Nr1h2

Functionⁱ

Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (By similarity). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
DNA bindingⁱ	75 – 152	Nuclear receptorPROSITE-ProRule annotationAdd BLAST	78
Zinc fingerⁱ	78 – 98	NR C4-typePROSITE-ProRule annotationAdd BLAST	21
Zinc fingerⁱ	116 – 140	NR C4-typePROSITE-ProRule annotationAdd BLAST	25

GO - Molecular functionⁱ

apolipoprotein A-I receptor binding Source: Ensembl
ATPase binding Source: Ensembl
DNA-binding transcription factor activity, RNA polymerase II-specific
Source: RGD
Inferred from direct assayⁱ
- 7892230
nuclear receptor activity Source: Ensembl
nuclear receptor transcription coactivator activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 10187832
retinoid X receptor binding
Source: RGD
Inferred from direct assayⁱ
- 7892230
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from mutant phenotypeⁱ
- 10187832
RNA polymerase II regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
signaling receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
steroid hormone receptor activity Source: InterPro
transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cellular lipid metabolic process Source: Ensembl
cellular response to lipopolysaccharide
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cholesterol homeostasis Source: UniProtKB
lipid homeostasis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
lipid metabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
multicellular organism development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of cholesterol storage Source: Ensembl
negative regulation of cold-induced thermogenesis
Source: YuBioLab
Inferred from sequence or structural similarityⁱ
- 21173252
negative regulation of gene expression
Source: RGD
Inferred from direct assayⁱ
- 7971966
negative regulation of lipid transport Source: Ensembl
negative regulation of pinocytosis Source: Ensembl
negative regulation of proteolysis Source: Ensembl
negative regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of cellular protein metabolic process Source: Ensembl
positive regulation of cholesterol efflux Source: Ensembl
positive regulation of fatty acid biosynthetic process Source: Ensembl
positive regulation of gene expression
Source: RGD
Inferred from direct assayⁱ
- 7971966
positive regulation of high-density lipoprotein particle assembly Source: Ensembl
positive regulation of lipid storage Source: Ensembl
positive regulation of lipoprotein lipase activity Source: Ensembl
positive regulation of pancreatic juice secretion Source: Ensembl
positive regulation of secretion of lysosomal enzymes Source: Ensembl
positive regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 10187832
positive regulation of triglyceride biosynthetic process Source: Ensembl
retinoic acid receptor signaling pathway
Source: RGD
Inferred from direct assayⁱ
- 7971966

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Receptor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-RNO-383280 Nuclear Receptor transcription pathway R-RNO-4090294 SUMOylation of intracellular receptors R-RNO-8866427 VLDLR internalisation and degradation

Reactomeⁱ

R-RNO-383280 Nuclear Receptor transcription pathway
R-RNO-4090294 SUMOylation of intracellular receptors
R-RNO-8866427 VLDLR internalisation and degradation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Oxysterols receptor LXR-beta Alternative name(s): Liver X receptor beta Nuclear receptor subfamily 1 group H member 2 Orphan nuclear receptor OR-1 Ubiquitously-expressed nuclear receptor Short name: UR
Gene namesⁱ	Name:Nr1h2 Synonyms:Lxrb
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 1

Organism-specific databases

Rat genome database More...RGDⁱ	61906 Nr1h2

RGDⁱ

61906 Nr1h2

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000053534	1 – 446	Oxysterols receptor LXR-betaAdd BLAST		446

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	395	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	433	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationⁱ

Sumoylated by SUMO2 at Lys-395 and Lys-433 during the hepatic acute phase response, leading to promote interaction with GPS2 and prevent N-Cor corepressor complex dissociation.By similarity

Keywords - PTMⁱ

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q62755
PRIDEⁱ	Q62755

PTM databases

PhosphoSitePlusⁱ	Q62755

PhosphoSitePlusⁱ

Q62755

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000019812 Expressed in 10 organ(s), highest expression level in adult mammalian kidney
Genevisibleⁱ	Q62755 RN

Interactionⁱ

Subunit structureⁱ

Forms a heterodimer with RXR. Interacts with CCAR2 (via N-terminus) in a ligand-independent manner. Interacts (when sumoylated) with GPS2; interaction with GPS2 onto hepatic acute phase protein promoters prevents N-Cor corepressor complex dissociation.By similarity

GO - Molecular functionⁱ

apolipoprotein A-I receptor binding Source: Ensembl
ATPase binding Source: Ensembl
retinoid X receptor binding
Source: RGD
Inferred from direct assayⁱ
- 7892230
transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000026862

STRINGⁱ

10116.ENSRNOP00000026862

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q62755
SMRⁱ	Q62755
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	208 – 446	NR LBDPROSITE-ProRule annotationAdd BLAST		239

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 76	Transactivation AF-1; required for ligand-independent transactivation functionBy similarityAdd BLAST		76
Regionⁱ	205 – 446	Transactivation AF-2; required for ligand-dependent transactivation function; mediates interaction with CCAR2By similarityAdd BLAST		242

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	162 – 168	Poly-Gln		7
Compositional biasⁱ	169 – 172	Poly-Pro		4

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family. NR1 subfamily.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	78 – 98	NR C4-typePROSITE-ProRule annotationAdd BLAST		21
Zinc fingerⁱ	116 – 140	NR C4-typePROSITE-ProRule annotationAdd BLAST		25

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG3575 Eukaryota ENOG410XRZC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00870000136372
HOGENOMⁱ	HOG000220845
HOVERGENⁱ	HBG108655
InParanoidⁱ	Q62755
KEGG Orthology (KO) More...KOⁱ	K08535
OMAⁱ	ELCQVCG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0I4P
PhylomeDBⁱ	Q62755
TreeFamⁱ	TF352167

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR023257 Liver_X_rcpt IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR02034 LIVERXRECPTR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q62755-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSSPTSSLDT PLPGNGSPQP STSSTSPTIK EEGQETDPPP GSEGSSSAYI 
        60         70         80         90        100
VVILEPEDEP ERKRKKGPAP KMLGHELCRV CGDKASGFHY NVLSCEGCKG 
       110        120        130        140        150
FFRRSVVHGG AGRYACRGSG TCQMDAFMRR KCQLCRLRKC KEAGMREQCV 
       160        170        180        190        200
LSEEQIRKKK IQKQQQQQPP PPTEPASGSS ARPAASPGTS EASSQGSGEG 
       210        220        230        240        250
EGIQLTAAQE LMIQQLVAAQ LQCNKRSFSD QPKVTPWPLG ADPQSRDARQ 
       260        270        280        290        300
QRFAHFTELA IISVQEIVDF AKQVPGFLQL GREDQIALLK ASTIEIMLLE 
       310        320        330        340        350
TARRYNHETE CITFLKDFTY SKDDFHRAGL QVEFINPIFE FSRAMRRLGL 
       360        370        380        390        400
DDAEYALLIA INIFSADRPN VQEPSRVEAL QQPYVEALLS YTRIKRPQDQ 
       410        420        430        440 
LRFPRMLMKL VSLRTLSSVH SEQVFALRLQ DKKLPPLLSE IWDVHE

Length:446

Mass (Da):49,736

Last modified:November 1, 1996 - v1

Checksum:ⁱ13DF6DC2F0F5FA4D

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	33	G → V in AAA52361 (PubMed:7971966).Curated	1
Sequence conflictⁱ	52 – 54	Missing in AAA52361 (PubMed:7971966).Curated	3
Sequence conflictⁱ	219	A → V in AAA52361 (PubMed:7971966).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U20389 mRNA Translation: AAA69522.1 U14533 mRNA Translation: AAA52361.1
PIRⁱ	I59354
NCBI Reference Sequences More...RefSeqⁱ	NP_113814.1, NM_031626.1
UniGeneⁱ	Rn.786

Genome annotation databases

Ensemblⁱ	ENSRNOT00000026862; ENSRNOP00000026862; ENSRNOG00000019812
GeneIDⁱ	58851
KEGGⁱ	rno:58851
UCSC genome browser More...UCSCⁱ	RGD:61906 rat

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q62755	Oxysterols receptor LXR-beta	)	HUMAN		460	UniRef90_P55055
Oxysterols receptor LXR-beta		MOUSE		446
Nuclear receptor subfamily 1 group H member 2		SAIBB		498
Uncharacterized protein		MACFA		480
Uncharacterized protein		CAVPO		463
+138

Protein	Similar proteins		Species	Score	Length	Source
Q62755	Oxysterols receptor LXR-beta	)	HUMAN		460	UniRef50_P55055
Oxysterols receptor LXR-beta		MOUSE		446
Oxysterols receptor LXR-beta		BOVIN		455
Nuclear receptor subfamily 1 group H member 2		SAIBB		498
Uncharacterized protein		MACFA		480
+259

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U20389 mRNA Translation: AAA69522.1 U14533 mRNA Translation: AAA52361.1
PIRⁱ	I59354
RefSeqⁱ	NP_113814.1, NM_031626.1
UniGeneⁱ	Rn.786

3D structure databases

ProteinModelPortalⁱ	Q62755
SMRⁱ	Q62755
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000026862

STRINGⁱ

10116.ENSRNOP00000026862

PTM databases

PhosphoSitePlusⁱ	Q62755

PhosphoSitePlusⁱ

Q62755

Proteomic databases

PaxDbⁱ	Q62755
PRIDEⁱ	Q62755

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000026862; ENSRNOP00000026862; ENSRNOG00000019812
GeneIDⁱ	58851
KEGGⁱ	rno:58851
UCSCⁱ	RGD:61906 rat

Organism-specific databases

CTDⁱ	7376
RGDⁱ	61906 Nr1h2

Phylogenomic databases

eggNOGⁱ	KOG3575 Eukaryota ENOG410XRZC LUCA
GeneTreeⁱ	ENSGT00870000136372
HOGENOMⁱ	HOG000220845
HOVERGENⁱ	HBG108655
InParanoidⁱ	Q62755
KOⁱ	K08535
OMAⁱ	ELCQVCG
OrthoDBⁱ	EOG091G0I4P
PhylomeDBⁱ	Q62755
TreeFamⁱ	TF352167

Enzyme and pathway databases

Reactomeⁱ	R-RNO-383280 Nuclear Receptor transcription pathway R-RNO-4090294 SUMOylation of intracellular receptors R-RNO-8866427 VLDLR internalisation and degradation

Reactomeⁱ

R-RNO-383280 Nuclear Receptor transcription pathway
R-RNO-4090294 SUMOylation of intracellular receptors
R-RNO-8866427 VLDLR internalisation and degradation

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q62755

PROⁱ

PR:Q62755

Gene expression databases

Bgeeⁱ	ENSRNOG00000019812 Expressed in 10 organ(s), highest expression level in adult mammalian kidney
Genevisibleⁱ	Q62755 RN

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR023257 Liver_X_rcpt IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR02034 LIVERXRECPTR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NR1H2_RAT
Accessionⁱ	Q62755Primary (citable) accession number: Q62755 Secondary accession number(s): Q62694
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	November 1, 1996
	Last modified:	November 7, 2018
	This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

Help

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Proteomes

Annotation systems

Supporting data

UniProtKB - Q62755 (NR1H2_RAT)

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Oxysterols receptor LXR-beta

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ