zinc finger protein 148		PONAB		794
ZNF148 isoform 1		PANTR		794
+148

Protein	Similar proteins		Species	Score	Length	Source
Q62806	Zinc finger protein 148		HUMAN		794	UniRef50_Q9UQR1
Zinc finger protein 148		BOVIN		794
Zinc finger protein 148		PONAB		794
Zinc finger protein 148		MOUSE		794
Zinc finger protein 148		DANRE		808
+417

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U30381 mRNA Translation: AAC52958.1
RefSeqⁱ	NP_113803.1, NM_031615.2
UniGeneⁱ	Rn.64671

3D structure databases

ProteinModelPortalⁱ	Q62806
SMRⁱ	Q62806
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000002435

STRINGⁱ

10116.ENSRNOP00000002435

PTM databases

CarbonylDBⁱ	Q62806
iPTMnetⁱ	Q62806
PhosphoSitePlusⁱ	Q62806

Proteomic databases

PaxDbⁱ	Q62806
PRIDEⁱ	Q62806

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000002435; ENSRNOP00000002435; ENSRNOG00000001789 ENSRNOT00000086955; ENSRNOP00000071067; ENSRNOG00000001789
GeneIDⁱ	58820
KEGGⁱ	rno:58820
UCSCⁱ	RGD:62063 rat

Organism-specific databases

CTDⁱ	22661
RGDⁱ	62063 Zfp148

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00530000063238
HOGENOMⁱ	HOG000293204
HOVERGENⁱ	HBG054247
InParanoidⁱ	Q62806
OMAⁱ	EMISHDE
OrthoDBⁱ	EOG091G02EU
PhylomeDBⁱ	Q62806
TreeFamⁱ	TF331779

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q62806

PROⁱ

PR:Q62806

Gene expression databases

Bgeeⁱ	ENSRNOG00000001789 Expressed in 9 organ(s), highest expression level in Ammon's horn
Genevisibleⁱ	Q62806 RN

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZN148_RAT
Accessionⁱ	Q62806Primary (citable) accession number: Q62806
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
	Last sequence update:	November 1, 1996
	Last modified:	November 7, 2018
	This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q62806 (ZN148_RAT)

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Zinc finger protein 148

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Golgi apparatus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ