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Entry version 175 (02 Jun 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Receptor-type tyrosine-protein phosphatase zeta

Gene

Ptprz1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity).

By similarity

Isoform 3 (phosphacan), previously designated 3F8 chondroitin sulfate proteoglycan or 3H1 keratan sulfate proteoglycan depending on the glycosylation status, is a soluble nervous tissue-specific proteoglycan. It is synthesized by glia and binds to neurons and to the neural cell adhesion molecules tenascin, N-CAM or NG-CAM but not to laminin and fibronectin. Phosphacan acts as a potent inhibitor of cell adhesion and neurite outgrowth.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1902SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1934Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei1978SubstrateBy similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei2224Ancestral active site1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-449836, Other interleukin signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase zeta (EC:3.1.3.481 Publication)
Short name:
R-PTP-zeta
Alternative name(s):
3F8 chondroitin sulfate proteoglycan
3H1 keratan sulfate proteoglycan
Phosphacan
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ptprz1
Synonyms:Ptprz, Ptpz
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
3455, Ptprz1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini25 – 1637ExtracellularSequence analysisAdd BLAST1613
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1638 – 1663HelicalSequence analysisAdd BLAST26
Topological domaini1664 – 2316CytoplasmicSequence analysisAdd BLAST653

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Add BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002546925 – 2316Receptor-type tyrosine-protein phosphatase zetaAdd BLAST2292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi56 ↔ 240By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi133 ↔ 264By similarity
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi223N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi232N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi324N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi381N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi497N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi552N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei572PhosphoserineCombined sources1
Modified residuei576PhosphoserineCombined sources1
Glycosylationi595O-linked (Xyl...) (chondroitin sulfate) serineSequence analysis1
Glycosylationi610N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei645Phosphoserine; alternateCombined sources1
Glycosylationi645O-linked (Xyl...) (chondroitin sulfate) serine; alternateSequence analysis1
Modified residuei647PhosphoserineCombined sources1
Glycosylationi685N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi786N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1005O-linked (Xyl...) (chondroitin sulfate) serineSequence analysis1
Glycosylationi1025N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1058N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1463N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1550O-linked (Xyl...) (chondroitin sulfate) serineSequence analysis1
Glycosylationi1552O-linked (Xyl...) (chondroitin sulfate) serineSequence analysis1
Glycosylationi1563N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1611N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1619N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1685PhosphothreonineBy similarity1
Modified residuei1688PhosphothreonineCombined sources1
Modified residuei2056PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q62656

PRoteomics IDEntifications database

More...
PRIDEi
Q62656

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q62656, 22 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q62656

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q62656

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q62656

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Nervous tissue specific.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with tenascin (PubMed:7512960).

Interacts with N-CAM and NG-CAM (PubMed:7528221). The carbonic-anhydrase like domain interacts with CNTN1 (contactin) (PubMed:7628014).

Interacts with PTN (PubMed:16814777). Interaction with PTN promotes formation of homooligomers; oligomerization impairs phosphatase activity (PubMed:16814777).

Interacts (via chondroitin sulfate chains) with MDK (via C-terminal); this interaction is inhibited by PTN; this interaction promotes neuronal migration (PubMed:10212223).

5 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
247642, 12 interactors

Database of interacting proteins

More...
DIPi
DIP-59715N

Protein interaction database and analysis system

More...
IntActi
Q62656, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000008719

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12316
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q62656

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 300Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST265
Domaini314 – 413Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST100
Domaini1718 – 1993Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST276
Domaini2024 – 2283Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST260

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni433 – 499DisorderedSequence analysisAdd BLAST67
Regioni518 – 537DisorderedSequence analysisAdd BLAST20
Regioni586 – 624DisorderedSequence analysisAdd BLAST39
Regioni636 – 720DisorderedSequence analysisAdd BLAST85
Regioni1141 – 1172DisorderedSequence analysisAdd BLAST32
Regioni1204 – 1228DisorderedSequence analysisAdd BLAST25
Regioni1401 – 1521DisorderedSequence analysisAdd BLAST121
Regioni1545 – 1622DisorderedSequence analysisAdd BLAST78
Regioni1934 – 1940Substrate bindingBy similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi444 – 499Polar residuesSequence analysisAdd BLAST56
Compositional biasi590 – 624Polar residuesSequence analysisAdd BLAST35
Compositional biasi662 – 691Polar residuesSequence analysisAdd BLAST30
Compositional biasi1423 – 1439Acidic residuesSequence analysisAdd BLAST17
Compositional biasi1451 – 1493Polar residuesSequence analysisAdd BLAST43
Compositional biasi1545 – 1570Polar residuesSequence analysisAdd BLAST26
Compositional biasi1592 – 1622Polar residuesSequence analysisAdd BLAST31

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0789, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q62656

Database of Orthologous Groups

More...
OrthoDBi
251520at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q62656

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03122, alpha_CARP_receptor_like, 1 hit
cd00063, FN3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
3.10.200.10, 1 hit
3.90.190.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041887, Alpha_CARP_receptor-type
IPR001148, CA_dom
IPR036398, CA_dom_sf
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
IPR029021, Prot-tyrosine_phosphatase-like
IPR000242, PTPase_domain
IPR016130, Tyr_Pase_AS
IPR003595, Tyr_Pase_cat
IPR000387, TYR_PHOSPHATASE_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00194, Carb_anhydrase, 1 hit
PF00041, fn3, 1 hit
PF00102, Y_phosphatase, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00700, PRTYPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01057, Carb_anhydrase, 1 hit
SM00060, FN3, 1 hit
SM00194, PTPc, 2 hits
SM00404, PTPc_motif, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265, SSF49265, 1 hit
SSF51069, SSF51069, 1 hit
SSF52799, SSF52799, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51144, ALPHA_CA_2, 1 hit
PS50853, FN3, 1 hit
PS00383, TYR_PHOSPHATASE_1, 1 hit
PS50056, TYR_PHOSPHATASE_2, 2 hits
PS50055, TYR_PHOSPHATASE_PTP, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q62656-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRILQSFLAC VQLLCVCRLD WAYGYYRQQR KLVEEIGWSY TGALNQKNWG
60 70 80 90 100
KKYPICNSPK QSPINIDEDL TQVNVNLKKL KFQGWEKPSL ENTFIHNTGK
110 120 130 140 150
TVEINLTNDY YLSGGLSEKV FKASKMTFHW GKCNVSSEGS EHSLEGQKFP
160 170 180 190 200
LEMQIYCFDA DRFSSFEETV KGKGRLRALS ILFEIGVEEN LDYKAIIDGT
210 220 230 240 250
ESVSRFGKQA ALDPFILQNL LPNSTDKYYI YNGSLTSPPC TDTVEWIVFK
260 270 280 290 300
DTVSISESQL AVFCEVLTMQ QSGYVMLMDY LQNNFREQQY KFSRQVFSSY
310 320 330 340 350
TGKEEIHEAV CSSEPENVQA DPENYTSLLI TWERPRVVYD TMIEKFAVLY
360 370 380 390 400
QPLEGNDQTK HEFLTDGYQD LGAILNNLIP NMSYVLQIVA ICSNGLYGKY
410 420 430 440 450
SDQLIVDMPT EDAELDLFPE LIGTEEIIKE ENYGKGNEED TGLNPGRDSA
460 470 480 490 500
TNQIRKKEPQ VSTTTHYNHM GTKYNEAKTN RSPTRGSEFS GKSDVLNTSL
510 520 530 540 550
NPTSQQVAEF NPEREMSLPS QIGTNLPPHS VEGTSASLNS GSKTLLVFPQ
560 570 580 590 600
MNLSGTAESL NMVSITEYKE VSADLSEEEN LLTDFKLDSG ADDSSGSSPA
610 620 630 640 650
SSTVPFSTDN LSHGYTSSSD TPEAVTYDVL RPESTRNALE DSAPSGSEES
660 670 680 690 700
LKDPSLEGSV WFPGSTDLTT QSETGSGREG FLQVNSTDFQ VDESRETTET
710 720 730 740 750
FSPDATASRG PSVTDMEMPH YSTFAYPPTE VTSHAFTPSS RPLDLAPTSN
760 770 780 790 800
ILHSQTTQPV YNGETPLQPS YSSEVFPLVT PLLLDNQTLN TTPAASSSDS
810 820 830 840 850
ALHATPVFPS VGVSFDSILS SYDDAPLLPF SSASFSSDLF HHLHTVSQTL
860 870 880 890 900
PQVTSAAERD ELSLHASLLV AGGDLLLEPS LVQYSDVMSH QVTIHAASDT
910 920 930 940 950
LEFGSESAVL YKTSMVSQIE SPSSDVVMHA YSSGPETSYA IEGSHHVLTV
960 970 980 990 1000
SSSSAIPVHD SVGVADQGSL LINPSHISLP ESSFITPTAS LLQLPPALSG
1010 1020 1030 1040 1050
DGEWSGASSD SELLLPDTDG LRTLNMSSPV SVADFTYTTS VSGDDIKPLS
1060 1070 1080 1090 1100
KGEMMYGNET ELKMSSFSDM AYPSKSTVVP KMSDIVNKWS ESLKETSVSV
1110 1120 1130 1140 1150
SSINSVFTES LVYPITKVFD QEISRVPEII FPVKPTHTAS QASGDTWLKP
1160 1170 1180 1190 1200
GLSTNSEPAL SDTASSEVSH PSTQPLLYEA ASPFNTEALL QPSFPASDVD
1210 1220 1230 1240 1250
TLLKTALPSG PRDPVLTETP MVEQSSSSVS LPLASESASS KSTLHFTSVP
1260 1270 1280 1290 1300
VLNMSPSDVH PTSLQRLTVP HSREEYFEQG LLKSKSPQQV LPSLHSHDEF
1310 1320 1330 1340 1350
FQTAHLDISQ AYPPKGRHAF ATPILSINEP QNTLINRLVY SEDIFMHPEI
1360 1370 1380 1390 1400
SITDKALTGL PTTVSDVLIA TDHSVPLGSG PISMTTVSPN RDDSVTTTKL
1410 1420 1430 1440 1450
LLPSKATSKP THSARSDADL VGGGEDGDDY DDDDYDDIDS DRFPVNKCMS
1460 1470 1480 1490 1500
CSPYRESQEK VMNDSDTQES SLVDQSDPIS HLLSENTEEE NGGTGVTRVD
1510 1520 1530 1540 1550
KSPDKSPPPS MLPQKHNDGR EDRDIQMGSA VLPHTPGSKA WAVLTSDEES
1560 1570 1580 1590 1600
GSGQGTSDSL NDNETSTDFS FPDVNEKDAD GVLEADDTGI APGSPRSSTP
1610 1620 1630 1640 1650
SVTSGHSGVS NSSEAEASNS SHESRIGLAE GLESEKKAVI PLVIVSALTF
1660 1670 1680 1690 1700
ICLVVLVGIL IYWRKCFQTA HFYLEDNTSP RVISTPPTPI FPISDDIGAI
1710 1720 1730 1740 1750
PIKHFPKHVA DLHASNGFTE EFETLKEFYQ EVQSCTVDLG ITADSSNHPD
1760 1770 1780 1790 1800
NKHKNRYVNI VAYDHSRVKL TQLAEKDGKL TDYINANYVD GYNRPKAYIA
1810 1820 1830 1840 1850
AQGPLKSTAE DFWRMIWEHN VEVIVMITNL VEKGRRKCDQ YWPTDGSEEY
1860 1870 1880 1890 1900
GSFLVNQKNV QVLAYYTVRN FTLRNTKIKK GSQKGRSSGR LVTQYHYTQW
1910 1920 1930 1940 1950
PDMGVPEYSL PVLAFVRKTA QAKRHAVGPV VVHCSAGVGR TGTYIVLDSM
1960 1970 1980 1990 2000
LQQIQHEGTV NIFGFLKHIR SQRNYLVQTE EQYVFIHDTL VEAILSKETE
2010 2020 2030 2040 2050
VPDSHIHSYV NTLLIPGPSG KTKLEKQFQL LSQSNILQSD YSTALKQCNR
2060 2070 2080 2090 2100
EKNRTSSIIP VERSRVGISS LSGEGTDYIN ASYIMGYYQS NEFIITQHPL
2110 2120 2130 2140 2150
LHTIKDFWRM IWDHNAQLVV MIPDGQNMAE DEFVYWPNKD EPINCESFKV
2160 2170 2180 2190 2200
TLMSEEHKCL SNEEKLIVQD FILEATQDDY VLEVRHFQCP KWPNPDSPIS
2210 2220 2230 2240 2250
KTFELISIIK EEAANRDGPM IVHDEHGGVT AGTFCALTTL MHQLEKENSM
2260 2270 2280 2290 2300
DVYQVAKMIN LMRPGVFTDI EQYQFLYKVV LSLVSTRQEE NPSTSLDSNG
2310
AALPDGNIAE SLESLV
Length:2,316
Mass (Da):255,342
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i419EA9B89BDD165F
GO
Isoform 2 (identifier: Q62656-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     763-1615: Missing.

Show »
Length:1,463
Mass (Da):164,596
Checksum:iFF524D7DA90C4BE0
GO
Isoform 3 (identifier: Q62656-3) [UniParc]FASTAAdd to basket
Also known as: Phosphacan

The sequence of this isoform differs from the canonical sequence as follows:
     1616-1616: E → G
     1617-2316: Missing.

Show »
Length:1,616
Mass (Da):175,839
Checksum:i6F02DDE391A41117
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1LMY3F1LMY3_RAT
Protein-tyrosine-phosphatase
Ptprz1
2,316Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_005152763 – 1615Missing in isoform 2. 1 PublicationAdd BLAST853
Alternative sequenceiVSP_0051531616E → G in isoform 3. 1 Publication1
Alternative sequenceiVSP_0051541617 – 2316Missing in isoform 3. 1 PublicationAdd BLAST700

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U09357 mRNA Translation: AAC52207.1
U04998 mRNA Translation: AAC52383.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A40169

NCBI Reference Sequences

More...
RefSeqi
NP_001164156.1, NM_001170685.1
NP_037212.2, NM_013080.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25613

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:25613

UCSC genome browser

More...
UCSCi
RGD:3455, rat [Q62656-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09357 mRNA Translation: AAC52207.1
U04998 mRNA Translation: AAC52383.1
PIRiA40169
RefSeqiNP_001164156.1, NM_001170685.1
NP_037212.2, NM_013080.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6J6UX-ray3.32A/B1699-2316[»]
SMRiQ62656
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi247642, 12 interactors
DIPiDIP-59715N
IntActiQ62656, 1 interactor
STRINGi10116.ENSRNOP00000008719

PTM databases

GlyGeniQ62656, 22 sites
iPTMnetiQ62656
PhosphoSitePlusiQ62656
SwissPalmiQ62656

Proteomic databases

PaxDbiQ62656
PRIDEiQ62656

Genome annotation databases

GeneIDi25613
KEGGirno:25613
UCSCiRGD:3455, rat [Q62656-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5803
RGDi3455, Ptprz1

Phylogenomic databases

eggNOGiKOG0789, Eukaryota
InParanoidiQ62656
OrthoDBi251520at2759
PhylomeDBiQ62656

Enzyme and pathway databases

ReactomeiR-RNO-449836, Other interleukin signaling

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q62656

Family and domain databases

CDDicd03122, alpha_CARP_receptor_like, 1 hit
cd00063, FN3, 1 hit
Gene3Di2.60.40.10, 1 hit
3.10.200.10, 1 hit
3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR041887, Alpha_CARP_receptor-type
IPR001148, CA_dom
IPR036398, CA_dom_sf
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
IPR029021, Prot-tyrosine_phosphatase-like
IPR000242, PTPase_domain
IPR016130, Tyr_Pase_AS
IPR003595, Tyr_Pase_cat
IPR000387, TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00194, Carb_anhydrase, 1 hit
PF00041, fn3, 1 hit
PF00102, Y_phosphatase, 2 hits
PRINTSiPR00700, PRTYPHPHTASE
SMARTiView protein in SMART
SM01057, Carb_anhydrase, 1 hit
SM00060, FN3, 1 hit
SM00194, PTPc, 2 hits
SM00404, PTPc_motif, 2 hits
SUPFAMiSSF49265, SSF49265, 1 hit
SSF51069, SSF51069, 1 hit
SSF52799, SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS51144, ALPHA_CA_2, 1 hit
PS50853, FN3, 1 hit
PS00383, TYR_PHOSPHATASE_1, 1 hit
PS50056, TYR_PHOSPHATASE_2, 2 hits
PS50055, TYR_PHOSPHATASE_PTP, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTPRZ_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q62656
Secondary accession number(s): Q62621
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: June 2, 2021
This is version 175 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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