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UniProtKB - Q62504 (MINT_MOUSE)

Protein

Msx2-interacting protein

Gene

Spen

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways, such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi1 – 574Add BLAST574

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActivator, DNA-binding, Repressor, RNA-binding
Biological processNotch signaling pathway, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Msx2-interacting protein
Alternative name(s):
SMART/HDAC1-associated repressor protein
SPEN homolog
Gene namesi
Name:Spen
Synonyms:Kiaa0929, Mint, Sharp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1891706 Spen

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000816281 – 3644Msx2-interacting proteinAdd BLAST3644

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei99PhosphoserineBy similarity1
Modified residuei108Omega-N-methylarginineBy similarity1
Modified residuei188PhosphoserineBy similarity1
Modified residuei190PhosphoserineBy similarity1
Modified residuei310PhosphoserineBy similarity1
Modified residuei647PhosphoserineBy similarity1
Modified residuei747PhosphoserineBy similarity1
Modified residuei749PhosphoserineBy similarity1
Modified residuei758PhosphoserineBy similarity1
Modified residuei762PhosphoserineBy similarity1
Modified residuei792PhosphoserineBy similarity1
Modified residuei852PhosphoserineCombined sources1
Modified residuei855PhosphoserineCombined sources1
Modified residuei869PhosphoserineCombined sources1
Modified residuei1077PhosphoserineBy similarity1
Modified residuei1183PhosphoserineBy similarity1
Modified residuei1209PhosphoserineBy similarity1
Modified residuei1237PhosphoserineBy similarity1
Modified residuei1267PhosphoserineBy similarity1
Modified residuei1276PhosphoserineBy similarity1
Modified residuei1283PhosphoserineBy similarity1
Modified residuei1293PhosphoserineBy similarity1
Modified residuei1298PhosphoserineBy similarity1
Modified residuei1302PhosphoserineBy similarity1
Modified residuei1348PhosphoserineBy similarity1
Modified residuei1395PhosphoserineCombined sources1
Modified residuei1397PhosphoserineBy similarity1
Modified residuei1454PhosphothreonineBy similarity1
Modified residuei1456PhosphothreonineBy similarity1
Modified residuei1634PhosphothreonineBy similarity1
Modified residuei1844PhosphothreonineBy similarity1
Modified residuei1915PhosphoserineBy similarity1
Modified residuei1936PhosphoserineBy similarity1
Modified residuei1965PhosphothreonineBy similarity1
Modified residuei2128PhosphoserineBy similarity1
Modified residuei2134PhosphoserineBy similarity1
Modified residuei2171PhosphothreonineBy similarity1
Modified residuei2366PhosphoserineBy similarity1
Modified residuei2419PhosphothreonineBy similarity1
Modified residuei2450PhosphoserineBy similarity1
Modified residuei2454PhosphoserineBy similarity1
Modified residuei2458PhosphothreonineBy similarity1
Modified residuei2491PhosphoserineBy similarity1
Modified residuei2913PhosphothreonineBy similarity1
Modified residuei2925PhosphothreonineBy similarity1
Modified residuei3088Asymmetric dimethylarginineBy similarity1
Modified residuei3096Asymmetric dimethylarginineBy similarity1
Modified residuei3413PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ62504
PeptideAtlasiQ62504
PRIDEiQ62504

PTM databases

iPTMnetiQ62504
PhosphoSitePlusiQ62504

Expressioni

Tissue specificityi

Highly expressed in testis. Expressed at lower level in brain, lung, spleen, liver and kidney. Weakly expressed in cardiac and skeletal muscles and ovary. In spleen, it is expressed in follicular B-cells, while it is weakly expressed in marginal zone B-cells.3 Publications

Interactioni

Subunit structurei

Interacts with NCOR2, HDAC1, HDAC2, RBBP4, MBD3 and MTA1L1. Interacts with the nuclear receptors RAR and PPARD. Interacts with RAR in absence of ligand. Binds to the steroid receptor RNA coactivator SRA (By similarity). Interacts with MSX2. Interacts with RBPSUH; this interaction may prevent the interaction between RBPSUH and NOTCH1. Binds to HIPK3.By similarity2 Publications

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi207942, 1 interactor
CORUMiQ62504
IntActiQ62504, 4 interactors
MINTiQ62504
STRINGi10090.ENSMUSP00000101412

Structurei

3D structure databases

ProteinModelPortaliQ62504
SMRiQ62504
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 81RRM 1PROSITE-ProRule annotationAdd BLAST76
Domaini336 – 416RRM 2PROSITE-ProRule annotationAdd BLAST81
Domaini439 – 514RRM 3PROSITE-ProRule annotationAdd BLAST76
Domaini518 – 590RRM 4PROSITE-ProRule annotationAdd BLAST73
Domaini2216 – 2704RIDAdd BLAST489
Domaini3478 – 3644SPOCPROSITE-ProRule annotationAdd BLAST167

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2138 – 2462Interaction with MSX21 PublicationAdd BLAST325
Regioni2706 – 2845Interaction with RBPSUHAdd BLAST140

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili559 – 575Sequence analysisAdd BLAST17
Coiled coili822 – 850Sequence analysisAdd BLAST29
Coiled coili1185 – 1206Sequence analysisAdd BLAST22
Coiled coili1509 – 1544Sequence analysisAdd BLAST36
Coiled coili1607 – 1627Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi125 – 277Arg-richAdd BLAST153
Compositional biasi236 – 326Ser-richAdd BLAST91
Compositional biasi648 – 721Tyr-richAdd BLAST74
Compositional biasi702 – 832Arg-richAdd BLAST131
Compositional biasi2101 – 2233Ala-richAdd BLAST133
Compositional biasi2377 – 2518Pro-richAdd BLAST142
Compositional biasi2950 – 3475Pro-richAdd BLAST526

Domaini

The RID domain mediates the interaction with nuclear receptors.
The SPOC domain, which mediates the interaction with NCOR2, is essential for the repressive activity.By similarity

Sequence similaritiesi

Belongs to the RRM Spen family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0112 Eukaryota
ENOG410ZT33 LUCA
HOGENOMiHOG000231295
HOVERGENiHBG045583
InParanoidiQ62504
PhylomeDBiQ62504

Family and domain databases

CDDicd12348 RRM1_SHARP, 1 hit
cd12349 RRM2_SHARP, 1 hit
cd12350 RRM3_SHARP, 1 hit
cd12351 RRM4_SHARP, 1 hit
Gene3Di2.40.290.10, 1 hit
3.30.70.330, 4 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034172 SHARP_RRM1
IPR034173 SHARP_RRM2
IPR034174 SHARP_RRM3
IPR034175 SHARP_RRM4
IPR016194 SPOC-like_C_dom_sf
IPR012921 SPOC_C
IPR010912 SPOC_met
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
PF07744 SPOC, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 4 hits
SUPFAMiSSF100939 SSF100939, 1 hit
SSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 4 hits
PS50917 SPOC, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q62504-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVRETRHLWV GNLPENVREE KIIEHFKRYG RVESVKILPK RGSEGGVAAF 
        60         70         80         90        100
VDFVDIKSAQ KAHNSVNKMG DRDLRTDYNE PGTIPSAARG LDETVSIASR 
       110        120        130        140        150
SREVSGFRGS AGGPAYGPPP SLHAREGRYE RRLDGASDNR ERAYEHSAYG 
       160        170        180        190        200
HHERGTGAFD RTRHYDQDYY RDPRERTLQH GLYYTSRSRS PNRFDAHDPR 
       210        220        230        240        250
YEPRAREQFT LPSVVHRDIY RDDITREVRG RRPERSYQHS RSRSPHSSQS 
       260        270        280        290        300
RNQSPQRLAS QASRPTRSPS GSGSRSRSSS SDSISSSSSS SNTDSSDSSS 
       310        320        330        340        350
TASDDSPARS VQSAAVPAPT SQLLSSLEKD EPRKSFGIKV QNLPVRSIDT 
       360        370        380        390        400
SLKDGLFHEF KKFGKVTSVQ IHGASEERYG LVFFRQQEDQ EKALTASKGK 
       410        420        430        440        450
LFFGMQIEVT AWVGPETESE NEFRPLDERI DEFHPKATRT LFIGNLEKTT 
       460        470        480        490        500
TYHDLRNIFQ RFGEIVDIDI KKVNGVPQYA FLQYCDIASV CKAIKKMDGE 
       510        520        530        540        550
YLGNNRLKLG FGKSMPTNCV WLDGLSSNVS DQYLTRHFCR YGPVVKVVFD 
       560        570        580        590        600
RLKGMALVLY SEIEDAQAAV KETKGRKIGG NKIKVDFANR ESQLAFYHCM 
       610        620        630        640        650
EKSGQDMRDF YEMLTERRAG QMAQSKHEDW SADAQSPHKC REERRGSYEY 
       660        670        680        690        700
SQERTYYENV RTPGTYPEDS RRDYPARGRE FYSEWETYQG EYYDSRYYDE 
       710        720        730        740        750
PREYREYRSD PYEQDIREYS YRQRERERER ERFESDRDHE RRPIERSQSP 
       760        770        780        790        800
VHLRRPQSPG VSPAHSERLP SDSERRLYRR SSERSGSCSS VSPPRYDKLE 
       810        820        830        840        850
KARLERYTKN EKADKERTFD PERVERERRI VRKEKGEKDK AERQKRKGKA 
       860        870        880        890        900
HSPSSQPSET EQENDREQSP EKPRGSTKLS RDRADKEGPA KNRLELVPCV 
       910        920        930        940        950
VLTRVKEKEG KVIEHPPPEK LKARLGRDTT KASALDQKPQ AAQGEPAKSD 
       960        970        980        990       1000
PARGKALREK VLPSHAEVGE KEGRTKLRKH LKAEQTPELS ALDLEKLEAR 
      1010       1020       1030       1040       1050
KRRFADSGLK IEKQKPEIKK TSPETEDTRI LLKKQPDTSR DGVLLREGES 
      1060       1070       1080       1090       1100
ERKPVRKEIL KRESKKTKLE RLNSALSPKD CQDPAAVSAG SGSRPSSDVH 
      1110       1120       1130       1140       1150
AGLGELTHGS VETQETQPKK AIPSKPQPKQ LQLLENQGPE KEEVRKNYCR 
      1160       1170       1180       1190       1200
PREEPAEHRA GQEKPHGGNA EEKLGIDIDH TQSYRKQMEQ SRRKQRMEME 
      1210       1220       1230       1240       1250
IAKAEKFGSP KKDVDDYERR SLVHEVGKPP QDVTDDSPPS KKRRTDHVDF 
      1260       1270       1280       1290       1300
DICTKRERNY RSSRQISEDS ERTSCSPSVR HGSFHDDDDP RGSPRLVSVK 
      1310       1320       1330       1340       1350
GSPKGDEKGL PYPNAAVRDD PLKCNPYDSG KREQTADTAK IKLSVLNSEG 
      1360       1370       1380       1390       1400
EPSRWDPPMK QDPSRFDVSF PNSVIKRDSL RKRSVRDLEP GEVPSDSDED 
      1410       1420       1430       1440       1450
AEHRSQSPRA SSFYDSPRLS FLLRDRDQKL RERDERLASS LERNKFYSFA 
      1460       1470       1480       1490       1500
LDKTITPDTK ALLERAKSLS SSREENWSFL DWDSRFANFR NNKDKEKVDS 
      1510       1520       1530       1540       1550
APRPIPSWYM KKKKIRTDSE GKLDDKKDER REEEQERQEL FASRFLHSSI 
      1560       1570       1580       1590       1600
FEQDSKRLQH LERKSEESDF PPGRLYGRQA SEGANSTSDS VQEPVVLFHS 
      1610       1620       1630       1640       1650
RFMELTRMQQ KEKEKDQKPK EAEKQEEPET HPKTPEPAAE TKEPEPKAPV 
      1660       1670       1680       1690       1700
SAGLPAVTIT VVTPEPASSA PEKAEEAAEA PSPAGEKPAE PAPVSEETKL 
      1710       1720       1730       1740       1750
VSEPVSVPVE QPRQSDVPPG EDSRDSQDSA ALAPSAPQES AATDAVPCVN 
      1760       1770       1780       1790       1800
AEPLTPGTTV SQVESSVDPK PSSPQPLSKL TQRSEEAEEG KVEKPDTTPS 
      1810       1820       1830       1840       1850
TEPDATQNAG VASEAQPPAS EDVEANPPVA AKDRKTNKSK RSKTSVQAAA 
      1860       1870       1880       1890       1900
ASVVEKPVTR KSERIDREKL KRSSSPRGEA QKLLELKMEA EKITRTASKS 
      1910       1920       1930       1940       1950
SGGDTEHPEP SLPLSRSRRR NVRSVYATMT DHESRSPAKE PVEQPRVTRK 
      1960       1970       1980       1990       2000
RLERELQEAV VPPTTPRRGR PPKTRRRAEE DGEHERKEPA ETPRPAEGWR 
      2010       2020       2030       2040       2050
SPRSQKSAAA AGPQGKRGRN EQKVEAAAEA GAQASTREGN PKSRGEREAA 
      2060       2070       2080       2090       2100
SEPKRDRRDP STDKSGPDTF PVEVLERKPP EKTYKSKRGR ARSTRSGMDR 
      2110       2120       2130       2140       2150
AAHQRSLEMA ARAAGQAADK EAGPAAASPQ ESESPQKGSG SSPQLANNPA 
      2160       2170       2180       2190       2200
DPDREAEEES ASASTAPPEG TQLARQIELE QAVQNIAKLP EPSAAAASKG 
      2210       2220       2230       2240       2250
TATATATAAS EEPAPEHGHK PAHQASETEL AAAIGSIISD ASGEPENFSA 
      2260       2270       2280       2290       2300
PPSVPPGSQT HPREGMEPGL HEAESGILET GTATESSAPQ VSALDPPEGS 
      2310       2320       2330       2340       2350
ADTKETRGNS GDSVQEAKGS KAEVTPPRKD KGRQKTTRRR KRNANKKVVA 
      2360       2370       2380       2390       2400
ITETRASEAE QTQSESPAAE EATAATPEAP QEEKPSEKPP SPPAECTFDP 
      2410       2420       2430       2440       2450
SKTPPAESLS QENSAAEKTP CKAPVLPALP PLSQPALMDD GPQARFKVHS 
      2460       2470       2480       2490       2500
IIESDPVTPP SDSGIPPPTI PLVTIAKLPP PVIPGGVPHQ SPPPKVTEWI 
      2510       2520       2530       2540       2550
TRQEEPRAQS TPSPALPPDT KASDMDTSSS TLRKILMDPK YVSATGVTST 
      2560       2570       2580       2590       2600
SVTTAIAEPV SAPCLQEAPA PPCDPKHPPL EGVSAAAVPN ADTQASEVPV 
      2610       2620       2630       2640       2650
AADKEKVAPV IAPKITSVIS RMPVSIDLEN SQKITLAKPA PQTLTGLVSA 
      2660       2670       2680       2690       2700
LTGLVNVSLV PVNALKGPVK GSVATLKGLV STPAGPVNLL KGPVNVLTGP 
      2710       2720       2730       2740       2750
VNVLTTPVSA TVGTVNAAPG PVTAACGVTA TTGTAAVTGA VTAPAAKGKQ 
      2760       2770       2780       2790       2800
RASSNENSRF HPGSMSVIDD RPADTGSGAG LRVNTSEGVV LLSYSGQKTE 
      2810       2820       2830       2840       2850
GPQRISAKIS QIPPASAMDI EFQQSVSKSQ VKADSITPTQ SAPKGPQTPS 
      2860       2870       2880       2890       2900
AFANVAAHST LVLTAQTYNA SPVISSVKTD RPSLEKPEPI HLSVSTPVTQ 
      2910       2920       2930       2940       2950
GGTVKVLTQG INTPPVLVHN QLVLTPSIVT TNKKLADPVT LKIETKVLQP 
      2960       2970       2980       2990       3000
ANLGPTLTPH HPPALPSKLP AEVNHVPSGP STPADRTIAH LATPKPDTHS 
      3010       3020       3030       3040       3050
PRPTGPTPGL FPRPCHPSST TSTALSTNAT VMLAAGIPVP QFISSIHPEQ 
      3060       3070       3080       3090       3100
SVIMPPHSIT QTVSLGHLSQ GEVRMSTPTL PSITYSIRPE TLHSPRAPLQ 
      3110       3120       3130       3140       3150
PQQIEARAPQ RVGTPQPATT GVPALATQHP PEEEVHYHLP VARAAAPVQS 
      3160       3170       3180       3190       3200
EVLVMQSEYR LHPYTVPRDV RIMVHPHVTA VSEQPRATEG VVKVPPANKA 
      3210       3220       3230       3240       3250
PQQLVKEAVK TSDAKAVPAP APVPVPVPVP TPAPPPHGEA RILTVTPSSQ 
      3260       3270       3280       3290       3300
LQGLPLTPPV VVTHGVQIVH SSGELFQEYR YGDVRTYHAP AQQLTHTQFP 
      3310       3320       3330       3340       3350
VASSISLASR TKTSAQVPPE GEPLQSTQSA QPAPSTQATQ PIPPAPPCQP 
      3360       3370       3380       3390       3400
SQLSQPAQPP SGKIPQVSQE AKGTQTGGVE QTRLPAIPTN RPSEPHAQLQ 
      3410       3420       3430       3440       3450
RAPVETAQPA HPSPVSVSMK PDLPSPLSSQ AAPKQPLFVP ANSGPSTPPG 
      3460       3470       3480       3490       3500
LALPHAEVQP APKQESSPHG TPQRPVDMVQ LLKKYPIVWQ GLLALKNDTA 
      3510       3520       3530       3540       3550
AVQLHFVSGN NVLAHRSLPL SEGGPPLRIA QRMRLEASQL EGVARRMTVE 
      3560       3570       3580       3590       3600
TDYCLLLALP CGRDQEDVVS QTESLKAAFI TYLQAKQAAG IINVPNPGSN 
      3610       3620       3630       3640 
QPAYVLQIFP PCEFSESHLS RLAPDLLASI SNISPHLMIV IASV
Length:3,644
Mass (Da):398,754
Last modified:October 10, 2003 - v2
Checksum:i9C7EC49A81A7DA4A
GO
Isoform 2 (identifier: Q62504-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     618-640: Missing.

Note: No experimental confirmation available.
Show »
Length:3,621
Mass (Da):396,203
Checksum:i878136C0D8CF0D22
GO
Isoform 3 (identifier: Q62504-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3318-3322: PPEGE → RKPAFF
     3550-3552: ETD → RLE
     3553-3644: Missing.

Note: No experimental confirmation available.
Show »
Length:3,553
Mass (Da):389,153
Checksum:i5915CA253DD7270B
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2ADB0A2ADB0_MOUSE
Msx2-interacting protein
Spen
3,643Annotation score:
A2ADB1A2ADB1_MOUSE
Msx2-interacting protein
Spen
3,620Annotation score:

Sequence cautioni

The sequence AAD55931 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB01562 differs from that shown. Reason: Frameshift at positions 446 and 561.Curated
The sequence CAB01562 differs from that shown. Reason: Erroneous termination at position 394. Translated as Leu.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti366V → E in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti394L → B in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti409V → E in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti413V → E in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti430I → K in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti454 – 462DLRNIFQRF → EPSETSFSAL in CAB01562 (PubMed:9119401).Curated9
Sequence conflicti511F → L in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti527S → P in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti537H → N in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti566A → V in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti569A → V in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti573 – 577TKGRK → DQGQE in CAB01562 (PubMed:9119401).Curated5
Sequence conflicti754R → G in BAB32786 (Ref. 3) Curated1
Sequence conflicti1524D → A in BAB32786 (Ref. 3) Curated1
Sequence conflicti1560H → Y in BAB32786 (Ref. 3) Curated1
Sequence conflicti1570F → L in BAB32786 (Ref. 3) Curated1
Sequence conflicti1574R → G in BAB32786 (Ref. 3) Curated1
Sequence conflicti1609Q → R in BAB32786 (Ref. 3) Curated1
Sequence conflicti1659I → V in BAB32786 (Ref. 3) Curated1
Sequence conflicti1669S → F in BAB32786 (Ref. 3) Curated1
Sequence conflicti1705V → A in BAB32786 (Ref. 3) Curated1
Sequence conflicti1815A → V in BAB32786 (Ref. 3) Curated1
Sequence conflicti2097G → A in BAB32786 (Ref. 3) Curated1
Sequence conflicti2201 – 2202Missing in BAB32786 (Ref. 3) Curated2
Sequence conflicti2322A → V in BAB32786 (Ref. 3) Curated1
Sequence conflicti2385P → Q in BAB32786 (Ref. 3) Curated1
Sequence conflicti2502R → K in BAB32786 (Ref. 3) Curated1
Sequence conflicti2505E → K in BAB32786 (Ref. 3) Curated1
Sequence conflicti2519D → N in BAB32786 (Ref. 3) Curated1
Sequence conflicti2554T → S in BAB32786 (Ref. 3) Curated1
Sequence conflicti2679 – 2688LVSTPAGPVN → VGEHPWWARD in BAB32786 (Ref. 3) Curated10
Sequence conflicti3010L → P in BAB32786 (Ref. 3) Curated1
Sequence conflicti3010L → P in BAC65684 (PubMed:12693553).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti348I → T2 Publications1
Natural varianti762S → F1 Publication1
Natural varianti773S → F1 Publication1
Natural varianti933S → L1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008564618 – 640Missing in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_0138023318 – 3322PPEGE → RKPAFF in isoform 3. 1 Publication5
Alternative sequenceiVSP_0138033550 – 3552ETD → RLE in isoform 3. 1 Publication3
Alternative sequenceiVSP_0138043553 – 3644Missing in isoform 3. 1 PublicationAdd BLAST92

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BY726481 mRNA No translation available.
AF156529 mRNA Translation: AAD55931.1 Different initiation.
AB055980 mRNA Translation: BAB32786.1
Z78160 mRNA Translation: CAB01562.1 Sequence problems.
AK122402 Transcribed RNA Translation: BAC65684.3
RefSeqiNP_062737.2, NM_019763.2
UniGeneiMm.299906

Genome annotation databases

GeneIDi56381
KEGGimmu:56381

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BY726481 mRNA No translation available.
AF156529 mRNA Translation: AAD55931.1 Different initiation.
AB055980 mRNA Translation: BAB32786.1
Z78160 mRNA Translation: CAB01562.1 Sequence problems.
AK122402 Transcribed RNA Translation: BAC65684.3
RefSeqiNP_062737.2, NM_019763.2
UniGeneiMm.299906

3D structure databases

ProteinModelPortaliQ62504
SMRiQ62504
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207942, 1 interactor
CORUMiQ62504
IntActiQ62504, 4 interactors
MINTiQ62504
STRINGi10090.ENSMUSP00000101412

PTM databases

iPTMnetiQ62504
PhosphoSitePlusiQ62504

Proteomic databases

PaxDbiQ62504
PeptideAtlasiQ62504
PRIDEiQ62504

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi56381
KEGGimmu:56381

Organism-specific databases

CTDi23013
MGIiMGI:1891706 Spen
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0112 Eukaryota
ENOG410ZT33 LUCA
HOGENOMiHOG000231295
HOVERGENiHBG045583
InParanoidiQ62504
PhylomeDBiQ62504

Miscellaneous databases

ChiTaRSiSpen mouse
PROiPR:Q62504
SOURCEiSearch...

Family and domain databases

CDDicd12348 RRM1_SHARP, 1 hit
cd12349 RRM2_SHARP, 1 hit
cd12350 RRM3_SHARP, 1 hit
cd12351 RRM4_SHARP, 1 hit
Gene3Di2.40.290.10, 1 hit
3.30.70.330, 4 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034172 SHARP_RRM1
IPR034173 SHARP_RRM2
IPR034174 SHARP_RRM3
IPR034175 SHARP_RRM4
IPR016194 SPOC-like_C_dom_sf
IPR012921 SPOC_C
IPR010912 SPOC_met
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
PF07744 SPOC, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 4 hits
SUPFAMiSSF100939 SSF100939, 1 hit
SSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 4 hits
PS50917 SPOC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMINT_MOUSE
AccessioniPrimary (citable) accession number: Q62504
Secondary accession number(s): Q80TN9, Q99PS4, Q9QZW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: November 7, 2018
This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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