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Protein

Estradiol 17-beta-dehydrogenase 2

Gene

Hsd17b2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Favors the oxidation of estradiol and testosterone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH (By similarity).By similarity

Catalytic activityi

17-beta-estradiol + NAD(P)+ = estrone + NAD(P)H.
Testosterone + NAD+ = androstenedione + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei220SubstrateBy similarity1
Active sitei233Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi83 – 112NADBy similarityAdd BLAST30

GO - Molecular functioni

  • estradiol 17-beta-dehydrogenase activity Source: RGD
  • testosterone dehydrogenase (NAD+) activity Source: RGD

GO - Biological processi

  • androgen biosynthetic process Source: RGD
  • bone development Source: RGD
  • cellular response to metal ion Source: RGD
  • estrogen biosynthetic process Source: RGD

Keywordsi

Molecular functionOxidoreductase
Biological processLipid biosynthesis, Lipid metabolism, Steroid biosynthesis
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Estradiol 17-beta-dehydrogenase 2 (EC:1.1.1.62)
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase type 2
Short name:
17-beta-HSD 2
Testosterone 17-beta-dehydrogenase (EC:1.1.1.239)
Gene namesi
Name:Hsd17b2
Synonyms:Edh17b2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621803 Hsd17b2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1914268

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000545721 – 381Estradiol 17-beta-dehydrogenase 2Add BLAST381

Proteomic databases

PaxDbiQ62730
PRIDEiQ62730

Expressioni

Tissue specificityi

Highest expression in placenta.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018795

Chemistry databases

BindingDBiQ62730

Structurei

3D structure databases

ProteinModelPortaliQ62730
SMRiQ62730
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1610 Eukaryota
ENOG410Y7FK LUCA
HOVERGENiHBG005482
InParanoidiQ62730
KOiK13368
PhylomeDBiQ62730

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

Q62730-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPFSSESAW LCLTATAVLG GMLLCKAWSS GQLRSQVVCL AGLWGGACLL
60 70 80 90 100
SLSLLCSLFL LSVSCFFLLY VSSSDQDLLP VDQKAVLVTG ADSGFGHALA
110 120 130 140 150
KHLDKLGFTV FAGVLDKEGP GAEELRKNCS ERLSVLQMDV TKPEQIKDVH
160 170 180 190 200
SEVAEKIQDK GLWAVVNNAG VLHFPIDGEL IPMTVYRKCM AVNFFGAVEV
210 220 230 240 250
TKVFLPLLRK SKGRLVNVSS MGAMIPFQMV AAYASTKAAI SMFSAVIRQE
260 270 280 290 300
LAKWGVKVVT IHPGGFQTNI VGSQDSWDKM EKEILDHFSK EIQENYGQEY
310 320 330 340 350
VHTQKLALPV MREMSNPDIT PVLRDIQHAI CAKNPSSFYC SGRMTYLWIC
360 370 380
FAAYSPISLL DYILKNYFTP KLMPRALRTA S
Length:381
Mass (Da):41,967
Last modified:November 1, 1996 - v1
Checksum:i8E1D08DF345DE136
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91234 mRNA Translation: CAA62617.1
RefSeqiNP_077367.1, NM_024391.1
UniGeneiRn.10515

Genome annotation databases

GeneIDi79243
KEGGirno:79243
UCSCiRGD:621803 rat

Similar proteinsi

Entry informationi

Entry nameiDHB2_RAT
AccessioniPrimary (citable) accession number: Q62730
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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