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Protein

E3 ubiquitin-protein ligase ZFP91

Gene

Zfp91

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.By similarity

Miscellaneous

In contrast to other E3 ubiquitin-protein ligase, does not contain any domain (RING-type zinc finger or HECT domain) known to mediate E3 ligase activity.

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri313 – 338C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri344 – 368C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri374 – 396C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri402 – 424C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri432 – 455C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase ZFP91 (EC:2.3.2.27)
Alternative name(s):
Penta Zf protein
RING-type E3 ubiquitin transferase ZFP91
Zinc finger protein 91 homolog
Short name:
Zfp-91
Zinc finger protein PZF
Gene namesi
Name:Zfp91
Synonyms:Pzf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:104854 Zfp91

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473131 – 572E3 ubiquitin-protein ligase ZFP91Add BLAST572

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei86PhosphoserineCombined sources1
Modified residuei106PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ62511
PeptideAtlasiQ62511
PRIDEiQ62511

PTM databases

iPTMnetiQ62511
PhosphoSitePlusiQ62511

Expressioni

Tissue specificityi

Found in all the examined tissues including brain, heart, kidney, lung, liver, spleen, thymus, skeletal muscle, ovary and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000024695 Expressed in 310 organ(s), highest expression level in heart
CleanExiMM_ZFP91
ExpressionAtlasiQ62511 baseline and differential
GenevisibleiQ62511 MM

Interactioni

Subunit structurei

Interacts with MAP3K14/NIK.By similarity

Protein-protein interaction databases

BioGridi225146, 2 interactors
STRINGi10090.ENSMUSP00000037971

Structurei

3D structure databases

ProteinModelPortaliQ62511
SMRiQ62511
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni340 – 370Interaction with MAP3K14/NIKBy similarityAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi211 – 284Glu-richAdd BLAST74

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri313 – 338C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri344 – 368C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri374 – 396C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri402 – 424C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri432 – 455C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063153
HOVERGENiHBG055547
InParanoidiQ62511
OrthoDBiEOG091G055J
PhylomeDBiQ62511
TreeFamiTF332664

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q62511-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPGETEEPRS PEQQDQEGGP AAAADAASEE LRPGAAAAPA APAETASSRV
60 70 80 90 100
LRGGRDRGRT AAAAAAAAAA VSRRRKAEYP RRRRSSPSNR PPDGPGHQPA
110 120 130 140 150
AAKPPSPAQG KKSPRLQCIE KLTTDKDPKE EKEDDSVLPQ EVSITTTRAS
160 170 180 190 200
RSWRSSSRTS ISRLRDSENT RSSRSKTGSL QLVCKTEPIT DQLDYDVPEE
210 220 230 240 250
HQSPGGISSD EEEEEEEEML ISEEEIPFKD DPRDETYKPH LERETPKPRR
260 270 280 290 300
KSGKVKEEKE KKEIKVEVEV EVKEEENEIR EDEEPPRKRG RRRKDDKSPR
310 320 330 340 350
LPKRRKKPPI QYVRCEMEGC GTVLAHPRYL QHHIKYQHLL KKKYVCPHPS
360 370 380 390 400
CGRLFRLQKQ LLRHAKHHTD QRDYICEYCA RAFKSSHNLA VHRMIHTGEK
410 420 430 440 450
PLQCEICGFT CRQKASLNWH MKKHDADSFY QFSCNICGKK FEKKDSVVAH
460 470 480 490 500
KAKSHPEVLI AEALAANAGA LITSTDILGT NPEPLTQPAD GQGLPLLPEP
510 520 530 540 550
LGNSTAGECL LLEAEGMSKS YCSGTERVSL MADGKIFVGS GSSGGTEGLV
560 570
MNSDILGATT EVLIEDTDST GP
Length:572
Mass (Da):63,389
Last modified:May 29, 2007 - v3
Checksum:iC57D976BA1DC07F4
GO
Isoform 2 (identifier: Q62511-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: Missing.
     112-128: KSPRLQCIEKLTTDKDP → MKTKKECEEDD

Show »
Length:455
Mass (Da):51,539
Checksum:iE4FD2449854B0B13
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CY81E0CY81_MOUSE
E3 ubiquitin-protein ligase ZFP91
Zfp91
529Annotation score:

Sequence cautioni

The sequence BAC26394 differs from that shown. Reason: Frameshift at position 341.Curated
The sequence BAC34808 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC40660 differs from that shown. Reason: Frameshift at position 341.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104P → A in BAE41195 (PubMed:16141072).Curated1
Sequence conflicti218E → Q in BAC40660 (PubMed:16141072).Curated1
Sequence conflicti256K → T in AAA81911 (PubMed:7835706).Curated1
Sequence conflicti256K → T in AAA81913 (PubMed:7835706).Curated1
Sequence conflicti297K → R in BAC40660 (PubMed:16141072).Curated1
Sequence conflicti331Q → E in AAA81911 (PubMed:7835706).Curated1
Sequence conflicti466A → V in AAA81911 (PubMed:7835706).Curated1
Sequence conflicti466A → V in AAA81913 (PubMed:7835706).Curated1
Sequence conflicti498P → T in BAC26394 (PubMed:16141072).Curated1
Sequence conflicti528 – 529VS → LI in AAA81911 (PubMed:7835706).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0257591 – 111Missing in isoform 2. 1 PublicationAdd BLAST111
Alternative sequenceiVSP_025760112 – 128KSPRL…TDKDP → MKTKKECEEDD in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05342 mRNA Translation: AAA81911.1
U05343 mRNA Translation: AAA81913.1
AK029319 mRNA Translation: BAC26394.1 Frameshift.
AK051904 mRNA Translation: BAC34808.1 Different initiation.
AK088933 mRNA Translation: BAC40660.1 Frameshift.
AK147502 mRNA Translation: BAE27956.1
AK147560 mRNA Translation: BAE27996.1
AK169477 mRNA Translation: BAE41195.1
BC057323 mRNA Translation: AAH57323.1
BC064766 mRNA Translation: AAH64766.1
BC083000 mRNA Translation: AAH83000.1
CCDSiCCDS37927.1 [Q62511-1]
PIRiI48722
I48724
RefSeqiNP_443735.2, NM_053009.3 [Q62511-1]
UniGeneiMm.290924
Mm.485066

Genome annotation databases

EnsembliENSMUST00000038627; ENSMUSP00000037971; ENSMUSG00000024695 [Q62511-1]
GeneIDi109910
KEGGimmu:109910
UCSCiuc008gup.2 mouse [Q62511-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05342 mRNA Translation: AAA81911.1
U05343 mRNA Translation: AAA81913.1
AK029319 mRNA Translation: BAC26394.1 Frameshift.
AK051904 mRNA Translation: BAC34808.1 Different initiation.
AK088933 mRNA Translation: BAC40660.1 Frameshift.
AK147502 mRNA Translation: BAE27956.1
AK147560 mRNA Translation: BAE27996.1
AK169477 mRNA Translation: BAE41195.1
BC057323 mRNA Translation: AAH57323.1
BC064766 mRNA Translation: AAH64766.1
BC083000 mRNA Translation: AAH83000.1
CCDSiCCDS37927.1 [Q62511-1]
PIRiI48722
I48724
RefSeqiNP_443735.2, NM_053009.3 [Q62511-1]
UniGeneiMm.290924
Mm.485066

3D structure databases

ProteinModelPortaliQ62511
SMRiQ62511
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi225146, 2 interactors
STRINGi10090.ENSMUSP00000037971

PTM databases

iPTMnetiQ62511
PhosphoSitePlusiQ62511

Proteomic databases

PaxDbiQ62511
PeptideAtlasiQ62511
PRIDEiQ62511

Protocols and materials databases

DNASUi109910
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038627; ENSMUSP00000037971; ENSMUSG00000024695 [Q62511-1]
GeneIDi109910
KEGGimmu:109910
UCSCiuc008gup.2 mouse [Q62511-1]

Organism-specific databases

CTDi80829
MGIiMGI:104854 Zfp91

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063153
HOVERGENiHBG055547
InParanoidiQ62511
OrthoDBiEOG091G055J
PhylomeDBiQ62511
TreeFamiTF332664

Enzyme and pathway databases

UniPathwayi
UPA00143

Miscellaneous databases

ChiTaRSiZfp91 mouse
PROiPR:Q62511
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024695 Expressed in 310 organ(s), highest expression level in heart
CleanExiMM_ZFP91
ExpressionAtlasiQ62511 baseline and differential
GenevisibleiQ62511 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZFP91_MOUSE
AccessioniPrimary (citable) accession number: Q62511
Secondary accession number(s): Q3TEQ3
, Q3UH61, Q62509, Q6P219, Q6PG06, Q8BPY3, Q8C2B4, Q8CDZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: May 29, 2007
Last modified: November 7, 2018
This is version 137 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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