UniProtKB - Q62635 (MUC2_RAT)
Protein
Mucin-2
Gene
Muc2
Organism
Rattus norvegicus (Rat)
Status
Functioni
Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer (By similarity).By similarity
GO - Molecular functioni
- identical protein binding Source: RGD
GO - Biological processi
- apoptotic process Source: RGD
- cellular response to tumor necrosis factor Source: RGD
- epithelial cell development Source: RGD
- maintenance of gastrointestinal epithelium Source: RGD
- negative regulation of cell migration Source: RGD
- negative regulation of cell population proliferation Source: RGD
- positive regulation of apoptotic process Source: RGD
- response to hormone Source: RGD
- response to lipopolysaccharide Source: RGD
- response to transforming growth factor beta Source: RGD
- response to vitamin A Source: RGD
Protein family/group databases
MEROPSi | I08.954 |
Names & Taxonomyi
Protein namesi | Recommended name: Mucin-2Short name: MUC-2 Alternative name(s): Intestinal mucin-2 |
Gene namesi | Name:Muc2 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3123, Muc2 |
Subcellular locationi
Extracellular region or secreted
Note: In the intestine, secreted into the inner and outer mucus layers.By similarity
Extracellular region or secreted
- extracellular matrix Source: RGD
- extracellular space Source: GO_Central
- inner mucus layer Source: UniProtKB
- mucus layer Source: RGD
- outer mucus layer Source: UniProtKB
Nucleus
- nucleus Source: RGD
Other locations
- cytoplasm Source: RGD
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000019282 | 21 – ›1513 | Mucin-2Add BLAST | ›1493 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 160 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 420 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 667 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 767 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 837 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 892 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1136 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1151 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1212 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1227 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1243 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1350 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
O-glycosylated.By similarity
May undergo proteolytic cleavage in the outer mucus layer of the colon, contributing to the expanded volume and loose nature of this layer which allows for bacterial colonization in contrast to the inner mucus layer which is dense and devoid of bacteria.By similarity
May undergo autocatalytic cleavage in vivo triggered by the low pH of the late secretory pathway.By similarity
Keywords - PTMi
Autocatalytic cleavage, Disulfide bond, GlycoproteinProteomic databases
PRIDEi | Q62635 |
PTM databases
GlyConnecti | 380, 63 O-Linked glycans 381, 28 O-Linked glycans |
GlyGeni | Q62635, 12 sites |
Expressioni
Tissue specificityi
Expressed in intestine and airway.
Interactioni
Subunit structurei
Homotrimer; disulfide-linked. Dimerizes in the endoplasmic reticulum via its C-terminal region and polymerizes via its N-terminal region by disulfide-linked trimerization.
Interacts with FCGBP (By similarity).
Interacts with AGR2; disulfide-linked (By similarity).
By similarityGO - Molecular functioni
- identical protein binding Source: RGD
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 33 – 237 | VWFD 1PROSITE-ProRule annotationAdd BLAST | 205 | |
Domaini | 292 – 348 | TILAdd BLAST | 57 | |
Domaini | 350 – 410 | VWFCAdd BLAST | 61 | |
Domaini | 387 – 601 | VWFD 2PROSITE-ProRule annotationAdd BLAST | 215 | |
Domaini | 857 – 1062 | VWFD 3PROSITE-ProRule annotationAdd BLAST | 206 | |
Repeati | 1392 – 1407 | 1Add BLAST | 16 | |
Repeati | 1408 – 1423 | 2Add BLAST | 16 | |
Repeati | 1424 – 1434 | 3Add BLAST | 11 | |
Repeati | 1435 – 1445 | 4Add BLAST | 11 | |
Repeati | 1446 – 1456 | 5Add BLAST | 11 | |
Repeati | 1457 – 1467 | 6Add BLAST | 11 | |
Repeati | 1468 – 1478 | 7Add BLAST | 11 | |
Repeati | 1479 – 1489 | 8Add BLAST | 11 | |
Repeati | 1490 – 1500 | 9Add BLAST | 11 | |
Repeati | 1501 – 1511 | 10Add BLAST | 11 | |
Repeati | 1512 – ›1513 | 11 | ›2 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1392 – ›1513 | Approximate repeatsAdd BLAST | ›122 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1257 – 1292 | Thr-richAdd BLAST | 36 | |
Compositional biasi | 1389 – 1512 | Ser-richAdd BLAST | 124 |
Keywords - Domaini
Repeat, SignalPhylogenomic databases
InParanoidi | Q62635 |
PhylomeDBi | Q62635 |
Family and domain databases
InterProi | View protein in InterPro IPR028580, MUC2 IPR036084, Ser_inhib-like_sf IPR002919, TIL_dom IPR014853, Unchr_dom_Cys-rich IPR001007, VWF_dom IPR001846, VWF_type-D IPR025155, WxxW_domain |
PANTHERi | PTHR11339:SF261, PTHR11339:SF261, 1 hit |
Pfami | View protein in Pfam PF08742, C8, 3 hits PF13330, Mucin2_WxxW, 1 hit PF01826, TIL, 1 hit PF00094, VWD, 3 hits |
SMARTi | View protein in SMART SM00832, C8, 3 hits SM00215, VWC_out, 2 hits SM00216, VWD, 3 hits |
SUPFAMi | SSF57567, SSF57567, 3 hits |
PROSITEi | View protein in PROSITE PS51233, VWFD, 3 hits |
i Sequence
Sequence statusi: Fragment.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q62635-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGLPLARLVA VCLVLALAKG LELQKEARSR NHVCSTWGDF HYKTFDGDVF
60 70 80 90 100
RFPGLCDYNF ASDCRDSYKE FAVHLKRGLD KAGGHSSIES VLITIKDDTI
110 120 130 140 150
YLTHKLAVVN GAMVSTPHYS SGLLIEKNDA YTKVYSRAGL SLMWNREDAL
160 170 180 190 200
MVELDGRFQN HTCGLCGDFN GMQANNEFLS DGIRFSAIEF GNMQKINKPE
210 220 230 240 250
VVCEDPEEVQ EPESCSEHRA ECERLLTSTA FEDCQARVPV ELYVLACMHD
260 270 280 290 300
RCQCPQGGAC ECSTLAEFSR QCSHAGGRPE NWRTASLCPK KCPGNMVYLE
310 320 330 340 350
SGSPWLDTCS HLEVSSLCEE HYMDGCFCPE GTVYDDITGS GCIPVSQCHC
360 370 380 390 400
KLHGHLYMPG QEITNDCEQC VCNAGRWMCK DLPCPETCAL EGGSHITTFD
410 420 430 440 450
GKKFTFHGDC YYVLTKTKYN DSYALLGELA SCGSTDKQTC LKTVVLLTDN
460 470 480 490 500
KKNVVAFKSG GSVLLNEMEV SLPHVAASFS IFKPSSYHIV VNTMFGLRLQ
510 520 530 540 550
IQLVPVMQLF VTLDQSAQGQ VQGLCGNFNG LESDDFMTSG GMVEATGAGF
560 570 580 590 600
ANTWKAQSSC HDKLDWLDDP CPLNIESANY AEHWCSLLKR SETPFARCHL
610 620 630 640 650
AVDPTEYYKR CKYDTCNCQN NEDCMCAALS SYARACAAKG VMLWGWRESV
660 670 680 690 700
CNKDVHACPS SQIFMYNLTT CQQTCRSISE GDTHCLKGFA PVEGCGCPDH
710 720 730 740 750
TFMDEKGRCV PLSKCSCYHH GLYLEAGDVI LRQEERCICR NGRLQCTQVK
760 770 780 790 800
LIGHTCLSPQ ILVDCNNLTA LAIREPRPTS CQTLVARYYH TECISGCVCP
810 820 830 840 850
DGLLDNGRGG CVVEDECPCI HNKQFYDSGK SIKLDCNNTC TCQKGRWECT
860 870 880 890 900
RYACHSTCSI YGSGHYITFD GKHYDFDGHC SYVAVQDYCG QNSTGSFSII
910 920 930 940 950
TENVPCGTTG VTCSKAIKIF IGGTELKLVD KHRVVKQLEE GHHVPFITRE
960 970 980 990 1000
VGLYLVVEVS SGIIVIWDKK TTIFIKLDPS YKGNVCGLCG NFDDQTKNDF
1010 1020 1030 1040 1050
TTRDHMVVAS ELDFGNSWKE ASTCPDVSHN PDPCSLNPHR RSWAEKQCSI
1060 1070 1080 1090 1100
IKSDVFLACH GKVDPTVFYD ACVHDSCSCD TGGDCECFCS AVASYAQECT
1110 1120 1130 1140 1150
KAEACVFWRT PDLCPVFCDY YNPPDECEWH YEPCGNRSFE TCRTLNGIHS
1160 1170 1180 1190 1200
NISVSYLEGC YPRCPEDRPI YDEDLKKCVS GDKCGCYIED TRYPPGGSVP
1210 1220 1230 1240 1250
TDEICMSCTC TNTSEIICRP DEGKIINQTQ DGIFCYWETC GSNGTVEKHF
1260 1270 1280 1290 1300
EICVSSTLSP TSMTSFTTTS TPISTTPIST TITTTSATAT TTVPCCFWSD
1310 1320 1330 1340 1350
WINNNHPTSG NGGDRENFEH VCSAPENIEC RAATDPKLDW TELGQKVQCN
1360 1370 1380 1390 1400
VSEGLICNNE DQYGTGQFEL CYDYEIRVNC CFPMEYCLST VSPTTSTPIS
1410 1420 1430 1440 1450
STPQPTSSPT TLPTTSPLTS SATSPTTSHI TSTVSPTTSP TTSTTSPTTS
1460 1470 1480 1490 1500
PTTSTTSPTT STTSPTPSPT TSTTSPTPSP TTSTTSPTPS PTTSTTSPTT
1510
SPITSPTTST TSP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1513 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U07615 mRNA Translation: AAA21655.2 |
PIRi | A54895 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U07615 mRNA Translation: AAA21655.2 |
PIRi | A54895 |
3D structure databases
SMRi | Q62635 |
ModBasei | Search... |
Protein family/group databases
MEROPSi | I08.954 |
PTM databases
GlyConnecti | 380, 63 O-Linked glycans 381, 28 O-Linked glycans |
GlyGeni | Q62635, 12 sites |
Proteomic databases
PRIDEi | Q62635 |
Organism-specific databases
RGDi | 3123, Muc2 |
Phylogenomic databases
InParanoidi | Q62635 |
PhylomeDBi | Q62635 |
Family and domain databases
InterProi | View protein in InterPro IPR028580, MUC2 IPR036084, Ser_inhib-like_sf IPR002919, TIL_dom IPR014853, Unchr_dom_Cys-rich IPR001007, VWF_dom IPR001846, VWF_type-D IPR025155, WxxW_domain |
PANTHERi | PTHR11339:SF261, PTHR11339:SF261, 1 hit |
Pfami | View protein in Pfam PF08742, C8, 3 hits PF13330, Mucin2_WxxW, 1 hit PF01826, TIL, 1 hit PF00094, VWD, 3 hits |
SMARTi | View protein in SMART SM00832, C8, 3 hits SM00215, VWC_out, 2 hits SM00216, VWD, 3 hits |
SUPFAMi | SSF57567, SSF57567, 3 hits |
PROSITEi | View protein in PROSITE PS51233, VWFD, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MUC2_RAT | |
Accessioni | Q62635Primary (citable) accession number: Q62635 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 17, 2003 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 105 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |