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Protein

Dorsal root ganglia homeobox protein

Gene

Drgx

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi33 – 92HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Dorsal root ganglia homeobox protein
Alternative name(s):
Dorsal root ganglion 11
Homeobox protein DRG11
Paired-related homeobox protein-like 1
Gene namesi
Name:Drgx
Synonyms:Drg11, Prrxl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628616 Drgx

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492581 – 263Dorsal root ganglia homeobox proteinAdd BLAST263

Proteomic databases

PaxDbiQ62798
PRIDEiQ62798

PTM databases

PhosphoSitePlusiQ62798

Expressioni

Tissue specificityi

Expressed in most sensory neurons but not in autonomic neurons. Also expressed in the dorsal horn of the spinal cord.

Developmental stagei

First detected at E12.5 in the nervous system and in the dorsal root ganglia of the trunk region. By E15.5, strong expression in trunk and dorsal spinal cord and at E17.5 expression increases in the dorsal horns.

Interactioni

Subunit structurei

Interacts with RGMB.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027186

Structurei

3D structure databases

ProteinModelPortaliQ62798
SMRiQ62798
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi204 – 217OARPROSITE-ProRule annotationAdd BLAST14

Sequence similaritiesi

Belongs to the paired homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
HOGENOMiHOG000231518
HOVERGENiHBG106743
InParanoidiQ62798
PhylomeDBiQ62798

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR003654 OAR_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03826 OAR, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS50803 OAR, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q62798-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFYFHCPPQL EGTAPFGNHS TGDFDDGFLR RKQRRNRTTF ALQQLEALEA
60 70 80 90 100
VFAQTHYPDV FTREELAMKI NLTEARVQVW FQNRRAKWRK TERGASDQEP
110 120 130 140 150
GAKEPMAEVT PPPVRNINSP PPGDQARGKK EALEAQQSLG RTVGPAGPFF
160 170 180 190 200
PSCLPGTLLN TATYAQALSH VASLKGGPLC SCCVPDPMGL SFLPTYGCQS
210 220 230 240 250
NRTASVAALR MKAREHSEAV LQSANLLPST SSSPGPASKQ VPPEGSQDKP
260
SPTKEQSEGE KSV
Length:263
Mass (Da):28,621
Last modified:November 1, 1996 - v1
Checksum:i195DBB44D5953D6F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V8N6G3V8N6_RAT
Dorsal root ganglia homeobox protei...
Drgx Prrxl1, rCG_42372
263Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29174 mRNA Translation: AAA87203.1
RefSeqiNP_665710.1, NM_145767.1
UniGeneiRn.10189

Genome annotation databases

GeneIDi252880
KEGGirno:252880
UCSCiRGD:628616 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29174 mRNA Translation: AAA87203.1
RefSeqiNP_665710.1, NM_145767.1
UniGeneiRn.10189

3D structure databases

ProteinModelPortaliQ62798
SMRiQ62798
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027186

PTM databases

PhosphoSitePlusiQ62798

Proteomic databases

PaxDbiQ62798
PRIDEiQ62798

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi252880
KEGGirno:252880
UCSCiRGD:628616 rat

Organism-specific databases

CTDi644168
RGDi628616 Drgx

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
HOGENOMiHOG000231518
HOVERGENiHBG106743
InParanoidiQ62798
PhylomeDBiQ62798

Miscellaneous databases

PROiPR:Q62798

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR003654 OAR_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03826 OAR, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS50803 OAR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDRGX_RAT
AccessioniPrimary (citable) accession number: Q62798
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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