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Entry version 191 (07 Oct 2020)
Sequence version 1 (01 Nov 1997)
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Protein

Disks large homolog 1

Gene

Dlg1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel (By similarity). May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (By similarity).By similarity4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.4.8, 5301

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-399719, Trafficking of AMPA receptors
R-RNO-438066, Unblocking of NMDA receptors, glutamate binding and activation
R-RNO-451308, Activation of Ca-permeable Kainate Receptor
R-RNO-5673001, RAF/MAP kinase cascade
R-RNO-8849932, Synaptic adhesion-like molecules

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Disks large homolog 1
Alternative name(s):
Synapse-associated protein 97
Short name:
SAP-97
Short name:
SAP97
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dlg1
Synonyms:Dlgh1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
2505, Dlg1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Endoplasmic reticulum, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi39S → A: No enrichment in postsynaptic density upon CaMK2 activation. 1 Publication1
Mutagenesisi39S → D: Localizes at the postsynaptic density. 1 Publication1
Mutagenesisi232S → A: No effect on association with GRIN2B. 1 Publication1
Mutagenesisi232S → D: Partial loss of association with GRIN2B. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000945501 – 911Disks large homolog 1Add BLAST911

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei39Phosphoserine; by CaMK21 Publication1
Modified residuei122PhosphoserineCombined sources1
Modified residuei138PhosphoserineCombined sources1
Modified residuei158PhosphoserineBy similarity1
Modified residuei232Phosphoserine; by CaMK21 Publication1
Modified residuei398PhosphotyrosineBy similarity1
Modified residuei567PhosphoserineBy similarity1
Modified residuei572PhosphoserineBy similarity1
Modified residuei574PhosphoserineBy similarity1
Modified residuei578PhosphoserineBy similarity1
Modified residuei597PhosphoserineBy similarity1
Modified residuei618PhosphoserineCombined sources1
Modified residuei684PhosphoserineBy similarity1
Modified residuei687PhosphoserineBy similarity1
Modified residuei841PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by MAPK12 (By similarity). Phosphorylation of Ser-39 modulates transport to the plasma membrane and phosphorylation of Ser-232 regulates association with GRIN2A.By similarity2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q62696

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q62696

PRoteomics IDEntifications database

More...
PRIDEi
Q62696

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q62696

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q62696

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q62696

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Strongly expressed in epithelial cells, in the small intestine it is only detected in the vili. Expressed in brain, heart (at protein level), muscle, lung and liver. In the brain it was detected in olfactory bulbs, cerebral cortex, hippocampus, and spinal cord (at protein level).2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By BDNF.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer (Probable).

Interacts (via guanylate kinase-like domain) with DLGAP1, DLGAP2, DLGAP3, DLGAP4 and MAP1A (PubMed:9115257, PubMed:9786987).

Interacts (via guanylate kinase-like domain) with KIF13B (By similarity). May interact with HTR2A (By similarity).

Interacts (via PDZ domains) with GRIA1 (PubMed:9677374).

Interacts (via PDZ domains) with GRIN2A (PubMed:12933808).

Interacts (via PDZ domains) with KCND2 and KCND3 (PubMed:19213956).

Interacts (via PDZ domains) with KCNA1, KCNA2, KCNA3 and KCNA4 (By similarity).

Interacts (via PDZ domains) with ADGRA3 (By similarity).

Interacts with KCNF1 (By similarity).

Interacts with CAMK2 (PubMed:19213956).

Interacts with cytoskeleton-associated protein EPB41 (By similarity).

Interacts with cytoskeleton-associated protein EZR (By similarity).

Found in a complex with KCNA5 and CAV3 (By similarity).

Found in a complex with APC and CTNNB1 (By similarity).

Interacts with CDH1 through binding to PIK3R1 (By similarity). Forms multiprotein complexes with CASK, LIN7A, LIN7B, LIN7C, APBA1, and KCNJ12 (PubMed:11865057, PubMed:14960569).

Interacts with TOPK (By similarity).

Forms a tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A or LIN7C) (By similarity). May interact with TJAP1 (By similarity).

Interacts with PTEN (PubMed:15951562).

Interacts with FRMPD4 (via C-terminus) (PubMed:19118189).

Interacts with LRFN1 and LRFN2 (PubMed:16495444, PubMed:16630835).

Interacts with LRFN4 and SFPQ (By similarity).

Interacts (via PDZ domains) with ADGRA2 (via PDZ-binding motif) (By similarity).

Interacts with ADAM10; this interaction recruits ADAM10 to the cell membrane during long-term depression in hippocampal neurons (By similarity).

By similarityCurated11 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
247292, 17 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q62696

Database of interacting proteins

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DIPi
DIP-31527N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q62696

Protein interaction database and analysis system

More...
IntActi
Q62696, 33 interactors

Molecular INTeraction database

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MINTi
Q62696

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000055672

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1911
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
Q62696

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q62696

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q62696

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 64L27PROSITE-ProRule annotationAdd BLAST61
Domaini224 – 310PDZ 1PROSITE-ProRule annotationAdd BLAST87
Domaini318 – 404PDZ 2PROSITE-ProRule annotationAdd BLAST87
Domaini465 – 545PDZ 3PROSITE-ProRule annotationAdd BLAST81
Domaini580 – 650SH3PROSITE-ProRule annotationAdd BLAST71
Domaini721 – 896Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST176

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni162 – 212Interaction with SH3 domainsBy similarityAdd BLAST51

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PDZ domains may also mediate association to membranes by binding to EPB41 and ADGRA2 together with the L27 domain that binds CASK and DLG2.By similarity
The L27 domain may regulate DLG1 self-association. The N-terminal alternatively spliced region is capable of binding several SH3 domains and also moderates the level of protein oligomerization (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MAGUK family.Curated

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0708, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q62696

KEGG Orthology (KO)

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KOi
K12076

Database of Orthologous Groups

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OrthoDBi
807583at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q62696

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.30.42.10, 3 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR016313, DLG1-like
IPR019590, DLG1_PEST_dom
IPR008145, GK/Ca_channel_bsu
IPR008144, Guanylate_kin-like_dom
IPR020590, Guanylate_kinase_CS
IPR015143, L27_1
IPR004172, L27_dom
IPR036892, L27_dom_sf
IPR027417, P-loop_NTPase
IPR001478, PDZ
IPR019583, PDZ_assoc
IPR036034, PDZ_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00625, Guanylate_kin, 1 hit
PF09058, L27_1, 1 hit
PF10608, MAGUK_N_PEST, 1 hit
PF00595, PDZ, 3 hits
PF10600, PDZ_assoc, 1 hit
PF00018, SH3_1, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001741, MAGUK_DLGH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00072, GuKc, 1 hit
SM00569, L27, 1 hit
SM01277, MAGUK_N_PEST, 1 hit
SM00228, PDZ, 3 hits
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101288, SSF101288, 1 hit
SSF50044, SSF50044, 1 hit
SSF50156, SSF50156, 3 hits
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00856, GUANYLATE_KINASE_1, 1 hit
PS50052, GUANYLATE_KINASE_2, 1 hit
PS51022, L27, 1 hit
PS50106, PDZ, 3 hits
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q62696-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVRKQDTQR ALHLLEEYRS KLSQTEDRQL RSSIERVISI FQSNLFQALI
60 70 80 90 100
DIQEFYEVTL LDNPKCVDHS KQCEPVQPGN PWESGSLSSA AVTSESLPGG
110 120 130 140 150
LSPPVEKYRY QDEEVLPSER ISPQVPNEVL GPELVHVSEK SLSEIENVHG
160 170 180 190 200
FVSHSHISPI KPTEAVPPSS PIVPVTPALP VPAESPVVLP STPQANPPPV
210 220 230 240 250
LVNTDSLETP TYVNGTDADY EYEEITLERG NSGLGFSIAG GTDNPHIGDD
260 270 280 290 300
SSIFITKIIT GGAAAQDGRL RVNDCILRVN EADVRDVTHS KAVEALKEAG
310 320 330 340 350
SIVRLYVKRR KAFRKNHEIK LIKGPKGLGF SIAGGVGNQH IPGDNSIYVT
360 370 380 390 400
KIIEGGAAHK DGKLQIGDKL LAVNSVCLEE VTHEEAVTAL KNTSDFVYLK
410 420 430 440 450
AAKPTSMYIN DGYAPPDITN SSSQSVDNHV SPSSYLGQTP ASPARYSPIS
460 470 480 490 500
KAVLGDDEIT REPRKVVLHR GSTGLGFNIV GGEDGEGIFI SFILAGGPAD
510 520 530 540 550
LSGELRKGDR IISVNSVDLR AASHEQAAAA LKNAGQAVTI VAQYRPEEYS
560 570 580 590 600
RFEAKIHDLR ETMMNSSVSS GSGSLRTSQK RSLYVRALFD YDKTKDSGLP
610 620 630 640 650
SQGLNFKFGD ILHVINASDD EWWQARQVTP DGESDEVGVI PSKRRVEKKE
660 670 680 690 700
RARLKTVKFN SKTRGDKGEI PDDMGSKGLK HVTSNASDSE SSYHEYGCSK
710 720 730 740 750
GGQEEYVLSY EPVNQQEVNY TRPVIILGPM KDRVNDDLIS EFPDKFGSCV
760 770 780 790 800
PHTTRPKRDY EVDGRDYHFV TSREQMEKDI QEHKFIEAGQ YNNHLYGTSV
810 820 830 840 850
QSVRAVAEKG KHCILDVSGN AIKRLQIAQL YPISIFIKPK SMENIMEMNK
860 870 880 890 900
RLTDEQARKT FERAVRLEQE FTEHFTAIVQ GDTLEDIYNQ VKQIIEEQSG
910
PYIWVPAKEK L
Length:911
Mass (Da):100,571
Last modified:November 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i18CEBD31DD0CAF8B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2K1M2A0A0G2K1M2_RAT
Disks large homolog 1
Dlg1
917Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1LNM0F1LNM0_RAT
Disks large homolog 1
Dlg1
911Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U14950 mRNA Translation: AAA79976.1

Protein sequence database of the Protein Information Resource

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PIRi
I56552

NCBI Reference Sequences

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RefSeqi
NP_036920.1, NM_012788.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
25252

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
rno:25252

UCSC genome browser

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UCSCi
RGD:2505, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14950 mRNA Translation: AAA79976.1
PIRiI56552
RefSeqiNP_036920.1, NM_012788.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RSONMR-A/C4-63[»]
1ZOKNMR-A221-313[»]
2AWUX-ray2.44A/B314-409[»]
2AWWX-ray2.21A/B314-409[»]
2AWXX-ray1.80A/B314-409[»]
2G2LX-ray2.35A/B314-409[»]
2I0IX-ray2.80A/B/C459-543[»]
2I0LX-ray2.31A/B318-401[»]
3UATX-ray2.70A578-911[»]
BMRBiQ62696
SMRiQ62696
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi247292, 17 interactors
CORUMiQ62696
DIPiDIP-31527N
ELMiQ62696
IntActiQ62696, 33 interactors
MINTiQ62696
STRINGi10116.ENSRNOP00000055672

PTM databases

iPTMnetiQ62696
PhosphoSitePlusiQ62696
SwissPalmiQ62696

Proteomic databases

jPOSTiQ62696
PaxDbiQ62696
PRIDEiQ62696

Genome annotation databases

GeneIDi25252
KEGGirno:25252
UCSCiRGD:2505, rat

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1739
RGDi2505, Dlg1

Phylogenomic databases

eggNOGiKOG0708, Eukaryota
InParanoidiQ62696
KOiK12076
OrthoDBi807583at2759
PhylomeDBiQ62696

Enzyme and pathway databases

BRENDAi2.7.4.8, 5301
ReactomeiR-RNO-399719, Trafficking of AMPA receptors
R-RNO-438066, Unblocking of NMDA receptors, glutamate binding and activation
R-RNO-451308, Activation of Ca-permeable Kainate Receptor
R-RNO-5673001, RAF/MAP kinase cascade
R-RNO-8849932, Synaptic adhesion-like molecules

Miscellaneous databases

EvolutionaryTraceiQ62696

Protein Ontology

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PROi
PR:Q62696

Family and domain databases

Gene3Di2.30.42.10, 3 hits
InterProiView protein in InterPro
IPR016313, DLG1-like
IPR019590, DLG1_PEST_dom
IPR008145, GK/Ca_channel_bsu
IPR008144, Guanylate_kin-like_dom
IPR020590, Guanylate_kinase_CS
IPR015143, L27_1
IPR004172, L27_dom
IPR036892, L27_dom_sf
IPR027417, P-loop_NTPase
IPR001478, PDZ
IPR019583, PDZ_assoc
IPR036034, PDZ_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PfamiView protein in Pfam
PF00625, Guanylate_kin, 1 hit
PF09058, L27_1, 1 hit
PF10608, MAGUK_N_PEST, 1 hit
PF00595, PDZ, 3 hits
PF10600, PDZ_assoc, 1 hit
PF00018, SH3_1, 1 hit
PIRSFiPIRSF001741, MAGUK_DLGH, 1 hit
SMARTiView protein in SMART
SM00072, GuKc, 1 hit
SM00569, L27, 1 hit
SM01277, MAGUK_N_PEST, 1 hit
SM00228, PDZ, 3 hits
SM00326, SH3, 1 hit
SUPFAMiSSF101288, SSF101288, 1 hit
SSF50044, SSF50044, 1 hit
SSF50156, SSF50156, 3 hits
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00856, GUANYLATE_KINASE_1, 1 hit
PS50052, GUANYLATE_KINASE_2, 1 hit
PS51022, L27, 1 hit
PS50106, PDZ, 3 hits
PS50002, SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDLG1_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q62696
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 7, 2020
This is version 191 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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