UniProtKB - Q62682 (CNTN3_RAT)
Protein
Contactin-3
Gene
Cntn3
Organism
Rattus norvegicus (Rat)
Status
Functioni
Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity.1 Publication
GO - Biological processi
- cell-cell adhesion Source: RGD
- nervous system development Source: RGD
Keywordsi
Biological process | Cell adhesion |
Enzyme and pathway databases
Reactomei | R-RNO-163125, Post-translational modification: synthesis of GPI-anchored proteins |
Names & Taxonomyi
Protein namesi | Recommended name: Contactin-3Alternative name(s): Brain-derived immunoglobulin superfamily protein 1 Short name: BIG-1 |
Gene namesi | Name:Cntn3 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3253, Cntn3 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- anchored component of plasma membrane Source: RGD
Other locations
- neuron projection Source: GO_Central
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000014709 | 20 – 1002 | Contactin-3Add BLAST | 983 | |
PropeptideiPRO_0000014710 | 1003 – 1028 | Removed in mature formSequence analysisAdd BLAST | 26 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 50 ↔ 100 | PROSITE-ProRule annotation | ||
Glycosylationi | 65 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 144 ↔ 196 | PROSITE-ProRule annotation | ||
Glycosylationi | 193 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 249 ↔ 297 | PROSITE-ProRule annotation | ||
Disulfide bondi | 339 ↔ 386 | PROSITE-ProRule annotation | ||
Glycosylationi | 377 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 431 ↔ 479 | PROSITE-ProRule annotation | ||
Glycosylationi | 468 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 489 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 521 ↔ 577 | PROSITE-ProRule annotation | ||
Glycosylationi | 538 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 765 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 860 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 895 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 913 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 931 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 956 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 1002 | GPI-anchor amidated serineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, GPI-anchor, LipoproteinProteomic databases
PaxDbi | Q62682 |
PRIDEi | Q62682 |
PTM databases
GlyGeni | Q62682, 12 sites |
Expressioni
Tissue specificityi
Specifically expressed in brain. Not expressed in peripheral tissues such as heart, lung, liver, spleen, kidney and skeletal muscle. In brain, it is restricted to subsets of neurons such as Purkinje cells of the cerebellum, granule cells of the dentate gyrus, and neurons in the superficial layers of the cerebral cortex.1 Publication
Developmental stagei
Weakly or not expressed from E12 to E20. Expressed at much higher level from postnatal day 2, reaching a maximum level in adult brain.1 Publication
Gene expression databases
Bgeei | ENSRNOG00000006144, Expressed in frontal cortex and 16 other tissues |
Genevisiblei | Q62682, RN |
Interactioni
Subunit structurei
Interacts with PTPRG.
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000008221 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 117 | Ig-like C2-type 1Add BLAST | 92 | |
Domaini | 122 – 208 | Ig-like C2-type 2Add BLAST | 87 | |
Domaini | 227 – 313 | Ig-like C2-type 3Add BLAST | 87 | |
Domaini | 318 – 402 | Ig-like C2-type 4Add BLAST | 85 | |
Domaini | 408 – 497 | Ig-like C2-type 5Add BLAST | 90 | |
Domaini | 499 – 593 | Ig-like C2-type 6Add BLAST | 95 | |
Domaini | 600 – 698 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 99 | |
Domaini | 703 – 800 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 98 | |
Domaini | 805 – 901 | Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST | 97 | |
Domaini | 902 – 998 | Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST | 97 |
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Repeat, SignalPhylogenomic databases
eggNOGi | KOG3513, Eukaryota |
GeneTreei | ENSGT00940000160282 |
HOGENOMi | CLU_005756_0_0_1 |
InParanoidi | Q62682 |
OMAi | DISFTWY |
OrthoDBi | 655902at2759 |
PhylomeDBi | Q62682 |
Family and domain databases
CDDi | cd00063, FN3, 4 hits |
Gene3Di | 2.60.40.10, 10 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 |
Pfami | View protein in Pfam PF00041, fn3, 3 hits PF07679, I-set, 2 hits |
SMARTi | View protein in SMART SM00060, FN3, 4 hits SM00409, IG, 6 hits SM00408, IGc2, 6 hits |
SUPFAMi | SSF48726, SSF48726, 6 hits SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 4 hits PS50835, IG_LIKE, 6 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q62682-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMLSWKQLIL LSFIGCLAGE LLLQGPVFVK EPSNSIFPVG SEDKKITLNC
60 70 80 90 100
EARGNPSPHY RWQLNGSDID TSLDHRYKLN GGNLIVINPN RNWDTGSYQC
110 120 130 140 150
FATNSLGTIV SREAKLQFAY LENFKSRMRS RVSVREGQGV VLLCGPPPHS
160 170 180 190 200
GELSYAWVFN EYPSFVEEDS RRFVSQETGH LYIAKVEPSD VGNYTCVVTS
210 220 230 240 250
TVTNARVLGS PTPLVLRSDG VMGEYEPKIE LQFPETLPAA KGSTVKLECF
260 270 280 290 300
ALGNPVPQIN WRRSDGMPFP TKIKLRKFNG VLEIPNFQQE DTGSYECIAE
310 320 330 340 350
NSRGKNVARG RLTYYAKPYW VQLLKDVETA VEDSLYWECR ASGKPKPSYR
360 370 380 390 400
WLKNGDALVL EERIQIENGA LTIANLNVSD SGMFQCIAEN KHGLIYSSAE
410 420 430 440 450
LKVLASAPDF SRNPMKKMIQ VQVGSLVILD CKPSASPRAL SFWKKGDTVV
460 470 480 490 500
REQARISLLN DGGLKIMNVT KADAGIYTCI AENQFGKANG TTQLVVTEPT
510 520 530 540 550
RIILAPSNMD VAVGESIILP CQVQHDPLLD IMFAWYFNGT LTDFKKDGSH
560 570 580 590 600
FEKVGGSSSG DLMIRNIQLK HSGKYVCMVQ TGVDSVSSAA ELIVRGSPGP
610 620 630 640 650
PENVKVDEIT DTTAQLSWTE GTDSHSPVIS YAVQARTPFS VGWQNVRTVP
660 670 680 690 700
EAIDGKTRTA TVVELNPWVE YEFRVVASNK IGGGEPSLPS EKVRTEEAAP
710 720 730 740 750
EVAPSEVSGG GGSRSELVIT WDPVPEELQN GGGFGYVVAF RPLGVTTWIQ
760 770 780 790 800
TVVTSPDNPR YVFRNESIVP FSPYEVKVGV YNNKGEGPFS PVTTVFSAEE
810 820 830 840 850
EPTVAPSHIS AHSLSSSEIE VSWNTIPWKS SNGRLLGYEV RYWNNGGEEE
860 870 880 890 900
SSSKVKVAGN QTSAVLRGLK SNLAYYTAVR AYNTAGAGPF SATVNATTKK
910 920 930 940 950
TPPSQPPGNV VWNATDTKVL LNWEQVKALE NESEVTGYKV FYRTSSQNNV
960 970 980 990 1000
QVLNTNKTSA ELLLPIKEDY IIEVKATTDG GDGTSSEQIR IPRITSMDAR
1010 1020
GSTSAISDIH PVSGYISVLL FFIVNALW
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U11031 mRNA Translation: AAA63607.1 |
PIRi | I58164 |
RefSeqi | NP_062202.1, NM_019329.2 XP_006237030.1, XM_006236968.3 |
Genome annotation databases
Ensembli | ENSRNOT00000008221; ENSRNOP00000008221; ENSRNOG00000006144 |
GeneIDi | 54279 |
KEGGi | rno:54279 |
UCSCi | RGD:3253, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U11031 mRNA Translation: AAA63607.1 |
PIRi | I58164 |
RefSeqi | NP_062202.1, NM_019329.2 XP_006237030.1, XM_006236968.3 |
3D structure databases
SMRi | Q62682 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000008221 |
PTM databases
GlyGeni | Q62682, 12 sites |
Proteomic databases
PaxDbi | Q62682 |
PRIDEi | Q62682 |
Genome annotation databases
Ensembli | ENSRNOT00000008221; ENSRNOP00000008221; ENSRNOG00000006144 |
GeneIDi | 54279 |
KEGGi | rno:54279 |
UCSCi | RGD:3253, rat |
Organism-specific databases
CTDi | 5067 |
RGDi | 3253, Cntn3 |
Phylogenomic databases
eggNOGi | KOG3513, Eukaryota |
GeneTreei | ENSGT00940000160282 |
HOGENOMi | CLU_005756_0_0_1 |
InParanoidi | Q62682 |
OMAi | DISFTWY |
OrthoDBi | 655902at2759 |
PhylomeDBi | Q62682 |
Enzyme and pathway databases
Reactomei | R-RNO-163125, Post-translational modification: synthesis of GPI-anchored proteins |
Miscellaneous databases
PROi | PR:Q62682 |
Gene expression databases
Bgeei | ENSRNOG00000006144, Expressed in frontal cortex and 16 other tissues |
Genevisiblei | Q62682, RN |
Family and domain databases
CDDi | cd00063, FN3, 4 hits |
Gene3Di | 2.60.40.10, 10 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 |
Pfami | View protein in Pfam PF00041, fn3, 3 hits PF07679, I-set, 2 hits |
SMARTi | View protein in SMART SM00060, FN3, 4 hits SM00409, IG, 6 hits SM00408, IGc2, 6 hits |
SUPFAMi | SSF48726, SSF48726, 6 hits SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 4 hits PS50835, IG_LIKE, 6 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CNTN3_RAT | |
Accessioni | Q62682Primary (citable) accession number: Q62682 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 23, 2004 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families