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Protein

HMG box-containing protein 1

Gene

Hbp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4 (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi433 – 501HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
HMG box-containing protein 1
Alternative name(s):
HMG box transcription factor 1
High mobility group box transcription factor 1
Gene namesi
Name:Hbp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620444 Hbp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000485491 – 513HMG box-containing protein 1Add BLAST513

Post-translational modificationi

Ubiquitinated by the CTLH E3 ubiquitin-protein ligase complex, leading to subsequent proteasomal degradation.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ62661
PRIDEiQ62661

PTM databases

iPTMnetiQ62661
PhosphoSitePlusiQ62661

Expressioni

Tissue specificityi

Highly expressed in liver, adipose tissue, lung, brain, spleen, kidney, skeletal muscle and heart.1 Publication

Developmental stagei

Not detectable in undifferentiated preadipocytes and myogenic cells. Accumulates at high levels during the terminal stages of the differentiation process.1 Publication

Inductioni

Up-regulated by insulin in differentiated cultured adipocytes.1 Publication

Interactioni

Subunit structurei

Binds TCF4 (By similarity). Binds RB1. Binds the second PAH repeat of SIN3A (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012004

Structurei

3D structure databases

ProteinModelPortaliQ62661
SMRiQ62661
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini202 – 343AXHPROSITE-ProRule annotationAdd BLAST142

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi196 – 199Poly-Asp4
Compositional biasi393 – 429Ser-richAdd BLAST37

Phylogenomic databases

eggNOGiENOG410IFNF Eukaryota
ENOG410XPPV LUCA
HOGENOMiHOG000065753
HOVERGENiHBG052810
InParanoidiQ62661
KOiK21644
PhylomeDBiQ62661
TreeFamiTF105381

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR003652 Ataxin_AXH_dom
IPR036096 Ataxin_AXH_dom_sf
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
PfamiView protein in Pfam
PF08517 AXH, 1 hit
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00536 AXH, 1 hit
SM00398 HMG, 1 hit
SUPFAMiSSF102031 SSF102031, 1 hit
SSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS51148 AXH, 1 hit
PS50118 HMG_BOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q62661-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVWEVKTNQR PHAVQRLLLV MDERATGVSD SLELLQCNEN VPSSPGYNSC
60 70 80 90 100
DEHMELDDLP ELQAVQSDPT QSAIYQLSSD VSHQEYPRPS WSQNTSDIPE
110 120 130 140 150
NTHREDEVDW LTELANIATS PQSPLMQCSF YNRSSPVHII ATSKSLHSYA
160 170 180 190 200
RPPPVSSAKS GPAFPHDHWK EETPVRHERA NSESESGIFC MSSLSDDDDL
210 220 230 240 250
GWCNSWPSTV WHCFLKGTRL CFHKESKKEW QDVEDFARAA SCDEEEIQMG
260 270 280 290 300
THKGYGSDGL KLLSHEESVS FGESVLKLTF DPGTVEDGLL TVECKLDHPF
310 320 330 340 350
YVKNKGWSSF YPSLTVVQHG IPCCEIHIGD VCLPPGHPDA INFDDSGVFD
360 370 380 390 400
TFKSYDFTPM DSSAVYVLSS MARQRRASLS CGGPGTGQEF AGSEFSKSCG
410 420 430 440 450
SPGSSQLSSS SLYTKAVKSH SSGTVSATSP NKCKRPMNAF MLFAKKYRVE
460 470 480 490 500
YTQMYPGKDN RAISVILGDR WKKMKNEERR MYTLEAKALA EEQKRLNPDC
510
WKRKRTNSGS QQH
Length:513
Mass (Da):57,430
Last modified:July 19, 2005 - v2
Checksum:iCC71A0918E793036
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Z4YNI2Z4YNI2_RAT
HMG box-containing protein 1
Hbp1 rCG_61751
523Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti144K → N in AAA53240 (PubMed:7937077).Curated1
Sequence conflicti241S → T in AAA53240 (PubMed:7937077).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09551 mRNA Translation: AAA53240.1
BC091165 mRNA Translation: AAH91165.1
PIRiI58311
RefSeqiNP_037353.2, NM_013221.2
UniGeneiRn.89226

Genome annotation databases

GeneIDi27080
KEGGirno:27080

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09551 mRNA Translation: AAA53240.1
BC091165 mRNA Translation: AAH91165.1
PIRiI58311
RefSeqiNP_037353.2, NM_013221.2
UniGeneiRn.89226

3D structure databases

ProteinModelPortaliQ62661
SMRiQ62661
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012004

PTM databases

iPTMnetiQ62661
PhosphoSitePlusiQ62661

Proteomic databases

PaxDbiQ62661
PRIDEiQ62661

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi27080
KEGGirno:27080

Organism-specific databases

CTDi26959
RGDi620444 Hbp1

Phylogenomic databases

eggNOGiENOG410IFNF Eukaryota
ENOG410XPPV LUCA
HOGENOMiHOG000065753
HOVERGENiHBG052810
InParanoidiQ62661
KOiK21644
PhylomeDBiQ62661
TreeFamiTF105381

Miscellaneous databases

PROiPR:Q62661

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR003652 Ataxin_AXH_dom
IPR036096 Ataxin_AXH_dom_sf
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
PfamiView protein in Pfam
PF08517 AXH, 1 hit
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00536 AXH, 1 hit
SM00398 HMG, 1 hit
SUPFAMiSSF102031 SSF102031, 1 hit
SSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS51148 AXH, 1 hit
PS50118 HMG_BOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHBP1_RAT
AccessioniPrimary (citable) accession number: Q62661
Secondary accession number(s): Q5BK86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: September 12, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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