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Entry version 142 (18 Sep 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Synaptotagmin-7

Gene

Syt7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ca2+ sensor involved in Ca2+-dependent exocytosis of secretory and synaptic vesicles through Ca2+ and phospholipid binding to the C2 domain (PubMed:11395007, PubMed:10725327, PubMed:11511344). Ca2+ induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (PubMed:11395007). SYT7 binds Ca2+ with high affinity and slow kinetics compared to other synaptotagmins (By similarity). Involved in Ca2+-triggered lysosomal exocytosis, a major component of the plasma membrane repair (PubMed:10725327, PubMed:11511344). Ca2+-regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages. Ca2+-triggered lysosomal exocytosis also plays a role in bone remodeling by regulating secretory pathways in osteoclasts and osteoblasts. Involved in cholesterol transport from lysosome to peroxisome by promoting membrane contacts between lysosomes and peroxisomes: probably acts by promoting vesicle fusion by binding phosphatidylinositol-4,5-bisphosphate on peroxisomal membranes. Acts as a key mediator of synaptic facilitation, a process also named short-term synaptic potentiation: synaptic facilitation takes place at synapses with a low initial release probability and is caused by influx of Ca2+ into the axon terminal after spike generation, increasing the release probability of neurotransmitters. Probably mediates synaptic facilitation by directly increasing the probability of release. May also contribute to synaptic facilitation by regulating synaptic vesicle replenishment, a process required to ensure that synaptic vesicles are ready for the arrival of the next action potential: SYT7 is required for synaptic vesicle replenishment by acting as a sensor for Ca2+ and by forming a complex with calmodulin. Also acts as a regulator of Ca2+-dependent insulin and glucagon secretion in beta-cells. Triggers exocytosis by promoting fusion pore opening and fusion pore expansion in chromaffin cells (By similarity). Also regulates the secretion of some non-synaptic secretory granules of specialized cells (PubMed:15456748).By similarity4 Publications

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+1 Publication1 PublicationNote: Binds 3 Ca2+ ions per C2 domain.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi166Calcium 1By similarity1
Metal bindingi166Calcium 2By similarity1
Metal bindingi172Calcium 11 Publication1
Metal bindingi225Calcium 11 Publication1
Metal bindingi225Calcium 21 Publication1
Metal bindingi227Calcium 1By similarity1
Metal bindingi227Calcium 2By similarity1
Metal bindingi227Calcium 3By similarity1
Metal bindingi230Calcium 3By similarity1
Metal bindingi233Calcium 2By similarity1
Metal bindingi233Calcium 3By similarity1
Metal bindingi297Calcium 4By similarity1
Metal bindingi297Calcium 5By similarity1
Metal bindingi303Calcium 5By similarity1
Metal bindingi357Calcium 4By similarity1
Metal bindingi357Calcium 5By similarity1
Metal bindingi359Calcium 4By similarity1
Metal bindingi359Calcium 5By similarity1
Metal bindingi359Calcium 6By similarity1
Metal bindingi362Calcium 6By similarity1
Metal bindingi365Calcium 4By similarity1
Metal bindingi365Calcium 6By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding
Biological processExocytosis
LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Synaptotagmin-7Curated
Alternative name(s):
Protein Syt7Imported
Synaptotagmin VII1 Publication
Short name:
SytVII1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Syt7Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Rat genome database

More...
RGDi
62013 Syt7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 16VesicularSequence analysisAdd BLAST16
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 403CytoplasmicSequence analysisAdd BLAST366

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasmic vesicle, Lysosome, Membrane, Peroxisome, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi172D → N: Loss of Ca(2+)-binding in the first C2 domain; when associated with N-225. 1 Publication1
Mutagenesisi225D → N: Loss of Ca(2+)-binding in the first C2 domain; when associated with N-172. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004360551 – 403Synaptotagmin-7Add BLAST403

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei52PhosphoserineCombined sources1
Modified residuei58PhosphothreonineCombined sources1
Modified residuei61PhosphoserineCombined sources1
Modified residuei119PhosphoserineCombined sources1
Modified residuei122PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Palmitoylated at its vesicular N-terminus; palmitoylation is required for localization to lysosome and phagocytosis in macrophages.By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q62747

PRoteomics IDEntifications database

More...
PRIDEi
Q62747

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q62747

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q62747

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q62747

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the brain (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000026432 Expressed in 10 organ(s), highest expression level in brain

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Can also form heterodimers with SYT6, SYT9 and SYT10.

Interacts with calmodulin (CALM1, CALM2 or CALM3).

Interacts with CD63; required for localization to lysosomes.

Interacts with APP (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Stx1aO355262EBI-16179541,EBI-400878From Mus musculus.

GO - Molecular functioni

Protein-protein interaction databases

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q62747

Database of interacting proteins

More...
DIPi
DIP-61710N

Protein interaction database and analysis system

More...
IntActi
Q62747, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000031195

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1403
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q62747

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini150 – 239C2 1PROSITE-ProRule annotationAdd BLAST90
Domaini280 – 371C2 2PROSITE-ProRule annotationAdd BLAST92

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C2 domains bind Ca2+ and membranes (PubMed:11823420). Binding to membranes involves Ca2+-dependent phospholipid binding (PubMed:11823420). Compared to other members of the family, the C2 domains of SYT7 dock and insert into cellular membranes in response to intracellular Ca2+ concentrations that are lower than those required for other synaptotagmins. The two C2 domains bind independently to planar membranes, without interdomain cooperativity. Moreover, SYT7 C2 domains insert more deeply into membranes compared to other synaptotagmins (By similarity).By similarity1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the synaptotagmin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KDM6 Eukaryota
ENOG410XS7N LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157180

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000205939

KEGG Orthology (KO)

More...
KOi
K19907

Identification of Orthologs from Complete Genome Data

More...
OMAi
NDNTVQQ

Database of Orthologous Groups

More...
OrthoDBi
925064at2759

TreeFam database of animal gene trees

More...
TreeFami
TF315600

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08386 C2A_Synaptotagmin-7, 1 hit
cd08405 C2B_Synaptotagmin-7, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037732 C2A_Synaptotagmin-7
IPR037741 C2B_Synaptotagmin-7
IPR001565 Synaptotagmin
IPR015427 Synaptotagmin7

The PANTHER Classification System

More...
PANTHERi
PTHR10024:SF357 PTHR10024:SF357, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168 C2, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00360 C2DOMAIN
PR00399 SYNAPTOTAGMN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239 C2, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004 C2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q62747-1) [UniParc]FASTAAdd to basket
Also known as: Synaptotagmin VIIs1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYRDPEAASP GAPTRDVLLV SAIITVSLSV TIVLCGLCHW CQRKLGKRYK
60 70 80 90 100
NSLETVGTPD SGRGRGEKKA IKLPAGGKAV NTAPVPGQTP HDESDRRTEP
110 120 130 140 150
RSSVSDLVNS LTSEMLMLSP GSEEDEAHEG CSRENLGRIQ FSVGYNFQES
160 170 180 190 200
TLTVKVMKAQ ELPAKDFSGT SDPFVKIYLL PDKKHKLETK VKRKNLNPHW
210 220 230 240 250
NETFLFEGFP YEKVVQRILY LQVLDYDRFS RNDPIGEVSI PLNKVDLTQM
260 270 280 290 300
QTFWKDLKPC SDGSGSRGEL LLSLCYNPSA NSIIVNIIKA RNLKAMDIGG
310 320 330 340 350
TSDPYVKVWL MYKDKRVEKK KTVTKKRNLN PIFNESFAFD IPTEKLRETT
360 370 380 390 400
IIITVMDKDK LSRNDVIGKI YLSWKSGPGE VKHWKDMIAR PRQPVAQWHQ

LKA
Note: Major isoform.1 Publication
Length:403
Mass (Da):45,482
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3153FD7FC1DEEEFB
GO
Isoform 2 (identifier: Q62747-2) [UniParc]FASTAAdd to basket
Also known as: Synaptotagmin VIIL1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     72-72: K → NDLDRDFWNN...QNQNAQGDKR

Show »
Length:687
Mass (Da):75,816
Checksum:i9D085A6E7B3794A1
GO
Isoform 3 (identifier: Q62747-3) [UniParc]FASTAAdd to basket
Also known as: Synaptotagmin VIId1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     72-72: K → NDLDRDFWNN...QNQNAQGDKR

Show »
Length:611
Mass (Da):68,335
Checksum:i3BDC3B272C47F56F
GO
Isoform 4 (identifier: Q62747-4) [UniParc]FASTAAdd to basket
Also known as: Synaptotagmin VIIe1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     72-72: K → NGTLLSGAKV...QNQNAQGDKR

Show »
Length:643
Mass (Da):70,617
Checksum:i5507974FFE5AFDDE
GO
Isoform 5 (identifier: Q62747-5) [UniParc]FASTAAdd to basket
Also known as: Synaptotagmin VIIb1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     72-72: K → NDLDRDFWNN...LAAGKLNLSK

Show »
Length:523
Mass (Da):58,162
Checksum:i78E6D8BE0CBD2DC3
GO
Isoform 6 (identifier: Q62747-6) [UniParc]FASTAAdd to basket
Also known as: Synaptotagmin VIIc1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     72-72: K → NFEDSTLSTA...QNQNAQGDKR

Show »
Length:567
Mass (Da):63,137
Checksum:i4BAF44D0ED872FE1
GO
Isoform 7 (identifier: Q62747-7) [UniParc]FASTAAdd to basket
Also known as: Synaptotagmin VIIa1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     72-72: K → NGTLLSGAKV...QNQNAQGDKR

Show »
Length:520
Mass (Da):57,442
Checksum:i409B9696CD46B502
GO
Isoform 8 (identifier: Q62747-8) [UniParc]FASTAAdd to basket
Also known as: Synaptotagmin VIIT11 Publication, Synaptotagmin VIIT21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     72-122: KLPAGGKAVN...SEMLMLSPGS → NDLDRDFWNN...LSLNPLFLRR
     123-403: Missing.

Show »
Length:122
Mass (Da):13,768
Checksum:i8AC5E757E3F4E417
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05823872 – 122KLPAG…LSPGS → NDLDRDFWNNNESTVQQKWS SYPPKEFILNISPYAPYGDP RLSLNPLFLRR in isoform 8. Add BLAST51
Alternative sequenceiVSP_05823972K → NDLDRDFWNNNESTVQQKWS SYPPKEFILNISPYAPYGDP RLSLNGTLLSGAKVATAAAG LAVEREGRLGEKPAPVPPPG EDALRSGGAAPSEPGSSGKA GRGRWRMVQSHLAAGKLNLS NFEDSTLSTATTLESIPSSA GEPKCQRPRTLMRQQSLQQP LSQNQRGRQPSQPTTSQSLG QLQAHAASAPGSNPRAYGRG QARQGTSAGSKYRAAGGRSR SNPGSWDHVVGQIRNRGLDM KSFLEGRMVVLSLVLGLSEQ DDFANIPDLQNPGTQQNQNA QGDKR in isoform 2. 1
Alternative sequenceiVSP_05824072K → NDLDRDFWNNNESTVQQKWS SYPPKEFILNISPYAPYGDP RLSLNFEDSTLSTATTLESI PSSAGEPKCQRPRTLMRQQS LQQPLSQNQRGRQPSQPTTS QSLGQLQAHAASAPGSNPRA YGRGQARQGTSAGSKYRAAG GRSRSNPGSWDHVVGQIRNR GLDMKSFLEGRMVVLSLVLG LSEQDDFANIPDLQNPGTQQ NQNAQGDKR in isoform 3. 1
Alternative sequenceiVSP_05824172K → NGTLLSGAKVATAAAGLAVE REGRLGEKPAPVPPPGEDAL RSGGAAPSEPGSSGKAGRGR WRMVQSHLAAGKLNLSNFED STLSTATTLESIPSSAGEPK CQRPRTLMRQQSLQQPLSQN QRGRQPSQPTTSQSLGQLQA HAASAPGSNPRAYGRGQARQ GTSAGSKYRAAGGRSRSNPG SWDHVVGQIRNRGLDMKSFL EGRMVVLSLVLGLSEQDDFA NIPDLQNPGTQQNQNAQGDK R in isoform 4. 1
Alternative sequenceiVSP_05824272K → NDLDRDFWNNNESTVQQKWS SYPPKEFILNISPYAPYGDP RLSLNGTLLSGAKVATAAAG LAVEREGRLGEKPAPVPPPG EDALRSGGAAPSEPGSSGKA GRGRWRMVQSHLAAGKLNLS K in isoform 5. 1
Alternative sequenceiVSP_05824372K → NFEDSTLSTATTLESIPSSA GEPKCQRPRTLMRQQSLQQP LSQNQRGRQPSQPTTSQSLG QLQAHAASAPGSNPRAYGRG QARQGTSAGSKYRAAGGRSR SNPGSWDHVVGQIRNRGLDM KSFLEGRMVVLSLVLGLSEQ DDFANIPDLQNPGTQQNQNA QGDKR in isoform 6. 1
Alternative sequenceiVSP_05824472K → NGTLLSGAKVATAAAGLAVE REGRLGEKPAPVPPPGEDAL RSGGAAPSEPGSSGKAGRGR WRMVQSHLAAGKLNLSKEGR MVVLSLVLGLSEQDDFANIP DLQNPGTQQNQNAQGDKR in isoform 7. 1
Alternative sequenceiVSP_058245123 – 403Missing in isoform 8. Add BLAST281

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U20106 mRNA Translation: AAA87725.1
AF336852 mRNA Translation: AAK01447.1
AF336853 mRNA Translation: AAK01448.1
AF336854 mRNA Translation: AAK01449.1
AF336855 mRNA Translation: AAK01450.1
AF336856 mRNA Translation: AAK01451.1
AF336857 mRNA Translation: AAK01452.1
AF336858 mRNA Translation: AAK01453.1
AF336859 mRNA Translation: AAK01454.1
AF336860 mRNA Translation: AAK01455.1
AC095662 Genomic DNA No translation available.
AC130565 Genomic DNA No translation available.
CH473953 Genomic DNA Translation: EDM12801.1
CH473953 Genomic DNA Translation: EDM12802.1
CH473953 Genomic DNA Translation: EDM12803.1
CH473953 Genomic DNA Translation: EDM12804.1
CH473953 Genomic DNA Translation: EDM12805.1
CH473953 Genomic DNA Translation: EDM12806.1
CH473953 Genomic DNA Translation: EDM12807.1

Protein sequence database of the Protein Information Resource

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PIRi
S58400

NCBI Reference Sequences

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RefSeqi
NP_067691.1, NM_021659.1 [Q62747-1]
XP_006231127.1, XM_006231065.3 [Q62747-2]
XP_006231129.1, XM_006231067.3 [Q62747-4]
XP_006231130.1, XM_006231068.3 [Q62747-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000007429; ENSRNOP00000007429; ENSRNOG00000026432 [Q62747-8]
ENSRNOT00000035576; ENSRNOP00000031890; ENSRNOG00000026432 [Q62747-4]
ENSRNOT00000036168; ENSRNOP00000031944; ENSRNOG00000026432 [Q62747-6]
ENSRNOT00000036180; ENSRNOP00000032388; ENSRNOG00000026432 [Q62747-3]
ENSRNOT00000036232; ENSRNOP00000031195; ENSRNOG00000026432 [Q62747-2]
ENSRNOT00000036283; ENSRNOP00000031816; ENSRNOG00000026432 [Q62747-7]
ENSRNOT00000047964; ENSRNOP00000049360; ENSRNOG00000026432 [Q62747-5]
ENSRNOT00000048704; ENSRNOP00000040667; ENSRNOG00000026432 [Q62747-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
59267

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
rno:59267

UCSC genome browser

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UCSCi
RGD:62013 rat

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20106 mRNA Translation: AAA87725.1
AF336852 mRNA Translation: AAK01447.1
AF336853 mRNA Translation: AAK01448.1
AF336854 mRNA Translation: AAK01449.1
AF336855 mRNA Translation: AAK01450.1
AF336856 mRNA Translation: AAK01451.1
AF336857 mRNA Translation: AAK01452.1
AF336858 mRNA Translation: AAK01453.1
AF336859 mRNA Translation: AAK01454.1
AF336860 mRNA Translation: AAK01455.1
AC095662 Genomic DNA No translation available.
AC130565 Genomic DNA No translation available.
CH473953 Genomic DNA Translation: EDM12801.1
CH473953 Genomic DNA Translation: EDM12802.1
CH473953 Genomic DNA Translation: EDM12803.1
CH473953 Genomic DNA Translation: EDM12804.1
CH473953 Genomic DNA Translation: EDM12805.1
CH473953 Genomic DNA Translation: EDM12806.1
CH473953 Genomic DNA Translation: EDM12807.1
PIRiS58400
RefSeqiNP_067691.1, NM_021659.1 [Q62747-1]
XP_006231127.1, XM_006231065.3 [Q62747-2]
XP_006231129.1, XM_006231067.3 [Q62747-4]
XP_006231130.1, XM_006231068.3 [Q62747-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6ANJX-ray1.70A134-262[»]
6ANKX-ray2.25A/B134-403[»]
SMRiQ62747
ModBaseiSearch...

Protein-protein interaction databases

CORUMiQ62747
DIPiDIP-61710N
IntActiQ62747, 1 interactor
STRINGi10116.ENSRNOP00000031195

PTM databases

iPTMnetiQ62747
PhosphoSitePlusiQ62747
SwissPalmiQ62747

Proteomic databases

PaxDbiQ62747
PRIDEiQ62747

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000007429; ENSRNOP00000007429; ENSRNOG00000026432 [Q62747-8]
ENSRNOT00000035576; ENSRNOP00000031890; ENSRNOG00000026432 [Q62747-4]
ENSRNOT00000036168; ENSRNOP00000031944; ENSRNOG00000026432 [Q62747-6]
ENSRNOT00000036180; ENSRNOP00000032388; ENSRNOG00000026432 [Q62747-3]
ENSRNOT00000036232; ENSRNOP00000031195; ENSRNOG00000026432 [Q62747-2]
ENSRNOT00000036283; ENSRNOP00000031816; ENSRNOG00000026432 [Q62747-7]
ENSRNOT00000047964; ENSRNOP00000049360; ENSRNOG00000026432 [Q62747-5]
ENSRNOT00000048704; ENSRNOP00000040667; ENSRNOG00000026432 [Q62747-1]
GeneIDi59267
KEGGirno:59267
UCSCiRGD:62013 rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9066
RGDi62013 Syt7

Phylogenomic databases

eggNOGiENOG410KDM6 Eukaryota
ENOG410XS7N LUCA
GeneTreeiENSGT00940000157180
HOGENOMiHOG000205939
KOiK19907
OMAiNDNTVQQ
OrthoDBi925064at2759
TreeFamiTF315600

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q62747

Gene expression databases

BgeeiENSRNOG00000026432 Expressed in 10 organ(s), highest expression level in brain

Family and domain databases

CDDicd08386 C2A_Synaptotagmin-7, 1 hit
cd08405 C2B_Synaptotagmin-7, 1 hit
Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037732 C2A_Synaptotagmin-7
IPR037741 C2B_Synaptotagmin-7
IPR001565 Synaptotagmin
IPR015427 Synaptotagmin7
PANTHERiPTHR10024:SF357 PTHR10024:SF357, 2 hits
PfamiView protein in Pfam
PF00168 C2, 2 hits
PRINTSiPR00360 C2DOMAIN
PR00399 SYNAPTOTAGMN
SMARTiView protein in SMART
SM00239 C2, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYT7_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q62747
Secondary accession number(s): F1M262
, Q99J98, Q99P33, Q99P34, Q99P35, Q99P36, Q99P37, Q99P38
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2016
Last sequence update: November 1, 1996
Last modified: September 18, 2019
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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