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Protein

Zinc finger protein 260

Gene

Znf260

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA. Also acts as a cofactor with GATA4, a key cardiac regulator.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri23 – 45C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri51 – 73C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri79 – 101C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri131 – 153C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri159 – 181C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri187 – 209C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri215 – 237C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri243 – 265C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 260
Short name:
Zfp-260
Gene namesi
Name:Znf260
Synonyms:Zfp260
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1347071 Zfp260

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473211 – 407Zinc finger protein 260Add BLAST407

Proteomic databases

MaxQBiQ62513
PaxDbiQ62513
PeptideAtlasiQ62513
PRIDEiQ62513

PTM databases

iPTMnetiQ62513
PhosphoSitePlusiQ62513

Expressioni

Tissue specificityi

Predominantly present in heart. Outside the heart, it is detected in embryonic and postnatal vascular smooth muscle cells and in epithelial cells of the lung, gut and kidney at sites of epithelial morphogenesis and in the spinal cord (at protein level).2 Publications

Developmental stagei

At E9.5, it is predominantly detected in cardiomyocyte nuclei This expression is maintained throughout embryonic development in the atria and in the ventricular walls and trabeculae. Also present in the outflow tract, the truncus arteriosus, the developing atrioventricular valve and the cushion mesenchyme. Appears to decrease after E14 and by E17.5; it is then spatially redistributed, with highest levels in subendocardial myocytes and the septum and no expression in epicardial and apical myocytes. It is also strongly expressed in the atrioventricular valve. During postnatal development, it decreases in both atria and ventricles. In the adult heart, expression is found in the aortic valve in scattered cells and in the atria, ventricles, and septum. Interestingly, it is markedly up-regulated in hypertrophied adult ventricles of transgenic mice overexpressing the angiotensin II receptor (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000049421 Expressed in 294 organ(s), highest expression level in gonadal ridge
CleanExiMM_ZFP260
ExpressionAtlasiQ62513 baseline and differential
GenevisibleiQ62513 MM

Interactioni

Subunit structurei

Binds DNA. Interacts with GATA4 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052200

Structurei

3D structure databases

ProteinModelPortaliQ62513
SMRiQ62513
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri23 – 45C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri51 – 73C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri79 – 101C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri131 – 153C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri159 – 181C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri187 – 209C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri215 – 237C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri243 – 265C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150959
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ62513
OMAiYECGKAS
OrthoDBiEOG091G02KC
PhylomeDBiQ62513
TreeFamiTF341817

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q62513-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLESLQPESH LLHDEPDPGE SVYECNECKE TFSLEQNFVE HKKTHSGEKS
60 70 80 90 100
PECTGCGEES SQASSLTLHL RSRPRRESYK CGECGKAFSQ RGNFLSHQKQ
110 120 130 140 150
HTEERPSESK KTPVPMTTTV RNQRNTGNKP YACKECGKAF NGKSYLKEHE
160 170 180 190 200
KIHTGEKPFE CSQCGRAFSQ KQYLIKHQNI HSGKKPFKCN ECGKAFSQKE
210 220 230 240 250
NLIIHQRIHT GEKPYECKGC GKAFIQKSSL IRHQRSHTGE KPYTCKECGK
260 270 280 290 300
AFSGKSNLTE HEKIHIGEKP YKCNECGTIF RQKQYLIKHH NIHTGEKPYE
310 320 330 340 350
CNKCGKAFSR ITSLIVHVRI HTGDKPYECK ICGKAFCQSS SLTVHMRSHT
360 370 380 390 400
GEKPYGCNEC GKAFSQFSTL ALHMRIHTGE KPYQCSECGK AFSQKSHHIR

HQRIHIH
Length:407
Mass (Da):46,443
Last modified:November 1, 1997 - v1
Checksum:iCC4076461018692A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z766D3Z766_MOUSE
Zinc finger protein 260
Zfp260
27Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11L → H in BAE33630 (PubMed:16141072).Curated1
Sequence conflicti121R → K (PubMed:10449921).Curated1
Sequence conflicti121R → K (PubMed:16141072).Curated1
Sequence conflicti249G → R in BAC40191 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224805 Genomic DNA Translation: CAB38535.1
D45210 mRNA Translation: BAA08144.1
AK088177 mRNA Translation: BAC40191.1
AK156219 mRNA Translation: BAE33630.1
BC082570 mRNA Translation: AAH82570.1
BC085180 mRNA Translation: AAH85180.1
CCDSiCCDS21078.1
RefSeqiNP_036111.2, NM_011981.4
XP_011248885.1, XM_011250583.1
XP_011248886.1, XM_011250584.2
UniGeneiMm.195092

Genome annotation databases

EnsembliENSMUST00000050735; ENSMUSP00000052200; ENSMUSG00000049421
ENSMUST00000108200; ENSMUSP00000103835; ENSMUSG00000049421
GeneIDi26466
KEGGimmu:26466
UCSCiuc009gde.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224805 Genomic DNA Translation: CAB38535.1
D45210 mRNA Translation: BAA08144.1
AK088177 mRNA Translation: BAC40191.1
AK156219 mRNA Translation: BAE33630.1
BC082570 mRNA Translation: AAH82570.1
BC085180 mRNA Translation: AAH85180.1
CCDSiCCDS21078.1
RefSeqiNP_036111.2, NM_011981.4
XP_011248885.1, XM_011250583.1
XP_011248886.1, XM_011250584.2
UniGeneiMm.195092

3D structure databases

ProteinModelPortaliQ62513
SMRiQ62513
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052200

PTM databases

iPTMnetiQ62513
PhosphoSitePlusiQ62513

Proteomic databases

MaxQBiQ62513
PaxDbiQ62513
PeptideAtlasiQ62513
PRIDEiQ62513

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050735; ENSMUSP00000052200; ENSMUSG00000049421
ENSMUST00000108200; ENSMUSP00000103835; ENSMUSG00000049421
GeneIDi26466
KEGGimmu:26466
UCSCiuc009gde.1 mouse

Organism-specific databases

CTDi26466
MGIiMGI:1347071 Zfp260

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150959
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ62513
OMAiYECGKAS
OrthoDBiEOG091G02KC
PhylomeDBiQ62513
TreeFamiTF341817

Miscellaneous databases

PROiPR:Q62513
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049421 Expressed in 294 organ(s), highest expression level in gonadal ridge
CleanExiMM_ZFP260
ExpressionAtlasiQ62513 baseline and differential
GenevisibleiQ62513 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN260_MOUSE
AccessioniPrimary (citable) accession number: Q62513
Secondary accession number(s): Q3U170, Q8C2Q6, Q9R2B4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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