UniProtKB - Q62747 (SYT7_RAT)
Synaptotagmin-7
Syt7
Functioni
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 166 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 166 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 172 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 225 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 225 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 227 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 227 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 227 | Calcium 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 230 | Calcium 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 233 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 233 | Calcium 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 297 | Calcium 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 297 | Calcium 5PROSITE-ProRule annotation | 1 | |
Metal bindingi | 303 | Calcium 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 357 | Calcium 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 357 | Calcium 5PROSITE-ProRule annotation | 1 | |
Metal bindingi | 359 | Calcium 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 359 | Calcium 5PROSITE-ProRule annotation | 1 | |
Metal bindingi | 359 | Calcium 6PROSITE-ProRule annotation | 1 | |
Metal bindingi | 362 | Calcium 6PROSITE-ProRule annotation | 1 | |
Metal bindingi | 365 | Calcium 4By similarity | 1 | |
Metal bindingi | 365 | Calcium 6PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- calcium-dependent phospholipid binding Source: UniProtKB
- calcium ion binding Source: RGD
- calmodulin binding Source: UniProtKB
- clathrin binding Source: BHF-UCL
- phosphatidylinositol-4,5-bisphosphate binding Source: UniProtKB
- phosphatidylserine binding Source: RGD
- SNARE binding Source: RGD
- syntaxin binding Source: BHF-UCL
GO - Biological processi
- calcium-dependent activation of synaptic vesicle fusion Source: RGD
- calcium-ion regulated exocytosis Source: UniProtKB
- calcium ion-regulated exocytosis of neurotransmitter Source: UniProtKB
- calcium ion regulated lysosome exocytosis Source: UniProtKB
- cellular response to calcium ion Source: GO_Central
- detection of calcium ion Source: RGD
- phagocytosis Source: UniProtKB
- phagosome-lysosome fusion Source: UniProtKB
- plasma membrane repair Source: UniProtKB
- positive regulation of calcium ion-dependent exocytosis Source: RGD
- regulation of bone remodeling Source: UniProtKB
- regulation of calcium ion-dependent exocytosis Source: RGD
- regulation of dopamine secretion Source: RGD
- regulation of glucagon secretion Source: UniProtKB
- regulation of insulin secretion Source: RGD
- regulation of phagocytosis Source: UniProtKB
- regulation of synaptic vesicle endocytosis Source: RGD
- short-term synaptic potentiation Source: UniProtKB
- synaptic vesicle recycling Source: UniProtKB
- vesicle-mediated cholesterol transport Source: UniProtKB
- vesicle-mediated transport Source: GO_Central
Keywordsi
Molecular function | Calmodulin-binding |
Biological process | Exocytosis |
Ligand | Calcium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Synaptotagmin-7CuratedAlternative name(s): Protein Syt7Imported Synaptotagmin VII1 Publication Short name: SytVII1 Publication |
Gene namesi | Name:Syt7Imported |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 62013, Syt7 |
Subcellular locationi
Peroxisome
- Peroxisome membrane By similarity; Single-pass membrane protein Sequence analysis
Plasma membrane
- Cell membrane 1 Publication; Single-pass membrane protein Sequence analysis
- presynaptic cell membrane By similarity; Single-pass membrane protein Sequence analysis
Lysosome
- Lysosome membrane 1 Publication; Single-pass membrane protein Sequence analysis
Other locations
- synaptic vesicle membrane 1 Publication; Single-pass membrane protein Sequence analysis
- phagosome membrane By similarity; Single-pass membrane protein Sequence analysis
- secretory vesicle membrane 1 Publication; Single-pass membrane protein Sequence analysis
Note: Localization to lysosomes is dependent on N-terminal palmitoylation and interaction with CD63.By similarity
Cytosol
- cytosol Source: GOC
Lysosome
- lysosomal membrane Source: UniProtKB-SubCell
- lysosome Source: UniProtKB
Peroxisome
- peroxisomal membrane Source: UniProtKB-SubCell
- peroxisome Source: UniProtKB
Plasma Membrane
- plasma membrane Source: RGD
- presynaptic membrane Source: RGD
Other locations
- axon terminus Source: RGD
- dendrite Source: RGD
- dense core granule Source: RGD
- early phagosome Source: UniProtKB
- exocytic vesicle Source: GO_Central
- GABA-ergic synapse Source: RGD
- glutamatergic synapse Source: RGD
- integral component of membrane Source: UniProtKB-KW
- neuronal cell body Source: RGD
- phagocytic vesicle membrane Source: UniProtKB-SubCell
- synaptic vesicle Source: UniProtKB
- synaptic vesicle membrane Source: UniProtKB-SubCell
- terminal bouton Source: ParkinsonsUK-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 16 | VesicularSequence analysisAdd BLAST | 16 | |
Transmembranei | 17 – 37 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 38 – 403 | CytoplasmicSequence analysisAdd BLAST | 366 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Cytoplasmic vesicle, Lysosome, Membrane, Peroxisome, SynapsePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 172 | D → N: Loss of Ca(2+)-binding in the first C2 domain; when associated with N-225. 1 Publication | 1 | |
Mutagenesisi | 225 | D → N: Loss of Ca(2+)-binding in the first C2 domain; when associated with N-172. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000436055 | 1 – 403 | Synaptotagmin-7Add BLAST | 403 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 52 | PhosphoserineCombined sources | 1 | |
Modified residuei | 58 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 61 | PhosphoserineCombined sources | 1 | |
Modified residuei | 119 | PhosphoserineCombined sources | 1 | |
Modified residuei | 122 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Lipoprotein, Palmitate, PhosphoproteinProteomic databases
PaxDbi | Q62747 |
PRIDEi | Q62747 |
PTM databases
iPTMneti | Q62747 |
PhosphoSitePlusi | Q62747 |
SwissPalmi | Q62747 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSRNOG00000026432, Expressed in frontal cortex and 22 other tissues |
Interactioni
Subunit structurei
Homodimer. Can also form heterodimers with SYT6, SYT9 and SYT10.
Interacts with calmodulin (CALM1, CALM2 or CALM3).
Interacts with CD63; required for localization to lysosomes.
Interacts with APP (By similarity).
By similarityBinary interactionsi
Q62747
With | #Exp. | IntAct |
---|---|---|
Stx1a [O35526] from Mus musculus. | 2 | EBI-16179541,EBI-400878 |
GO - Molecular functioni
- calmodulin binding Source: UniProtKB
- clathrin binding Source: BHF-UCL
- SNARE binding Source: RGD
- syntaxin binding Source: BHF-UCL
Protein-protein interaction databases
CORUMi | Q62747 |
DIPi | DIP-61710N |
IntActi | Q62747, 1 interactor |
STRINGi | 10116.ENSRNOP00000031195 |
Structurei
Secondary structure
3D structure databases
SMRi | Q62747 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 135 – 255 | C2 1PROSITE-ProRule annotationAdd BLAST | 121 | |
Domaini | 266 – 399 | C2 2PROSITE-ProRule annotationAdd BLAST | 134 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1028, Eukaryota |
GeneTreei | ENSGT00940000157180 |
HOGENOMi | CLU_023008_11_3_1 |
OMAi | WCQRRLG |
OrthoDBi | 925064at2759 |
TreeFami | TF315600 |
Family and domain databases
CDDi | cd08386, C2A_Synaptotagmin-7, 1 hit cd08405, C2B_Synaptotagmin-7, 1 hit |
Gene3Di | 2.60.40.150, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR037732, C2A_Synaptotagmin-7 IPR037741, C2B_Synaptotagmin-7 IPR001565, Synaptotagmin IPR015427, Synaptotagmin7 |
PANTHERi | PTHR10024:SF357, PTHR10024:SF357, 2 hits |
Pfami | View protein in Pfam PF00168, C2, 2 hits |
PRINTSi | PR00360, C2DOMAIN PR00399, SYNAPTOTAGMN |
SMARTi | View protein in SMART SM00239, C2, 2 hits |
PROSITEi | View protein in PROSITE PS50004, C2, 2 hits |
s (8)i Sequence
Sequence statusi: Complete.
This entry describes 8 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MYRDPEAASP GAPTRDVLLV SAIITVSLSV TIVLCGLCHW CQRKLGKRYK
60 70 80 90 100
NSLETVGTPD SGRGRGEKKA IKLPAGGKAV NTAPVPGQTP HDESDRRTEP
110 120 130 140 150
RSSVSDLVNS LTSEMLMLSP GSEEDEAHEG CSRENLGRIQ FSVGYNFQES
160 170 180 190 200
TLTVKVMKAQ ELPAKDFSGT SDPFVKIYLL PDKKHKLETK VKRKNLNPHW
210 220 230 240 250
NETFLFEGFP YEKVVQRILY LQVLDYDRFS RNDPIGEVSI PLNKVDLTQM
260 270 280 290 300
QTFWKDLKPC SDGSGSRGEL LLSLCYNPSA NSIIVNIIKA RNLKAMDIGG
310 320 330 340 350
TSDPYVKVWL MYKDKRVEKK KTVTKKRNLN PIFNESFAFD IPTEKLRETT
360 370 380 390 400
IIITVMDKDK LSRNDVIGKI YLSWKSGPGE VKHWKDMIAR PRQPVAQWHQ
LKA
The sequence of this isoform differs from the canonical sequence as follows:
72-122: KLPAGGKAVN...SEMLMLSPGS → NDLDRDFWNN...LSLNPLFLRR
123-403: Missing.
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_058238 | 72 – 122 | KLPAG…LSPGS → NDLDRDFWNNNESTVQQKWS SYPPKEFILNISPYAPYGDP RLSLNPLFLRR in isoform 8. Add BLAST | 51 | |
Alternative sequenceiVSP_058239 | 72 | K → NDLDRDFWNNNESTVQQKWS SYPPKEFILNISPYAPYGDP RLSLNGTLLSGAKVATAAAG LAVEREGRLGEKPAPVPPPG EDALRSGGAAPSEPGSSGKA GRGRWRMVQSHLAAGKLNLS NFEDSTLSTATTLESIPSSA GEPKCQRPRTLMRQQSLQQP LSQNQRGRQPSQPTTSQSLG QLQAHAASAPGSNPRAYGRG QARQGTSAGSKYRAAGGRSR SNPGSWDHVVGQIRNRGLDM KSFLEGRMVVLSLVLGLSEQ DDFANIPDLQNPGTQQNQNA QGDKR in isoform 2. | 1 | |
Alternative sequenceiVSP_058240 | 72 | K → NDLDRDFWNNNESTVQQKWS SYPPKEFILNISPYAPYGDP RLSLNFEDSTLSTATTLESI PSSAGEPKCQRPRTLMRQQS LQQPLSQNQRGRQPSQPTTS QSLGQLQAHAASAPGSNPRA YGRGQARQGTSAGSKYRAAG GRSRSNPGSWDHVVGQIRNR GLDMKSFLEGRMVVLSLVLG LSEQDDFANIPDLQNPGTQQ NQNAQGDKR in isoform 3. | 1 | |
Alternative sequenceiVSP_058241 | 72 | K → NGTLLSGAKVATAAAGLAVE REGRLGEKPAPVPPPGEDAL RSGGAAPSEPGSSGKAGRGR WRMVQSHLAAGKLNLSNFED STLSTATTLESIPSSAGEPK CQRPRTLMRQQSLQQPLSQN QRGRQPSQPTTSQSLGQLQA HAASAPGSNPRAYGRGQARQ GTSAGSKYRAAGGRSRSNPG SWDHVVGQIRNRGLDMKSFL EGRMVVLSLVLGLSEQDDFA NIPDLQNPGTQQNQNAQGDK R in isoform 4. | 1 | |
Alternative sequenceiVSP_058242 | 72 | K → NDLDRDFWNNNESTVQQKWS SYPPKEFILNISPYAPYGDP RLSLNGTLLSGAKVATAAAG LAVEREGRLGEKPAPVPPPG EDALRSGGAAPSEPGSSGKA GRGRWRMVQSHLAAGKLNLS K in isoform 5. | 1 | |
Alternative sequenceiVSP_058243 | 72 | K → NFEDSTLSTATTLESIPSSA GEPKCQRPRTLMRQQSLQQP LSQNQRGRQPSQPTTSQSLG QLQAHAASAPGSNPRAYGRG QARQGTSAGSKYRAAGGRSR SNPGSWDHVVGQIRNRGLDM KSFLEGRMVVLSLVLGLSEQ DDFANIPDLQNPGTQQNQNA QGDKR in isoform 6. | 1 | |
Alternative sequenceiVSP_058244 | 72 | K → NGTLLSGAKVATAAAGLAVE REGRLGEKPAPVPPPGEDAL RSGGAAPSEPGSSGKAGRGR WRMVQSHLAAGKLNLSKEGR MVVLSLVLGLSEQDDFANIP DLQNPGTQQNQNAQGDKR in isoform 7. | 1 | |
Alternative sequenceiVSP_058245 | 123 – 403 | Missing in isoform 8. Add BLAST | 281 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U20106 mRNA Translation: AAA87725.1 AF336852 mRNA Translation: AAK01447.1 AF336853 mRNA Translation: AAK01448.1 AF336854 mRNA Translation: AAK01449.1 AF336855 mRNA Translation: AAK01450.1 AF336856 mRNA Translation: AAK01451.1 AF336857 mRNA Translation: AAK01452.1 AF336858 mRNA Translation: AAK01453.1 AF336859 mRNA Translation: AAK01454.1 AF336860 mRNA Translation: AAK01455.1 AC095662 Genomic DNA No translation available. AC130565 Genomic DNA No translation available. CH473953 Genomic DNA Translation: EDM12801.1 CH473953 Genomic DNA Translation: EDM12802.1 CH473953 Genomic DNA Translation: EDM12803.1 CH473953 Genomic DNA Translation: EDM12804.1 CH473953 Genomic DNA Translation: EDM12805.1 CH473953 Genomic DNA Translation: EDM12806.1 CH473953 Genomic DNA Translation: EDM12807.1 |
PIRi | S58400 |
RefSeqi | NP_067691.1, NM_021659.1 [Q62747-1] XP_006231127.1, XM_006231065.3 [Q62747-2] XP_006231129.1, XM_006231067.3 [Q62747-4] XP_006231130.1, XM_006231068.3 [Q62747-3] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U20106 mRNA Translation: AAA87725.1 AF336852 mRNA Translation: AAK01447.1 AF336853 mRNA Translation: AAK01448.1 AF336854 mRNA Translation: AAK01449.1 AF336855 mRNA Translation: AAK01450.1 AF336856 mRNA Translation: AAK01451.1 AF336857 mRNA Translation: AAK01452.1 AF336858 mRNA Translation: AAK01453.1 AF336859 mRNA Translation: AAK01454.1 AF336860 mRNA Translation: AAK01455.1 AC095662 Genomic DNA No translation available. AC130565 Genomic DNA No translation available. CH473953 Genomic DNA Translation: EDM12801.1 CH473953 Genomic DNA Translation: EDM12802.1 CH473953 Genomic DNA Translation: EDM12803.1 CH473953 Genomic DNA Translation: EDM12804.1 CH473953 Genomic DNA Translation: EDM12805.1 CH473953 Genomic DNA Translation: EDM12806.1 CH473953 Genomic DNA Translation: EDM12807.1 |
PIRi | S58400 |
RefSeqi | NP_067691.1, NM_021659.1 [Q62747-1] XP_006231127.1, XM_006231065.3 [Q62747-2] XP_006231129.1, XM_006231067.3 [Q62747-4] XP_006231130.1, XM_006231068.3 [Q62747-3] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6ANJ | X-ray | 1.70 | A | 134-262 | [»] | |
6ANK | X-ray | 2.25 | A/B | 134-403 | [»] | |
SMRi | Q62747 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
CORUMi | Q62747 |
DIPi | DIP-61710N |
IntActi | Q62747, 1 interactor |
STRINGi | 10116.ENSRNOP00000031195 |
PTM databases
iPTMneti | Q62747 |
PhosphoSitePlusi | Q62747 |
SwissPalmi | Q62747 |
Proteomic databases
PaxDbi | Q62747 |
PRIDEi | Q62747 |
Genome annotation databases
Organism-specific databases
CTDi | 9066 |
RGDi | 62013, Syt7 |
Phylogenomic databases
eggNOGi | KOG1028, Eukaryota |
GeneTreei | ENSGT00940000157180 |
HOGENOMi | CLU_023008_11_3_1 |
OMAi | WCQRRLG |
OrthoDBi | 925064at2759 |
TreeFami | TF315600 |
Miscellaneous databases
PROi | PR:Q62747 |
Gene expression databases
Bgeei | ENSRNOG00000026432, Expressed in frontal cortex and 22 other tissues |
Family and domain databases
CDDi | cd08386, C2A_Synaptotagmin-7, 1 hit cd08405, C2B_Synaptotagmin-7, 1 hit |
Gene3Di | 2.60.40.150, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR037732, C2A_Synaptotagmin-7 IPR037741, C2B_Synaptotagmin-7 IPR001565, Synaptotagmin IPR015427, Synaptotagmin7 |
PANTHERi | PTHR10024:SF357, PTHR10024:SF357, 2 hits |
Pfami | View protein in Pfam PF00168, C2, 2 hits |
PRINTSi | PR00360, C2DOMAIN PR00399, SYNAPTOTAGMN |
SMARTi | View protein in SMART SM00239, C2, 2 hits |
PROSITEi | View protein in PROSITE PS50004, C2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SYT7_RAT | |
Accessioni | Q62747Primary (citable) accession number: Q62747 Secondary accession number(s): F1M262 Q99P38 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 13, 2016 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families