Syt7

Functionⁱ

Ca²⁺ sensor involved in Ca²⁺-dependent exocytosis of secretory and synaptic vesicles through Ca²⁺ and phospholipid binding to the C2 domain (PubMed:11395007, PubMed:10725327, PubMed:11511344). Ca²⁺ induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (PubMed:11395007). SYT7 binds Ca²⁺ with high affinity and slow kinetics compared to other synaptotagmins (By similarity). Involved in Ca²⁺-triggered lysosomal exocytosis, a major component of the plasma membrane repair (PubMed:10725327, PubMed:11511344). Ca²⁺-regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages. Ca²⁺-triggered lysosomal exocytosis also plays a role in bone remodeling by regulating secretory pathways in osteoclasts and osteoblasts. Involved in cholesterol transport from lysosome to peroxisome by promoting membrane contacts between lysosomes and peroxisomes: probably acts by promoting vesicle fusion by binding phosphatidylinositol-4,5-bisphosphate on peroxisomal membranes. Acts as a key mediator of synaptic facilitation, a process also named short-term synaptic potentiation: synaptic facilitation takes place at synapses with a low initial release probability and is caused by influx of Ca²⁺ into the axon terminal after spike generation, increasing the release probability of neurotransmitters. Probably mediates synaptic facilitation by directly increasing the probability of release. May also contribute to synaptic facilitation by regulating synaptic vesicle replenishment, a process required to ensure that synaptic vesicles are ready for the arrival of the next action potential: SYT7 is required for synaptic vesicle replenishment by acting as a sensor for Ca²⁺ and by forming a complex with calmodulin. Also acts as a regulator of Ca²⁺-dependent insulin and glucagon secretion in beta-cells. Triggers exocytosis by promoting fusion pore opening and fusion pore expansion in chromaffin cells (By similarity). Also regulates the secretion of some non-synaptic secretory granules of specialized cells (PubMed:15456748).By similarity4 Publications

Cofactorⁱ

Ca²⁺1 Publication1 PublicationNote: Binds 3 Ca²⁺ ions per C2 domain.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	166	Calcium 1By similarity	1
Metal bindingⁱ	166	Calcium 2By similarity	1
Metal bindingⁱ	172	Calcium 11 Publication	1
Metal bindingⁱ	225	Calcium 11 Publication	1
Metal bindingⁱ	225	Calcium 21 Publication	1
Metal bindingⁱ	227	Calcium 1By similarity	1
Metal bindingⁱ	227	Calcium 2By similarity	1
Metal bindingⁱ	227	Calcium 3By similarity	1
Metal bindingⁱ	230	Calcium 3By similarity	1
Metal bindingⁱ	233	Calcium 2By similarity	1
Metal bindingⁱ	233	Calcium 3By similarity	1
Metal bindingⁱ	297	Calcium 4By similarity	1
Metal bindingⁱ	297	Calcium 5By similarity	1
Metal bindingⁱ	303	Calcium 5By similarity	1
Metal bindingⁱ	357	Calcium 4By similarity	1
Metal bindingⁱ	357	Calcium 5By similarity	1
Metal bindingⁱ	359	Calcium 4By similarity	1
Metal bindingⁱ	359	Calcium 5By similarity	1
Metal bindingⁱ	359	Calcium 6By similarity	1
Metal bindingⁱ	362	Calcium 6By similarity	1
Metal bindingⁱ	365	Calcium 4By similarity	1
Metal bindingⁱ	365	Calcium 6By similarity	1

GO - Molecular functionⁱ

calcium-dependent phospholipid binding
Source: UniProtKB
Inferred from direct assayⁱ
- 11395007
calcium ion binding
Source: RGD
Inferred from mutant phenotypeⁱ
- 11395007
calmodulin binding Source: UniProtKB
clathrin binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 7791877
phosphatidylinositol-4,5-bisphosphate binding Source: UniProtKB
phosphatidylserine binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
SNARE binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
syntaxin binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 7791877

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

calcium-dependent activation of synaptic vesicle fusion Source: Ensembl
calcium ion regulated exocytosis
Source: UniProtKB
Inferred from direct assayⁱ
- 11395007
calcium ion-regulated exocytosis of neurotransmitter Source: UniProtKB
calcium ion regulated lysosome exocytosis
Source: UniProtKB
Inferred from direct assayⁱ
- 10725327
- 11511344
cellular response to calcium ion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
detection of calcium ion
Source: RGD
Inferred by curatorⁱ
- 21551071
phagocytosis Source: UniProtKB
phagosome-lysosome fusion Source: UniProtKB
plasma membrane repair
Source: UniProtKB
Inferred from direct assayⁱ
- 11511344
positive regulation of calcium ion-dependent exocytosis
Source: RGD
Inferred from direct assayⁱ
- 21551071
regulation of bone remodeling Source: UniProtKB
regulation of calcium ion-dependent exocytosis
Source: RGD
Inferred from mutant phenotypeⁱ
- 10725327
- 20016973
regulation of dopamine secretion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of glucagon secretion Source: UniProtKB
regulation of insulin secretion
Source: RGD
Inferred from mutant phenotypeⁱ
- 17709608
regulation of phagocytosis Source: UniProtKB
regulation of synaptic vesicle endocytosis Source: Ensembl
short-term synaptic potentiation Source: UniProtKB
synaptic vesicle recycling Source: UniProtKB
vesicle-mediated cholesterol transport Source: UniProtKB
vesicle-mediated transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Calmodulin-binding
Biological process	Exocytosis
Ligand	Calcium, Metal-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Synaptotagmin-7Curated Alternative name(s): Protein Syt7Imported Synaptotagmin VII1 Publication Short name: SytVII1 Publication
Gene namesⁱ	Name:Syt7Imported
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 1

Organism-specific databases

Rat genome database More...RGDⁱ	62013 Syt7

RGDⁱ

62013 Syt7

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 16	VesicularSequence analysisAdd BLAST	16
Transmembraneⁱ	17 – 37	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	38 – 403	CytoplasmicSequence analysisAdd BLAST	366

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Cytoplasmic vesicle, Lysosome, Membrane, Peroxisome, Synapse

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	172	D → N: Loss of Ca(2+)-binding in the first C2 domain; when associated with N-225. 1 Publication		1
Mutagenesisⁱ	225	D → N: Loss of Ca(2+)-binding in the first C2 domain; when associated with N-172. 1 Publication		1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000436055	1 – 403	Synaptotagmin-7Add BLAST		403

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	52	PhosphoserineCombined sources	1
Modified residueⁱ	58	PhosphothreonineCombined sources	1
Modified residueⁱ	61	PhosphoserineCombined sources	1
Modified residueⁱ	119	PhosphoserineCombined sources	1
Modified residueⁱ	122	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Palmitoylated at its vesicular N-terminus; palmitoylation is required for localization to lysosome and phagocytosis in macrophages.By similarity

Keywords - PTMⁱ

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q62747
PRIDEⁱ	Q62747

PTM databases

iPTMnetⁱ	Q62747
PhosphoSitePlusⁱ	Q62747
SwissPalmⁱ	Q62747

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000026432 Expressed in 10 organ(s), highest expression level in brain

Bgeeⁱ

ENSRNOG00000026432 Expressed in 10 organ(s), highest expression level in brain

Interactionⁱ

Subunit structureⁱ

Homodimer. Can also form heterodimers with SYT6, SYT9 and SYT10. Interacts with calmodulin (CALM1, CALM2 or CALM3). Interacts with CD63; required for localization to lysosomes.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Stx1a	O35526	2	EBI-16179541,EBI-400878	From Mus musculus.

With

Entry

#Exp.

IntAct

Notes

Stx1a

O35526

2

EBI-16179541,EBI-400878

From Mus musculus.

GO - Molecular functionⁱ

calmodulin binding Source: UniProtKB
clathrin binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 7791877
SNARE binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
syntaxin binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 7791877

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

CORUMⁱ	Q62747
Database of interacting proteins More...DIPⁱ	DIP-61710N
IntActⁱ	Q62747, 1 interactor
STRINGⁱ	10116.ENSRNOP00000031195

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	138 – 146	Combined sources	9
Turnⁱ	147 – 150	Combined sources	4
Beta strandⁱ	151 – 161	Combined sources	11
Beta strandⁱ	173 – 180	Combined sources	8
Beta strandⁱ	182 – 188	Combined sources	7
Beta strandⁱ	199 – 206	Combined sources	8
Helixⁱ	211 – 214	Combined sources	4
Beta strandⁱ	218 – 225	Combined sources	8
Beta strandⁱ	228 – 230	Combined sources	3
Beta strandⁱ	233 – 241	Combined sources	9
Helixⁱ	242 – 244	Combined sources	3
Beta strandⁱ	251 – 256	Combined sources	6
Beta strandⁱ	269 – 277	Combined sources	9
Turnⁱ	278 – 281	Combined sources	4
Beta strandⁱ	282 – 292	Combined sources	11
Turnⁱ	298 – 300	Combined sources	3
Beta strandⁱ	304 – 312	Combined sources	9
Beta strandⁱ	315 – 321	Combined sources	7
Beta strandⁱ	332 – 340	Combined sources	9
Helixⁱ	343 – 345	Combined sources	3
Beta strandⁱ	349 – 357	Combined sources	9
Beta strandⁱ	365 – 376	Combined sources	12
Helixⁱ	378 – 389	Combined sources	12
Beta strandⁱ	395 – 400	Combined sources	6

Show more details

3D structure databases

ProteinModelPortalⁱ	Q62747
SMRⁱ	Q62747
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	150 – 239	C2 1PROSITE-ProRule annotationAdd BLAST		90
Domainⁱ	280 – 371	C2 2PROSITE-ProRule annotationAdd BLAST		92

Domainⁱ

The C2 domains bind Ca²⁺ and membranes (PubMed:11823420). Binding to membranes involves Ca²⁺-dependent phospholipid binding (PubMed:11823420). Compared to other members of the family, the C2 domains of SYT7 dock and insert into cellular membranes in response to intracellular Ca²⁺ concentrations that are lower than those required for other synaptotagmins. The two C2 domains bind independently to planar membranes, without interdomain cooperativity. Moreover, SYT7 C2 domains insert more deeply into membranes compared to other synaptotagmins (By similarity).By similarity1 Publication

Sequence similaritiesⁱ

Belongs to the synaptotagmin family.Curated

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410KDM6 Eukaryota ENOG410XS7N LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118973
HOGENOMⁱ	HOG000205939
HOVERGENⁱ	HBG005010
KEGG Orthology (KO) More...KOⁱ	K19907
OMAⁱ	NDNTVQQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08NG
TreeFamⁱ	TF315600

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08386 C2A_Synaptotagmin-7, 1 hit cd08405 C2B_Synaptotagmin-7, 1 hit
Gene3Dⁱ	2.60.40.150, 2 hits
InterProⁱ	View protein in InterPro IPR000008 C2_dom IPR035892 C2_domain_sf IPR037732 C2A_Synaptotagmin-7 IPR037741 C2B_Synaptotagmin-7 IPR001565 Synaptotagmin IPR015427 Synaptotagmin7
PANTHERⁱ	PTHR10024:SF206 PTHR10024:SF206, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00168 C2, 2 hits
PRINTSⁱ	PR00360 C2DOMAIN PR00399 SYNAPTOTAGMN
SMARTⁱ	View protein in SMART SM00239 C2, 2 hits
PROSITEⁱ	View protein in PROSITE PS50004 C2, 2 hits

Sequences (8)ⁱ

Sequence statusⁱ: Complete.

This entry describes 8 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q62747-1) [UniParc]FASTA Add to basket

Also known as: Synaptotagmin VIIs1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYRDPEAASP GAPTRDVLLV SAIITVSLSV TIVLCGLCHW CQRKLGKRYK 
        60         70         80         90        100
NSLETVGTPD SGRGRGEKKA IKLPAGGKAV NTAPVPGQTP HDESDRRTEP 
       110        120        130        140        150
RSSVSDLVNS LTSEMLMLSP GSEEDEAHEG CSRENLGRIQ FSVGYNFQES 
       160        170        180        190        200
TLTVKVMKAQ ELPAKDFSGT SDPFVKIYLL PDKKHKLETK VKRKNLNPHW 
       210        220        230        240        250
NETFLFEGFP YEKVVQRILY LQVLDYDRFS RNDPIGEVSI PLNKVDLTQM 
       260        270        280        290        300
QTFWKDLKPC SDGSGSRGEL LLSLCYNPSA NSIIVNIIKA RNLKAMDIGG 
       310        320        330        340        350
TSDPYVKVWL MYKDKRVEKK KTVTKKRNLN PIFNESFAFD IPTEKLRETT 
       360        370        380        390        400
IIITVMDKDK LSRNDVIGKI YLSWKSGPGE VKHWKDMIAR PRQPVAQWHQ 

LKA

Note: Major isoform.1 Publication

Length:403

Mass (Da):45,482

Last modified:November 1, 1996 - v1

Checksum:ⁱ3153FD7FC1DEEEFB

GO

Isoform 2 (identifier: Q62747-2) [UniParc]FASTA Add to basket

Also known as: Synaptotagmin VIIL1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
72-72: K → NDLDRDFWNN...QNQNAQGDKR

« Hide

        10         20         30         40         50
MYRDPEAASP GAPTRDVLLV SAIITVSLSV TIVLCGLCHW CQRKLGKRYK 
        60         70         80         90        100
NSLETVGTPD SGRGRGEKKA INDLDRDFWN NNESTVQQKW SSYPPKEFIL 
       110        120        130        140        150
NISPYAPYGD PRLSLNGTLL SGAKVATAAA GLAVEREGRL GEKPAPVPPP 
       160        170        180        190        200
GEDALRSGGA APSEPGSSGK AGRGRWRMVQ SHLAAGKLNL SNFEDSTLST 
       210        220        230        240        250
ATTLESIPSS AGEPKCQRPR TLMRQQSLQQ PLSQNQRGRQ PSQPTTSQSL 
       260        270        280        290        300
GQLQAHAASA PGSNPRAYGR GQARQGTSAG SKYRAAGGRS RSNPGSWDHV 
       310        320        330        340        350
VGQIRNRGLD MKSFLEGRMV VLSLVLGLSE QDDFANIPDL QNPGTQQNQN 
       360        370        380        390        400
AQGDKRLPAG GKAVNTAPVP GQTPHDESDR RTEPRSSVSD LVNSLTSEML 
       410        420        430        440        450
MLSPGSEEDE AHEGCSRENL GRIQFSVGYN FQESTLTVKV MKAQELPAKD 
       460        470        480        490        500
FSGTSDPFVK IYLLPDKKHK LETKVKRKNL NPHWNETFLF EGFPYEKVVQ 
       510        520        530        540        550
RILYLQVLDY DRFSRNDPIG EVSIPLNKVD LTQMQTFWKD LKPCSDGSGS 
       560        570        580        590        600
RGELLLSLCY NPSANSIIVN IIKARNLKAM DIGGTSDPYV KVWLMYKDKR 
       610        620        630        640        650
VEKKKTVTKK RNLNPIFNES FAFDIPTEKL RETTIIITVM DKDKLSRNDV 
       660        670        680 
IGKIYLSWKS GPGEVKHWKD MIARPRQPVA QWHQLKA

Show »

Length:687

Mass (Da):75,816

Checksum:ⁱ9D085A6E7B3794A1

GO

Isoform 3 (identifier: Q62747-3) [UniParc]FASTA Add to basket

Also known as: Synaptotagmin VIId1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
72-72: K → NDLDRDFWNN...QNQNAQGDKR

« Hide

        10         20         30         40         50
MYRDPEAASP GAPTRDVLLV SAIITVSLSV TIVLCGLCHW CQRKLGKRYK 
        60         70         80         90        100
NSLETVGTPD SGRGRGEKKA INDLDRDFWN NNESTVQQKW SSYPPKEFIL 
       110        120        130        140        150
NISPYAPYGD PRLSLNFEDS TLSTATTLES IPSSAGEPKC QRPRTLMRQQ 
       160        170        180        190        200
SLQQPLSQNQ RGRQPSQPTT SQSLGQLQAH AASAPGSNPR AYGRGQARQG 
       210        220        230        240        250
TSAGSKYRAA GGRSRSNPGS WDHVVGQIRN RGLDMKSFLE GRMVVLSLVL 
       260        270        280        290        300
GLSEQDDFAN IPDLQNPGTQ QNQNAQGDKR LPAGGKAVNT APVPGQTPHD 
       310        320        330        340        350
ESDRRTEPRS SVSDLVNSLT SEMLMLSPGS EEDEAHEGCS RENLGRIQFS 
       360        370        380        390        400
VGYNFQESTL TVKVMKAQEL PAKDFSGTSD PFVKIYLLPD KKHKLETKVK 
       410        420        430        440        450
RKNLNPHWNE TFLFEGFPYE KVVQRILYLQ VLDYDRFSRN DPIGEVSIPL 
       460        470        480        490        500
NKVDLTQMQT FWKDLKPCSD GSGSRGELLL SLCYNPSANS IIVNIIKARN 
       510        520        530        540        550
LKAMDIGGTS DPYVKVWLMY KDKRVEKKKT VTKKRNLNPI FNESFAFDIP 
       560        570        580        590        600
TEKLRETTII ITVMDKDKLS RNDVIGKIYL SWKSGPGEVK HWKDMIARPR 
       610 
QPVAQWHQLK A

Show »

Length:611

Mass (Da):68,335

Checksum:ⁱ3BDC3B272C47F56F

GO

Isoform 4 (identifier: Q62747-4) [UniParc]FASTA Add to basket

Also known as: Synaptotagmin VIIe1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
72-72: K → NGTLLSGAKV...QNQNAQGDKR

« Hide

        10         20         30         40         50
MYRDPEAASP GAPTRDVLLV SAIITVSLSV TIVLCGLCHW CQRKLGKRYK 
        60         70         80         90        100
NSLETVGTPD SGRGRGEKKA INGTLLSGAK VATAAAGLAV EREGRLGEKP 
       110        120        130        140        150
APVPPPGEDA LRSGGAAPSE PGSSGKAGRG RWRMVQSHLA AGKLNLSNFE 
       160        170        180        190        200
DSTLSTATTL ESIPSSAGEP KCQRPRTLMR QQSLQQPLSQ NQRGRQPSQP 
       210        220        230        240        250
TTSQSLGQLQ AHAASAPGSN PRAYGRGQAR QGTSAGSKYR AAGGRSRSNP 
       260        270        280        290        300
GSWDHVVGQI RNRGLDMKSF LEGRMVVLSL VLGLSEQDDF ANIPDLQNPG 
       310        320        330        340        350
TQQNQNAQGD KRLPAGGKAV NTAPVPGQTP HDESDRRTEP RSSVSDLVNS 
       360        370        380        390        400
LTSEMLMLSP GSEEDEAHEG CSRENLGRIQ FSVGYNFQES TLTVKVMKAQ 
       410        420        430        440        450
ELPAKDFSGT SDPFVKIYLL PDKKHKLETK VKRKNLNPHW NETFLFEGFP 
       460        470        480        490        500
YEKVVQRILY LQVLDYDRFS RNDPIGEVSI PLNKVDLTQM QTFWKDLKPC 
       510        520        530        540        550
SDGSGSRGEL LLSLCYNPSA NSIIVNIIKA RNLKAMDIGG TSDPYVKVWL 
       560        570        580        590        600
MYKDKRVEKK KTVTKKRNLN PIFNESFAFD IPTEKLRETT IIITVMDKDK 
       610        620        630        640 
LSRNDVIGKI YLSWKSGPGE VKHWKDMIAR PRQPVAQWHQ LKA

Show »

Length:643

Mass (Da):70,617

Checksum:ⁱ5507974FFE5AFDDE

GO

Isoform 5 (identifier: Q62747-5) [UniParc]FASTA Add to basket

Also known as: Synaptotagmin VIIb1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
72-72: K → NDLDRDFWNN...LAAGKLNLSK

« Hide

        10         20         30         40         50
MYRDPEAASP GAPTRDVLLV SAIITVSLSV TIVLCGLCHW CQRKLGKRYK 
        60         70         80         90        100
NSLETVGTPD SGRGRGEKKA INDLDRDFWN NNESTVQQKW SSYPPKEFIL 
       110        120        130        140        150
NISPYAPYGD PRLSLNGTLL SGAKVATAAA GLAVEREGRL GEKPAPVPPP 
       160        170        180        190        200
GEDALRSGGA APSEPGSSGK AGRGRWRMVQ SHLAAGKLNL SKLPAGGKAV 
       210        220        230        240        250
NTAPVPGQTP HDESDRRTEP RSSVSDLVNS LTSEMLMLSP GSEEDEAHEG 
       260        270        280        290        300
CSRENLGRIQ FSVGYNFQES TLTVKVMKAQ ELPAKDFSGT SDPFVKIYLL 
       310        320        330        340        350
PDKKHKLETK VKRKNLNPHW NETFLFEGFP YEKVVQRILY LQVLDYDRFS 
       360        370        380        390        400
RNDPIGEVSI PLNKVDLTQM QTFWKDLKPC SDGSGSRGEL LLSLCYNPSA 
       410        420        430        440        450
NSIIVNIIKA RNLKAMDIGG TSDPYVKVWL MYKDKRVEKK KTVTKKRNLN 
       460        470        480        490        500
PIFNESFAFD IPTEKLRETT IIITVMDKDK LSRNDVIGKI YLSWKSGPGE 
       510        520 
VKHWKDMIAR PRQPVAQWHQ LKA

Show »

Length:523

Mass (Da):58,162

Checksum:ⁱ78E6D8BE0CBD2DC3

GO

Isoform 6 (identifier: Q62747-6) [UniParc]FASTA Add to basket

Also known as: Synaptotagmin VIIc1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
72-72: K → NFEDSTLSTA...QNQNAQGDKR

« Hide

        10         20         30         40         50
MYRDPEAASP GAPTRDVLLV SAIITVSLSV TIVLCGLCHW CQRKLGKRYK 
        60         70         80         90        100
NSLETVGTPD SGRGRGEKKA INFEDSTLST ATTLESIPSS AGEPKCQRPR 
       110        120        130        140        150
TLMRQQSLQQ PLSQNQRGRQ PSQPTTSQSL GQLQAHAASA PGSNPRAYGR 
       160        170        180        190        200
GQARQGTSAG SKYRAAGGRS RSNPGSWDHV VGQIRNRGLD MKSFLEGRMV 
       210        220        230        240        250
VLSLVLGLSE QDDFANIPDL QNPGTQQNQN AQGDKRLPAG GKAVNTAPVP 
       260        270        280        290        300
GQTPHDESDR RTEPRSSVSD LVNSLTSEML MLSPGSEEDE AHEGCSRENL 
       310        320        330        340        350
GRIQFSVGYN FQESTLTVKV MKAQELPAKD FSGTSDPFVK IYLLPDKKHK 
       360        370        380        390        400
LETKVKRKNL NPHWNETFLF EGFPYEKVVQ RILYLQVLDY DRFSRNDPIG 
       410        420        430        440        450
EVSIPLNKVD LTQMQTFWKD LKPCSDGSGS RGELLLSLCY NPSANSIIVN 
       460        470        480        490        500
IIKARNLKAM DIGGTSDPYV KVWLMYKDKR VEKKKTVTKK RNLNPIFNES 
       510        520        530        540        550
FAFDIPTEKL RETTIIITVM DKDKLSRNDV IGKIYLSWKS GPGEVKHWKD 
       560 
MIARPRQPVA QWHQLKA

Show »

Length:567

Mass (Da):63,137

Checksum:ⁱ4BAF44D0ED872FE1

GO

Isoform 7 (identifier: Q62747-7) [UniParc]FASTA Add to basket

Also known as: Synaptotagmin VIIa1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
72-72: K → NGTLLSGAKV...QNQNAQGDKR

« Hide

        10         20         30         40         50
MYRDPEAASP GAPTRDVLLV SAIITVSLSV TIVLCGLCHW CQRKLGKRYK 
        60         70         80         90        100
NSLETVGTPD SGRGRGEKKA INGTLLSGAK VATAAAGLAV EREGRLGEKP 
       110        120        130        140        150
APVPPPGEDA LRSGGAAPSE PGSSGKAGRG RWRMVQSHLA AGKLNLSKEG 
       160        170        180        190        200
RMVVLSLVLG LSEQDDFANI PDLQNPGTQQ NQNAQGDKRL PAGGKAVNTA 
       210        220        230        240        250
PVPGQTPHDE SDRRTEPRSS VSDLVNSLTS EMLMLSPGSE EDEAHEGCSR 
       260        270        280        290        300
ENLGRIQFSV GYNFQESTLT VKVMKAQELP AKDFSGTSDP FVKIYLLPDK 
       310        320        330        340        350
KHKLETKVKR KNLNPHWNET FLFEGFPYEK VVQRILYLQV LDYDRFSRND 
       360        370        380        390        400
PIGEVSIPLN KVDLTQMQTF WKDLKPCSDG SGSRGELLLS LCYNPSANSI 
       410        420        430        440        450
IVNIIKARNL KAMDIGGTSD PYVKVWLMYK DKRVEKKKTV TKKRNLNPIF 
       460        470        480        490        500
NESFAFDIPT EKLRETTIII TVMDKDKLSR NDVIGKIYLS WKSGPGEVKH 
       510        520
WKDMIARPRQ PVAQWHQLKA

Show »

Length:520

Mass (Da):57,442

Checksum:ⁱ409B9696CD46B502

GO

Isoform 8 (identifier: Q62747-8) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
72-122: KLPAGGKAVN...SEMLMLSPGS → NDLDRDFWNN...LSLNPLFLRR
123-403: Missing.

« Hide

        10         20         30         40         50
MYRDPEAASP GAPTRDVLLV SAIITVSLSV TIVLCGLCHW CQRKLGKRYK 
        60         70         80         90        100
NSLETVGTPD SGRGRGEKKA INDLDRDFWN NNESTVQQKW SSYPPKEFIL 
       110        120 
NISPYAPYGD PRLSLNPLFL RR

Show »

Length:122

Mass (Da):13,768

Checksum:ⁱ8AC5E757E3F4E417

GO

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_058238	72 – 122	KLPAG…LSPGS → NDLDRDFWNNNESTVQQKWS SYPPKEFILNISPYAPYGDP RLSLNPLFLRR in isoform 8. Add BLAST	51
Alternative sequenceⁱVSP_058239	72	K → NDLDRDFWNNNESTVQQKWS SYPPKEFILNISPYAPYGDP RLSLNGTLLSGAKVATAAAG LAVEREGRLGEKPAPVPPPG EDALRSGGAAPSEPGSSGKA GRGRWRMVQSHLAAGKLNLS NFEDSTLSTATTLESIPSSA GEPKCQRPRTLMRQQSLQQP LSQNQRGRQPSQPTTSQSLG QLQAHAASAPGSNPRAYGRG QARQGTSAGSKYRAAGGRSR SNPGSWDHVVGQIRNRGLDM KSFLEGRMVVLSLVLGLSEQ DDFANIPDLQNPGTQQNQNA QGDKR in isoform 2.	1
Alternative sequenceⁱVSP_058240	72	K → NDLDRDFWNNNESTVQQKWS SYPPKEFILNISPYAPYGDP RLSLNFEDSTLSTATTLESI PSSAGEPKCQRPRTLMRQQS LQQPLSQNQRGRQPSQPTTS QSLGQLQAHAASAPGSNPRA YGRGQARQGTSAGSKYRAAG GRSRSNPGSWDHVVGQIRNR GLDMKSFLEGRMVVLSLVLG LSEQDDFANIPDLQNPGTQQ NQNAQGDKR in isoform 3.	1
Alternative sequenceⁱVSP_058241	72	K → NGTLLSGAKVATAAAGLAVE REGRLGEKPAPVPPPGEDAL RSGGAAPSEPGSSGKAGRGR WRMVQSHLAAGKLNLSNFED STLSTATTLESIPSSAGEPK CQRPRTLMRQQSLQQPLSQN QRGRQPSQPTTSQSLGQLQA HAASAPGSNPRAYGRGQARQ GTSAGSKYRAAGGRSRSNPG SWDHVVGQIRNRGLDMKSFL EGRMVVLSLVLGLSEQDDFA NIPDLQNPGTQQNQNAQGDK R in isoform 4.	1
Alternative sequenceⁱVSP_058242	72	K → NDLDRDFWNNNESTVQQKWS SYPPKEFILNISPYAPYGDP RLSLNGTLLSGAKVATAAAG LAVEREGRLGEKPAPVPPPG EDALRSGGAAPSEPGSSGKA GRGRWRMVQSHLAAGKLNLS K in isoform 5.	1
Alternative sequenceⁱVSP_058243	72	K → NFEDSTLSTATTLESIPSSA GEPKCQRPRTLMRQQSLQQP LSQNQRGRQPSQPTTSQSLG QLQAHAASAPGSNPRAYGRG QARQGTSAGSKYRAAGGRSR SNPGSWDHVVGQIRNRGLDM KSFLEGRMVVLSLVLGLSEQ DDFANIPDLQNPGTQQNQNA QGDKR in isoform 6.	1
Alternative sequenceⁱVSP_058244	72	K → NGTLLSGAKVATAAAGLAVE REGRLGEKPAPVPPPGEDAL RSGGAAPSEPGSSGKAGRGR WRMVQSHLAAGKLNLSKEGR MVVLSLVLGLSEQDDFANIP DLQNPGTQQNQNAQGDKR in isoform 7.	1
Alternative sequenceⁱVSP_058245	123 – 403	Missing in isoform 8. Add BLAST	281

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U20106 mRNA Translation: AAA87725.1 AF336852 mRNA Translation: AAK01447.1 AF336853 mRNA Translation: AAK01448.1 AF336854 mRNA Translation: AAK01449.1 AF336855 mRNA Translation: AAK01450.1 AF336856 mRNA Translation: AAK01451.1 AF336857 mRNA Translation: AAK01452.1 AF336858 mRNA Translation: AAK01453.1 AF336859 mRNA Translation: AAK01454.1 AF336860 mRNA Translation: AAK01455.1 AC095662 Genomic DNA No translation available. AC130565 Genomic DNA No translation available. CH473953 Genomic DNA Translation: EDM12801.1 CH473953 Genomic DNA Translation: EDM12802.1 CH473953 Genomic DNA Translation: EDM12803.1 CH473953 Genomic DNA Translation: EDM12804.1 CH473953 Genomic DNA Translation: EDM12805.1 CH473953 Genomic DNA Translation: EDM12806.1 CH473953 Genomic DNA Translation: EDM12807.1
PIRⁱ	S58400
NCBI Reference Sequences More...RefSeqⁱ	NP_067691.1, NM_021659.1 [Q62747-1] XP_006231127.1, XM_006231065.3 [Q62747-2] XP_006231129.1, XM_006231067.3 [Q62747-4] XP_006231130.1, XM_006231068.3 [Q62747-3]
UniGeneⁱ	Rn.91884

Genome annotation databases

Ensemblⁱ	ENSRNOT00000007429; ENSRNOP00000007429; ENSRNOG00000026432 [Q62747-8] ENSRNOT00000035576; ENSRNOP00000031890; ENSRNOG00000026432 [Q62747-4] ENSRNOT00000036168; ENSRNOP00000031944; ENSRNOG00000026432 [Q62747-6] ENSRNOT00000036180; ENSRNOP00000032388; ENSRNOG00000026432 [Q62747-3] ENSRNOT00000036232; ENSRNOP00000031195; ENSRNOG00000026432 [Q62747-2] ENSRNOT00000036283; ENSRNOP00000031816; ENSRNOG00000026432 [Q62747-7] ENSRNOT00000047964; ENSRNOP00000049360; ENSRNOG00000026432 [Q62747-5] ENSRNOT00000048704; ENSRNOP00000040667; ENSRNOG00000026432 [Q62747-1]
GeneIDⁱ	59267
KEGGⁱ	rno:59267
UCSC genome browser More...UCSCⁱ	RGD:62013 rat

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q62747	Synaptotagmin-7	)	MOUSE		403	UniRef90_Q9R0N7
Synaptotagmin-7	)	HUMAN		403
Uncharacterized protein		CERAT		409
Synaptotagmin 7		COLAP		404
Synaptotagmin VII (Fragment)		MACMU		400
+79
Q62747-2	Synaptotagmin-7 (Fragment)		MOUSE		224	UniRef90_Q62747-2
synaptotagmin-7		NEOSC		698
Synaptotagmin 7		AILME		690
Synaptotagmin 7		BOVIN		689
Synaptotagmin 7		ICTTR		688
+53
Q62747-3	synaptotagmin-7 isoform X5		DELLE		630	UniRef90_Q62747-3
Uncharacterized protein		FELCA		612
Synaptotagmin 7		HORSE		612
Uncharacterized protein		PAPAN		611
Uncharacterized protein		MACNE		611
+47
Q62747-4	synaptotagmin-7 isoform X3		DELLE		661	UniRef90_Q62747-4
Uncharacterized protein		MACMU		648
synaptotagmin-7 isoform X2		MESAU		643
UPI000A34BCDB		HETGA		764
UPI0005F4ED5D		MACNE		654
+18
Q62747-5	synaptotagmin-7		BALAS		550	UniRef90_Q62747-5
synaptotagmin-7 isoform X8		DELLE		541
Uncharacterized protein		PROCO		522
SYT7 isoform 3		PONAB		522
Uncharacterized protein		Cebus capucinus imitator		522
+24
Q62747-6	Isoform 4 of Synaptotagmin-7		MOUSE		567	UniRef90_Q9R0N7-4
Uncharacterized protein		MACMU		577
Synaptotagmin 7		HORSE		567
Uncharacterized protein		PIG		567
synaptotagmin-7 isoform X4		MESAU		567
+26
Q62747-7	Uncharacterized protein		MACMU		507	UniRef90_Q62747-7
UPI00077DC780		PERMB		520
UPI000B4F818C		MERUN		520
Q62747-8	Synaptotagmin-7		HUMAN		122	UniRef90_Q62747-8
SYT7 isoform 5		PANTR		122
SYT7 isoform 8		PONAB		122
Uncharacterized protein		PAPAN		122
Uncharacterized protein		PANPA		119
+5

Protein	Similar proteins		Species	Score	Length	Source
Q62747	Synaptotagmin-7	)	MOUSE		403	UniRef50_Q9R0N7
Synaptotagmin-7	)	HUMAN		403
Uncharacterized protein		CERAT		409
Synaptotagmin 7		COLAP		404
Synaptotagmin VII (Fragment)		MACMU		400
+288
Q62747-2	Synaptotagmin-7 (Fragment)		MOUSE		224	UniRef50_Q62747-2
synaptotagmin-7		NEOSC		698
Synaptotagmin 7		AILME		690
Synaptotagmin 7		BOVIN		689
Synaptotagmin 7		ICTTR		688
+148
Q62747-3	Isoform 4 of Synaptotagmin-7		MOUSE		567	UniRef50_Q9R0N7-4
Uncharacterized protein		MACMU		577
synaptotagmin-7 isoform X4		MESAU		567
Isoform 6 of Synaptotagmin-7		RAT		567
Uncharacterized protein		PIG		567
+294
Q62747-4	Isoform 2 of Synaptotagmin-7		RAT		687	UniRef50_Q62747-2
Synaptotagmin-7 (Fragment)		MOUSE		224
synaptotagmin-7		NEOSC		698
Synaptotagmin 7		AILME		690
Synaptotagmin 7		BOVIN		689
+148
Q62747-5	synaptotagmin-7		BALAS		550	UniRef50_Q62747-5
synaptotagmin-7 isoform X8		DELLE		541
Uncharacterized protein		RHIRO		522
SYT7 isoform 3		PONAB		522
Uncharacterized protein		Cebus capucinus imitator		522
+126
Q62747-6	Isoform 4 of Synaptotagmin-7		MOUSE		567	UniRef50_Q9R0N7-4
Uncharacterized protein		MACMU		577
synaptotagmin-7 isoform X4		MESAU		567
Uncharacterized protein		PIG		567
Synaptotagmin 7		HORSE		567
+294
Q62747-8	Synaptotagmin-7		HUMAN		122	UniRef50_Q62747-8
SYT7 isoform 5		PANTR		122
SYT7 isoform 8		PONAB		122
Uncharacterized protein		PAPAN		122
Uncharacterized protein		PANPA		119
+16

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U20106 mRNA Translation: AAA87725.1 AF336852 mRNA Translation: AAK01447.1 AF336853 mRNA Translation: AAK01448.1 AF336854 mRNA Translation: AAK01449.1 AF336855 mRNA Translation: AAK01450.1 AF336856 mRNA Translation: AAK01451.1 AF336857 mRNA Translation: AAK01452.1 AF336858 mRNA Translation: AAK01453.1 AF336859 mRNA Translation: AAK01454.1 AF336860 mRNA Translation: AAK01455.1 AC095662 Genomic DNA No translation available. AC130565 Genomic DNA No translation available. CH473953 Genomic DNA Translation: EDM12801.1 CH473953 Genomic DNA Translation: EDM12802.1 CH473953 Genomic DNA Translation: EDM12803.1 CH473953 Genomic DNA Translation: EDM12804.1 CH473953 Genomic DNA Translation: EDM12805.1 CH473953 Genomic DNA Translation: EDM12806.1 CH473953 Genomic DNA Translation: EDM12807.1
PIRⁱ	S58400
RefSeqⁱ	NP_067691.1, NM_021659.1 [Q62747-1] XP_006231127.1, XM_006231065.3 [Q62747-2] XP_006231129.1, XM_006231067.3 [Q62747-4] XP_006231130.1, XM_006231068.3 [Q62747-3]
UniGeneⁱ	Rn.91884

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	6ANJ	X-ray	1.70	A	134-262	[»]
	6ANK	X-ray	2.25	A/B	134-403	[»]
ProteinModelPortalⁱ	Q62747
SMRⁱ	Q62747
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

CORUMⁱ	Q62747
DIPⁱ	DIP-61710N
IntActⁱ	Q62747, 1 interactor
STRINGⁱ	10116.ENSRNOP00000031195

PTM databases

iPTMnetⁱ	Q62747
PhosphoSitePlusⁱ	Q62747
SwissPalmⁱ	Q62747

Proteomic databases

PaxDbⁱ	Q62747
PRIDEⁱ	Q62747

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000007429; ENSRNOP00000007429; ENSRNOG00000026432 [Q62747-8] ENSRNOT00000035576; ENSRNOP00000031890; ENSRNOG00000026432 [Q62747-4] ENSRNOT00000036168; ENSRNOP00000031944; ENSRNOG00000026432 [Q62747-6] ENSRNOT00000036180; ENSRNOP00000032388; ENSRNOG00000026432 [Q62747-3] ENSRNOT00000036232; ENSRNOP00000031195; ENSRNOG00000026432 [Q62747-2] ENSRNOT00000036283; ENSRNOP00000031816; ENSRNOG00000026432 [Q62747-7] ENSRNOT00000047964; ENSRNOP00000049360; ENSRNOG00000026432 [Q62747-5] ENSRNOT00000048704; ENSRNOP00000040667; ENSRNOG00000026432 [Q62747-1]
GeneIDⁱ	59267
KEGGⁱ	rno:59267
UCSCⁱ	RGD:62013 rat

Organism-specific databases

CTDⁱ	9066
RGDⁱ	62013 Syt7

Phylogenomic databases

eggNOGⁱ	ENOG410KDM6 Eukaryota ENOG410XS7N LUCA
GeneTreeⁱ	ENSGT00760000118973
HOGENOMⁱ	HOG000205939
HOVERGENⁱ	HBG005010
KOⁱ	K19907
OMAⁱ	NDNTVQQ
OrthoDBⁱ	EOG091G08NG
TreeFamⁱ	TF315600

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q62747

PROⁱ

PR:Q62747

Gene expression databases

Bgeeⁱ	ENSRNOG00000026432 Expressed in 10 organ(s), highest expression level in brain

Bgeeⁱ

ENSRNOG00000026432 Expressed in 10 organ(s), highest expression level in brain

Family and domain databases

CDDⁱ	cd08386 C2A_Synaptotagmin-7, 1 hit cd08405 C2B_Synaptotagmin-7, 1 hit
Gene3Dⁱ	2.60.40.150, 2 hits
InterProⁱ	View protein in InterPro IPR000008 C2_dom IPR035892 C2_domain_sf IPR037732 C2A_Synaptotagmin-7 IPR037741 C2B_Synaptotagmin-7 IPR001565 Synaptotagmin IPR015427 Synaptotagmin7
PANTHERⁱ	PTHR10024:SF206 PTHR10024:SF206, 1 hit
Pfamⁱ	View protein in Pfam PF00168 C2, 2 hits
PRINTSⁱ	PR00360 C2DOMAIN PR00399 SYNAPTOTAGMN
SMARTⁱ	View protein in SMART SM00239 C2, 2 hits
PROSITEⁱ	View protein in PROSITE PS50004 C2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SYT7_RAT
Accessionⁱ	Q62747Primary (citable) accession number: Q62747 Secondary accession number(s): F1M262 Q99P38
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 13, 2016
	Last sequence update:	November 1, 1996
	Last modified:	November 7, 2018
	This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

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UniProtKB - Q62747 (SYT7_RAT)

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Synaptotagmin-7

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Lysosome

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Cytosol

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Peroxisome

Plasma Membrane

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Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ