UniProtKB - Q62599 (MTA1_RAT)

BLAST

>sp|Q62599|MTA1_RAT Metastasis-associated protein MTA1 OS=Rattus norvegicus OX=10116 GN=Mta1 PE=1 SV=1
MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTANGNVEAKVVCFYRRRDISSSLIALAD
KHATLSVCYRAGPGADTGEEGEVEEEVENPEMVDLPEKLKHQLRHRELFLSRQLESLPAT
HIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKTLLADKGEIRVGNRYQADITDL
LKDGEEDGRDQSKLETKVWEAHNPLVDKQIDQFLVVARSVGTFARALDCSSSVRQPSLHM
SAAAASRDITLFHAMDTLHKNIYDISKAISALVPQGGPVLCRDEMEEWSASEANLFEEAL
EKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPNYN
KPNPNQISVNSVKASVVNGTGTPGQSPGAGRACESCYTTQSYQWYSWGPPNMQCRLCASC
WTYWKKYGGLKMPTRLDGERPGPNRNNMSPHGIPARSSGSPKFAMKTRQAFYLHTTKLTR
IARRLCREILRPWHAARHPYMPINSAAIKAECTARLPEASQSPLVLKQVVRKPLEAVLRY
LETHPRPPKPDPVKSSSSVLSSLTPAKSAPVINNGSPTILGKRSYEQHNGVDGLANHGQT
RHMGPSRNLLLNGKSYPTKVRLIRGGSLPPVKRRRMNWIDAPDDVFYMATEETRKIRKLL
SSSETKRAARRPYKPIALRQSQALPLRPPPPAPVNDEPIVIED

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History
Entry version 153 (07 Nov 2018)
Sequence version 1 (01 Nov 1996)
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Protein

Metastasis-associated protein MTA1

Gene

Mta1

Organism

Rattus norvegicus (Rat)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator. As a part of the histone-deacetylase multiprotein complex (NuRD), regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA. In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A. Acts as a transcriptional coactivator of BCAS3, PAX5 and SUMO2, independent of the NuRD complex. Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3. Regulates p53-dependent and -independent DNA repair processes following genotoxic stress. Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair. Plays an important role in tumorigenesis, tumor invasion, and metastasis. Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles. Positively regulates the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1. Regulates deacetylation of ARNTL/BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (By similarity). Isoform 2 may be involved in the sorting of amylase during zymogen granule formation in the pancreas. With Tfcp2l1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity).By similarity1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	393 – 420	GATA-type; atypicalAdd BLAST		28

GO - Molecular functionⁱ

chromatin binding Source: InterPro
enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10933808
histone deacetylase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II distal enhancer sequence-specific DNA binding Source: UniProtKB
RNA polymerase II repressing transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription coactivator activity Source: UniProtKB
transcription corepressor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

circadian regulation of gene expression Source: UniProtKB
double-strand break repair Source: UniProtKB
entrainment of circadian clock by photoperiod Source: UniProtKB
female pregnancy
Source: RGD
Inferred from expression patternⁱ
- 25217305
histone deacetylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
locomotor rhythm Source: UniProtKB
negative regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of protein autoubiquitination Source: UniProtKB
proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
regulation of gene expression, epigenetic Source: UniProtKB
response to ionizing radiation Source: UniProtKB
secretory granule organization
Source: UniProtKB
Inferred from direct assayⁱ
- 10933808

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Repressor
Biological process	Biological rhythms, Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Metastasis-associated protein MTA1
Gene namesⁱ	Name:Mta1 Synonyms:Zg29
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Unplaced

Organism-specific databases

Rat genome database More...RGDⁱ	621018 Mta1

RGDⁱ

621018 Mta1

Keywords - Cellular componentⁱ

Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endoplasmic reticulum, Golgi apparatus, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000083495	1 – 703	Metastasis-associated protein MTA1Add BLAST		703

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	182	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residueⁱ	386	PhosphoserineBy similarity	1
Modified residueⁱ	449	PhosphoserineBy similarity	1
Cross-linkⁱ	509	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2 and SUMO3)By similarity
Modified residueⁱ	522	PhosphoserineCombined sources	1
Cross-linkⁱ	549	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	564	PhosphothreonineBy similarity	1
Modified residueⁱ	576	PhosphoserineCombined sources	1
Modified residueⁱ	578	PhosphothreonineBy similarity	1
Modified residueⁱ	614	N6-acetyllysine; alternateBy similarity	1
Cross-linkⁱ	614	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity
Modified residueⁱ	627	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Phosphorylation by CSNK1G2/CK1 triggered by estrogen enhances corepression of estrogen receptor (ER).By similarity

Acetylation is essential for its transcriptional coactivator activity.By similarity

Sumoylation positively regulates its transcriptional corepressor activity but does not affect the protein stability. Sumoylated preferentially by SUMO2 or SUMO3 than SUMO1. Sumoylation is enhanced by PIAS1/3/4 and preferentially sumoylated by SUMO2 in the presence of PIAS1/3/4. Desumoylated by SENP1 (By similarity).By similarity

Ubiquitinated by COP1, which leads to proteasomal degradation.By similarity

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q62599
PRIDEⁱ	Q62599

PTM databases

iPTMnetⁱ	Q62599
PhosphoSitePlusⁱ	Q62599

Expressionⁱ

Tissue specificityⁱ

Isoform 1 abundant in testis and expressed at low levels in brain, heart, lung, liver, and kidney. Isoform 2 abundant in adrenal gland, brain, colon, heart, liver, lung, muscle, prostate, stomach, testis, and thymus and expressed at low levels in duodenum, kidney, pancreas, parotid, and spleen.1 Publication

Developmental stageⁱ

Isoform 1 is highly expressed in metastatic cells.

Inductionⁱ

Isoform 1 is induced by dexamethasone and, in pancreas, by treatment with the proteinase inhibitor FOY-305 which binds to activated trypsin and induces release of cholecystokinin.1 Publication

Gene expression databases

Genevisibleⁱ	Q62599 RN

Genevisibleⁱ

Q62599 RN

Interactionⁱ

Subunit structureⁱ

Isoform 1 is a component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts with HDAC1 and ITGB3BP/CENPR. Binds to CSNK1G2 in the cytoplasm. Isoform 2 interacts with amylase. Interacts with NACC2. Interacts with ARNTL/BMAL1 and CLOCK. Interacts with EP300, TFAP2C, IFI16, TPR, HDAC2, UBE2I/UBC9, PIAS1, PIAS3, PIAS4, p53/TP53, MDM2, COP1, SUMO1, SUMO2, SENP1 and SENP2. Interacts with SIX3; facilitates the binding of SIX3 to the core DNA motif of SIX3 promoter. Interacts with TFCP2L1; which is indispensable for TFCP2L1-mediated self-renewal-promoting effect and endoderm-inhibiting action (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Six3	Q9ET75	2	EBI-349237,EBI-15649593

With

Entry

#Exp.

IntAct

Notes

Six3

Q9ET75

EBI-349237,EBI-15649593

GO - Molecular functionⁱ

enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10933808
histone deacetylase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II repressing transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	249104, 1 interactor
Database of interacting proteins More...DIPⁱ	DIP-33254N
IntActⁱ	Q62599, 3 interactors
Molecular INTeraction database More...MINTⁱ	Q62599
STRINGⁱ	10116.ENSRNOP00000051141

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q62599
SMRⁱ	Q62599
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	1 – 164	BAHPROSITE-ProRule annotationAdd BLAST	164
Domainⁱ	165 – 276	ELM2PROSITE-ProRule annotationAdd BLAST	112
Domainⁱ	283 – 335	SANTPROSITE-ProRule annotationAdd BLAST	53

Motif

Feature key	Position(s)	DescriptionActions	Length
Motifⁱ	545 – 552	SH3-bindingSequence analysis	8
Motifⁱ	684 – 693	SH3-bindingSequence analysis	10
Motifⁱ	699 – 703	SUMO interaction motif 1 (SIM); crucial for efficient sumoylationBy similarity	5

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	688 – 693	Poly-Pro		6

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	393 – 420	GATA-type; atypicalAdd BLAST		28

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG3554 Eukaryota ENOG410XSAJ LUCA
HOGENOMⁱ	HOG000045387
HOVERGENⁱ	HBG002598
InParanoidⁱ	Q62599
KEGG Orthology (KO) More...KOⁱ	K11660
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04Z4
PhylomeDBⁱ	Q62599

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00202 ZnF_GATA, 1 hit
InterProⁱ	View protein in InterPro IPR001025 BAH_dom IPR000949 ELM2_dom IPR009057 Homeobox-like_sf IPR035170 MTA1_R1 IPR001005 SANT/Myb IPR017884 SANT_dom IPR000679 Znf_GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01426 BAH, 1 hit PF01448 ELM2, 1 hit PF00320 GATA, 1 hit PF17226 MTA_R1, 2 hits PF00249 Myb_DNA-binding, 1 hit
SMARTⁱ	View protein in SMART SM00439 BAH, 1 hit SM01189 ELM2, 1 hit SM00717 SANT, 1 hit SM00401 ZnF_GATA, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS51038 BAH, 1 hit PS51156 ELM2, 1 hit PS51293 SANT, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing and alternative initiation. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q62599-1) [UniParc]FASTA Add to basket

Also known as: MTA1, MTA1p

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAANMYRVGD YVYFENSSSN PYLIRRIEEL NKTANGNVEA KVVCFYRRRD 
        60         70         80         90        100
ISSSLIALAD KHATLSVCYR AGPGADTGEE GEVEEEVENP EMVDLPEKLK 
       110        120        130        140        150
HQLRHRELFL SRQLESLPAT HIRGKCSVTL LNETESLKSY LEREDFFFYS 
       160        170        180        190        200
LVYDPQQKTL LADKGEIRVG NRYQADITDL LKDGEEDGRD QSKLETKVWE 
       210        220        230        240        250
AHNPLVDKQI DQFLVVARSV GTFARALDCS SSVRQPSLHM SAAAASRDIT 
       260        270        280        290        300
LFHAMDTLHK NIYDISKAIS ALVPQGGPVL CRDEMEEWSA SEANLFEEAL 
       310        320        330        340        350
EKYGKDFTDI QQDFLPWKSL TSIIEYYYMW KTTDRYVQQK RLKAAEAESK 
       360        370        380        390        400
LKQVYIPNYN KPNPNQISVN SVKASVVNGT GTPGQSPGAG RACESCYTTQ 
       410        420        430        440        450
SYQWYSWGPP NMQCRLCASC WTYWKKYGGL KMPTRLDGER PGPNRNNMSP 
       460        470        480        490        500
HGIPARSSGS PKFAMKTRQA FYLHTTKLTR IARRLCREIL RPWHAARHPY 
       510        520        530        540        550
MPINSAAIKA ECTARLPEAS QSPLVLKQVV RKPLEAVLRY LETHPRPPKP 
       560        570        580        590        600
DPVKSSSSVL SSLTPAKSAP VINNGSPTIL GKRSYEQHNG VDGLANHGQT 
       610        620        630        640        650
RHMGPSRNLL LNGKSYPTKV RLIRGGSLPP VKRRRMNWID APDDVFYMAT 
       660        670        680        690        700
EETRKIRKLL SSSETKRAAR RPYKPIALRQ SQALPLRPPP PAPVNDEPIV 

IED

Length:703

Mass (Da):79,412

Last modified:November 1, 1996 - v1

Checksum:ⁱF05D8D287C45F13A

Isoform 2 (identifier: Q62599-2) [UniParc]FASTA Add to basket

Also known as: ZG29, ZG29p

The sequence of this isoform differs from the canonical sequence as follows:
1-464: Missing.
593-593: G → GNMKKRLLMPSRG

« Hide

        10         20         30         40         50
MKTRQAFYLH TTKLTRIARR LCREILRPWH AARHPYMPIN SAAIKAECTA 
        60         70         80         90        100
RLPEASQSPL VLKQVVRKPL EAVLRYLETH PRPPKPDPVK SSSSVLSSLT 
       110        120        130        140        150
PAKSAPVINN GSPTILGKRS YEQHNGVDGN MKKRLLMPSR GLANHGQTRH 
       160        170        180        190        200
MGPSRNLLLN GKSYPTKVRL IRGGSLPPVK RRRMNWIDAP DDVFYMATEE 
       210        220        230        240        250
TRKIRKLLSS SETKRAARRP YKPIALRQSQ ALPLRPPPPA PVNDEPIVIE 

D

Note: Produced by alternative splicing and alternative initiation at Met-465 of isoform 1.

Show »

Length:251

Mass (Da):28,309

Checksum:ⁱB15F54E8BC71CF61

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A140TA98	A0A140TA98_RAT	Metastasis-associated protein MTA1 Metastasis-associated protein MTA1	Mta1	733	Annotation score:
F1LQS1	F1LQS1_RAT	Metastasis-associated protein MTA1 Metastasis-associated protein MTA1	Mta1	695	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_019712	1 – 464	Missing in isoform 2. 1 PublicationAdd BLAST		464
Alternative sequenceⁱVSP_019713	593	G → GNMKKRLLMPSRG in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U02522 mRNA Translation: AAA82722.1 AJ132046 mRNA Translation: CAB38718.1
PIRⁱ	A54766
NCBI Reference Sequences More...RefSeqⁱ	NP_072110.1, NM_022588.1 [Q62599-1]
UniGeneⁱ	Rn.5840

Genome annotation databases

GeneIDⁱ	64520
KEGGⁱ	rno:64520
UCSC genome browser More...UCSCⁱ	RGD:621018 rat [Q62599-1]

Keywords - Coding sequence diversityⁱ

Alternative initiation, Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q62599	Metastasis-associated protein MTA1	)	HUMAN		715	UniRef90_Q13330
Metastasis-associated protein MTA1		MOUSE		715
metastasis-associated protein MTA1		Enhydra lutris kenyoni		877
metastasis-associated protein MTA1 isoform X2		MESAU		761
metastasis-associated protein MTA1		TARSY		755
+193
Q62599-2	Uncharacterized protein		ICTTR		689	UniRef90_I3MB11
Metastasis-associated protein MTA1		CRIGR		824
Uncharacterized protein		MACFA		699
Uncharacterized protein		MACNE		699
Uncharacterized protein		RHIRO		697
+4

Protein	Similar proteins		Species	Score	Length	Source
Q62599	Metastasis-associated protein MTA1	)	HUMAN		715	UniRef50_Q13330
Metastasis-associated protein MTA1		MOUSE		715
metastasis-associated protein MTA1		Enhydra lutris kenyoni		877
metastasis-associated protein MTA1 isoform X2		MESAU		761
metastasis-associated protein MTA1		TARSY		755
+314

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U02522 mRNA Translation: AAA82722.1 AJ132046 mRNA Translation: CAB38718.1
PIRⁱ	A54766
RefSeqⁱ	NP_072110.1, NM_022588.1 [Q62599-1]
UniGeneⁱ	Rn.5840

3D structure databases

ProteinModelPortalⁱ	Q62599
SMRⁱ	Q62599
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	249104, 1 interactor
DIPⁱ	DIP-33254N
IntActⁱ	Q62599, 3 interactors
MINTⁱ	Q62599
STRINGⁱ	10116.ENSRNOP00000051141

PTM databases

iPTMnetⁱ	Q62599
PhosphoSitePlusⁱ	Q62599

Proteomic databases

PaxDbⁱ	Q62599
PRIDEⁱ	Q62599

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	64520
KEGGⁱ	rno:64520
UCSCⁱ	RGD:621018 rat [Q62599-1]

Organism-specific databases

CTDⁱ	9112
RGDⁱ	621018 Mta1

Phylogenomic databases

eggNOGⁱ	KOG3554 Eukaryota ENOG410XSAJ LUCA
HOGENOMⁱ	HOG000045387
HOVERGENⁱ	HBG002598
InParanoidⁱ	Q62599
KOⁱ	K11660
OrthoDBⁱ	EOG091G04Z4
PhylomeDBⁱ	Q62599

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q62599

PROⁱ

PR:Q62599

Gene expression databases

Genevisibleⁱ	Q62599 RN

Genevisibleⁱ

Q62599 RN

Family and domain databases

CDDⁱ	cd00202 ZnF_GATA, 1 hit
InterProⁱ	View protein in InterPro IPR001025 BAH_dom IPR000949 ELM2_dom IPR009057 Homeobox-like_sf IPR035170 MTA1_R1 IPR001005 SANT/Myb IPR017884 SANT_dom IPR000679 Znf_GATA
Pfamⁱ	View protein in Pfam PF01426 BAH, 1 hit PF01448 ELM2, 1 hit PF00320 GATA, 1 hit PF17226 MTA_R1, 2 hits PF00249 Myb_DNA-binding, 1 hit
SMARTⁱ	View protein in SMART SM00439 BAH, 1 hit SM01189 ELM2, 1 hit SM00717 SANT, 1 hit SM00401 ZnF_GATA, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS51038 BAH, 1 hit PS51156 ELM2, 1 hit PS51293 SANT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MTA1_RAT
Accessionⁱ	Q62599Primary (citable) accession number: Q62599 Secondary accession number(s): Q9Z0N8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1996
	Last modified:	November 7, 2018
	This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q62599 (MTA1_RAT)

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Metastasis-associated protein MTA1

Mta1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Nucleus

Other locations

Golgi apparatus

Endoplasmic reticulum

Other locations

Cytoskeleton

Endoplasmic reticulum

Golgi apparatus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Compositional bias

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

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