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Entry version 157 (12 Aug 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Protein unc-13 homolog A

Gene

Unc13a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). Also involved in secretory granule priming in insulin secretion. Plays a role in dendrite formation by melanocytes (By similarity).By similarity3 Publications

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi580Zinc 11
Metal bindingi583Zinc 11
Metal bindingi597Zinc 21
Metal bindingi600Zinc 21
Metal bindingi608Zinc 11
Metal bindingi616Zinc 21
Metal bindingi705Calcium 1PROSITE-ProRule annotation1
Metal bindingi705Calcium 2PROSITE-ProRule annotation1
Metal bindingi711Calcium 1PROSITE-ProRule annotation1
Metal bindingi757Calcium 1PROSITE-ProRule annotation1
Metal bindingi757Calcium 2PROSITE-ProRule annotation1
Metal bindingi759Calcium 1PROSITE-ProRule annotation1
Metal bindingi759Calcium 2PROSITE-ProRule annotation1
Metal bindingi776Calcium 2PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri566 – 616Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST51

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation, Exocytosis
LigandCalcium, Metal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein unc-13 homolog ACurated
Alternative name(s):
Munc13-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Unc13aImported
Synonyms:Unc13h1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
619722, Unc13a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi22T → I: No effect on binding to RIMS1. 1 Publication1
Mutagenesisi23Y → N: No effect on binding to RIMS1. 1 Publication1
Mutagenesisi64V → M: No effect on binding to RIMS1. 1 Publication1
Mutagenesisi119H → R: No effect on binding to RIMS1. 1 Publication1
Mutagenesisi121I → N: Abolishes binding to RIMS1. 1 Publication1
Mutagenesisi567H → K: Loss of phorbol-ester binding. 1 Publication1
Mutagenesisi1190Q → R: Loss of binding to STX1B and priming activity; when associated with P-1279 and E-1655. 1 Publication1
Mutagenesisi1279L → P: Loss of binding to STX1B and priming activity; when associated with R-1190 and E-1655. 1 Publication1
Mutagenesisi1364I → F: Loss of binding to STX1B and priming activity. 1 Publication1
Mutagenesisi1603V → D: Loss of binding to STX1B and priming activity. 1 Publication1
Mutagenesisi1655D → E: Loss of binding to STX1B and priming activity; when associated with R-1190 and P-1279. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001885741 – 1735Protein unc-13 homolog AAdd BLAST1735

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei239PhosphoserineCombined sources1
Modified residuei241PhosphoserineCombined sources1
Modified residuei244PhosphoserineCombined sources1
Modified residuei255PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q62768

PRoteomics IDEntifications database

More...
PRIDEi
Q62768

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q62768

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q62768

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q62768

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q62768

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, with highest levels in the olfactory bulb, striatum, cerebral cortex, hippocampus and cerebellum. Also expressed in pancreatic islet cells.3 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

First detected at birth, after which expression level is steadily increasing until it reaches a plateau at P15.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the N-termini of STX1A and/or STX1B1 and DOC2A (PubMed:8999968, PubMed:9195900, PubMed:9736751).

Interacts with BSN (PubMed:12163476, PubMed:14734538).

Interacts with RIMS1 which recruits UNC13A to the active zone (PubMed:11343654, PubMed:16704978). Forms homodimers via its first C2 domain.

Also interacts via this domain with the zinc finger domain of RIMS2 (PubMed:16052212, PubMed:16732694).

Part of a complex consisting of ERC2, RIMS1 and UNC13A (PubMed:12163476). Also part of a complex consisting of UNC13A, RIMS2 and RAB3A.

Interacts with FBXO45 (via SRY domain); leading to the degradation of UNC13A by the proteasome (By similarity).

By similarity9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
249207, 1 interactor

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q62768

Database of interacting proteins

More...
DIPi
DIP-29191N

Protein interaction database and analysis system

More...
IntActi
Q62768, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000025162

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11735
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q62768

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q62768

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 97C2 1PROSITE-ProRule annotationAdd BLAST97
Domaini672 – 796C2 2PROSITE-ProRule annotationAdd BLAST125
Domaini1106 – 1249MHD1PROSITE-ProRule annotationAdd BLAST144
Domaini1358 – 1525MHD2PROSITE-ProRule annotationAdd BLAST168
Domaini1558 – 1685C2 3PROSITE-ProRule annotationAdd BLAST128

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili319 – 370Sequence analysisAdd BLAST52

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi320 – 452Glu-richAdd BLAST133

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C2 domains are not involved in calcium-dependent phospholipid binding.1 Publication
The C-terminal region containing both MHD domains and the third C2 domain is required for synaptic vesicle priming activity.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the unc-13 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri566 – 616Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1011, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q62768

KEGG Orthology (KO)

More...
KOi
K15293

Database of Orthologous Groups

More...
OrthoDBi
117172at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q62768

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00029, C1, 1 hit
cd04027, C2B_Munc13, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.150, 3 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR010439, CAPS_dom
IPR014770, Munc13_1
IPR014772, Munc13_dom-2
IPR019558, Munc13_subgr_dom-2
IPR002219, PE/DAG-bd
IPR027080, Unc-13
IPR037302, Unc-13_C2B
IPR027082, Unc13A

The PANTHER Classification System

More...
PANTHERi
PTHR10480, PTHR10480, 1 hit
PTHR10480:SF1, PTHR10480:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00130, C1_1, 1 hit
PF00168, C2, 3 hits
PF06292, DUF1041, 1 hit
PF10540, Membr_traf_MHD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00109, C1, 1 hit
SM00239, C2, 3 hits
SM01145, DUF1041, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004, C2, 3 hits
PS51258, MHD1, 1 hit
PS51259, MHD2, 1 hit
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q62768-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLLCVGVKK AKFDGAQEKF NTYVTLKVQN VKSTTIAVRG SQPSWEQDFM
60 70 80 90 100
FEINRLDLGL TVEVWNKGLI WDTMVGTVWI PLRTIRQSNE EGPGEWLTLD
110 120 130 140 150
SQAIMADSEI CGTKDPTFHR ILLDAHFELP LDIPEEEARY WAKKLEQLNA
160 170 180 190 200
MRDQDEYSFQ DQQDKPLPVP SSQCCNWNYF GWGEQNDDPD SAVDDRDSDY
210 220 230 240 250
RSETSNSIPP PYYTTSQPNA SVHQYSVRPP PLGSRESYSD SMHSYEEFSE
260 270 280 290 300
PRALSPTGSS RYASSGELSQ GSSQLSEDFD PDEHSLQGSE LDDERDRDSY
310 320 330 340 350
HSCHSSVSYH KDSPRWDQDE EDLEDLEDLE DEELPEEEEL EEEELEEEEE
360 370 380 390 400
LEEEELELEE EEEVPDDLAS YTQQEDTTVA EPKEFKRISF PTAAPQKEDK
410 420 430 440 450
VSAVPIEAPD VSKGIPKAAT PEEKAAAECA QEAEPPKSEE SFRSREAEEG
460 470 480 490 500
QEGQDAMSRA KANWLRAFNK VRMQLQEARG EGEMSKSLWF KGGPGGGLII
510 520 530 540 550
IDSMPDIRKR KPIPLVSDLA MSLVQSRKAG ITSALASSTL NNEELKNHVY
560 570 580 590 600
KKTLQALIYP ISCTTPHNFE VWTATTPTYC YECEGLLWGI ARQGMRCTEC
610 620 630 640 650
GVKCHEKCQD LLNADCLQRA AEKSSKHGAE DRTQNIIMVL KDRMKIRERN
660 670 680 690 700
KPEIFELIQE VFAVTKSAHT QQMKAVKQSV LDGTSKWSAK ISITVVCAQG
710 720 730 740 750
LQAKDKTGSS DPYVTVQVGK TKKRTKTIYG NLNPVWEENF HFECHNSSDR
760 770 780 790 800
IKVRVLDEDD DIKSRVKQRF KRESDDFLGQ TIIEVRTLSG EMDVWYNLDK
810 820 830 840 850
RTDKSAVSGA IRLHISVEIK GEEKVAPYHV QYTCLHENLF HFVTDVQNNG
860 870 880 890 900
VVKIPDAKGD DAWKVYYDET AQEIVDEFAM RYGVESIYQA MTHFACLSSK
910 920 930 940 950
YMCPGVPAVM STLLANINAY YAHTTASTNV SASDRFAASN FGKERFVKLL
960 970 980 990 1000
DQLHNSLRID LSMYRNNFPA SSPERLQDLK STVDLLTSIT FFRMKVQELQ
1010 1020 1030 1040 1050
SPPRASQVVK DCVKACLNST YEYIFNNCHE LYGREYQTDP AKKGEVPPEE
1060 1070 1080 1090 1100
QGPSIKNLDF WSKLITLIVS IIEEDKNSYT PCLNQFPQEL NVGKISAEVM
1110 1120 1130 1140 1150
WSLFAQDMKY AMEEHDKHRL CKSADYMNLH FKVKWLYNEY VAELPTFKDR
1160 1170 1180 1190 1200
VPEYPAWFEP FVIQWLDENE EVSRDFLHGA LERDKKDGFQ QTSEHALFSC
1210 1220 1230 1240 1250
SVVDVFSQLN QSFEIIKKLE CPDPQIVGHY MRRFAKTISN VLLQYADIVS
1260 1270 1280 1290 1300
KDFASYCSKE KEKVPCILMN NTQQLRVQLE KMFEAMGGKE LDAEASGTLK
1310 1320 1330 1340 1350
ELQVKLNNVL DELSHVFATS FQPHIEECVR QMGDILSQVK GTGNVPASAC
1360 1370 1380 1390 1400
SSVAQDADNV LQPIMDLLDS NLTLFAKICE KTVLKRVLKE LWKLVMNTME
1410 1420 1430 1440 1450
RTIVLPPLTD QTMIGTLLRK HGKGLEKGRV KLPSHSDGTQ MIFNAAKELG
1460 1470 1480 1490 1500
QLSKLKDHMV REEAKSLTPK QCAVVELALD TIKQYFHAGG VGLKKTFLEK
1510 1520 1530 1540 1550
SPDLQSLRYA LSLYTQATDL LIKTFVQTQS AQVHGGKGTR FTLSEDVCPE
1560 1570 1580 1590 1600
MGSGVEDPVG EVSVHVELFT HPGTGEQKVT VKVVAANDLK WQTSGIFRPF
1610 1620 1630 1640 1650
IEVNIVGPQL SDKKRKFATK SKNNSWAPKY NESFQFSLSA DAGPECYELQ
1660 1670 1680 1690 1700
VCVKDYCFAR EDRTVELAVL QLRELAQRGS AACWLPLGRR IHMDDTGLTV
1710 1720 1730
LRILSQRSND EVAKEFVKLK SDTRSAEEGG AAPAP
Length:1,735
Mass (Da):196,356
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBFE7D0467D258900
GO
Isoform 2 (identifier: Q62768-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1434-1456: Missing.

Show »
Length:1,712
Mass (Da):193,870
Checksum:i567EDEFA1D78F775
GO
Isoform 3 (identifier: Q62768-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1541-1559: Missing.

Show »
Length:1,716
Mass (Da):194,363
Checksum:i2F917D1CE8A33D1E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1M378F1M378_RAT
Protein unc-13 homolog A
Unc13a
1,730Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0113821434 – 1456Missing in isoform 2. CuratedAdd BLAST23
Alternative sequenceiVSP_0113831541 – 1559Missing in isoform 3. CuratedAdd BLAST19

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U24070 mRNA Translation: AAC52266.1

Protein sequence database of the Protein Information Resource

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PIRi
A57607

NCBI Reference Sequences

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RefSeqi
NP_074052.1, NM_022861.1 [Q62768-1]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
64829

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:64829

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24070 mRNA Translation: AAC52266.1
PIRiA57607
RefSeqiNP_074052.1, NM_022861.1 [Q62768-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y8FNMR-A567-616[»]
2CJSX-ray1.78A/B2-150[»]
2CJTX-ray1.44A/B/C/D1-128[»]
2KDUNMR-B458-492[»]
3SWHX-ray2.65A/B1148-1407[»]
A/B1453-1531[»]
4Y21X-ray2.90A942-1407[»]
A1453-1523[»]
5UE8X-ray3.35A/B529-1407[»]
A/B1452-1531[»]
5UF7X-ray2.90A942-1407[»]
A1453-1531[»]
6A30X-ray2.79A944-1407[»]
A1453-1523[»]
6NYCX-ray1.89A675-820[»]
6NYTX-ray1.37A675-820[»]
SMRiQ62768
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi249207, 1 interactor
CORUMiQ62768
DIPiDIP-29191N
IntActiQ62768, 3 interactors
STRINGi10116.ENSRNOP00000025162

PTM databases

CarbonylDBiQ62768
iPTMnetiQ62768
PhosphoSitePlusiQ62768
SwissPalmiQ62768

Proteomic databases

PaxDbiQ62768
PRIDEiQ62768

Genome annotation databases

GeneIDi64829
KEGGirno:64829

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23025
RGDi619722, Unc13a

Phylogenomic databases

eggNOGiKOG1011, Eukaryota
InParanoidiQ62768
KOiK15293
OrthoDBi117172at2759
PhylomeDBiQ62768

Miscellaneous databases

EvolutionaryTraceiQ62768

Protein Ontology

More...
PROi
PR:Q62768

Family and domain databases

CDDicd00029, C1, 1 hit
cd04027, C2B_Munc13, 1 hit
Gene3Di2.60.40.150, 3 hits
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR010439, CAPS_dom
IPR014770, Munc13_1
IPR014772, Munc13_dom-2
IPR019558, Munc13_subgr_dom-2
IPR002219, PE/DAG-bd
IPR027080, Unc-13
IPR037302, Unc-13_C2B
IPR027082, Unc13A
PANTHERiPTHR10480, PTHR10480, 1 hit
PTHR10480:SF1, PTHR10480:SF1, 1 hit
PfamiView protein in Pfam
PF00130, C1_1, 1 hit
PF00168, C2, 3 hits
PF06292, DUF1041, 1 hit
PF10540, Membr_traf_MHD, 1 hit
SMARTiView protein in SMART
SM00109, C1, 1 hit
SM00239, C2, 3 hits
SM01145, DUF1041, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 3 hits
PS51258, MHD1, 1 hit
PS51259, MHD2, 1 hit
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUN13A_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q62768
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: November 1, 1996
Last modified: August 12, 2020
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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