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UniProtKB - Q62513 (ZN260_MOUSE)
Protein
Zinc finger protein 260
Gene
Znf260
Organism
Mus musculus (Mouse)
Status
Functioni
Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA. Also acts as a cofactor with GATA4, a key cardiac regulator.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 23 – 45 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 51 – 73 | C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 79 – 101 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 131 – 153 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 159 – 181 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 187 – 209 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 215 – 237 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 243 – 265 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 271 – 293 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 299 – 321 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 327 – 349 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 355 – 377 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 383 – 405 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 260Short name: Zfp-260 |
Gene namesi | Name:Znf260 Synonyms:Zfp260 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1347071, Zfp260 |
VEuPathDBi | HostDB:ENSMUSG00000049421 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytosol
- cytosol Source: MGI
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047321 | 1 – 407 | Zinc finger protein 260Add BLAST | 407 |
Proteomic databases
EPDi | Q62513 |
MaxQBi | Q62513 |
PaxDbi | Q62513 |
PeptideAtlasi | Q62513 |
PRIDEi | Q62513 |
ProteomicsDBi | 275005 |
PTM databases
iPTMneti | Q62513 |
PhosphoSitePlusi | Q62513 |
Expressioni
Tissue specificityi
Predominantly present in heart. Outside the heart, it is detected in embryonic and postnatal vascular smooth muscle cells and in epithelial cells of the lung, gut and kidney at sites of epithelial morphogenesis and in the spinal cord (at protein level).2 Publications
Developmental stagei
At 9.5 dpc, it is predominantly detected in cardiomyocyte nuclei This expression is maintained throughout embryonic development in the atria and in the ventricular walls and trabeculae. Also present in the outflow tract, the truncus arteriosus, the developing atrioventricular valve and the cushion mesenchyme. Appears to decrease after 14 dpc and by 17.5 dpc; it is then spatially redistributed, with highest levels in subendocardial myocytes and the septum and no expression in epicardial and apical myocytes. It is also strongly expressed in the atrioventricular valve. During postnatal development, it decreases in both atria and ventricles. In the adult heart, expression is found in the aortic valve in scattered cells and in the atria, ventricles, and septum. Interestingly, it is markedly up-regulated in hypertrophied adult ventricles of transgenic mice overexpressing the angiotensin II receptor (at protein level).1 Publication
Gene expression databases
Bgeei | ENSMUSG00000049421, Expressed in gonadal ridge and 315 other tissues |
Genevisiblei | Q62513, MM |
Interactioni
Subunit structurei
Binds DNA.
Interacts with GATA4 (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000052200 |
Miscellaneous databases
RNActi | Q62513, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 21 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 39 – 72 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 96 – 124 | DisorderedSequence analysisAdd BLAST | 29 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 55 – 69 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 23 – 45 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 51 – 73 | C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 79 – 101 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 131 – 153 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 159 – 181 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 187 – 209 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 215 – 237 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 243 – 265 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 271 – 293 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 299 – 321 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 327 – 349 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 355 – 377 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 383 – 405 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162468 |
HOGENOMi | CLU_002678_44_0_1 |
InParanoidi | Q62513 |
OMAi | FSQKSHY |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q62513 |
TreeFami | TF341817 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 11 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 13 hits |
SUPFAMi | SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 12 hits PS50157, ZINC_FINGER_C2H2_2, 12 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q62513-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLESLQPESH LLHDEPDPGE SVYECNECKE TFSLEQNFVE HKKTHSGEKS
60 70 80 90 100
PECTGCGEES SQASSLTLHL RSRPRRESYK CGECGKAFSQ RGNFLSHQKQ
110 120 130 140 150
HTEERPSESK KTPVPMTTTV RNQRNTGNKP YACKECGKAF NGKSYLKEHE
160 170 180 190 200
KIHTGEKPFE CSQCGRAFSQ KQYLIKHQNI HSGKKPFKCN ECGKAFSQKE
210 220 230 240 250
NLIIHQRIHT GEKPYECKGC GKAFIQKSSL IRHQRSHTGE KPYTCKECGK
260 270 280 290 300
AFSGKSNLTE HEKIHIGEKP YKCNECGTIF RQKQYLIKHH NIHTGEKPYE
310 320 330 340 350
CNKCGKAFSR ITSLIVHVRI HTGDKPYECK ICGKAFCQSS SLTVHMRSHT
360 370 380 390 400
GEKPYGCNEC GKAFSQFSTL ALHMRIHTGE KPYQCSECGK AFSQKSHHIR
HQRIHIH
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD3Z766 | D3Z766_MOUSE | Zinc finger protein 260 | Zfp260 | 27 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 11 | L → H in BAE33630 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 121 | R → K (PubMed:10449921).Curated | 1 | |
Sequence conflicti | 121 | R → K (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 249 | G → R in BAC40191 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ224805 Genomic DNA Translation: CAB38535.1 D45210 mRNA Translation: BAA08144.1 AK088177 mRNA Translation: BAC40191.1 AK156219 mRNA Translation: BAE33630.1 BC082570 mRNA Translation: AAH82570.1 BC085180 mRNA Translation: AAH85180.1 |
CCDSi | CCDS21078.1 |
RefSeqi | NP_036111.2, NM_011981.4 XP_011248885.1, XM_011250583.1 XP_011248886.1, XM_011250584.2 |
Genome annotation databases
Ensembli | ENSMUST00000050735; ENSMUSP00000052200; ENSMUSG00000049421 ENSMUST00000108200; ENSMUSP00000103835; ENSMUSG00000049421 |
GeneIDi | 26466 |
KEGGi | mmu:26466 |
UCSCi | uc009gde.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ224805 Genomic DNA Translation: CAB38535.1 D45210 mRNA Translation: BAA08144.1 AK088177 mRNA Translation: BAC40191.1 AK156219 mRNA Translation: BAE33630.1 BC082570 mRNA Translation: AAH82570.1 BC085180 mRNA Translation: AAH85180.1 |
CCDSi | CCDS21078.1 |
RefSeqi | NP_036111.2, NM_011981.4 XP_011248885.1, XM_011250583.1 XP_011248886.1, XM_011250584.2 |
3D structure databases
SMRi | Q62513 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000052200 |
PTM databases
iPTMneti | Q62513 |
PhosphoSitePlusi | Q62513 |
Proteomic databases
EPDi | Q62513 |
MaxQBi | Q62513 |
PaxDbi | Q62513 |
PeptideAtlasi | Q62513 |
PRIDEi | Q62513 |
ProteomicsDBi | 275005 |
Protocols and materials databases
Antibodypediai | 48040, 48 antibodies from 11 providers |
DNASUi | 26466 |
Genome annotation databases
Ensembli | ENSMUST00000050735; ENSMUSP00000052200; ENSMUSG00000049421 ENSMUST00000108200; ENSMUSP00000103835; ENSMUSG00000049421 |
GeneIDi | 26466 |
KEGGi | mmu:26466 |
UCSCi | uc009gde.1, mouse |
Organism-specific databases
CTDi | 26466 |
MGIi | MGI:1347071, Zfp260 |
VEuPathDBi | HostDB:ENSMUSG00000049421 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162468 |
HOGENOMi | CLU_002678_44_0_1 |
InParanoidi | Q62513 |
OMAi | FSQKSHY |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q62513 |
TreeFami | TF341817 |
Miscellaneous databases
BioGRID-ORCSi | 26466, 0 hits in 64 CRISPR screens |
ChiTaRSi | Zfp260, mouse |
PROi | PR:Q62513 |
RNActi | Q62513, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000049421, Expressed in gonadal ridge and 315 other tissues |
Genevisiblei | Q62513, MM |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 11 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 13 hits |
SUPFAMi | SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 12 hits PS50157, ZINC_FINGER_C2H2_2, 12 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN260_MOUSE | |
Accessioni | Q62513Primary (citable) accession number: Q62513 Secondary accession number(s): Q3U170, Q8C2Q6, Q9R2B4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 162 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families