UniProtKB - Q62600 (NOS3_RAT)
Nitric oxide synthase, endothelial
Nos3
Functioni
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
Catalytic activityi
- EC:1.14.13.39
Cofactori
Protein has several cofactor binding sites:- heme
- FADNote: Binds 1 FAD.
- FMNNote: Binds 1 FMN.
- (6R)-L-erythro-5,6,7,8-tetrahydrobiopterinNote: Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme.
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 93 | ZincBy similarity | 1 | |
Metal bindingi | 98 | ZincBy similarity | 1 | |
Metal bindingi | 183 | Iron (heme axial ligand)By similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 648 – 679 | FMNPROSITE-ProRule annotationAdd BLAST | 32 | |
Nucleotide bindingi | 792 – 803 | FADBy similarityAdd BLAST | 12 | |
Nucleotide bindingi | 1009 – 1027 | NADPBy similarityAdd BLAST | 19 | |
Nucleotide bindingi | 1107 – 1122 | NADPBy similarityAdd BLAST | 16 |
GO - Molecular functioni
- actin binding Source: RGD
- actin monomer binding Source: RGD
- arginine binding Source: RGD
- beta-catenin binding Source: RGD
- cadherin binding Source: RGD
- calmodulin binding Source: RGD
- flavin adenine dinucleotide binding Source: GO_Central
- FMN binding Source: GO_Central
- heme binding Source: RGD
- Hsp90 protein binding Source: RGD
- metal ion binding Source: UniProtKB-KW
- NADP binding Source: InterPro
- nitric-oxide synthase activity Source: RGD
- nitric-oxide synthase binding Source: RGD
- oxidoreductase activity Source: GO_Central
- scaffold protein binding Source: RGD
- tetrahydrobiopterin binding Source: RGD
GO - Biological processi
- aging Source: RGD
- angiogenesis Source: RGD
- aortic valve morphogenesis Source: RGD
- arginine catabolic process Source: RGD
- blood vessel diameter maintenance Source: RGD
- blood vessel remodeling Source: RGD
- bone development Source: RGD
- cellular response to cAMP Source: RGD
- cellular response to growth factor stimulus Source: RGD
- cellular response to heat Source: RGD
- cellular response to high density lipoprotein particle stimulus Source: RGD
- cellular response to insulin stimulus Source: RGD
- cellular response to low-density lipoprotein particle stimulus Source: RGD
- cellular response to magnesium ion Source: RGD
- cellular response to mechanical stimulus Source: RGD
- cellular response to organic cyclic compound Source: RGD
- cellular response to rotenone Source: RGD
- cellular response to transforming growth factor beta stimulus Source: RGD
- cellular response to tumor necrosis factor Source: RGD
- endocardial cushion morphogenesis Source: RGD
- endothelial cell migration Source: RGD
- female pregnancy Source: RGD
- homeostasis of number of cells within a tissue Source: RGD
- in utero embryonic development Source: RGD
- lipopolysaccharide-mediated signaling pathway Source: RGD
- lung development Source: RGD
- negative regulation of biomineral tissue development Source: RGD
- negative regulation of blood pressure Source: GO_Central
- negative regulation of calcium ion transport Source: RGD
- negative regulation of cell population proliferation Source: RGD
- negative regulation of hydrolase activity Source: RGD
- negative regulation of muscle hyperplasia Source: RGD
- negative regulation of potassium ion transport Source: RGD
- negative regulation of smooth muscle cell proliferation Source: RGD
- nitric oxide biosynthetic process Source: RGD
- nitric oxide mediated signal transduction Source: GO_Central
- ovulation from ovarian follicle Source: RGD
- positive regulation of angiogenesis Source: RGD
- positive regulation of apoptotic process Source: RGD
- positive regulation of blood vessel endothelial cell migration Source: RGD
- positive regulation of gene expression Source: RGD
- positive regulation of guanylate cyclase activity Source: RGD
- pulmonary valve morphogenesis Source: RGD
- regulation of nervous system process Source: RGD
- regulation of sodium ion transport Source: RGD
- regulation of systemic arterial blood pressure by endothelin Source: RGD
- regulation of the force of heart contraction by chemical signal Source: RGD
- removal of superoxide radicals Source: RGD
- response to activity Source: RGD
- response to amino acid Source: RGD
- response to axon injury Source: RGD
- response to candesartan Source: RGD
- response to carbohydrate Source: RGD
- response to corticosterone Source: RGD
- response to cytokine Source: RGD
- response to erythropoietin Source: RGD
- response to estradiol Source: RGD
- response to ethanol Source: RGD
- response to fluid shear stress Source: RGD
- response to fructose Source: RGD
- response to hormone Source: GO_Central
- response to hyperoxia Source: RGD
- response to hypoxia Source: RGD
- response to ketone Source: RGD
- response to L-arginine Source: RGD
- response to lead ion Source: RGD
- response to lipopolysaccharide Source: RGD
- response to magnetism Source: RGD
- response to mechanical stimulus Source: RGD
- response to mercury ion Source: RGD
- response to metal ion Source: RGD
- response to metformin Source: RGD
- response to nicotine Source: RGD
- response to nutrient levels Source: RGD
- response to organic cyclic compound Source: RGD
- response to peptide Source: RGD
- response to peptide hormone Source: RGD
- response to salt Source: RGD
- response to ultrasound Source: RGD
- response to xenobiotic stimulus Source: RGD
- retina development in camera-type eye Source: RGD
- signal transduction Source: RGD
- smooth muscle hyperplasia Source: RGD
- ventricular septum morphogenesis Source: RGD
Keywordsi
Molecular function | Calmodulin-binding, Oxidoreductase |
Ligand | Calcium, FAD, Flavoprotein, FMN, Heme, Iron, Metal-binding, NADP, Zinc |
Enzyme and pathway databases
BRENDAi | 1.14.13.39, 5301 |
Reactomei | R-RNO-1222556, ROS and RNS production in phagocytes R-RNO-1474151, Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-RNO-203615, eNOS activation R-RNO-203641, NOSTRIN mediated eNOS trafficking R-RNO-203754, NOSIP mediated eNOS trafficking R-RNO-392154, Nitric oxide stimulates guanylate cyclase R-RNO-5218920, VEGFR2 mediated vascular permeability R-RNO-9009391, Extra-nuclear estrogen signaling |
SABIO-RKi | Q62600 |
Names & Taxonomyi
Protein namesi | Recommended name: Nitric oxide synthase, endothelial (EC:1.14.13.39)Alternative name(s): Constitutive NOS Short name: cNOS EC-NOS Endothelial NOS Short name: eNOS NOS type III Short name: NOSIII |
Gene namesi | Name:Nos3 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3186, Nos3 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity
Cytoskeleton
- cytoskeleton By similarity
Golgi apparatus
- Golgi apparatus By similarity
Other locations
- caveola By similarity
Note: Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle, which is favored by interaction with NOSIP and results in a reduced enzymatic activity.By similarity
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Cytosol
- cytosol Source: RGD
Golgi apparatus
- Golgi apparatus Source: RGD
Mitochondrion
- mitochondrion Source: RGD
Nucleus
Plasma Membrane
- caveola Source: RGD
- plasma membrane Source: RGD
- sarcolemma Source: RGD
Other locations
- apical part of cell Source: RGD
- cytoplasm Source: BHF-UCL
- membrane raft Source: RGD
- vesicle membrane Source: RGD
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Cytoskeleton, Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000170946 | 2 – 1202 | Nitric oxide synthase, endothelialAdd BLAST | 1201 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 2 | N-myristoyl glycineBy similarity | 1 | |
Lipidationi | 15 | S-palmitoyl cysteineBy similarity | 1 | |
Lipidationi | 26 | S-palmitoyl cysteineBy similarity | 1 | |
Modified residuei | 494 | Phosphothreonine; by AMPK1 Publication | 1 | |
Modified residuei | 614 | PhosphoserineBy similarity | 1 | |
Modified residuei | 632 | PhosphoserineBy similarity | 1 | |
Modified residuei | 637 | PhosphoserineBy similarity | 1 | |
Modified residuei | 835 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1174 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1176 | Phosphoserine; by AMPKCombined sources1 Publication | 1 | |
Modified residuei | 1178 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Lipoprotein, Myristate, Palmitate, PhosphoproteinProteomic databases
PaxDbi | Q62600 |
PRIDEi | Q62600 |
PTM databases
iPTMneti | Q62600 |
PhosphoSitePlusi | Q62600 |
SwissPalmi | Q62600 |
Expressioni
Tissue specificityi
Developmental stagei
Interactioni
Subunit structurei
Homodimer.
Interacts with NOSIP and NOSTRIN (By similarity).
Interacts with HSP90AB1 (By similarity).
Forms a complex with ASL, ASS1 and SLC7A1; the complex regulates cell-autonomous L-arginine synthesis and citrulline recycling while channeling extracellular L-arginine to nitric oxide synthesis pathway (By similarity).
By similarityBinary interactionsi
Q62600
With | #Exp. | IntAct |
---|---|---|
CALM [P62157] from Bos taurus. | 2 | EBI-7052018,EBI-397403 |
GO - Molecular functioni
- actin binding Source: RGD
- actin monomer binding Source: RGD
- beta-catenin binding Source: RGD
- cadherin binding Source: RGD
- calmodulin binding Source: RGD
- Hsp90 protein binding Source: RGD
- nitric-oxide synthase binding Source: RGD
- scaffold protein binding Source: RGD
Protein-protein interaction databases
CORUMi | Q62600 |
DIPi | DIP-41833N |
IntActi | Q62600, 2 interactors |
MINTi | Q62600 |
STRINGi | 10116.ENSRNOP00000013058 |
Chemistry databases
BindingDBi | Q62600 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 519 – 702 | Flavodoxin-likePROSITE-ProRule annotationAdd BLAST | 184 | |
Domaini | 755 – 1001 | FAD-binding FR-typePROSITE-ProRule annotationAdd BLAST | 247 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 70 | DisorderedSequence analysisAdd BLAST | 70 | |
Regioni | 97 – 485 | Interaction with NOSIPBy similarityAdd BLAST | 389 | |
Regioni | 489 – 509 | Calmodulin-bindingSequence analysisAdd BLAST | 21 | |
Regioni | 817 – 843 | DisorderedSequence analysisAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 35 – 64 | Pro residuesSequence analysisAdd BLAST | 30 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1158, Eukaryota |
InParanoidi | Q62600 |
OrthoDBi | 90349at2759 |
PhylomeDBi | Q62600 |
Family and domain databases
Gene3Di | 1.20.990.10, 1 hit 3.40.50.360, 1 hit 3.40.50.80, 1 hit 3.90.1230.10, 1 hit 3.90.340.10, 1 hit 3.90.440.10, 1 hit |
InterProi | View protein in InterPro IPR003097, CysJ-like_FAD-binding IPR017927, FAD-bd_FR_type IPR001094, Flavdoxin-like IPR008254, Flavodoxin/NO_synth IPR001709, Flavoprot_Pyr_Nucl_cyt_Rdtase IPR029039, Flavoprotein-like_sf IPR039261, FNR_nucleotide-bd IPR023173, NADPH_Cyt_P450_Rdtase_alpha IPR044943, NOS_dom_1 IPR044940, NOS_dom_2 IPR044944, NOS_dom_3 IPR012144, NOS_euk IPR004030, NOS_N IPR036119, NOS_N_sf IPR001433, OxRdtase_FAD/NAD-bd IPR017938, Riboflavin_synthase-like_b-brl |
Pfami | View protein in Pfam PF00667, FAD_binding_1, 1 hit PF00258, Flavodoxin_1, 1 hit PF00175, NAD_binding_1, 1 hit PF02898, NO_synthase, 1 hit |
PIRSFi | PIRSF000333, NOS, 1 hit |
PRINTSi | PR00369, FLAVODOXIN PR00371, FPNCR |
SUPFAMi | SSF52218, SSF52218, 1 hit SSF52343, SSF52343, 1 hit SSF56512, SSF56512, 1 hit SSF63380, SSF63380, 1 hit |
PROSITEi | View protein in PROSITE PS51384, FAD_FR, 1 hit PS50902, FLAVODOXIN_LIKE, 1 hit PS60001, NOS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MGNLKSVGQE PGPPCGLGLG LGLGLCGKQG PASPAPEPSQ APVPPSPTRP
60 70 80 90 100
APDHSPPLTR PPDGPKFPRV KNWEVGSITY DTLSAQAQQD GPCTPRRCLG
110 120 130 140 150
SLVFPRKLQS RPTQGPSPTE QLLGQARDFI NQYYNSIKRS GSQAHEQRLQ
160 170 180 190 200
EVEAEVVATG TYQLRESELV FGAKQAWRNA PRCVGRIQWG KLQVFDARDC
210 220 230 240 250
RTAQEMFTYI CNHIKYATNR GNLRSAITVF PQRYAGRGDF RIWNSQLVRY
260 270 280 290 300
AGYRQQDGSV RGDPANVEIT ELCIQHGWTP GNGRFDVLPL LLQAPDEPPE
310 320 330 340 350
LFTLPPELVL EVPLEHPTLE WFAALGLRWY ALPAVSNMLL EIGGLEFPAA
360 370 380 390 400
PFSGWYMSSE IGMRDLCDPH RYNILEDVAV CMDLDTRTTS SLWKDKAAVE
410 420 430 440 450
INVAVLYSYQ LAKVTIVDHH AATASFMKHL ENEQKARGGC PADWAWIVPP
460 470 480 490 500
ISGSLTPVFH QEMVNYFLSP AFRYQPDPWK GSAAKGTGIT RKKTFKEVAN
510 520 530 540 550
AVKISASLMG TVMAKRVKAT ILYGSETGRA QSYAQQLGRL FRKAFDPRVL
560 570 580 590 600
CMDEYDVVSL EHEALVLVVT STFGNGDPPE NGESFAAALM EMSGPYNSSP
610 620 630 640 650
RPEQHKSYKI RFNSVSCSDP LVSSWRRKRK ESSNTDSAGA LGTLRFCVFG
660 670 680 690 700
LGSRAYPHFC AFARAVDTRL EELGGERLLQ LGQGDELCGQ EEAFRGWAQA
710 720 730 740 750
AFQAACETFC VGEDAKAAAR DIFSPKRSWK RQRYRLSTQA ESLQLLPRLT
760 770 780 790 800
HVHRRKMFQA TILSVENLQS SKSTRATILV RLDTGSQEGL QYQPGDHIGV
810 820 830 840 850
CPPNRPGLVE ALLSRVEDPP PSTEPVAVEQ LEKGSPGGPP PGWVRDPRLP
860 870 880 890 900
PCTLRQALTY FLDITSPPSP RLLRLLSTLA EESSEQQELE ALSQDPRRYE
910 920 930 940 950
EWKWFRCPTL LEVLEQFPSV ALPAPLILTQ LPLLQPRYYS VSSAPSAHPG
960 970 980 990 1000
EIHLTVAVLA YRTQDGLGPL HYGVCSTWMS QLKAGDPVPC FIRGAPSFRL
1010 1020 1030 1040 1050
PPDPNLPCIL VGPGTGIAPF RGFWQDRLHD IEIKGLQPAP MTLVFGCRCS
1060 1070 1080 1090 1100
QLDHLYRDEV LDAQQRGVFG QVLTAFSRDP GSPKTYVQDL LRTELAAEVH
1110 1120 1130 1140 1150
RVLCLEQGHM FVCGDVTMAT SVLQTVQRIL ATEGSMELDE AGDVIGVLRD
1160 1170 1180 1190 1200
QQRYHEDIFG LTLRTQEVTS RIRTQSFSLQ ERQLRGAVPW SFDPPTQETP
GS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF1LQC7 | F1LQC7_RAT | Nitric oxide synthase | Nos3 | 1,106 | Annotation score: | ||
A0A8I6A2Y1 | A0A8I6A2Y1_RAT | Nitric oxide synthase, endothelial | Nos3 | 1,202 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 232 – 233 | QR → PS in AAC34677 (Ref. 2) Curated | 2 | |
Sequence conflicti | 249 | R → S in AAC34677 (Ref. 2) Curated | 1 | |
Sequence conflicti | 298 – 304 | Missing in AAT99567 (PubMed:15808839).Curated | 7 | |
Sequence conflicti | 600 | P → L in CAA09493 (Ref. 4) Curated | 1 | |
Sequence conflicti | 735 | R → G in AAT99567 (PubMed:15808839).Curated | 1 | |
Sequence conflicti | 739 | Q → P in AAT99567 (PubMed:15808839).Curated | 1 | |
Sequence conflicti | 748 | R → G in BAD15356 (PubMed:15105416).Curated | 1 | |
Sequence conflicti | 771 | S → T in AAT99567 (PubMed:15808839).Curated | 1 | |
Sequence conflicti | 852 – 854 | CTL → GTV in AAA96141 (PubMed:7527874).Curated | 3 | |
Sequence conflicti | 966 | G → V in BAD15356 (PubMed:15105416).Curated | 1 | |
Sequence conflicti | 997 – 998 | SF → FL in AAT99567 (PubMed:15808839).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB176831 mRNA Translation: BAD15356.1 AF085195 mRNA Translation: AAC34677.1 AY695391 mRNA Translation: AAT99567.1 AJ011115 mRNA Translation: CAA09493.1 AJ011116 mRNA Translation: CAA09494.1 U02534 mRNA Translation: AAA96141.1 AF093837 mRNA Translation: AAC64178.1 U18336 mRNA Translation: AAC52188.1 |
PIRi | I51917 I56979 |
RefSeqi | NP_068610.1, NM_021838.2 |
Genome annotation databases
GeneIDi | 24600 |
KEGGi | rno:24600 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB176831 mRNA Translation: BAD15356.1 AF085195 mRNA Translation: AAC34677.1 AY695391 mRNA Translation: AAT99567.1 AJ011115 mRNA Translation: CAA09493.1 AJ011116 mRNA Translation: CAA09494.1 U02534 mRNA Translation: AAA96141.1 AF093837 mRNA Translation: AAC64178.1 U18336 mRNA Translation: AAC52188.1 |
PIRi | I51917 I56979 |
RefSeqi | NP_068610.1, NM_021838.2 |
3D structure databases
AlphaFoldDBi | Q62600 |
BMRBi | Q62600 |
SMRi | Q62600 |
ModBasei | Search... |
Protein-protein interaction databases
CORUMi | Q62600 |
DIPi | DIP-41833N |
IntActi | Q62600, 2 interactors |
MINTi | Q62600 |
STRINGi | 10116.ENSRNOP00000013058 |
Chemistry databases
BindingDBi | Q62600 |
ChEMBLi | CHEMBL1075230 |
PTM databases
iPTMneti | Q62600 |
PhosphoSitePlusi | Q62600 |
SwissPalmi | Q62600 |
Proteomic databases
PaxDbi | Q62600 |
PRIDEi | Q62600 |
Genome annotation databases
GeneIDi | 24600 |
KEGGi | rno:24600 |
Organism-specific databases
CTDi | 4846 |
RGDi | 3186, Nos3 |
Phylogenomic databases
eggNOGi | KOG1158, Eukaryota |
InParanoidi | Q62600 |
OrthoDBi | 90349at2759 |
PhylomeDBi | Q62600 |
Enzyme and pathway databases
BRENDAi | 1.14.13.39, 5301 |
Reactomei | R-RNO-1222556, ROS and RNS production in phagocytes R-RNO-1474151, Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-RNO-203615, eNOS activation R-RNO-203641, NOSTRIN mediated eNOS trafficking R-RNO-203754, NOSIP mediated eNOS trafficking R-RNO-392154, Nitric oxide stimulates guanylate cyclase R-RNO-5218920, VEGFR2 mediated vascular permeability R-RNO-9009391, Extra-nuclear estrogen signaling |
SABIO-RKi | Q62600 |
Miscellaneous databases
PROi | PR:Q62600 |
Family and domain databases
Gene3Di | 1.20.990.10, 1 hit 3.40.50.360, 1 hit 3.40.50.80, 1 hit 3.90.1230.10, 1 hit 3.90.340.10, 1 hit 3.90.440.10, 1 hit |
InterProi | View protein in InterPro IPR003097, CysJ-like_FAD-binding IPR017927, FAD-bd_FR_type IPR001094, Flavdoxin-like IPR008254, Flavodoxin/NO_synth IPR001709, Flavoprot_Pyr_Nucl_cyt_Rdtase IPR029039, Flavoprotein-like_sf IPR039261, FNR_nucleotide-bd IPR023173, NADPH_Cyt_P450_Rdtase_alpha IPR044943, NOS_dom_1 IPR044940, NOS_dom_2 IPR044944, NOS_dom_3 IPR012144, NOS_euk IPR004030, NOS_N IPR036119, NOS_N_sf IPR001433, OxRdtase_FAD/NAD-bd IPR017938, Riboflavin_synthase-like_b-brl |
Pfami | View protein in Pfam PF00667, FAD_binding_1, 1 hit PF00258, Flavodoxin_1, 1 hit PF00175, NAD_binding_1, 1 hit PF02898, NO_synthase, 1 hit |
PIRSFi | PIRSF000333, NOS, 1 hit |
PRINTSi | PR00369, FLAVODOXIN PR00371, FPNCR |
SUPFAMi | SSF52218, SSF52218, 1 hit SSF52343, SSF52343, 1 hit SSF56512, SSF56512, 1 hit SSF63380, SSF63380, 1 hit |
PROSITEi | View protein in PROSITE PS51384, FAD_FR, 1 hit PS50902, FLAVODOXIN_LIKE, 1 hit PS60001, NOS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NOS3_RAT | |
Accessioni | Q62600Primary (citable) accession number: Q62600 Secondary accession number(s): O88672 Q75NE4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 188 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families