Zinc finger protein 148

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Cloning and characterization of a transcription factor that binds to the proximal promoters of the two mouse type I collagen genes."
    Hasegawa T., Takeuchi A., Miyaishi O., Isobe K., de Crombrugghe B.
    J. Biol. Chem. 272:4915-4923(1997) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: RGDInferred from sequence orthologyⁱ
  • "Cloning and characterization of a transcription factor that binds to the proximal promoters of the two mouse type I collagen genes."
    Hasegawa T., Takeuchi A., Miyaishi O., Isobe K., de Crombrugghe B.
    J. Biol. Chem. 272:4915-4923(1997) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGDInferred from sequence orthologyⁱ
  • "ZBP-89 represses vimentin gene transcription by interacting with the transcriptional activator, Sp1."
    Zhang X., Diab I.H., Zehner Z.E.
    Nucleic Acids Res. 31:2900-2914(2003) [PubMed] [Europe PMC] [Abstract]
• double-stranded DNA binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.1

    "ZBP-89, a Kruppel-like zinc finger protein, inhibits epidermal growth factor induction of the gastrin promoter."
    Merchant J.L., Iyer G.R., Taylor B.R., Kitchen J.R., Mortensen E.R., Wang Z., Flintoft R.J., Michel J., Bassel-Duby R.
    Mol. Cell. Biol. 16:6644-6653(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
• metal ion binding Source: UniProtKB-KW
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "ZBP-89 represses vimentin gene transcription by interacting with the transcriptional activator, Sp1."
    Zhang X., Diab I.H., Zehner Z.E.
    Nucleic Acids Res. 31:2900-2914(2003) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "ZBP-89 represses vimentin gene transcription by interacting with the transcriptional activator, Sp1."
    Zhang X., Diab I.H., Zehner Z.E.
    Nucleic Acids Res. 31:2900-2914(2003) [PubMed] [Europe PMC] [Abstract]
• transcription regulatory region DNA binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• transcription regulatory region sequence-specific DNA binding Source: RGDInferred from direct assayⁱ
  • Ref.1

    "ZBP-89, a Kruppel-like zinc finger protein, inhibits epidermal growth factor induction of the gastrin promoter."
    Merchant J.L., Iyer G.R., Taylor B.R., Kitchen J.R., Mortensen E.R., Wang Z., Flintoft R.J., Michel J., Bassel-Duby R.
    Mol. Cell. Biol. 16:6644-6653(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

GO - Biological processⁱ

• gamete generation Source: RGDInferred from sequence orthologyⁱ
  • "Heterozygosity with respect to Zfp148 causes complete loss of fetal germ cells during mouse embryogenesis."
    Takeuchi A., Mishina Y., Miyaishi O., Kojima E., Hasegawa T., Isobe K.
    Nat. Genet. 33:172-176(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gene expression Source: RGDInferred from sequence orthologyⁱ
  • "ZBP-89 represses vimentin gene transcription by interacting with the transcriptional activator, Sp1."
    Zhang X., Diab I.H., Zehner Z.E.
    Nucleic Acids Res. 31:2900-2914(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription, DNA-templated Source: RGDInferred from sequence orthologyⁱ
  • "ZBP-89 represses vimentin gene transcription by interacting with the transcriptional activator, Sp1."
    Zhang X., Diab I.H., Zehner Z.E.
    Nucleic Acids Res. 31:2900-2914(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: RGDInferred from direct assayⁱ
  • Ref.1

    "ZBP-89, a Kruppel-like zinc finger protein, inhibits epidermal growth factor induction of the gastrin promoter."
    Merchant J.L., Iyer G.R., Taylor B.R., Kitchen J.R., Mortensen E.R., Wang Z., Flintoft R.J., Michel J., Bassel-Duby R.
    Mol. Cell. Biol. 16:6644-6653(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
• positive regulation of transcription by RNA polymerase II Source: RGDInferred from sequence orthologyⁱ
  • "Cloning and characterization of a transcription factor that binds to the proximal promoters of the two mouse type I collagen genes."
    Hasegawa T., Takeuchi A., Miyaishi O., Isobe K., de Crombrugghe B.
    J. Biol. Chem. 272:4915-4923(1997) [PubMed] [Europe PMC] [Abstract]
• protein-containing complex assembly Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.1

    "ZBP-89, a Kruppel-like zinc finger protein, inhibits epidermal growth factor induction of the gastrin promoter."
    Merchant J.L., Iyer G.R., Taylor B.R., Kitchen J.R., Mortensen E.R., Wang Z., Flintoft R.J., Michel J., Bassel-Duby R.
    Mol. Cell. Biol. 16:6644-6653(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MNIDDKLEGL FLKCGGIDEM QSSRAMVVMG GVSGQSAVSG ELQESVLQDR 
        60         70         80         90        100
SLPHQEILAA DEVLQESEMR QQDMISHDEL MVHEETVKND EEQTDTHERL 
       110        120        130        140        150
PQGLQYALNV PISVKQEITF TDVSEQLMRD KKQVREPVDL QKKKKRKQRS 
       160        170        180        190        200
PAKILTINED GSLGLKTPKS HVCEHCNAAF RTNYHLQRHV FIHTGEKPFQ 
       210        220        230        240        250
CSQCDMRFIQ KYLLQRHEKI HTGEKPFRCD ECGMRFIQKY HMERHKRTHS 
       260        270        280        290        300
GEKPYQCEYC LQYFSRTDRV LKHKRMCHEN HDKKLNRCAI KGGLLTSEED 
       310        320        330        340        350
SGFSTSPKDN SLPKKKRQKP EKKSSGMDKE SVLDKSDTKK DRNDYLPLYS 
       360        370        380        390        400
SSTKVKDEYM VAEYAVEMPH SSVGGSHLED ASGEIHPPKL VLKKINSKRS 
       410        420        430        440        450
LKQPLEQSQT ISPLSTYEDS KVSKYAFELV DKQALLDSEG SADIDQVDNL 
       460        470        480        490        500
QEGPSKPVHS STNYDDAMQF LKKKRYLQAA SNNSREYALN VGTIASQPSV 
       510        520        530        540        550
TQAAVASVID ENTTASILDS QALNVEIKSN HDKNVIPDEV LQTLLDHYSH 
       560        570        580        590        600
KANGQHEISF SVADTEVTSS ISINSSDVPE VTQSENVGSS SQASSSDKAN 
       610        620        630        640        650
MLQEYSKFLQ QALDRTSQND AYLNSPSLNF VTDNQTLPNP PAFSSIDKQV 
       660        670        680        690        700
YAAMPINSFR SGMNSPLRTT PDKSHFGLIV GDSQHPFPFS GDETNHASAT 
       710        720        730        740        750
STADFLDQVT SQKKAEAQPV HQAYQMSSFE QPFRAPYHGS RAGIATQFST 
       760        770        780        790 
ANGQVNLRGP GTSAEFSEFP LVNVNDNRAG MTSSPDATTG QTFG       

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families