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Entry version 140 (16 Oct 2019)
Sequence version 3 (22 Feb 2012)
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Protein

E3 ubiquitin-protein ligase UBR5

Gene

Ubr5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) for the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (By similarity).By similarity

Miscellaneous

A cysteine residue is required for ubiquitin-thioester formation.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.26

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei2757Glycyl thioester intermediatePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1166 – 1234UBR-typePROSITE-ProRule annotationAdd BLAST69

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processDNA damage, DNA repair, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase UBR5 (EC:2.3.2.26)
Alternative name(s):
100 kDa protein
E3 ubiquitin-protein ligase, HECT domain-containing 1
HECT-type E3 ubiquitin transferase UBR5
Hyperplastic discs protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ubr5
Synonyms:Dd5, Edd, Edd1, Hyd
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
621236 Ubr5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000869331 – 2788E3 ubiquitin-protein ligase UBR5Add BLAST2788

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei100PhosphoserineBy similarity1
Modified residuei317PhosphoserineBy similarity1
Modified residuei342PhosphoserineBy similarity1
Modified residuei567PhosphoserineBy similarity1
Modified residuei601PhosphoserineBy similarity1
Modified residuei626PhosphothreonineBy similarity1
Modified residuei797PhosphoserineBy similarity1
Modified residuei917PhosphoserineBy similarity1
Modified residuei1007PhosphoserineBy similarity1
Modified residuei1104PhosphothreonineBy similarity1
Modified residuei1124PhosphothreonineBy similarity1
Modified residuei1216PhosphoserineBy similarity1
Modified residuei1297PhosphoserineBy similarity1
Modified residuei1344PhosphoserineBy similarity1
Modified residuei1364PhosphoserineBy similarity1
Modified residuei1470PhosphoserineBy similarity1
Modified residuei1538PhosphoserineBy similarity1
Modified residuei1725PhosphothreonineBy similarity1
Modified residuei1730PhosphoserineBy similarity1
Modified residuei1735PhosphotyrosineBy similarity1
Modified residuei1769PhosphoserineBy similarity1
Modified residuei1959PhosphothreonineBy similarity1
Modified residuei1980PhosphoserineBy similarity1
Modified residuei2016PhosphoserineBy similarity1
Modified residuei2018PhosphoserineBy similarity1
Modified residuei2020PhosphothreonineBy similarity1
Modified residuei2066PhosphoserineBy similarity1
Modified residuei2203PhosphothreonineBy similarity1
Modified residuei2231PhosphoserineCombined sources1
Modified residuei2279PhosphoserineBy similarity1
Modified residuei2459PhosphoserineBy similarity1
Modified residuei2473PhosphoserineBy similarity1
Modified residuei2475PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q62671

PRoteomics IDEntifications database

More...
PRIDEi
Q62671

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q62671

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q62671

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest levels found in testis. Also present in liver, kidney, lung and brain.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In early postnatal life, expression in the testis increases to reach a maximum around day 28.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds TOPBP1. Associates with CDK9 and TFIIS/TCEA1 and forms a transcription regulatory complex made of CDK9, RNAP II, UBR5 and TFIIS/TCEA1 that can stimulate target gene transcription by recruiting their promoters.

Interacts with PIH1D1.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q62671

Protein interaction database and analysis system

More...
IntActi
Q62671, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000009115

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12788
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q62671

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2367 – 2444PABCPROSITE-ProRule annotationAdd BLAST78
Domaini2451 – 2788HECTPROSITE-ProRule annotationAdd BLAST338

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1613 – 1670Ser-richAdd BLAST58
Compositional biasi2319 – 2366Arg-richAdd BLAST48

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1166 – 1234UBR-typePROSITE-ProRule annotationAdd BLAST69

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0943 Eukaryota
COG5021 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000046848

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q62671

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14423 CUE_UBR5, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024725 E3_UbLigase_EDD_UBA
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR036053 PABP-dom
IPR002004 PABP_HYD
IPR009091 RCC1/BLIP-II
IPR003126 Znf_UBR

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11547 E3_UbLigase_EDD, 1 hit
PF00632 HECT, 1 hit
PF00658 PABP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00119 HECTc, 1 hit
SM00517 PolyA, 1 hit
SM00396 ZnF_UBR1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50985 SSF50985, 1 hit
SSF56204 SSF56204, 1 hit
SSF63570 SSF63570, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50237 HECT, 1 hit
PS51309 PABC, 1 hit
PS51157 ZF_UBR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q62671-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKQAVKRLH MLREVSEKLN KYNLNSHPPL NVLEQATIKQ CVVGPNHAAF
60 70 80 90 100
LLEDGRICRI GFSVQPDRLE LGKPDNNDGS KLNSSSGTGR TSRPGRTSDS
110 120 130 140 150
PWFLSGSETL GRLAGNTLGS RWSSGVGGSG GGSSGRSSAG ARDSRRQTRV
160 170 180 190 200
IRTGRDRGSG LLGSQPQPVI PASVIPEELI SQAQVVLQGK SRSVIIRELQ
210 220 230 240 250
RTNLDVNLAV NNLLSRDDED GDDGDDTASE SYLPGEDLMS LLDADIHSAH
260 270 280 290 300
PSVIIDADAM FSEDISYFGY PSFRRSSLSR LGSSRVLLLP LERDSELLRE
310 320 330 340 350
RESVLRLRER RWLDGASFDN ERGSTSKEGE PNPDKKNTPV QSPVSLGEDL
360 370 380 390 400
QWWPDKDGTK FTCIGALYSE LVAVSSKGEL YQWKWTESEP YRNAQNPSLH
410 420 430 440 450
HPRATFLGLT NEKIVLLSAN SIRATVATEN NKVATWVDET LSSVASKLEH
460 470 480 490 500
TAQTYSELQG ERIVSLHCCA LYTCAQLENN LYWWGVVPFS QRKKMLEKAR
510 520 530 540 550
AKNKKPKSSA GVQSLNVRGG RQVCLRNNPL YHAGAVAFSI SAGIPKVGVL
560 570 580 590 600
MESVWNMNDS CRFQLRSPES LKSMEKASKT IETKPESKQE PVKTEMGPPP
610 620 630 640 650
SPASTCSDAS SIASSASMPY KRRRSTPAPK EEEKVNEEQW SLREVVFVED
660 670 680 690 700
VKNVPVGKVL KVDGAYVAVK FPGTSSNTNC QNSSGPDADP SSLLQDCRLL
710 720 730 740 750
RIDELQVVKT GGTPKVPDCF QRTPKKLCIP EKTEILAVNV DSKGVHAVLK
760 770 780 790 800
TGNWVRYCIF DLATGKAEQE NNFPTSSVAF LGQNERSVAI FTAGQESPII
810 820 830 840 850
LRDGNGTIYP MAKDCMGGIR DPDWLDLPPI SSLGMGVHSL INLPANSTIK
860 870 880 890 900
KKAAIIIMAV EKQTLMQHIL RCDYEACRQY LVNLEQAVVL EQNLQMLQTF
910 920 930 940 950
ISHRCDGNRN ILHACVSVCF PTSNKETKEE EEAERSERNT FAERLSAVEA
960 970 980 990 1000
IANAISVVSS NGPGNRAGSS SSRSLRLREM MRRSLRAAGL GRHEAGASSS
1010 1020 1030 1040 1050
DHQDPVSPPI APPSWVPDPP SMDPDGDIDF ILAPAVGSLT TAATGGGQGP
1060 1070 1080 1090 1100
STSTIPGPST EPSVVESKDR KANAHFILKL LCDSAVLQPY LRELLSAKDA
1110 1120 1130 1140 1150
RGMTPFMSAV SGRAYPAAIT ILETAQKIAK AEVSGSEKEE DVFMGMVCPS
1160 1170 1180 1190 1200
GTNPDDSPLY VLCCNDTCSF TWTGAEHINQ DIFECRTCGL LESLCCCTEC
1210 1220 1230 1240 1250
ARVCHKGHDC KLKRTSPTAY CDCWEKCKCK TLIAGQKSAR LDLLYRLLTA
1260 1270 1280 1290 1300
TNLVTLPNSR GEHLLLFLVQ TVARQTVEHC QYRPPRIRED RNRKTASPDD
1310 1320 1330 1340 1350
SDMPDHDLEP PRFAQLALER VLQDWNALRS MIMFGSQENK DPLSASSRIG
1360 1370 1380 1390 1400
HLLPEEQVYL NQQSGTIRLD CFTHCLIVKC TADILLLDTL LGTLVKELQN
1410 1420 1430 1440 1450
KYTPGRREEA IAVTMRFLRS VARVFVILSV EMASSKKKNN FIPQPIGKCK
1460 1470 1480 1490 1500
RVFQALLPYA VEELCNVAES LIVPVRMGIA RPTAPFTLAS TSIDAMQGSE
1510 1520 1530 1540 1550
ELFSVEPLPP RPSSDQSSSS SQSQSSYIIR NPQQRRISQS QPVRGREEEQ
1560 1570 1580 1590 1600
DDIVSADVEE VEVVEGVAGE EDHHDEQEEH GEENAEAEGH HDEHDEDGSD
1610 1620 1630 1640 1650
MELDLLAAAE TESDSESNHS NQDNASGRRS VVTAATAGSE AGASSVPAFF
1660 1670 1680 1690 1700
SEDDSQSNDS SDSDSSSSQS DDIEQETFML DEPLERTTNS SHANGAAQAP
1710 1720 1730 1740 1750
RSMQWAVRNT QHQRAASTAP SSTSTPAASS AGLIYIDPSN LRRSGTISTS
1760 1770 1780 1790 1800
AAAAAAALEA SNASSYLTSA SSLARAYSIV IRQISDLMGL IPKYNHLVYS
1810 1820 1830 1840 1850
QIPAAVKLTY QDAVNLQNYV EEKLIPTWNW MVSIMDSTEA QLRYGSALAS
1860 1870 1880 1890 1900
AGDPGHPNHP LHASQNSARR ERMTAREEAS LRTLEGRRRR ATLLSARQGM
1910 1920 1930 1940 1950
MSARGDFLNY ALSLMRSHND EHSDVLPVLD VCSLKHVAYV FQALIYWIKA
1960 1970 1980 1990 2000
MNQQTTLDTP QLERKRTREL LELGIDNEDS EHENDDDTSQ SATLNDKDDE
2010 2020 2030 2040 2050
SLPAETGQNH PFFRRSDSMT FLGCIPPNPF EVPLAEAIPL ADQPHLLQPN
2060 2070 2080 2090 2100
ARKEDLFGRP SQGLYSSSAG SGKCLVEVTM DRNCLEVLPT KMSYAANLKN
2110 2120 2130 2140 2150
VMNMQNRQKK AGEDQSMLAE EADSSKPGPS AHDVAAQLKS SLLAEIGLTE
2160 2170 2180 2190 2200
SEGPPLTSFR PQCSFMGMVI SHDMLLGRWR LSLELFGRVF MEDVGAEPGS
2210 2220 2230 2240 2250
ILTELGGFEV KESKFRREME KLRNQQSRDL SLEVDRDRDL LIQQTMRQLN
2260 2270 2280 2290 2300
NHFGRRCATT PMAVHRVKVT FKDEPGEGSG VARSFYTAIA QAFLSNEKLP
2310 2320 2330 2340 2350
NLDCIQNANK GTHTSLMQRL RNRGERDRER EREREMRRSS GLRAGSRRDR
2360 2370 2380 2390 2400
DRDFRRQLSI DTRPFRPASE GNPSDDPDPL PAHRQALGER LYPRVQAMQP
2410 2420 2430 2440 2450
AFASKITGML LELSPAQLLL LLASEDSLRA RVEEAMELIV AHGRENGADS
2460 2470 2480 2490 2500
ILDLGLLDSS EKVQENRKRH GSSRSVVDMD LDDTDDGDDN APLFYQPGKR
2510 2520 2530 2540 2550
GFYTPRPGKN TEARLNCFRN IGRILGLCLL QNELCPITLN RHVIKVLLGR
2560 2570 2580 2590 2600
KVNWHDFAFF DPVMYESLRQ LILASQSSDA DAVFSAMDLA FAVDLCKEEG
2610 2620 2630 2640 2650
GGQVELIPNG VNIPVTPQNV YEYVRKYAEH RMLVVAEQPL HAMRKGLLDV
2660 2670 2680 2690 2700
LPKNSLEDLT AEDFRLLVNG CGEVNVQMLI SFTSFNDESG ENAEKLLQFK
2710 2720 2730 2740 2750
RWFWSIVERM SMTERQDLVY FWTSSPSLPA SEEGFQPMPS ITIRPPDDQH
2760 2770 2780
LPTANTCISR LYVPLYSSKQ ILKQKLLLAI KTKNFGFV
Length:2,788
Mass (Da):308,027
Last modified:February 22, 2012 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC2EA68B962627231
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H9KVE3H9KVE3_RAT
E3 ubiquitin-protein ligase UBR5
Ubr5
2,430Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA45756 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1890Missing in CAA45756 (PubMed:1533713).Curated1

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X64411 mRNA Translation: CAA45756.1 Frameshift.

Protein sequence database of the Protein Information Resource

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PIRi
S22659

Genome annotation databases

UCSC genome browser

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UCSCi
RGD:621236 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64411 mRNA Translation: CAA45756.1 Frameshift.
PIRiS22659

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NTWX-ray2.60A/C2383-2442[»]
SMRiQ62671
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

ELMiQ62671
IntActiQ62671, 1 interactor
STRINGi10116.ENSRNOP00000009115

PTM databases

iPTMnetiQ62671
PhosphoSitePlusiQ62671

Proteomic databases

PaxDbiQ62671
PRIDEiQ62671

Genome annotation databases

UCSCiRGD:621236 rat

Organism-specific databases

RGDi621236 Ubr5

Phylogenomic databases

eggNOGiKOG0943 Eukaryota
COG5021 LUCA
HOGENOMiHOG000046848
InParanoidiQ62671

Enzyme and pathway databases

UniPathwayiUPA00143

Miscellaneous databases

Protein Ontology

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PROi
PR:Q62671

Family and domain databases

CDDicd14423 CUE_UBR5, 1 hit
InterProiView protein in InterPro
IPR024725 E3_UbLigase_EDD_UBA
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR036053 PABP-dom
IPR002004 PABP_HYD
IPR009091 RCC1/BLIP-II
IPR003126 Znf_UBR
PfamiView protein in Pfam
PF11547 E3_UbLigase_EDD, 1 hit
PF00632 HECT, 1 hit
PF00658 PABP, 1 hit
SMARTiView protein in SMART
SM00119 HECTc, 1 hit
SM00517 PolyA, 1 hit
SM00396 ZnF_UBR1, 1 hit
SUPFAMiSSF50985 SSF50985, 1 hit
SSF56204 SSF56204, 1 hit
SSF63570 SSF63570, 1 hit
PROSITEiView protein in PROSITE
PS50237 HECT, 1 hit
PS51309 PABC, 1 hit
PS51157 ZF_UBR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBR5_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q62671
Secondary accession number(s): F1LRS0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 22, 2012
Last modified: October 16, 2019
This is version 140 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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