UniProtKB - Q62504 (MINT_MOUSE)
Msx2-interacting protein
Spen
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 1 – 574 | Add BLAST | 574 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: MGI
- nucleic acid binding Source: GO_Central
- RNA binding Source: UniProtKB-KW
- RNA polymerase II transcription factor binding Source: MGI
- single-stranded DNA binding Source: MGI
- transcription corepressor activity Source: MGI
GO - Biological processi
- mRNA splicing, via spliceosome Source: GO_Central
- negative regulation of transcription, DNA-templated Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- Notch signaling pathway Source: UniProtKB-KW
- positive regulation of neurogenesis Source: MGI
- positive regulation of transcription, DNA-templated Source: MGI
Keywordsi
Molecular function | Activator, DNA-binding, Repressor, RNA-binding |
Biological process | Notch signaling pathway, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Msx2-interacting proteinAlternative name(s): SMART/HDAC1-associated repressor protein SPEN homolog |
Gene namesi | Name:Spen Synonyms:Kiaa0929, Mint, Sharp |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1891706, Spen |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Note: Associates with chromatin.
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: MGI
Other locations
- transcription repressor complex Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000081628 | 1 – 3644 | Msx2-interacting proteinAdd BLAST | 3644 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 99 | PhosphoserineBy similarity | 1 | |
Modified residuei | 108 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 188 | PhosphoserineBy similarity | 1 | |
Modified residuei | 190 | PhosphoserineBy similarity | 1 | |
Modified residuei | 310 | PhosphoserineBy similarity | 1 | |
Modified residuei | 647 | PhosphoserineBy similarity | 1 | |
Modified residuei | 747 | PhosphoserineBy similarity | 1 | |
Modified residuei | 749 | PhosphoserineBy similarity | 1 | |
Modified residuei | 758 | PhosphoserineBy similarity | 1 | |
Modified residuei | 762 | PhosphoserineBy similarity | 1 | |
Modified residuei | 792 | PhosphoserineBy similarity | 1 | |
Modified residuei | 852 | PhosphoserineCombined sources | 1 | |
Modified residuei | 855 | PhosphoserineCombined sources | 1 | |
Modified residuei | 869 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1077 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1183 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1209 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1237 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1267 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1276 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1283 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1293 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1298 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1302 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1348 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1395 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1397 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1454 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1456 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1634 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1844 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1915 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1936 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1965 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 2128 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2134 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2171 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 2366 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2419 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 2450 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2454 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2458 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 2491 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2913 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 2925 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 3088 | Asymmetric dimethylarginineBy similarity | 1 | |
Modified residuei | 3096 | Asymmetric dimethylarginineBy similarity | 1 | |
Modified residuei | 3413 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
jPOSTi | Q62504 |
PaxDbi | Q62504 |
PeptideAtlasi | Q62504 |
PRIDEi | Q62504 |
ProteomicsDBi | 295607 [Q62504-1] 295608 [Q62504-2] 295609 [Q62504-3] |
PTM databases
iPTMneti | Q62504 |
PhosphoSitePlusi | Q62504 |
Expressioni
Tissue specificityi
Interactioni
Subunit structurei
Interacts with NCOR2, HDAC1, HDAC2, RBBP4, MBD3 and MTA1L1.
Interacts with the nuclear receptors RAR and PPARD.
Interacts with RAR in absence of ligand. Binds to the steroid receptor RNA coactivator SRA (By similarity).
Interacts with MSX2.
Interacts with RBPSUH; this interaction may prevent the interaction between RBPSUH and NOTCH1. Binds to HIPK3.
By similarity2 PublicationsGO - Molecular functioni
- RNA polymerase II transcription factor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 207942, 33 interactors |
CORUMi | Q62504 |
IntActi | Q62504, 4 interactors |
MINTi | Q62504 |
STRINGi | 10090.ENSMUSP00000101412 |
Miscellaneous databases
RNActi | Q62504, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 81 | RRM 1PROSITE-ProRule annotationAdd BLAST | 76 | |
Domaini | 336 – 416 | RRM 2PROSITE-ProRule annotationAdd BLAST | 81 | |
Domaini | 439 – 514 | RRM 3PROSITE-ProRule annotationAdd BLAST | 76 | |
Domaini | 518 – 590 | RRM 4PROSITE-ProRule annotationAdd BLAST | 73 | |
Domaini | 2216 – 2704 | RIDAdd BLAST | 489 | |
Domaini | 3478 – 3644 | SPOCPROSITE-ProRule annotationAdd BLAST | 167 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2138 – 2462 | Interaction with MSX21 PublicationAdd BLAST | 325 | |
Regioni | 2706 – 2845 | Interaction with RBPSUHAdd BLAST | 140 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 559 – 575 | Sequence analysisAdd BLAST | 17 | |
Coiled coili | 822 – 850 | Sequence analysisAdd BLAST | 29 | |
Coiled coili | 1185 – 1206 | Sequence analysisAdd BLAST | 22 | |
Coiled coili | 1509 – 1544 | Sequence analysisAdd BLAST | 36 | |
Coiled coili | 1607 – 1627 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 125 – 277 | Arg-richAdd BLAST | 153 | |
Compositional biasi | 236 – 326 | Ser-richAdd BLAST | 91 | |
Compositional biasi | 648 – 721 | Tyr-richAdd BLAST | 74 | |
Compositional biasi | 702 – 832 | Arg-richAdd BLAST | 131 | |
Compositional biasi | 2101 – 2233 | Ala-richAdd BLAST | 133 | |
Compositional biasi | 2377 – 2518 | Pro-richAdd BLAST | 142 | |
Compositional biasi | 2950 – 3475 | Pro-richAdd BLAST | 526 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG0112, Eukaryota |
InParanoidi | Q62504 |
OrthoDBi | 367857at2759 |
PhylomeDBi | Q62504 |
Family and domain databases
CDDi | cd12348, RRM1_SHARP, 1 hit cd12349, RRM2_SHARP, 1 hit cd12350, RRM3_SHARP, 1 hit cd12351, RRM4_SHARP, 1 hit |
Gene3Di | 2.40.290.10, 1 hit 3.30.70.330, 4 hits |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR034172, SHARP_RRM1 IPR034173, SHARP_RRM2 IPR034174, SHARP_RRM3 IPR034175, SHARP_RRM4 IPR016194, SPOC-like_C_dom_sf IPR012921, SPOC_C IPR010912, SPOC_met |
Pfami | View protein in Pfam PF00076, RRM_1, 3 hits PF07744, SPOC, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 4 hits |
SUPFAMi | SSF100939, SSF100939, 1 hit SSF54928, SSF54928, 2 hits |
PROSITEi | View protein in PROSITE PS50102, RRM, 4 hits PS50917, SPOC, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVRETRHLWV GNLPENVREE KIIEHFKRYG RVESVKILPK RGSEGGVAAF
60 70 80 90 100
VDFVDIKSAQ KAHNSVNKMG DRDLRTDYNE PGTIPSAARG LDETVSIASR
110 120 130 140 150
SREVSGFRGS AGGPAYGPPP SLHAREGRYE RRLDGASDNR ERAYEHSAYG
160 170 180 190 200
HHERGTGAFD RTRHYDQDYY RDPRERTLQH GLYYTSRSRS PNRFDAHDPR
210 220 230 240 250
YEPRAREQFT LPSVVHRDIY RDDITREVRG RRPERSYQHS RSRSPHSSQS
260 270 280 290 300
RNQSPQRLAS QASRPTRSPS GSGSRSRSSS SDSISSSSSS SNTDSSDSSS
310 320 330 340 350
TASDDSPARS VQSAAVPAPT SQLLSSLEKD EPRKSFGIKV QNLPVRSIDT
360 370 380 390 400
SLKDGLFHEF KKFGKVTSVQ IHGASEERYG LVFFRQQEDQ EKALTASKGK
410 420 430 440 450
LFFGMQIEVT AWVGPETESE NEFRPLDERI DEFHPKATRT LFIGNLEKTT
460 470 480 490 500
TYHDLRNIFQ RFGEIVDIDI KKVNGVPQYA FLQYCDIASV CKAIKKMDGE
510 520 530 540 550
YLGNNRLKLG FGKSMPTNCV WLDGLSSNVS DQYLTRHFCR YGPVVKVVFD
560 570 580 590 600
RLKGMALVLY SEIEDAQAAV KETKGRKIGG NKIKVDFANR ESQLAFYHCM
610 620 630 640 650
EKSGQDMRDF YEMLTERRAG QMAQSKHEDW SADAQSPHKC REERRGSYEY
660 670 680 690 700
SQERTYYENV RTPGTYPEDS RRDYPARGRE FYSEWETYQG EYYDSRYYDE
710 720 730 740 750
PREYREYRSD PYEQDIREYS YRQRERERER ERFESDRDHE RRPIERSQSP
760 770 780 790 800
VHLRRPQSPG VSPAHSERLP SDSERRLYRR SSERSGSCSS VSPPRYDKLE
810 820 830 840 850
KARLERYTKN EKADKERTFD PERVERERRI VRKEKGEKDK AERQKRKGKA
860 870 880 890 900
HSPSSQPSET EQENDREQSP EKPRGSTKLS RDRADKEGPA KNRLELVPCV
910 920 930 940 950
VLTRVKEKEG KVIEHPPPEK LKARLGRDTT KASALDQKPQ AAQGEPAKSD
960 970 980 990 1000
PARGKALREK VLPSHAEVGE KEGRTKLRKH LKAEQTPELS ALDLEKLEAR
1010 1020 1030 1040 1050
KRRFADSGLK IEKQKPEIKK TSPETEDTRI LLKKQPDTSR DGVLLREGES
1060 1070 1080 1090 1100
ERKPVRKEIL KRESKKTKLE RLNSALSPKD CQDPAAVSAG SGSRPSSDVH
1110 1120 1130 1140 1150
AGLGELTHGS VETQETQPKK AIPSKPQPKQ LQLLENQGPE KEEVRKNYCR
1160 1170 1180 1190 1200
PREEPAEHRA GQEKPHGGNA EEKLGIDIDH TQSYRKQMEQ SRRKQRMEME
1210 1220 1230 1240 1250
IAKAEKFGSP KKDVDDYERR SLVHEVGKPP QDVTDDSPPS KKRRTDHVDF
1260 1270 1280 1290 1300
DICTKRERNY RSSRQISEDS ERTSCSPSVR HGSFHDDDDP RGSPRLVSVK
1310 1320 1330 1340 1350
GSPKGDEKGL PYPNAAVRDD PLKCNPYDSG KREQTADTAK IKLSVLNSEG
1360 1370 1380 1390 1400
EPSRWDPPMK QDPSRFDVSF PNSVIKRDSL RKRSVRDLEP GEVPSDSDED
1410 1420 1430 1440 1450
AEHRSQSPRA SSFYDSPRLS FLLRDRDQKL RERDERLASS LERNKFYSFA
1460 1470 1480 1490 1500
LDKTITPDTK ALLERAKSLS SSREENWSFL DWDSRFANFR NNKDKEKVDS
1510 1520 1530 1540 1550
APRPIPSWYM KKKKIRTDSE GKLDDKKDER REEEQERQEL FASRFLHSSI
1560 1570 1580 1590 1600
FEQDSKRLQH LERKSEESDF PPGRLYGRQA SEGANSTSDS VQEPVVLFHS
1610 1620 1630 1640 1650
RFMELTRMQQ KEKEKDQKPK EAEKQEEPET HPKTPEPAAE TKEPEPKAPV
1660 1670 1680 1690 1700
SAGLPAVTIT VVTPEPASSA PEKAEEAAEA PSPAGEKPAE PAPVSEETKL
1710 1720 1730 1740 1750
VSEPVSVPVE QPRQSDVPPG EDSRDSQDSA ALAPSAPQES AATDAVPCVN
1760 1770 1780 1790 1800
AEPLTPGTTV SQVESSVDPK PSSPQPLSKL TQRSEEAEEG KVEKPDTTPS
1810 1820 1830 1840 1850
TEPDATQNAG VASEAQPPAS EDVEANPPVA AKDRKTNKSK RSKTSVQAAA
1860 1870 1880 1890 1900
ASVVEKPVTR KSERIDREKL KRSSSPRGEA QKLLELKMEA EKITRTASKS
1910 1920 1930 1940 1950
SGGDTEHPEP SLPLSRSRRR NVRSVYATMT DHESRSPAKE PVEQPRVTRK
1960 1970 1980 1990 2000
RLERELQEAV VPPTTPRRGR PPKTRRRAEE DGEHERKEPA ETPRPAEGWR
2010 2020 2030 2040 2050
SPRSQKSAAA AGPQGKRGRN EQKVEAAAEA GAQASTREGN PKSRGEREAA
2060 2070 2080 2090 2100
SEPKRDRRDP STDKSGPDTF PVEVLERKPP EKTYKSKRGR ARSTRSGMDR
2110 2120 2130 2140 2150
AAHQRSLEMA ARAAGQAADK EAGPAAASPQ ESESPQKGSG SSPQLANNPA
2160 2170 2180 2190 2200
DPDREAEEES ASASTAPPEG TQLARQIELE QAVQNIAKLP EPSAAAASKG
2210 2220 2230 2240 2250
TATATATAAS EEPAPEHGHK PAHQASETEL AAAIGSIISD ASGEPENFSA
2260 2270 2280 2290 2300
PPSVPPGSQT HPREGMEPGL HEAESGILET GTATESSAPQ VSALDPPEGS
2310 2320 2330 2340 2350
ADTKETRGNS GDSVQEAKGS KAEVTPPRKD KGRQKTTRRR KRNANKKVVA
2360 2370 2380 2390 2400
ITETRASEAE QTQSESPAAE EATAATPEAP QEEKPSEKPP SPPAECTFDP
2410 2420 2430 2440 2450
SKTPPAESLS QENSAAEKTP CKAPVLPALP PLSQPALMDD GPQARFKVHS
2460 2470 2480 2490 2500
IIESDPVTPP SDSGIPPPTI PLVTIAKLPP PVIPGGVPHQ SPPPKVTEWI
2510 2520 2530 2540 2550
TRQEEPRAQS TPSPALPPDT KASDMDTSSS TLRKILMDPK YVSATGVTST
2560 2570 2580 2590 2600
SVTTAIAEPV SAPCLQEAPA PPCDPKHPPL EGVSAAAVPN ADTQASEVPV
2610 2620 2630 2640 2650
AADKEKVAPV IAPKITSVIS RMPVSIDLEN SQKITLAKPA PQTLTGLVSA
2660 2670 2680 2690 2700
LTGLVNVSLV PVNALKGPVK GSVATLKGLV STPAGPVNLL KGPVNVLTGP
2710 2720 2730 2740 2750
VNVLTTPVSA TVGTVNAAPG PVTAACGVTA TTGTAAVTGA VTAPAAKGKQ
2760 2770 2780 2790 2800
RASSNENSRF HPGSMSVIDD RPADTGSGAG LRVNTSEGVV LLSYSGQKTE
2810 2820 2830 2840 2850
GPQRISAKIS QIPPASAMDI EFQQSVSKSQ VKADSITPTQ SAPKGPQTPS
2860 2870 2880 2890 2900
AFANVAAHST LVLTAQTYNA SPVISSVKTD RPSLEKPEPI HLSVSTPVTQ
2910 2920 2930 2940 2950
GGTVKVLTQG INTPPVLVHN QLVLTPSIVT TNKKLADPVT LKIETKVLQP
2960 2970 2980 2990 3000
ANLGPTLTPH HPPALPSKLP AEVNHVPSGP STPADRTIAH LATPKPDTHS
3010 3020 3030 3040 3050
PRPTGPTPGL FPRPCHPSST TSTALSTNAT VMLAAGIPVP QFISSIHPEQ
3060 3070 3080 3090 3100
SVIMPPHSIT QTVSLGHLSQ GEVRMSTPTL PSITYSIRPE TLHSPRAPLQ
3110 3120 3130 3140 3150
PQQIEARAPQ RVGTPQPATT GVPALATQHP PEEEVHYHLP VARAAAPVQS
3160 3170 3180 3190 3200
EVLVMQSEYR LHPYTVPRDV RIMVHPHVTA VSEQPRATEG VVKVPPANKA
3210 3220 3230 3240 3250
PQQLVKEAVK TSDAKAVPAP APVPVPVPVP TPAPPPHGEA RILTVTPSSQ
3260 3270 3280 3290 3300
LQGLPLTPPV VVTHGVQIVH SSGELFQEYR YGDVRTYHAP AQQLTHTQFP
3310 3320 3330 3340 3350
VASSISLASR TKTSAQVPPE GEPLQSTQSA QPAPSTQATQ PIPPAPPCQP
3360 3370 3380 3390 3400
SQLSQPAQPP SGKIPQVSQE AKGTQTGGVE QTRLPAIPTN RPSEPHAQLQ
3410 3420 3430 3440 3450
RAPVETAQPA HPSPVSVSMK PDLPSPLSSQ AAPKQPLFVP ANSGPSTPPG
3460 3470 3480 3490 3500
LALPHAEVQP APKQESSPHG TPQRPVDMVQ LLKKYPIVWQ GLLALKNDTA
3510 3520 3530 3540 3550
AVQLHFVSGN NVLAHRSLPL SEGGPPLRIA QRMRLEASQL EGVARRMTVE
3560 3570 3580 3590 3600
TDYCLLLALP CGRDQEDVVS QTESLKAAFI TYLQAKQAAG IINVPNPGSN
3610 3620 3630 3640
QPAYVLQIFP PCEFSESHLS RLAPDLLASI SNISPHLMIV IASV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA2ADB0 | A2ADB0_MOUSE | Msx2-interacting protein | Spen | 3,643 | Annotation score: | ||
A2ADB1 | A2ADB1_MOUSE | Msx2-interacting protein | Spen | 3,620 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 366 | V → E in CAB01562 (PubMed:9119401).Curated | 1 | |
Sequence conflicti | 394 | L → B in CAB01562 (PubMed:9119401).Curated | 1 | |
Sequence conflicti | 409 | V → E in CAB01562 (PubMed:9119401).Curated | 1 | |
Sequence conflicti | 413 | V → E in CAB01562 (PubMed:9119401).Curated | 1 | |
Sequence conflicti | 430 | I → K in CAB01562 (PubMed:9119401).Curated | 1 | |
Sequence conflicti | 454 – 462 | DLRNIFQRF → EPSETSFSAL in CAB01562 (PubMed:9119401).Curated | 9 | |
Sequence conflicti | 511 | F → L in CAB01562 (PubMed:9119401).Curated | 1 | |
Sequence conflicti | 527 | S → P in CAB01562 (PubMed:9119401).Curated | 1 | |
Sequence conflicti | 537 | H → N in CAB01562 (PubMed:9119401).Curated | 1 | |
Sequence conflicti | 566 | A → V in CAB01562 (PubMed:9119401).Curated | 1 | |
Sequence conflicti | 569 | A → V in CAB01562 (PubMed:9119401).Curated | 1 | |
Sequence conflicti | 573 – 577 | TKGRK → DQGQE in CAB01562 (PubMed:9119401).Curated | 5 | |
Sequence conflicti | 754 | R → G in BAB32786 (Ref. 3) Curated | 1 | |
Sequence conflicti | 1524 | D → A in BAB32786 (Ref. 3) Curated | 1 | |
Sequence conflicti | 1560 | H → Y in BAB32786 (Ref. 3) Curated | 1 | |
Sequence conflicti | 1570 | F → L in BAB32786 (Ref. 3) Curated | 1 | |
Sequence conflicti | 1574 | R → G in BAB32786 (Ref. 3) Curated | 1 | |
Sequence conflicti | 1609 | Q → R in BAB32786 (Ref. 3) Curated | 1 | |
Sequence conflicti | 1659 | I → V in BAB32786 (Ref. 3) Curated | 1 | |
Sequence conflicti | 1669 | S → F in BAB32786 (Ref. 3) Curated | 1 | |
Sequence conflicti | 1705 | V → A in BAB32786 (Ref. 3) Curated | 1 | |
Sequence conflicti | 1815 | A → V in BAB32786 (Ref. 3) Curated | 1 | |
Sequence conflicti | 2097 | G → A in BAB32786 (Ref. 3) Curated | 1 | |
Sequence conflicti | 2201 – 2202 | Missing in BAB32786 (Ref. 3) Curated | 2 | |
Sequence conflicti | 2322 | A → V in BAB32786 (Ref. 3) Curated | 1 | |
Sequence conflicti | 2385 | P → Q in BAB32786 (Ref. 3) Curated | 1 | |
Sequence conflicti | 2502 | R → K in BAB32786 (Ref. 3) Curated | 1 | |
Sequence conflicti | 2505 | E → K in BAB32786 (Ref. 3) Curated | 1 | |
Sequence conflicti | 2519 | D → N in BAB32786 (Ref. 3) Curated | 1 | |
Sequence conflicti | 2554 | T → S in BAB32786 (Ref. 3) Curated | 1 | |
Sequence conflicti | 2679 – 2688 | LVSTPAGPVN → VGEHPWWARD in BAB32786 (Ref. 3) Curated | 10 | |
Sequence conflicti | 3010 | L → P in BAB32786 (Ref. 3) Curated | 1 | |
Sequence conflicti | 3010 | L → P in BAC65684 (PubMed:12693553).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 348 | I → T2 Publications | 1 | |
Natural varianti | 762 | S → F1 Publication | 1 | |
Natural varianti | 773 | S → F1 Publication | 1 | |
Natural varianti | 933 | S → L1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_008564 | 618 – 640 | Missing in isoform 2. 1 PublicationAdd BLAST | 23 | |
Alternative sequenceiVSP_013802 | 3318 – 3322 | PPEGE → RKPAFF in isoform 3. 1 Publication | 5 | |
Alternative sequenceiVSP_013803 | 3550 – 3552 | ETD → RLE in isoform 3. 1 Publication | 3 | |
Alternative sequenceiVSP_013804 | 3553 – 3644 | Missing in isoform 3. 1 PublicationAdd BLAST | 92 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BY726481 mRNA No translation available. AF156529 mRNA Translation: AAD55931.1 Different initiation. AB055980 mRNA Translation: BAB32786.1 Z78160 mRNA Translation: CAB01562.1 Sequence problems. AK122402 Transcribed RNA Translation: BAC65684.3 |
RefSeqi | NP_062737.2, NM_019763.2 |
Genome annotation databases
GeneIDi | 56381 |
KEGGi | mmu:56381 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BY726481 mRNA No translation available. AF156529 mRNA Translation: AAD55931.1 Different initiation. AB055980 mRNA Translation: BAB32786.1 Z78160 mRNA Translation: CAB01562.1 Sequence problems. AK122402 Transcribed RNA Translation: BAC65684.3 |
RefSeqi | NP_062737.2, NM_019763.2 |
3D structure databases
BMRBi | Q62504 |
SMRi | Q62504 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 207942, 33 interactors |
CORUMi | Q62504 |
IntActi | Q62504, 4 interactors |
MINTi | Q62504 |
STRINGi | 10090.ENSMUSP00000101412 |
PTM databases
iPTMneti | Q62504 |
PhosphoSitePlusi | Q62504 |
Proteomic databases
jPOSTi | Q62504 |
PaxDbi | Q62504 |
PeptideAtlasi | Q62504 |
PRIDEi | Q62504 |
ProteomicsDBi | 295607 [Q62504-1] 295608 [Q62504-2] 295609 [Q62504-3] |
Genome annotation databases
GeneIDi | 56381 |
KEGGi | mmu:56381 |
Organism-specific databases
CTDi | 23013 |
MGIi | MGI:1891706, Spen |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG0112, Eukaryota |
InParanoidi | Q62504 |
OrthoDBi | 367857at2759 |
PhylomeDBi | Q62504 |
Miscellaneous databases
BioGRID-ORCSi | 56381, 9 hits in 53 CRISPR screens |
ChiTaRSi | Spen, mouse |
PROi | PR:Q62504 |
RNActi | Q62504, protein |
SOURCEi | Search... |
Family and domain databases
CDDi | cd12348, RRM1_SHARP, 1 hit cd12349, RRM2_SHARP, 1 hit cd12350, RRM3_SHARP, 1 hit cd12351, RRM4_SHARP, 1 hit |
Gene3Di | 2.40.290.10, 1 hit 3.30.70.330, 4 hits |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR034172, SHARP_RRM1 IPR034173, SHARP_RRM2 IPR034174, SHARP_RRM3 IPR034175, SHARP_RRM4 IPR016194, SPOC-like_C_dom_sf IPR012921, SPOC_C IPR010912, SPOC_met |
Pfami | View protein in Pfam PF00076, RRM_1, 3 hits PF07744, SPOC, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 4 hits |
SUPFAMi | SSF100939, SSF100939, 1 hit SSF54928, SSF54928, 2 hits |
PROSITEi | View protein in PROSITE PS50102, RRM, 4 hits PS50917, SPOC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MINT_MOUSE | |
Accessioni | Q62504Primary (citable) accession number: Q62504 Secondary accession number(s): Q80TN9, Q99PS4, Q9QZW2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2003 |
Last sequence update: | October 10, 2003 | |
Last modified: | April 7, 2021 | |
This is version 178 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families