UniProtKB - Q62627 (PAWR_RAT)
PRKC apoptosis WT1 regulator protein
Pawr
Functioni
GO - Molecular functioni
- actin binding Source: UniProtKB
- enzyme binding Source: RGD
- leucine zipper domain binding Source: RGD
- protein kinase C binding Source: RGD
- protein phosphatase 1 binding Source: RGD
GO - Biological processi
- actin filament bundle assembly Source: UniProtKB
- activation of cysteine-type endopeptidase activity Source: RGD
- apoptotic process Source: UniProtKB
- apoptotic signaling pathway Source: RGD
- calcium ion import across plasma membrane Source: RGD
- cellular response to estradiol stimulus Source: RGD
- cellular response to follicle-stimulating hormone stimulus Source: RGD
- cellular response to interleukin-1 Source: RGD
- cellular response to vitamin E Source: RGD
- detection of mechanical stimulus involved in sensory perception of pain Source: RGD
- detection of temperature stimulus involved in sensory perception of pain Source: RGD
- interleukin-2 production Source: RGD
- negative regulation of B cell proliferation Source: RGD
- negative regulation of calcium ion import Source: RGD
- negative regulation of fibroblast proliferation Source: RGD
- negative regulation of gene expression Source: RGD
- negative regulation of T cell proliferation Source: RGD
- negative regulation of T cell receptor signaling pathway Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- positive regulation of action potential Source: RGD
- positive regulation of amyloid precursor protein biosynthetic process Source: RGD
- positive regulation of apoptotic process Source: RGD
- positive regulation of cellular senescence Source: RGD
- positive regulation of gene expression Source: RGD
- positive regulation of hindgut contraction Source: RGD
- positive regulation of hydrogen peroxide-mediated programmed cell death Source: RGD
- positive regulation of leukocyte tethering or rolling Source: RGD
- positive regulation of neuronal action potential Source: RGD
- positive regulation of neuron apoptotic process Source: RGD
- positive regulation of neutrophil extravasation Source: RGD
- positive regulation of phosphoprotein phosphatase activity Source: RGD
- positive regulation of relaxation of smooth muscle Source: RGD
- response to estradiol Source: RGD
- response to iron(II) ion Source: RGD
- response to lipopolysaccharide Source: RGD
- response to wounding Source: RGD
Keywordsi
Biological process | Apoptosis, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: PRKC apoptosis WT1 regulator proteinAlternative name(s): Prostate apoptosis response 4 protein Short name: Par-4 Transcriptional repressor Par-4-like protein PAWR |
Gene namesi | Name:Pawr Synonyms:Par4 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 69065, Pawr |
Subcellular locationi
Nucleus
- Nucleus By similarity
Other locations
- Cytoplasm By similarity
Note: Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis. Nuclear localization includes nucleoplasm and PML nuclear bodies (By similarity).By similarity
Nucleus
- nuclear chromatin Source: RGD
- nucleus Source: RGD
Other locations
- axon Source: RGD
- cytoplasm Source: RGD
- neuron projection Source: RGD
- neuronal cell body Source: RGD
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000058238 | 1 – 332 | PRKC apoptosis WT1 regulator proteinAdd BLAST | 332 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 155 | Phosphothreonine; by PKA1 Publication | 1 | |
Modified residuei | 223 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q62627 |
PRIDEi | Q62627 |
PTM databases
iPTMneti | Q62627 |
PhosphoSitePlusi | Q62627 |
Expressioni
Inductioni
Interactioni
Subunit structurei
Homooligomer.
Interacts (via the C-terminal region) with WT1.
Interacts with THAP1.
Interacts with AATF.
Interacts with BACE1.
Interacts with SPSB1 (via B30.2/SPRY domain); this interaction is direct and occurs in association with the Elongin BC complex.
Interacts with SPSB2 (via B30.2/SPRY domain); this interaction occurs in association with the Elongin BC complex.
Interacts with SPSB4 (via B30.2/SPRY domain); this interaction occurs in association with the Elongin BC complex.
Component of a ternary complex composed of SQSTM1 and PRKCZ (By similarity).
Interacts with actin (PubMed:15817164).
By similarity1 PublicationBinary interactionsi
Hide detailsQ62627
With | #Exp. | IntAct |
---|---|---|
Dapk3 [O88764] | 5 | EBI-1187240,EBI-4404236 |
Tfpt [Q9JMG6] | 8 | EBI-1187240,EBI-1767101 |
HSPA5 [P11021] from Homo sapiens. | 4 | EBI-1187240,EBI-354921 |
GO - Molecular functioni
- actin binding Source: UniProtKB
- enzyme binding Source: RGD
- leucine zipper domain binding Source: RGD
- protein kinase C binding Source: RGD
- protein phosphatase 1 binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 249098, 3 interactors |
IntActi | Q62627, 5 interactors |
STRINGi | 10116.ENSRNOP00000008222 |
Structurei
Secondary structure
3D structure databases
SMRi | Q62627 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 137 – 195 | Selective for apoptosis induction in cancer cells (SAC)Add BLAST | 59 | |
Regioni | 292 – 332 | Leucine-zipperAdd BLAST | 41 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 176 – 198 | Sequence analysisAdd BLAST | 23 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 61 – 65 | B30.2/SPRY domain-binding motifBy similarity | 5 | |
Motifi | 137 – 153 | Nuclear localization signalAdd BLAST | 17 |
Domaini
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QVUF, Eukaryota |
InParanoidi | Q62627 |
OrthoDBi | 1363165at2759 |
PhylomeDBi | Q62627 |
Family and domain databases
DisProti | DP00940 |
InterProi | View protein in InterPro IPR026117, Par-4 |
PANTHERi | PTHR15093, PTHR15093, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MATGGYRSSG STTDFLEEWK AKREKMRAKQ NPVGPGSSGG DPAAKSPAGP
60 70 80 90 100
LAQTTAAGTS ELNHGPAGAA APAAPGPGAL NCAHGSSALP RGAPGSRRPE
110 120 130 140 150
DECPIAAGAA GAPASRGDEE EPDSAPEKGR SSGPSARKGK GQIEKRKLRE
160 170 180 190 200
KRRSTGVVNI PAAECLDEYE DDEAGQKERK REDAITQQNT IQNEAASLPD
210 220 230 240 250
PGTSYLPQDP SRTVPGRYKS TISAPEEEIL NRYPRTDRSG FSRHNRDTSA
260 270 280 290 300
PANFASSSTL EKRIEDLEKE VLRERQENLR LTRLMQDKEE MIGKLKEEID
310 320 330
LLNRDLDDME DENEQLKQEN KTLLKVVGQL TR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V6S1 | G3V6S1_RAT | PRKC apoptosis WT1 regulator protei... | Pawr rCG_49193 | 332 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U05989 mRNA Translation: AAA16492.1 |
RefSeqi | NP_277020.1, NM_033485.2 |
Genome annotation databases
GeneIDi | 64513 |
KEGGi | rno:64513 |
UCSCi | RGD:69065, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U05989 mRNA Translation: AAA16492.1 |
RefSeqi | NP_277020.1, NM_033485.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5FIY | X-ray | 3.00 | A/B/C/D/E/F/G | 240-332 | [»] | |
SMRi | Q62627 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 249098, 3 interactors |
IntActi | Q62627, 5 interactors |
STRINGi | 10116.ENSRNOP00000008222 |
PTM databases
iPTMneti | Q62627 |
PhosphoSitePlusi | Q62627 |
Proteomic databases
PaxDbi | Q62627 |
PRIDEi | Q62627 |
Protocols and materials databases
DNASUi | 64513 |
Genome annotation databases
GeneIDi | 64513 |
KEGGi | rno:64513 |
UCSCi | RGD:69065, rat |
Organism-specific databases
CTDi | 5074 |
RGDi | 69065, Pawr |
Phylogenomic databases
eggNOGi | ENOG502QVUF, Eukaryota |
InParanoidi | Q62627 |
OrthoDBi | 1363165at2759 |
PhylomeDBi | Q62627 |
Miscellaneous databases
PROi | PR:Q62627 |
Family and domain databases
DisProti | DP00940 |
InterProi | View protein in InterPro IPR026117, Par-4 |
PANTHERi | PTHR15093, PTHR15093, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PAWR_RAT | |
Accessioni | Q62627Primary (citable) accession number: Q62627 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 24, 2005 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references