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Entry version 140 (18 Sep 2019)
Sequence version 2 (16 Aug 2004)
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Protein

Protein unc-13 homolog B

Gene

Unc13b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP), Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri490 – 540Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST51

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-181429 Serotonin Neurotransmitter Release Cycle
R-RNO-181430 Norepinephrine Neurotransmitter Release Cycle
R-RNO-210500 Glutamate Neurotransmitter Release Cycle
R-RNO-212676 Dopamine Neurotransmitter Release Cycle
R-RNO-264642 Acetylcholine Neurotransmitter Release Cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein unc-13 homolog B
Alternative name(s):
Munc13-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Unc13b
Synonyms:Unc13h2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
619723 Unc13b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001885771 – 1622Protein unc-13 homolog BAdd BLAST1622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei16PhosphoserineBy similarity1
Modified residuei307PhosphoserineBy similarity1
Modified residuei378PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q62769

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q62769

PRoteomics IDEntifications database

More...
PRIDEi
Q62769

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is ubiquitously expressed. Isoform 2 is expressed in brain, predominantly in cerebral cortex, hippocampus and striatum.3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

First detected at birth, after which expression level is steadily increasing until it reaches a plateau at P15.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RIMS1.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q62769

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000058802

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q62769

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 79C2 1PROSITE-ProRule annotationAdd BLAST79
Domaini600 – 706C2 2PROSITE-ProRule annotationAdd BLAST107
Domaini1025 – 1168MHD1PROSITE-ProRule annotationAdd BLAST144
Domaini1275 – 1417MHD2PROSITE-ProRule annotationAdd BLAST143
Domaini1456 – 1561C2 3PROSITE-ProRule annotationAdd BLAST106

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1210 – 1231Sequence analysisAdd BLAST22

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C2 domains are not involved in calcium-dependent phospholipid binding.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the unc-13 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri490 – 540Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1011 Eukaryota
ENOG410XS5D LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231404

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q62769

KEGG Orthology (KO)

More...
KOi
K15293

Database of Orthologous Groups

More...
OrthoDBi
117172at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00029 C1, 1 hit
cd04027 C2B_Munc13, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.150, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR010439 CAPS_dom
IPR014770 Munc13_1
IPR014772 Munc13_dom-2
IPR019558 Munc13_subgr_dom-2
IPR002219 PE/DAG-bd
IPR027080 Unc-13
IPR037302 Unc-13_C2B

The PANTHER Classification System

More...
PANTHERi
PTHR10480 PTHR10480, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00130 C1_1, 1 hit
PF00168 C2, 3 hits
PF06292 DUF1041, 1 hit
PF10540 Membr_traf_MHD, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00360 C2DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00109 C1, 1 hit
SM00239 C2, 3 hits
SM01145 DUF1041, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004 C2, 2 hits
PS51258 MHD1, 1 hit
PS51259 MHD2, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q62769-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLLCVRVKR AKFQGSPDKF NTYVTLKVQN VKSTTVAVRG DQPSWEQDFM
60 70 80 90 100
FEISRLDLGL SVEVWNKGLI WDTMVGTVWI ALKTIRQSDE EGPGEWSTLE
110 120 130 140 150
AETLMKNDEI CGTKNPTPHK ILLGTRFELP FDIPEEEARY WTYKLEQINA
160 170 180 190 200
LADDNEYSSQ EESQRKLLPT AAAQCRHWTY LGWGEHQTFE DPDSAVDDRD
210 220 230 240 250
SDYRSETSNS APPPYHTTTQ PNASAHQFPM PVPLPQQLFL QGSSRDSCND
260 270 280 290 300
SMQSYDLDYP ERRALSPTSS SRYGSSCNVS RGSSLLSELD QYHEQDDDGR
310 320 330 340 350
ERDSIHSSHS YGSLSRDGQA GLGEQEKALE VACESQKEKT GESKERDDAT
360 370 380 390 400
VCPPSDLMLH KDLTLGPQES FPEEKASSPF TQARAHWFRA VTKVRLQLQE
410 420 430 440 450
ISDDGDPSLP QWLPEGPAGG LYGIDSMPDL RRKKPLPLVS DLAMSLVQSR
460 470 480 490 500
KAGITSAMAT RTSLKDEDLK SHVYKKTLQA LIYPISCTTP HNFEVWSATT
510 520 530 540 550
PTYCYECEGL LWGLARQGMR CSECGVKCHE KCQDLLNADC LQRAAEKSSK
560 570 580 590 600
HGAEDRTQNI IMAMKDRMKI RERNKPEIFE VIRDVFTVSK VAHVQQMKTV
610 620 630 640 650
KQSVLDGTSK WSAKITITVV CAQGLQAKDK TGSSDPYVTV QVGKTKKRTK
660 670 680 690 700
TIFGNLNPVW EEKFHFECHN SSDRIKVRVW DEDDDIKSRV KQRLKRESDD
710 720 730 740 750
FLGQTIIEVR TLSGEMDVWY NLEKRTDKSA VSGAIRLQIN VEIKGEEKVA
760 770 780 790 800
PYHVQYTCLH ENLFHYLTDI QGSGGVWIPD ARGDDAWKVY FDETAQEIVD
810 820 830 840 850
EFAMRYGIES IYQAMTHFAC LSSKYMCPGV PAVMSTLLAN INAYYAHTTA
860 870 880 890 900
STNVSASDRF AASNFGKERF VKLLDQLHNS LRIDLSTYRN NFPAGSPERL
910 920 930 940 950
QDLKSTVDLL TSITFFRMKV QELQSPPRAS QVVKDCVKAC LNSTYEYIFN
960 970 980 990 1000
NCHDLYSHQY QLQEQPLEEP GPSIRNLDFW PKLITLIVSI IEEDKNSYTP
1010 1020 1030 1040 1050
VLNQFPQELN VGKVSAEVMW HLFAQDMKYA LEEHEKDRLC KSADYMNLHF
1060 1070 1080 1090 1100
KVKWLHNEYV RELPALQGQV PEYPAWFEQF VLQWLDENED VSLEFLRGGL
1110 1120 1130 1140 1150
ERDKRDGFQQ TSEHALFSCS VVDVFTQLNQ SFEIIRKLEC PDPSILAHYM
1160 1170 1180 1190 1200
RRFAKTIGKV LIQYADILSK NFPAYCTKER LPCILMNNMQ QLRVQLEKMF
1210 1220 1230 1240 1250
EAMGGKELDS EAADSLKELQ VKLNTVLDEL SMVFGNSFQV RIDECVRQMA
1260 1270 1280 1290 1300
DILGQVRGTG NASPNARASV AQDADSVLRP LMDFLDGNLT LFATVCEKTV
1310 1320 1330 1340 1350
LKRVLKELWR VVMNTMERVI VLPPLIDQTG TQLILTAAKE LSQLSKLKDH
1360 1370 1380 1390 1400
MVREETRNLT PKQCAVLDLA LDTVKQYFHA GGNGLKKTFL EKSPDLQSLR
1410 1420 1430 1440 1450
YALSLYTQTT DTLIKTFVRS QTAQVHDGKG IRFTANEDIR PEKGAGVDDP
1460 1470 1480 1490 1500
VGEVSIQVDL FTHPGTGEHK VTVKVVAAND LKWQTAGMFR PFVEVTMVGP
1510 1520 1530 1540 1550
HQSDKKRKFT TKSKSNSWTP KYNETFHFLL GNEEGPEAYE LQICVKDYCF
1560 1570 1580 1590 1600
AREDRVIGLA VMPLRDVAAK GSCACWCPLG RKIHMDETGM TILRILSQRS
1610 1620
NDEVAREFVK LKSESRSIEE GS
Length:1,622
Mass (Da):184,063
Last modified:August 16, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i885C210A13086ACD
GO
Isoform 2 (identifier: Q62769-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-400: MSLLCVRVKR...VTKVRLQLQE → MKRLLRESEE...PSEGKREALQ

Show »
Length:1,985
Mass (Da):222,076
Checksum:iAA3A008870DAC5E4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2K511A0A0G2K511_RAT
Protein unc-13 homolog B
Unc13b
1,985Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z9Y2D3Z9Y2_RAT
Protein unc-13 homolog B
Unc13b
1,985Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1LXM4F1LXM4_RAT
Protein unc-13 homolog B
Unc13b
1,601Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1LTC1F1LTC1_RAT
Protein unc-13 homolog B
Unc13b
1,268Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0113841 – 400MSLLC…LQLQE → MKRLLRESEEEIMLTLGPSS SLSPDQVRTETVCIVKGKST GPTGSLPEDNFPPPCCESAD STTSGERDRNLAQLGSFEQQ ASSQPSLACTACASGSDSRE LSPASITSCSEPSERNKARP IFPRGPGQRCRHEHQEPLGD VVEYIIRELQGISRLQSEIA ELQQHLNQVRGSVDEVSSCV DSVLSEIEGLHVGSSSLGKV RHGEKAQELHVERSREEAIL YLYGLPEHDGESTVELVDNF LAKHLCVNGMQCNRYVREAY RAGTAPAPRPTVVKLVHPEH RDLILQKSILLQSVGVRVAT REEPVWPEGCKNPPKESLSC LQQFQDHSRNHQGKPALQLE TGNRRQMSGPHQMRTQNQHR ELQASEHQGLSFLPKDGSAK QSDVSKLQDEVKGTSGAPQV ISDPCGELSLLHQLEGSSPV LIPKEEDCGKLQIFKQDSQE HKACNVTKLQSDCNNAIKAS SCLSLSGPLKAEKVNAEDRM LGGEDGLDILSPKQLEDLLA DKSRRFATLNPDSAVEEVII GPETFSNMVHIDLNEEETCT AQVLKNVFDKSSCVLGGSQE DEDVEIKFHTTKLSRAIHHF RLALQGVFQKLENNGSISPE DLESNESGSQSENSDRLLWT VSSGGAHDCSVESPASQGSE SLLSVVSGGVGISVQGDQTP QAPSNFSLASNNSPLTNSLL SFPLAPGLGNETCSRPDSPN QGKLSLEQVCAETIYLNKCI NNFKNVLREKRLRQKKLLQE LVQTASHLSVEDIPSEGKRE ALQ in isoform 2. 1 PublicationAdd BLAST400

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U24071 mRNA Translation: AAC52267.1
AF159706 mRNA Translation: AAD41910.1

Protein sequence database of the Protein Information Resource

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PIRi
I61776

NCBI Reference Sequences

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RefSeqi
NP_001036044.1, NM_001042579.1 [Q62769-1]
NP_074053.1, NM_022862.1 [Q62769-2]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
64830

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
rno:64830

UCSC genome browser

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UCSCi
RGD:619723 rat [Q62769-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24071 mRNA Translation: AAC52267.1
AF159706 mRNA Translation: AAD41910.1
PIRiI61776
RefSeqiNP_001036044.1, NM_001042579.1 [Q62769-1]
NP_074053.1, NM_022862.1 [Q62769-2]

3D structure databases

SMRiQ62769
ModBaseiSearch...

Protein-protein interaction databases

CORUMiQ62769
STRINGi10116.ENSRNOP00000058802

Proteomic databases

jPOSTiQ62769
PaxDbiQ62769
PRIDEiQ62769

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi64830
KEGGirno:64830
UCSCiRGD:619723 rat [Q62769-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10497
RGDi619723 Unc13b

Phylogenomic databases

eggNOGiKOG1011 Eukaryota
ENOG410XS5D LUCA
HOGENOMiHOG000231404
InParanoidiQ62769
KOiK15293
OrthoDBi117172at2759

Enzyme and pathway databases

ReactomeiR-RNO-181429 Serotonin Neurotransmitter Release Cycle
R-RNO-181430 Norepinephrine Neurotransmitter Release Cycle
R-RNO-210500 Glutamate Neurotransmitter Release Cycle
R-RNO-212676 Dopamine Neurotransmitter Release Cycle
R-RNO-264642 Acetylcholine Neurotransmitter Release Cycle

Miscellaneous databases

Protein Ontology

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PROi
PR:Q62769

Family and domain databases

CDDicd00029 C1, 1 hit
cd04027 C2B_Munc13, 1 hit
Gene3Di2.60.40.150, 3 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR010439 CAPS_dom
IPR014770 Munc13_1
IPR014772 Munc13_dom-2
IPR019558 Munc13_subgr_dom-2
IPR002219 PE/DAG-bd
IPR027080 Unc-13
IPR037302 Unc-13_C2B
PANTHERiPTHR10480 PTHR10480, 1 hit
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF00168 C2, 3 hits
PF06292 DUF1041, 1 hit
PF10540 Membr_traf_MHD, 1 hit
PRINTSiPR00360 C2DOMAIN
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00239 C2, 3 hits
SM01145 DUF1041, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
PS51258 MHD1, 1 hit
PS51259 MHD2, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUN13B_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q62769
Secondary accession number(s): Q9WV40
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: September 18, 2019
This is version 140 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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