Znf260

Functionⁱ

Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA. Also acts as a cofactor with GATA4, a key cardiac regulator.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	23 – 45	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	51 – 73	C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	79 – 101	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	131 – 153	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	159 – 181	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	187 – 209	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	215 – 237	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	243 – 265	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	271 – 293	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	299 – 321	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	327 – 349	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	355 – 377	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	383 – 405	C2H2-type 13PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

multicellular organism development Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Developmental protein, DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 260 Short name: Zfp-260
Gene namesⁱ	Name:Znf260 Synonyms:Zfp260
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:1347071 Zfp260

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047321	1 – 407	Zinc finger protein 260Add BLAST		407

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q62513
PaxDbⁱ	Q62513
PeptideAtlas More...PeptideAtlasⁱ	Q62513
PRIDEⁱ	Q62513

PTM databases

iPTMnetⁱ	Q62513
PhosphoSitePlusⁱ	Q62513

Expressionⁱ

Tissue specificityⁱ

Predominantly present in heart. Outside the heart, it is detected in embryonic and postnatal vascular smooth muscle cells and in epithelial cells of the lung, gut and kidney at sites of epithelial morphogenesis and in the spinal cord (at protein level).2 Publications

Developmental stageⁱ

At E9.5, it is predominantly detected in cardiomyocyte nuclei This expression is maintained throughout embryonic development in the atria and in the ventricular walls and trabeculae. Also present in the outflow tract, the truncus arteriosus, the developing atrioventricular valve and the cushion mesenchyme. Appears to decrease after E14 and by E17.5; it is then spatially redistributed, with highest levels in subendocardial myocytes and the septum and no expression in epicardial and apical myocytes. It is also strongly expressed in the atrioventricular valve. During postnatal development, it decreases in both atria and ventricles. In the adult heart, expression is found in the aortic valve in scattered cells and in the atria, ventricles, and septum. Interestingly, it is markedly up-regulated in hypertrophied adult ventricles of transgenic mice overexpressing the angiotensin II receptor (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000049421 Expressed in 294 organ(s), highest expression level in gonadal ridge
CleanExⁱ	MM_ZFP260
ExpressionAtlasⁱ	Q62513 baseline and differential
Genevisibleⁱ	Q62513 MM

Interactionⁱ

Subunit structureⁱ

Binds DNA. Interacts with GATA4 (By similarity).By similarity

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000052200

STRINGⁱ

10090.ENSMUSP00000052200

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q62513
SMRⁱ	Q62513
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	23 – 45	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	51 – 73	C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	79 – 101	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	131 – 153	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	159 – 181	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	187 – 209	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	215 – 237	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	243 – 265	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	271 – 293	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	299 – 321	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	327 – 349	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	355 – 377	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	383 – 405	C2H2-type 13PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150959
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	Q62513
OMAⁱ	YECGKAS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	Q62513
TreeFamⁱ	TF341817

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 11 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 13 hits
SUPFAMⁱ	SSF57667 SSF57667, 7 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 12 hits PS50157 ZINC_FINGER_C2H2_2, 12 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q62513-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLESLQPESH LLHDEPDPGE SVYECNECKE TFSLEQNFVE HKKTHSGEKS 
        60         70         80         90        100
PECTGCGEES SQASSLTLHL RSRPRRESYK CGECGKAFSQ RGNFLSHQKQ 
       110        120        130        140        150
HTEERPSESK KTPVPMTTTV RNQRNTGNKP YACKECGKAF NGKSYLKEHE 
       160        170        180        190        200
KIHTGEKPFE CSQCGRAFSQ KQYLIKHQNI HSGKKPFKCN ECGKAFSQKE 
       210        220        230        240        250
NLIIHQRIHT GEKPYECKGC GKAFIQKSSL IRHQRSHTGE KPYTCKECGK 
       260        270        280        290        300
AFSGKSNLTE HEKIHIGEKP YKCNECGTIF RQKQYLIKHH NIHTGEKPYE 
       310        320        330        340        350
CNKCGKAFSR ITSLIVHVRI HTGDKPYECK ICGKAFCQSS SLTVHMRSHT 
       360        370        380        390        400
GEKPYGCNEC GKAFSQFSTL ALHMRIHTGE KPYQCSECGK AFSQKSHHIR 

HQRIHIH

Length:407

Mass (Da):46,443

Last modified:November 1, 1997 - v1

Checksum:ⁱCC4076461018692A

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	D3Z766	D3Z766_MOUSE		Zinc finger protein 260 Zinc finger protein 260	Zfp260	27	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	11	L → H in BAE33630 (PubMed:16141072).Curated	1
Sequence conflictⁱ	121	R → K (PubMed:10449921).Curated	1
Sequence conflictⁱ	121	R → K (PubMed:16141072).Curated	1
Sequence conflictⁱ	249	G → R in BAC40191 (PubMed:16141072).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ224805 Genomic DNA Translation: CAB38535.1 D45210 mRNA Translation: BAA08144.1 AK088177 mRNA Translation: BAC40191.1 AK156219 mRNA Translation: BAE33630.1 BC082570 mRNA Translation: AAH82570.1 BC085180 mRNA Translation: AAH85180.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS21078.1
NCBI Reference Sequences More...RefSeqⁱ	NP_036111.2, NM_011981.4 XP_011248885.1, XM_011250583.1 XP_011248886.1, XM_011250584.2
UniGeneⁱ	Mm.195092

Genome annotation databases

Ensemblⁱ	ENSMUST00000050735; ENSMUSP00000052200; ENSMUSG00000049421 ENSMUST00000108200; ENSMUSP00000103835; ENSMUSG00000049421
GeneIDⁱ	26466
KEGGⁱ	mmu:26466
UCSC genome browser More...UCSCⁱ	uc009gde.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q62513	Zinc finger protein 260 (Fragment)		MOUSE		27	UniRef100_Q62513

Protein	Similar proteins		Species	Score	Length	Source
Q62513	Zinc finger protein 260		RAT		407	UniRef90_Q62981
Zinc finger protein 260 (Fragment)		MOUSE		27
UPI000A3045E6		MUSPA		407
UPI000A31463F		MUSCR		407

Protein	Similar proteins		Species	Score	Length	Source
Q62513	Zinc finger protein 260		RAT		407	UniRef50_Q62981
Zinc finger protein 260 (Fragment)		MOUSE		27
Zinc finger protein 146		OTOGA		403
Zinc finger protein 146		SAIBB		292
Uncharacterized protein		AOTNA		292
+11

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ224805 Genomic DNA Translation: CAB38535.1 D45210 mRNA Translation: BAA08144.1 AK088177 mRNA Translation: BAC40191.1 AK156219 mRNA Translation: BAE33630.1 BC082570 mRNA Translation: AAH82570.1 BC085180 mRNA Translation: AAH85180.1
CCDSⁱ	CCDS21078.1
RefSeqⁱ	NP_036111.2, NM_011981.4 XP_011248885.1, XM_011250583.1 XP_011248886.1, XM_011250584.2
UniGeneⁱ	Mm.195092

3D structure databases

ProteinModelPortalⁱ	Q62513
SMRⁱ	Q62513
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000052200

STRINGⁱ

10090.ENSMUSP00000052200

PTM databases

iPTMnetⁱ	Q62513
PhosphoSitePlusⁱ	Q62513

Proteomic databases

MaxQBⁱ	Q62513
PaxDbⁱ	Q62513
PeptideAtlasⁱ	Q62513
PRIDEⁱ	Q62513

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000050735; ENSMUSP00000052200; ENSMUSG00000049421 ENSMUST00000108200; ENSMUSP00000103835; ENSMUSG00000049421
GeneIDⁱ	26466
KEGGⁱ	mmu:26466
UCSCⁱ	uc009gde.1 mouse

Organism-specific databases

CTDⁱ	26466
MGIⁱ	MGI:1347071 Zfp260

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00930000150959
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	Q62513
OMAⁱ	YECGKAS
OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	Q62513
TreeFamⁱ	TF341817

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q62513
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000049421 Expressed in 294 organ(s), highest expression level in gonadal ridge
CleanExⁱ	MM_ZFP260
ExpressionAtlasⁱ	Q62513 baseline and differential
Genevisibleⁱ	Q62513 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 11 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 13 hits
SUPFAMⁱ	SSF57667 SSF57667, 7 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 12 hits PS50157 ZINC_FINGER_C2H2_2, 12 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZN260_MOUSE
Accessionⁱ	Q62513Primary (citable) accession number: Q62513 Secondary accession number(s): Q3U170, Q8C2Q6, Q9R2B4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1997
	Last modified:	November 7, 2018
	This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q62513 (ZN260_MOUSE)

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Zinc finger protein 260

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ