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Protein

Neuronatin

Gene

Nnat

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system.

GO - Biological processi

  • brain development Source: RGD
  • neuron differentiation Source: RGD
  • positive regulation of insulin secretion Source: GO_Central

Keywordsi

Molecular functionDevelopmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronatin
Gene namesi
Name:Nnat
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi620155 Nnat

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000968841 – 81NeuronatinAdd BLAST81

Proteomic databases

PaxDbiQ62649
PRIDEiQ62649

Expressioni

Tissue specificityi

Brain.

Developmental stagei

Appears in the mid embryonic period and becomes abundant at E16-19. Postnatally its expression decline and only minimal levels were present in adulthood.

Gene expression databases

BgeeiENSRNOG00000024923 Expressed in 10 organ(s), highest expression level in brain
GenevisibleiQ62649 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064325

Structurei

3D structure databases

SMRiQ62649
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the neuronatin family.Curated

Phylogenomic databases

eggNOGiENOG410JDHY Eukaryota
ENOG41117T6 LUCA
GeneTreeiENSGT00390000007412
HOGENOMiHOG000185187
HOVERGENiHBG001605
InParanoidiQ62649
OMAiMGERRQR
OrthoDBiEOG091G1AP2
PhylomeDBiQ62649

Family and domain databases

InterProiView protein in InterPro
IPR024885 Neuronatin
PANTHERiPTHR15285 PTHR15285, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform Alpha (identifier: Q62649-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAVAAASAE LLIIGWYIFR VLLQVFLECC IYWVGFAFRN PPGTQPIARS
60 70 80
EVFRYSLQKL AHTVSRTGRQ VLGERRHRAP N
Length:81
Mass (Da):9,220
Last modified:November 1, 1996 - v1
Checksum:i067086DB1D7E3D20
GO
Isoform Beta (identifier: Q62649-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-51: Missing.

Show »
Length:54
Mass (Da):6,136
Checksum:i184E7C8A39406C87
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00433425 – 51Missing in isoform Beta. 3 PublicationsAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08290 mRNA Translation: AAA92998.1
U09785 mRNA Translation: AAA92999.1
BC127473 mRNA Translation: AAI27474.1
PIRiI60594
JC2325
RefSeqiNP_001257796.1, NM_001270867.1
NP_446053.1, NM_053601.2 [Q62649-1]
NP_859015.1, NM_181687.2 [Q62649-2]
UniGeneiRn.5785

Genome annotation databases

EnsembliENSRNOT00000034166; ENSRNOP00000034212; ENSRNOG00000024923 [Q62649-2]
ENSRNOT00000072502; ENSRNOP00000064325; ENSRNOG00000024923 [Q62649-1]
GeneIDi94270
KEGGirno:94270
UCSCiRGD:620155 rat [Q62649-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08290 mRNA Translation: AAA92998.1
U09785 mRNA Translation: AAA92999.1
BC127473 mRNA Translation: AAI27474.1
PIRiI60594
JC2325
RefSeqiNP_001257796.1, NM_001270867.1
NP_446053.1, NM_053601.2 [Q62649-1]
NP_859015.1, NM_181687.2 [Q62649-2]
UniGeneiRn.5785

3D structure databases

SMRiQ62649
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064325

Proteomic databases

PaxDbiQ62649
PRIDEiQ62649

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000034166; ENSRNOP00000034212; ENSRNOG00000024923 [Q62649-2]
ENSRNOT00000072502; ENSRNOP00000064325; ENSRNOG00000024923 [Q62649-1]
GeneIDi94270
KEGGirno:94270
UCSCiRGD:620155 rat [Q62649-1]

Organism-specific databases

CTDi4826
RGDi620155 Nnat

Phylogenomic databases

eggNOGiENOG410JDHY Eukaryota
ENOG41117T6 LUCA
GeneTreeiENSGT00390000007412
HOGENOMiHOG000185187
HOVERGENiHBG001605
InParanoidiQ62649
OMAiMGERRQR
OrthoDBiEOG091G1AP2
PhylomeDBiQ62649

Miscellaneous databases

PROiPR:Q62649

Gene expression databases

BgeeiENSRNOG00000024923 Expressed in 10 organ(s), highest expression level in brain
GenevisibleiQ62649 RN

Family and domain databases

InterProiView protein in InterPro
IPR024885 Neuronatin
PANTHERiPTHR15285 PTHR15285, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNNAT_RAT
AccessioniPrimary (citable) accession number: Q62649
Secondary accession number(s): A0JPK6, Q62663
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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