Oxysterols receptor LXR-beta

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• apolipoprotein A-I receptor binding Source: RGDInferred from sequence orthologyⁱ
  • "ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis."
    Fu Y., Mukhamedova N., Ip S., D'Souza W., Henley K.J., DiTommaso T., Kesani R., Ditiatkovski M., Jones L., Lane R.M., Jennings G., Smyth I.M., Kile B.T., Sviridov D.
    Cell Metab. 18:225-238(2013) [PubMed] [Europe PMC] [Abstract]
• ATPase binding Source: RGDInferred from sequence orthologyⁱ
  • "ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis."
    Fu Y., Mukhamedova N., Ip S., D'Souza W., Henley K.J., DiTommaso T., Kesani R., Ditiatkovski M., Jones L., Lane R.M., Jennings G., Smyth I.M., Kile B.T., Sviridov D.
    Cell Metab. 18:225-238(2013) [PubMed] [Europe PMC] [Abstract]
• DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes."
    Volle D.H., Repa J.J., Mazur A., Cummins C.L., Val P., Henry-Berger J., Caira F., Veyssiere G., Mangelsdorf D.J., Lobaccaro J.M.
    Mol. Endocrinol. 18:888-898(2004) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Identification of a novel DNA binding site for nuclear orphan receptor OR1."
    Feltkamp D., Wiebel F.F., Alberti S., Gustafsson J.A.
    J. Biol. Chem. 274:10421-10429(1999) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: RGDInferred from sequence orthologyⁱ
  • "Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes."
    Volle D.H., Repa J.J., Mazur A., Cummins C.L., Val P., Henry-Berger J., Caira F., Veyssiere G., Mangelsdorf D.J., Lobaccaro J.M.
    Mol. Endocrinol. 18:888-898(2004) [PubMed] [Europe PMC] [Abstract]
  • "Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors."
    Seol W., Choi H.S., Moore D.D.
    Mol. Endocrinol. 9:72-85(1995) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: RGDInferred from direct assayⁱ
  • Ref.1

    "OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor."
    Teboul M., Enmark E., Li Q., Wikstroem A.-C., Pelto-Huikko M., Gustafsson J.-A.
    Proc. Natl. Acad. Sci. U.S.A. 92:2096-2100(1995) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• ligand-activated transcription factor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• nuclear receptor activity Source: RGDInferred from sequence orthologyⁱ
  • "Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes."
    Volle D.H., Repa J.J., Mazur A., Cummins C.L., Val P., Henry-Berger J., Caira F., Veyssiere G., Mangelsdorf D.J., Lobaccaro J.M.
    Mol. Endocrinol. 18:888-898(2004) [PubMed] [Europe PMC] [Abstract]
• nuclear receptor transcription coactivator activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• retinoid X receptor binding Source: RGDInferred from direct assayⁱ
  • Ref.1

    "OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor."
    Teboul M., Enmark E., Li Q., Wikstroem A.-C., Pelto-Huikko M., Gustafsson J.-A.
    Proc. Natl. Acad. Sci. U.S.A. 92:2096-2100(1995) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Identification of a novel DNA binding site for nuclear orphan receptor OR1."
    Feltkamp D., Wiebel F.F., Alberti S., Gustafsson J.A.
    J. Biol. Chem. 274:10421-10429(1999) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• signaling receptor activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• steroid hormone receptor activity Source: InterPro
• transcription factor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• transcription regulatory region sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• cell differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular lipid metabolic process Source: RGDInferred from sequence orthologyⁱ
  • "Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes."
    Volle D.H., Repa J.J., Mazur A., Cummins C.L., Val P., Henry-Berger J., Caira F., Veyssiere G., Mangelsdorf D.J., Lobaccaro J.M.
    Mol. Endocrinol. 18:888-898(2004) [PubMed] [Europe PMC] [Abstract]
• cellular response to lipopolysaccharide Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cholesterol homeostasis Source: UniProtKB
• lipid homeostasis Source: RGDInferred from sequence orthologyⁱ
  • "Pancreatic exocrine insufficiency in LXRbeta-/- mice is associated with a reduction in aquaporin-1 expression."
    Gabbi C., Kim H.J., Hultenby K., Bouton D., Toresson G., Warner M., Gustafsson J.A.
    Proc. Natl. Acad. Sci. U.S.A. 105:15052-15057(2008) [PubMed] [Europe PMC] [Abstract]
• lipid metabolic process Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• multicellular organism development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cholesterol storage Source: RGDInferred from sequence orthologyⁱ
  • "Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL."
    Buono C., Li Y., Waldo S.W., Kruth H.S.
    J. Lipid Res. 48:2411-2418(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cold-induced thermogenesis Source: YuBioLab <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • "Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity."
    Korach-Andre M., Archer A., Barros R.P., Parini P., Gustafsson J.A.
    Proc. Natl. Acad. Sci. U.S.A. 108:403-408(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gene expression Source: RGDInferred from direct assayⁱ
  • Ref.2

    "Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors."
    Song C., Kokontis J.M., Hiipakka R.A., Liao S.
    Proc. Natl. Acad. Sci. U.S.A. 91:10809-10813(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• negative regulation of lipid transport Source: RGDInferred from sequence orthologyⁱ
  • "Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL."
    Buono C., Li Y., Waldo S.W., Kruth H.S.
    J. Lipid Res. 48:2411-2418(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of pinocytosis Source: RGDInferred from sequence orthologyⁱ
  • "Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL."
    Buono C., Li Y., Waldo S.W., Kruth H.S.
    J. Lipid Res. 48:2411-2418(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of proteolysis Source: RGDInferred from sequence orthologyⁱ
  • "Pancreatic exocrine insufficiency in LXRbeta-/- mice is associated with a reduction in aquaporin-1 expression."
    Gabbi C., Kim H.J., Hultenby K., Bouton D., Toresson G., Warner M., Gustafsson J.A.
    Proc. Natl. Acad. Sci. U.S.A. 105:15052-15057(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription, DNA-templated Source: RGDInferred from sequence orthologyⁱ
  • "Regulation of ALK-1 signaling by the nuclear receptor LXRbeta."
    Mo J., Fang S.J., Chen W., Blobe G.C.
    J. Biol. Chem. 277:50788-50794(2002) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: RGDInferred from sequence orthologyⁱ
  • "Non-redundant roles for LXRalpha and LXRbeta in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice."
    Bischoff E.D., Daige C.L., Petrowski M., Dedman H., Pattison J., Juliano J., Li A.C., Schulman I.G.
    J. Lipid Res. 51:900-906(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cellular protein metabolic process Source: RGDInferred from sequence orthologyⁱ
  • "Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol."
    Beyea M.M., Heslop C.L., Sawyez C.G., Edwards J.Y., Markle J.G., Hegele R.A., Huff M.W.
    J. Biol. Chem. 282:5207-5216(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cholesterol efflux Source: RGDInferred from sequence orthologyⁱ
  • "Liver X receptor (LXR)-beta regulation in LXRalpha-deficient mice: implications for therapeutic targeting."
    Quinet E.M., Savio D.A., Halpern A.R., Chen L., Schuster G.U., Gustafsson J.A., Basso M.D., Nambi P.
    Mol. Pharmacol. 70:1340-1349(2006) [PubMed] [Europe PMC] [Abstract]
  • "Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol."
    Beyea M.M., Heslop C.L., Sawyez C.G., Edwards J.Y., Markle J.G., Hegele R.A., Huff M.W.
    J. Biol. Chem. 282:5207-5216(2007) [PubMed] [Europe PMC] [Abstract]
  • "Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE."
    Bradley M.N., Hong C., Chen M., Joseph S.B., Wilpitz D.C., Wang X., Lusis A.J., Collins A., Hseuh W.A., Collins J.L., Tangirala R.K., Tontonoz P.
    J. Clin. Invest. 117:2337-2346(2007) [PubMed] [Europe PMC] [Abstract]
  • "ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis."
    Fu Y., Mukhamedova N., Ip S., D'Souza W., Henley K.J., DiTommaso T., Kesani R., Ditiatkovski M., Jones L., Lane R.M., Jennings G., Smyth I.M., Kile B.T., Sviridov D.
    Cell Metab. 18:225-238(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cholesterol transport Source: RGDInferred from sequence orthologyⁱ
  • "Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages."
    Rigamonti E., Helin L., Lestavel S., Mutka A.L., Lepore M., Fontaine C., Bouhlel M.A., Bultel S., Fruchart J.C., Ikonen E., Clavey V., Staels B., Chinetti-Gbaguidi G.
    Circ. Res. 97:682-689(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of fatty acid biosynthetic process Source: RGDInferred from sequence orthologyⁱ
  • "Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol."
    Beyea M.M., Heslop C.L., Sawyez C.G., Edwards J.Y., Markle J.G., Hegele R.A., Huff M.W.
    J. Biol. Chem. 282:5207-5216(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gene expression Source: RGDInferred from direct assayⁱ
  • Ref.2

    "Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors."
    Song C., Kokontis J.M., Hiipakka R.A., Liao S.
    Proc. Natl. Acad. Sci. U.S.A. 91:10809-10813(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• positive regulation of high-density lipoprotein particle assembly Source: RGDInferred from sequence orthologyⁱ
  • "Liver X receptor (LXR)-beta regulation in LXRalpha-deficient mice: implications for therapeutic targeting."
    Quinet E.M., Savio D.A., Halpern A.R., Chen L., Schuster G.U., Gustafsson J.A., Basso M.D., Nambi P.
    Mol. Pharmacol. 70:1340-1349(2006) [PubMed] [Europe PMC] [Abstract]
  • "Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE."
    Bradley M.N., Hong C., Chen M., Joseph S.B., Wilpitz D.C., Wang X., Lusis A.J., Collins A., Hseuh W.A., Collins J.L., Tangirala R.K., Tontonoz P.
    J. Clin. Invest. 117:2337-2346(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of lipid storage Source: RGDInferred from sequence orthologyⁱ
  • "Pancreatic exocrine insufficiency in LXRbeta-/- mice is associated with a reduction in aquaporin-1 expression."
    Gabbi C., Kim H.J., Hultenby K., Bouton D., Toresson G., Warner M., Gustafsson J.A.
    Proc. Natl. Acad. Sci. U.S.A. 105:15052-15057(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of lipoprotein lipase activity Source: RGDInferred from sequence orthologyⁱ
  • "Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol."
    Beyea M.M., Heslop C.L., Sawyez C.G., Edwards J.Y., Markle J.G., Hegele R.A., Huff M.W.
    J. Biol. Chem. 282:5207-5216(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of pancreatic juice secretion Source: RGDInferred from sequence orthologyⁱ
  • "Pancreatic exocrine insufficiency in LXRbeta-/- mice is associated with a reduction in aquaporin-1 expression."
    Gabbi C., Kim H.J., Hultenby K., Bouton D., Toresson G., Warner M., Gustafsson J.A.
    Proc. Natl. Acad. Sci. U.S.A. 105:15052-15057(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of secretion of lysosomal enzymes Source: RGDInferred from sequence orthologyⁱ
  • "Pancreatic exocrine insufficiency in LXRbeta-/- mice is associated with a reduction in aquaporin-1 expression."
    Gabbi C., Kim H.J., Hultenby K., Bouton D., Toresson G., Warner M., Gustafsson J.A.
    Proc. Natl. Acad. Sci. U.S.A. 105:15052-15057(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: RGDInferred from sequence orthologyⁱ
  • "CCAR2 negatively regulates nuclear receptor LXRalpha by competing with SIRT1 deacetylase."
    Sakurabashi A., Wada-Hiraike O., Hirano M., Fu H., Isono W., Fukuda T., Morita Y., Tanikawa M., Miyamoto Y., Oda K., Kawana K., Osuga Y., Fujii T.
    J. Steroid Biochem. Mol. Biol. 149:80-88(2015) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: NTNU_SBInferred from direct assayⁱ
  • "Identification of a novel DNA binding site for nuclear orphan receptor OR1."
    Feltkamp D., Wiebel F.F., Alberti S., Gustafsson J.A.
    J. Biol. Chem. 274:10421-10429(1999) [PubMed] [Europe PMC] [Abstract]
• positive regulation of triglyceride biosynthetic process Source: RGDInferred from sequence orthologyⁱ
  • "Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol."
    Beyea M.M., Heslop C.L., Sawyez C.G., Edwards J.Y., Markle J.G., Hegele R.A., Huff M.W.
    J. Biol. Chem. 282:5207-5216(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription, DNA-templated Source: RGDInferred from sequence orthologyⁱ
  • "Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes."
    Volle D.H., Repa J.J., Mazur A., Cummins C.L., Val P., Henry-Berger J., Caira F., Veyssiere G., Mangelsdorf D.J., Lobaccaro J.M.
    Mol. Endocrinol. 18:888-898(2004) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: RGDInferred from sequence orthologyⁱ
  • "Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors."
    Seol W., Choi H.S., Moore D.D.
    Mol. Endocrinol. 9:72-85(1995) [PubMed] [Europe PMC] [Abstract]
• response to lipid Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• retinoic acid receptor signaling pathway Source: RGDInferred from direct assayⁱ
  • Ref.2

    "Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors."
    Song C., Kokontis J.M., Hiipakka R.A., Liao S.
    Proc. Natl. Acad. Sci. U.S.A. 91:10809-10813(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• apolipoprotein A-I receptor binding Source: RGDInferred from sequence orthologyⁱ
  • "ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis."
    Fu Y., Mukhamedova N., Ip S., D'Souza W., Henley K.J., DiTommaso T., Kesani R., Ditiatkovski M., Jones L., Lane R.M., Jennings G., Smyth I.M., Kile B.T., Sviridov D.
    Cell Metab. 18:225-238(2013) [PubMed] [Europe PMC] [Abstract]
• ATPase binding Source: RGDInferred from sequence orthologyⁱ
  • "ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis."
    Fu Y., Mukhamedova N., Ip S., D'Souza W., Henley K.J., DiTommaso T., Kesani R., Ditiatkovski M., Jones L., Lane R.M., Jennings G., Smyth I.M., Kile B.T., Sviridov D.
    Cell Metab. 18:225-238(2013) [PubMed] [Europe PMC] [Abstract]
• retinoid X receptor binding Source: RGDInferred from direct assayⁱ
  • Ref.1

    "OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor."
    Teboul M., Enmark E., Li Q., Wikstroem A.-C., Pelto-Huikko M., Gustafsson J.-A.
    Proc. Natl. Acad. Sci. U.S.A. 92:2096-2100(1995) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• transcription factor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSSPTSSLDT PLPGNGSPQP STSSTSPTIK EEGQETDPPP GSEGSSSAYI 
        60         70         80         90        100
VVILEPEDEP ERKRKKGPAP KMLGHELCRV CGDKASGFHY NVLSCEGCKG 
       110        120        130        140        150
FFRRSVVHGG AGRYACRGSG TCQMDAFMRR KCQLCRLRKC KEAGMREQCV 
       160        170        180        190        200
LSEEQIRKKK IQKQQQQQPP PPTEPASGSS ARPAASPGTS EASSQGSGEG 
       210        220        230        240        250
EGIQLTAAQE LMIQQLVAAQ LQCNKRSFSD QPKVTPWPLG ADPQSRDARQ 
       260        270        280        290        300
QRFAHFTELA IISVQEIVDF AKQVPGFLQL GREDQIALLK ASTIEIMLLE 
       310        320        330        340        350
TARRYNHETE CITFLKDFTY SKDDFHRAGL QVEFINPIFE FSRAMRRLGL 
       360        370        380        390        400
DDAEYALLIA INIFSADRPN VQEPSRVEAL QQPYVEALLS YTRIKRPQDQ 
       410        420        430        440 
LRFPRMLMKL VSLRTLSSVH SEQVFALRLQ DKKLPPLLSE IWDVHE     

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families