UniProtKB - Q62797 (Q62797_RAT)
Protein
Protein-tyrosine-phosphatase
Gene
Ptpro
Organism
Rattus norvegicus (Rat)
Status
Functioni
Catalytic activityi
- EC:3.1.3.48ARBA annotation
GO - Molecular functioni
- cadherin binding Source: RGD
- protein homodimerization activity Source: UniProtKB
- protein tyrosine phosphatase activity Source: RGD
- Wnt-protein binding Source: UniProtKB
GO - Biological processi
- axon guidance Source: UniProtKB
- cell morphogenesis Source: UniProtKB
- glomerular visceral epithelial cell differentiation Source: UniProtKB
- glomerulus development Source: UniProtKB
- lamellipodium assembly Source: UniProtKB
- monocyte chemotaxis Source: UniProtKB
- negative regulation of canonical Wnt signaling pathway Source: UniProtKB
- negative regulation of glomerular filtration Source: UniProtKB
- nervous system development Source: RGD
- peptidyl-tyrosine dephosphorylation Source: UniProtKB
- peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity Source: RGD
- regulation of glomerular filtration Source: UniProtKB
- regulation of synapse organization Source: RGD
- slit diaphragm assembly Source: UniProtKB
Keywordsi
Molecular function | Hydrolase, Protein phosphataseARBA annotation, ReceptorImported |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PtproImported ORF Names:rCG_30002Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 62068, Ptpro |
Subcellular locationi
Plasma Membrane
- apical plasma membrane Source: UniProtKB
- integral component of postsynaptic density membrane Source: RGD
- lateral plasma membrane Source: UniProtKB
- plasma membrane Source: UniProtKB
Other locations
- dendritic spine Source: UniProtKB
- GABA-ergic synapse Source: RGD
- glutamatergic synapse Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 820 – 844 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 880 – 901 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | Sequence analysisAdd BLAST | 29 | |
ChainiPRO_5014106078 | 30 – 1216 | Protein-tyrosine-phosphataseSequence analysisAdd BLAST | 1187 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000006231, Expressed in kidney and 21 other tissues |
Interactioni
GO - Molecular functioni
- cadherin binding Source: RGD
- protein homodimerization activity Source: UniProtKB
- Wnt-protein binding Source: UniProtKB
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000044055 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 329 – 425 | Fibronectin type-IIIInterPro annotationAdd BLAST | 97 | |
Domaini | 435 – 531 | Fibronectin type-IIIInterPro annotationAdd BLAST | 97 | |
Domaini | 532 – 634 | Fibronectin type-IIIInterPro annotationAdd BLAST | 103 | |
Domaini | 725 – 817 | Fibronectin type-IIIInterPro annotationAdd BLAST | 93 | |
Domaini | 938 – 1195 | Tyrosine-protein phosphataseInterPro annotationAdd BLAST | 258 | |
Domaini | 1112 – 1186 | TYR_PHOSPHATASE_2InterPro annotationAdd BLAST | 75 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 258 – 295 | DisorderedSequence analysisAdd BLAST | 38 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 273 – 295 | PolarSequence analysisAdd BLAST | 23 |
Keywords - Domaini
SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | KOG0791, Eukaryota |
GeneTreei | ENSGT00940000154814 |
HOGENOMi | CLU_007724_0_0_1 |
OMAi | KNATTFH |
OrthoDBi | 411281at2759 |
TreeFami | TF351926 |
Family and domain databases
CDDi | cd00063, FN3, 3 hits |
Gene3Di | 2.60.40.10, 3 hits 3.90.190.10, 1 hit |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold IPR029021, Prot-tyrosine_phosphatase-like IPR000242, PTPase_domain IPR042996, PTPRO IPR016130, Tyr_Pase_AS IPR003595, Tyr_Pase_cat IPR000387, TYR_PHOSPHATASE_dom |
PANTHERi | PTHR47028, PTHR47028, 1 hit |
Pfami | View protein in Pfam PF00041, fn3, 2 hits PF00102, Y_phosphatase, 1 hit |
PRINTSi | PR00700, PRTYPHPHTASE |
SMARTi | View protein in SMART SM00060, FN3, 4 hits SM00194, PTPc, 1 hit SM00404, PTPc_motif, 1 hit |
SUPFAMi | SSF49265, SSF49265, 2 hits SSF52799, SSF52799, 1 hit |
PROSITEi | View protein in PROSITE PS50853, FN3, 4 hits PS00383, TYR_PHOSPHATASE_1, 1 hit PS50056, TYR_PHOSPHATASE_2, 1 hit PS50055, TYR_PHOSPHATASE_PTP, 1 hit |
i Sequence
Sequence statusi: Complete.
Q62797-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGHLPRERRG GRRLLPLLGL FVLLKIVSTF HVTVRDDNNI VVSLEASDVV
60 70 80 90 100
SPTSVYVVRV AGESKNYFFE FEESNGTLPP PVVFKATYHG LYYIISLVVV
110 120 130 140 150
SGNVVTKPSR SITVLTKPLP VTSVSIYDYK PSPETGVLFE IHYPEKYNVF
160 170 180 190 200
SRVNISYWEG KDFRTMLYKD FLKGKTVFNH WLPGICYSNI TFQLVSEATF
210 220 230 240 250
NKSTLVECSG VSHEPKQHRT APYPPRNISV RFVNLNKNNW EEPSGSFPED
260 270 280 290 300
SFIKPQDAIG RDRPFHFPEE TPETPASNAS SGWPDPNGTE YESTSQPYWW
310 320 330 340 350
DSASAAPENE EDFVSVLPAD YDTEATLGRT EKPTADPFSA FPVQMTLSWL
360 370 380 390 400
PPKPPTAFDG FNILIEREGN FTDYLTVDEE AHEFVAELKE PGKYRLSVTT
410 420 430 440 450
FSSSGACETR KSQSAKSLSF YISPTGEWIE ELTEKPQHVS VHVLSSTTAL
460 470 480 490 500
LSWTSSQENY NSTIVSVVSL TCQKQKESQR LEKQYCTQVN SSKPVIENLV
510 520 530 540 550
PGAQYQVVMY LRKGPLIGPP SDPVTFAIVP TGIKDLMLYP LGPTAVVLSW
560 570 580 590 600
TRPYLGVFRK YVVEMFYFNP TTMTSEWTTY YEIAATVSLT SSVRIANLLP
610 620 630 640 650
AWYYNFRVTM VTWGDPELSC CDSSTISFIT APVAPEITSV EYFNSLLYIS
660 670 680 690 700
WTYGDATTDL SHSRMLHWMV VAEGRRKIKK SVTRNVMTAI LSLPPGDIYN
710 720 730 740 750
LSVTACTERG SNTSMLRLVK LEPAPPKSLF AVNKTQTSVT LLWVEEGVAD
760 770 780 790 800
FFEVLCQKLG SGHDGKLQEP VAVSSHVVTI SSLLPATAYN CSVTSFSHDS
810 820 830 840 850
PSVPTFIAVS TMVTEVNPNV VVISVLAILS ILLIGLLLVT LVILRKKHLQ
860 870 880 890 900
MARECGAGTF VNFASLEREG KLPYSWRRSV FTFLTLLPSC LWTDYLLAFY
910 920 930 940 950
INPWSKNGLK KRKLTNPVQL DDFDSYIKDM AKDSDYKFSL QFEELKLIGL
960 970 980 990 1000
DIPHFAADLP LNRCKNRYTN ILPYDFSRVR LVSMNEEEGA DYINANYIPG
1010 1020 1030 1040 1050
YNSPQEYIAT QGPLPETRND FWKMVLQQKS RIIVMLTQCN EKRRVKCDHY
1060 1070 1080 1090 1100
WPFTEEPIAY GDITVEMVSE EEQEDWASRH FRINYADEAQ DVMHFNYTAW
1110 1120 1130 1140 1150
PDHGVPPANA AESILQFVYT VRQQATKSKG PMIIHCSAGV GRTGTFIALD
1160 1170 1180 1190 1200
RLLQHIRDHE FVDILGLVSE MRSYRMSMVQ TEEQYIFIHQ CVQLMWLKKK
1210
QQFCISDVIY ENVSKS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07062356 Genomic DNA No translation available. U28938 mRNA Translation: AAB51771.1 CH473964 Genomic DNA Translation: EDM01587.1 |
RefSeqi | NP_059032.1, NM_017336.1 |
Genome annotation databases
Ensembli | ENSRNOT00000040576; ENSRNOP00000044055; ENSRNOG00000006231 |
GeneIDi | 50677 |
KEGGi | rno:50677 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07062356 Genomic DNA No translation available. U28938 mRNA Translation: AAB51771.1 CH473964 Genomic DNA Translation: EDM01587.1 |
RefSeqi | NP_059032.1, NM_017336.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000044055 |
Genome annotation databases
Ensembli | ENSRNOT00000040576; ENSRNOP00000044055; ENSRNOG00000006231 |
GeneIDi | 50677 |
KEGGi | rno:50677 |
Organism-specific databases
CTDi | 5800 |
RGDi | 62068, Ptpro |
Phylogenomic databases
eggNOGi | KOG0791, Eukaryota |
GeneTreei | ENSGT00940000154814 |
HOGENOMi | CLU_007724_0_0_1 |
OMAi | KNATTFH |
OrthoDBi | 411281at2759 |
TreeFami | TF351926 |
Gene expression databases
Bgeei | ENSRNOG00000006231, Expressed in kidney and 21 other tissues |
Family and domain databases
CDDi | cd00063, FN3, 3 hits |
Gene3Di | 2.60.40.10, 3 hits 3.90.190.10, 1 hit |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold IPR029021, Prot-tyrosine_phosphatase-like IPR000242, PTPase_domain IPR042996, PTPRO IPR016130, Tyr_Pase_AS IPR003595, Tyr_Pase_cat IPR000387, TYR_PHOSPHATASE_dom |
PANTHERi | PTHR47028, PTHR47028, 1 hit |
Pfami | View protein in Pfam PF00041, fn3, 2 hits PF00102, Y_phosphatase, 1 hit |
PRINTSi | PR00700, PRTYPHPHTASE |
SMARTi | View protein in SMART SM00060, FN3, 4 hits SM00194, PTPc, 1 hit SM00404, PTPc_motif, 1 hit |
SUPFAMi | SSF49265, SSF49265, 2 hits SSF52799, SSF52799, 1 hit |
PROSITEi | View protein in PROSITE PS50853, FN3, 4 hits PS00383, TYR_PHOSPHATASE_1, 1 hit PS50056, TYR_PHOSPHATASE_2, 1 hit PS50055, TYR_PHOSPHATASE_PTP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q62797_RAT | |
Accessioni | Q62797Primary (citable) accession number: Q62797 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 1, 1996 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 169 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |