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UniProtKB - Q62806 (ZN148_RAT)
Protein
Zinc finger protein 148
Gene
Znf148
Organism
Rattus norvegicus (Rat)
Status
Functioni
Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 171 – 193 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 199 – 221 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 227 – 249 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 255 – 278 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: RGD
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGD
- double-stranded DNA binding Source: RGD
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific DNA binding Source: RGD
- transcription cis-regulatory region binding Source: RGD
GO - Biological processi
- gamete generation Source: RGD
- negative regulation of gene expression Source: RGD
- negative regulation of transcription, DNA-templated Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- protein-containing complex assembly Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 148Alternative name(s): Transcription factor ZBP-89 Zinc finger DNA-binding protein 89 |
Gene namesi | Name:Znf148 Synonyms:Zbp89, Zfp148 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 62063, Zfp148 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Golgi apparatus
- Golgi apparatus Source: Ensembl
Nucleus
- nucleoplasm Source: Ensembl
- nucleus Source: RGD
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047429 | 1 – 794 | Zinc finger protein 148Add BLAST | 794 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 6 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 51 | PhosphoserineBy similarity | 1 | |
Cross-linki | 88 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 115 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 132 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 194 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 250 | PhosphoserineBy similarity | 1 | |
Cross-linki | 291 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 301 | PhosphoserineBy similarity | 1 | |
Modified residuei | 306 | PhosphoserineCombined sources | 1 | |
Cross-linki | 308 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 356 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity | ||
Cross-linki | 356 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Cross-linki | 402 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 412 | PhosphoserineCombined sources | 1 | |
Cross-linki | 421 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 424 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 607 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 665 | PhosphoserineBy similarity | 1 | |
Modified residuei | 784 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Sumoylated with SUMO2. Desumoylated by SENP3, resulting in the stimulation of transcription of its target genes (By similarity).By similarity
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | Q62806 |
PaxDbi | Q62806 |
PTM databases
CarbonylDBi | Q62806 |
iPTMneti | Q62806 |
PhosphoSitePlusi | Q62806 |
Expressioni
Tissue specificityi
Expressed in heart, lung, kidney, skeletal muscle, liver, brain and spleen.1 Publication
Gene expression databases
Bgeei | ENSRNOG00000001789, Expressed in Ammon's horn and 20 other tissues |
Genevisiblei | Q62806, RN |
Interactioni
Subunit structurei
Interacts with HNRNPDL.
Interacts with the 5FMC complex; the interaction requires association with CHTOP.
Interacts with CAVIN1.
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000002435 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 298 – 346 | DisorderedSequence analysisAdd BLAST | 49 | |
Regioni | 574 – 596 | DisorderedSequence analysisAdd BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 310 – 344 | Basic and acidic residuesSequence analysisAdd BLAST | 35 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 171 – 193 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 199 – 221 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 227 – 249 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 255 – 278 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000157406 |
InParanoidi | Q62806 |
OMAi | FDQNFRS |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q62806 |
TreeFami | TF331779 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
i Sequence
Sequence statusi: Complete.
Q62806-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNIDDKLEGL FLKCGGIDEM QSSRAMVVMG GVSGQSAVSG ELQESVLQDR
60 70 80 90 100
SLPHQEILAA DEVLQESEMR QQDMISHDEL MVHEETVKND EEQTDTHERL
110 120 130 140 150
PQGLQYALNV PISVKQEITF TDVSEQLMRD KKQVREPVDL QKKKKRKQRS
160 170 180 190 200
PAKILTINED GSLGLKTPKS HVCEHCNAAF RTNYHLQRHV FIHTGEKPFQ
210 220 230 240 250
CSQCDMRFIQ KYLLQRHEKI HTGEKPFRCD ECGMRFIQKY HMERHKRTHS
260 270 280 290 300
GEKPYQCEYC LQYFSRTDRV LKHKRMCHEN HDKKLNRCAI KGGLLTSEED
310 320 330 340 350
SGFSTSPKDN SLPKKKRQKP EKKSSGMDKE SVLDKSDTKK DRNDYLPLYS
360 370 380 390 400
SSTKVKDEYM VAEYAVEMPH SSVGGSHLED ASGEIHPPKL VLKKINSKRS
410 420 430 440 450
LKQPLEQSQT ISPLSTYEDS KVSKYAFELV DKQALLDSEG SADIDQVDNL
460 470 480 490 500
QEGPSKPVHS STNYDDAMQF LKKKRYLQAA SNNSREYALN VGTIASQPSV
510 520 530 540 550
TQAAVASVID ENTTASILDS QALNVEIKSN HDKNVIPDEV LQTLLDHYSH
560 570 580 590 600
KANGQHEISF SVADTEVTSS ISINSSDVPE VTQSENVGSS SQASSSDKAN
610 620 630 640 650
MLQEYSKFLQ QALDRTSQND AYLNSPSLNF VTDNQTLPNP PAFSSIDKQV
660 670 680 690 700
YAAMPINSFR SGMNSPLRTT PDKSHFGLIV GDSQHPFPFS GDETNHASAT
710 720 730 740 750
STADFLDQVT SQKKAEAQPV HQAYQMSSFE QPFRAPYHGS RAGIATQFST
760 770 780 790
ANGQVNLRGP GTSAEFSEFP LVNVNDNRAG MTSSPDATTG QTFG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U30381 mRNA Translation: AAC52958.1 |
RefSeqi | NP_113803.1, NM_031615.2 |
Genome annotation databases
Ensembli | ENSRNOT00000002435; ENSRNOP00000002435; ENSRNOG00000001789 ENSRNOT00000086955; ENSRNOP00000071067; ENSRNOG00000001789 |
GeneIDi | 58820 |
KEGGi | rno:58820 |
UCSCi | RGD:62063, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U30381 mRNA Translation: AAC52958.1 |
RefSeqi | NP_113803.1, NM_031615.2 |
3D structure databases
SMRi | Q62806 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000002435 |
PTM databases
CarbonylDBi | Q62806 |
iPTMneti | Q62806 |
PhosphoSitePlusi | Q62806 |
Proteomic databases
jPOSTi | Q62806 |
PaxDbi | Q62806 |
Genome annotation databases
Ensembli | ENSRNOT00000002435; ENSRNOP00000002435; ENSRNOG00000001789 ENSRNOT00000086955; ENSRNOP00000071067; ENSRNOG00000001789 |
GeneIDi | 58820 |
KEGGi | rno:58820 |
UCSCi | RGD:62063, rat |
Organism-specific databases
CTDi | 22661 |
RGDi | 62063, Zfp148 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000157406 |
InParanoidi | Q62806 |
OMAi | FDQNFRS |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q62806 |
TreeFami | TF331779 |
Miscellaneous databases
PROi | PR:Q62806 |
Gene expression databases
Bgeei | ENSRNOG00000001789, Expressed in Ammon's horn and 20 other tissues |
Genevisiblei | Q62806, RN |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN148_RAT | |
Accessioni | Q62806Primary (citable) accession number: Q62806 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2001 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families