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Entry version 166 (16 Jan 2019)
Sequence version 2 (10 Oct 2003)
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Protein

Msx2-interacting protein

Gene

Spen

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways, such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi1 – 574Add BLAST574

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Repressor, RNA-binding
Biological processNotch signaling pathway, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Msx2-interacting protein
Alternative name(s):
SMART/HDAC1-associated repressor protein
SPEN homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Spen
Synonyms:Kiaa0929, Mint, Sharp
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1891706 Spen

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000816281 – 3644Msx2-interacting proteinAdd BLAST3644

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei99PhosphoserineBy similarity1
Modified residuei108Omega-N-methylarginineBy similarity1
Modified residuei188PhosphoserineBy similarity1
Modified residuei190PhosphoserineBy similarity1
Modified residuei310PhosphoserineBy similarity1
Modified residuei647PhosphoserineBy similarity1
Modified residuei747PhosphoserineBy similarity1
Modified residuei749PhosphoserineBy similarity1
Modified residuei758PhosphoserineBy similarity1
Modified residuei762PhosphoserineBy similarity1
Modified residuei792PhosphoserineBy similarity1
Modified residuei852PhosphoserineCombined sources1
Modified residuei855PhosphoserineCombined sources1
Modified residuei869PhosphoserineCombined sources1
Modified residuei1077PhosphoserineBy similarity1
Modified residuei1183PhosphoserineBy similarity1
Modified residuei1209PhosphoserineBy similarity1
Modified residuei1237PhosphoserineBy similarity1
Modified residuei1267PhosphoserineBy similarity1
Modified residuei1276PhosphoserineBy similarity1
Modified residuei1283PhosphoserineBy similarity1
Modified residuei1293PhosphoserineBy similarity1
Modified residuei1298PhosphoserineBy similarity1
Modified residuei1302PhosphoserineBy similarity1
Modified residuei1348PhosphoserineBy similarity1
Modified residuei1395PhosphoserineCombined sources1
Modified residuei1397PhosphoserineBy similarity1
Modified residuei1454PhosphothreonineBy similarity1
Modified residuei1456PhosphothreonineBy similarity1
Modified residuei1634PhosphothreonineBy similarity1
Modified residuei1844PhosphothreonineBy similarity1
Modified residuei1915PhosphoserineBy similarity1
Modified residuei1936PhosphoserineBy similarity1
Modified residuei1965PhosphothreonineBy similarity1
Modified residuei2128PhosphoserineBy similarity1
Modified residuei2134PhosphoserineBy similarity1
Modified residuei2171PhosphothreonineBy similarity1
Modified residuei2366PhosphoserineBy similarity1
Modified residuei2419PhosphothreonineBy similarity1
Modified residuei2450PhosphoserineBy similarity1
Modified residuei2454PhosphoserineBy similarity1
Modified residuei2458PhosphothreonineBy similarity1
Modified residuei2491PhosphoserineBy similarity1
Modified residuei2913PhosphothreonineBy similarity1
Modified residuei2925PhosphothreonineBy similarity1
Modified residuei3088Asymmetric dimethylarginineBy similarity1
Modified residuei3096Asymmetric dimethylarginineBy similarity1
Modified residuei3413PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q62504

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q62504

PeptideAtlas

More...
PeptideAtlasi
Q62504

PRoteomics IDEntifications database

More...
PRIDEi
Q62504

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q62504

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q62504

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in testis. Expressed at lower level in brain, lung, spleen, liver and kidney. Weakly expressed in cardiac and skeletal muscles and ovary. In spleen, it is expressed in follicular B-cells, while it is weakly expressed in marginal zone B-cells.3 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NCOR2, HDAC1, HDAC2, RBBP4, MBD3 and MTA1L1. Interacts with the nuclear receptors RAR and PPARD. Interacts with RAR in absence of ligand. Binds to the steroid receptor RNA coactivator SRA (By similarity). Interacts with MSX2. Interacts with RBPSUH; this interaction may prevent the interaction between RBPSUH and NOTCH1. Binds to HIPK3.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
207942, 1 interactor

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q62504

Protein interaction database and analysis system

More...
IntActi
Q62504, 4 interactors

Molecular INTeraction database

More...
MINTi
Q62504

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000101412

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q62504

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q62504

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 81RRM 1PROSITE-ProRule annotationAdd BLAST76
Domaini336 – 416RRM 2PROSITE-ProRule annotationAdd BLAST81
Domaini439 – 514RRM 3PROSITE-ProRule annotationAdd BLAST76
Domaini518 – 590RRM 4PROSITE-ProRule annotationAdd BLAST73
Domaini2216 – 2704RIDAdd BLAST489
Domaini3478 – 3644SPOCPROSITE-ProRule annotationAdd BLAST167

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2138 – 2462Interaction with MSX21 PublicationAdd BLAST325
Regioni2706 – 2845Interaction with RBPSUHAdd BLAST140

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili559 – 575Sequence analysisAdd BLAST17
Coiled coili822 – 850Sequence analysisAdd BLAST29
Coiled coili1185 – 1206Sequence analysisAdd BLAST22
Coiled coili1509 – 1544Sequence analysisAdd BLAST36
Coiled coili1607 – 1627Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi125 – 277Arg-richAdd BLAST153
Compositional biasi236 – 326Ser-richAdd BLAST91
Compositional biasi648 – 721Tyr-richAdd BLAST74
Compositional biasi702 – 832Arg-richAdd BLAST131
Compositional biasi2101 – 2233Ala-richAdd BLAST133
Compositional biasi2377 – 2518Pro-richAdd BLAST142
Compositional biasi2950 – 3475Pro-richAdd BLAST526

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RID domain mediates the interaction with nuclear receptors.
The SPOC domain, which mediates the interaction with NCOR2, is essential for the repressive activity.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RRM Spen family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0112 Eukaryota
ENOG410ZT33 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231295

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG045583

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q62504

Database of Orthologous Groups

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OrthoDBi
367857at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q62504

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12348 RRM1_SHARP, 1 hit
cd12349 RRM2_SHARP, 1 hit
cd12350 RRM3_SHARP, 1 hit
cd12351 RRM4_SHARP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.40.290.10, 1 hit
3.30.70.330, 4 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034172 SHARP_RRM1
IPR034173 SHARP_RRM2
IPR034174 SHARP_RRM3
IPR034175 SHARP_RRM4
IPR016194 SPOC-like_C_dom_sf
IPR012921 SPOC_C
IPR010912 SPOC_met

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00076 RRM_1, 3 hits
PF07744 SPOC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00360 RRM, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100939 SSF100939, 1 hit
SSF54928 SSF54928, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102 RRM, 4 hits
PS50917 SPOC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q62504-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MVRETRHLWV GNLPENVREE KIIEHFKRYG RVESVKILPK RGSEGGVAAF
60 70 80 90 100
VDFVDIKSAQ KAHNSVNKMG DRDLRTDYNE PGTIPSAARG LDETVSIASR
110 120 130 140 150
SREVSGFRGS AGGPAYGPPP SLHAREGRYE RRLDGASDNR ERAYEHSAYG
160 170 180 190 200
HHERGTGAFD RTRHYDQDYY RDPRERTLQH GLYYTSRSRS PNRFDAHDPR
210 220 230 240 250
YEPRAREQFT LPSVVHRDIY RDDITREVRG RRPERSYQHS RSRSPHSSQS
260 270 280 290 300
RNQSPQRLAS QASRPTRSPS GSGSRSRSSS SDSISSSSSS SNTDSSDSSS
310 320 330 340 350
TASDDSPARS VQSAAVPAPT SQLLSSLEKD EPRKSFGIKV QNLPVRSIDT
360 370 380 390 400
SLKDGLFHEF KKFGKVTSVQ IHGASEERYG LVFFRQQEDQ EKALTASKGK
410 420 430 440 450
LFFGMQIEVT AWVGPETESE NEFRPLDERI DEFHPKATRT LFIGNLEKTT
460 470 480 490 500
TYHDLRNIFQ RFGEIVDIDI KKVNGVPQYA FLQYCDIASV CKAIKKMDGE
510 520 530 540 550
YLGNNRLKLG FGKSMPTNCV WLDGLSSNVS DQYLTRHFCR YGPVVKVVFD
560 570 580 590 600
RLKGMALVLY SEIEDAQAAV KETKGRKIGG NKIKVDFANR ESQLAFYHCM
610 620 630 640 650
EKSGQDMRDF YEMLTERRAG QMAQSKHEDW SADAQSPHKC REERRGSYEY
660 670 680 690 700
SQERTYYENV RTPGTYPEDS RRDYPARGRE FYSEWETYQG EYYDSRYYDE
710 720 730 740 750
PREYREYRSD PYEQDIREYS YRQRERERER ERFESDRDHE RRPIERSQSP
760 770 780 790 800
VHLRRPQSPG VSPAHSERLP SDSERRLYRR SSERSGSCSS VSPPRYDKLE
810 820 830 840 850
KARLERYTKN EKADKERTFD PERVERERRI VRKEKGEKDK AERQKRKGKA
860 870 880 890 900
HSPSSQPSET EQENDREQSP EKPRGSTKLS RDRADKEGPA KNRLELVPCV
910 920 930 940 950
VLTRVKEKEG KVIEHPPPEK LKARLGRDTT KASALDQKPQ AAQGEPAKSD
960 970 980 990 1000
PARGKALREK VLPSHAEVGE KEGRTKLRKH LKAEQTPELS ALDLEKLEAR
1010 1020 1030 1040 1050
KRRFADSGLK IEKQKPEIKK TSPETEDTRI LLKKQPDTSR DGVLLREGES
1060 1070 1080 1090 1100
ERKPVRKEIL KRESKKTKLE RLNSALSPKD CQDPAAVSAG SGSRPSSDVH
1110 1120 1130 1140 1150
AGLGELTHGS VETQETQPKK AIPSKPQPKQ LQLLENQGPE KEEVRKNYCR
1160 1170 1180 1190 1200
PREEPAEHRA GQEKPHGGNA EEKLGIDIDH TQSYRKQMEQ SRRKQRMEME
1210 1220 1230 1240 1250
IAKAEKFGSP KKDVDDYERR SLVHEVGKPP QDVTDDSPPS KKRRTDHVDF
1260 1270 1280 1290 1300
DICTKRERNY RSSRQISEDS ERTSCSPSVR HGSFHDDDDP RGSPRLVSVK
1310 1320 1330 1340 1350
GSPKGDEKGL PYPNAAVRDD PLKCNPYDSG KREQTADTAK IKLSVLNSEG
1360 1370 1380 1390 1400
EPSRWDPPMK QDPSRFDVSF PNSVIKRDSL RKRSVRDLEP GEVPSDSDED
1410 1420 1430 1440 1450
AEHRSQSPRA SSFYDSPRLS FLLRDRDQKL RERDERLASS LERNKFYSFA
1460 1470 1480 1490 1500
LDKTITPDTK ALLERAKSLS SSREENWSFL DWDSRFANFR NNKDKEKVDS
1510 1520 1530 1540 1550
APRPIPSWYM KKKKIRTDSE GKLDDKKDER REEEQERQEL FASRFLHSSI
1560 1570 1580 1590 1600
FEQDSKRLQH LERKSEESDF PPGRLYGRQA SEGANSTSDS VQEPVVLFHS
1610 1620 1630 1640 1650
RFMELTRMQQ KEKEKDQKPK EAEKQEEPET HPKTPEPAAE TKEPEPKAPV
1660 1670 1680 1690 1700
SAGLPAVTIT VVTPEPASSA PEKAEEAAEA PSPAGEKPAE PAPVSEETKL
1710 1720 1730 1740 1750
VSEPVSVPVE QPRQSDVPPG EDSRDSQDSA ALAPSAPQES AATDAVPCVN
1760 1770 1780 1790 1800
AEPLTPGTTV SQVESSVDPK PSSPQPLSKL TQRSEEAEEG KVEKPDTTPS
1810 1820 1830 1840 1850
TEPDATQNAG VASEAQPPAS EDVEANPPVA AKDRKTNKSK RSKTSVQAAA
1860 1870 1880 1890 1900
ASVVEKPVTR KSERIDREKL KRSSSPRGEA QKLLELKMEA EKITRTASKS
1910 1920 1930 1940 1950
SGGDTEHPEP SLPLSRSRRR NVRSVYATMT DHESRSPAKE PVEQPRVTRK
1960 1970 1980 1990 2000
RLERELQEAV VPPTTPRRGR PPKTRRRAEE DGEHERKEPA ETPRPAEGWR
2010 2020 2030 2040 2050
SPRSQKSAAA AGPQGKRGRN EQKVEAAAEA GAQASTREGN PKSRGEREAA
2060 2070 2080 2090 2100
SEPKRDRRDP STDKSGPDTF PVEVLERKPP EKTYKSKRGR ARSTRSGMDR
2110 2120 2130 2140 2150
AAHQRSLEMA ARAAGQAADK EAGPAAASPQ ESESPQKGSG SSPQLANNPA
2160 2170 2180 2190 2200
DPDREAEEES ASASTAPPEG TQLARQIELE QAVQNIAKLP EPSAAAASKG
2210 2220 2230 2240 2250
TATATATAAS EEPAPEHGHK PAHQASETEL AAAIGSIISD ASGEPENFSA
2260 2270 2280 2290 2300
PPSVPPGSQT HPREGMEPGL HEAESGILET GTATESSAPQ VSALDPPEGS
2310 2320 2330 2340 2350
ADTKETRGNS GDSVQEAKGS KAEVTPPRKD KGRQKTTRRR KRNANKKVVA
2360 2370 2380 2390 2400
ITETRASEAE QTQSESPAAE EATAATPEAP QEEKPSEKPP SPPAECTFDP
2410 2420 2430 2440 2450
SKTPPAESLS QENSAAEKTP CKAPVLPALP PLSQPALMDD GPQARFKVHS
2460 2470 2480 2490 2500
IIESDPVTPP SDSGIPPPTI PLVTIAKLPP PVIPGGVPHQ SPPPKVTEWI
2510 2520 2530 2540 2550
TRQEEPRAQS TPSPALPPDT KASDMDTSSS TLRKILMDPK YVSATGVTST
2560 2570 2580 2590 2600
SVTTAIAEPV SAPCLQEAPA PPCDPKHPPL EGVSAAAVPN ADTQASEVPV
2610 2620 2630 2640 2650
AADKEKVAPV IAPKITSVIS RMPVSIDLEN SQKITLAKPA PQTLTGLVSA
2660 2670 2680 2690 2700
LTGLVNVSLV PVNALKGPVK GSVATLKGLV STPAGPVNLL KGPVNVLTGP
2710 2720 2730 2740 2750
VNVLTTPVSA TVGTVNAAPG PVTAACGVTA TTGTAAVTGA VTAPAAKGKQ
2760 2770 2780 2790 2800
RASSNENSRF HPGSMSVIDD RPADTGSGAG LRVNTSEGVV LLSYSGQKTE
2810 2820 2830 2840 2850
GPQRISAKIS QIPPASAMDI EFQQSVSKSQ VKADSITPTQ SAPKGPQTPS
2860 2870 2880 2890 2900
AFANVAAHST LVLTAQTYNA SPVISSVKTD RPSLEKPEPI HLSVSTPVTQ
2910 2920 2930 2940 2950
GGTVKVLTQG INTPPVLVHN QLVLTPSIVT TNKKLADPVT LKIETKVLQP
2960 2970 2980 2990 3000
ANLGPTLTPH HPPALPSKLP AEVNHVPSGP STPADRTIAH LATPKPDTHS
3010 3020 3030 3040 3050
PRPTGPTPGL FPRPCHPSST TSTALSTNAT VMLAAGIPVP QFISSIHPEQ
3060 3070 3080 3090 3100
SVIMPPHSIT QTVSLGHLSQ GEVRMSTPTL PSITYSIRPE TLHSPRAPLQ
3110 3120 3130 3140 3150
PQQIEARAPQ RVGTPQPATT GVPALATQHP PEEEVHYHLP VARAAAPVQS
3160 3170 3180 3190 3200
EVLVMQSEYR LHPYTVPRDV RIMVHPHVTA VSEQPRATEG VVKVPPANKA
3210 3220 3230 3240 3250
PQQLVKEAVK TSDAKAVPAP APVPVPVPVP TPAPPPHGEA RILTVTPSSQ
3260 3270 3280 3290 3300
LQGLPLTPPV VVTHGVQIVH SSGELFQEYR YGDVRTYHAP AQQLTHTQFP
3310 3320 3330 3340 3350
VASSISLASR TKTSAQVPPE GEPLQSTQSA QPAPSTQATQ PIPPAPPCQP
3360 3370 3380 3390 3400
SQLSQPAQPP SGKIPQVSQE AKGTQTGGVE QTRLPAIPTN RPSEPHAQLQ
3410 3420 3430 3440 3450
RAPVETAQPA HPSPVSVSMK PDLPSPLSSQ AAPKQPLFVP ANSGPSTPPG
3460 3470 3480 3490 3500
LALPHAEVQP APKQESSPHG TPQRPVDMVQ LLKKYPIVWQ GLLALKNDTA
3510 3520 3530 3540 3550
AVQLHFVSGN NVLAHRSLPL SEGGPPLRIA QRMRLEASQL EGVARRMTVE
3560 3570 3580 3590 3600
TDYCLLLALP CGRDQEDVVS QTESLKAAFI TYLQAKQAAG IINVPNPGSN
3610 3620 3630 3640
QPAYVLQIFP PCEFSESHLS RLAPDLLASI SNISPHLMIV IASV
Length:3,644
Mass (Da):398,754
Last modified:October 10, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9C7EC49A81A7DA4A
GO
Isoform 2 (identifier: Q62504-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     618-640: Missing.

Note: No experimental confirmation available.
Show »
Length:3,621
Mass (Da):396,203
Checksum:i878136C0D8CF0D22
GO
Isoform 3 (identifier: Q62504-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3318-3322: PPEGE → RKPAFF
     3550-3552: ETD → RLE
     3553-3644: Missing.

Note: No experimental confirmation available.
Show »
Length:3,553
Mass (Da):389,153
Checksum:i5915CA253DD7270B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2ADB0A2ADB0_MOUSE
Msx2-interacting protein
Spen
3,643Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2ADB1A2ADB1_MOUSE
Msx2-interacting protein
Spen
3,620Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD55931 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB01562 differs from that shown. Reason: Frameshift at positions 446 and 561.Curated
The sequence CAB01562 differs from that shown. Reason: Erroneous termination at position 394. Translated as Leu.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti366V → E in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti394L → B in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti409V → E in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti413V → E in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti430I → K in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti454 – 462DLRNIFQRF → EPSETSFSAL in CAB01562 (PubMed:9119401).Curated9
Sequence conflicti511F → L in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti527S → P in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti537H → N in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti566A → V in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti569A → V in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti573 – 577TKGRK → DQGQE in CAB01562 (PubMed:9119401).Curated5
Sequence conflicti754R → G in BAB32786 (Ref. 3) Curated1
Sequence conflicti1524D → A in BAB32786 (Ref. 3) Curated1
Sequence conflicti1560H → Y in BAB32786 (Ref. 3) Curated1
Sequence conflicti1570F → L in BAB32786 (Ref. 3) Curated1
Sequence conflicti1574R → G in BAB32786 (Ref. 3) Curated1
Sequence conflicti1609Q → R in BAB32786 (Ref. 3) Curated1
Sequence conflicti1659I → V in BAB32786 (Ref. 3) Curated1
Sequence conflicti1669S → F in BAB32786 (Ref. 3) Curated1
Sequence conflicti1705V → A in BAB32786 (Ref. 3) Curated1
Sequence conflicti1815A → V in BAB32786 (Ref. 3) Curated1
Sequence conflicti2097G → A in BAB32786 (Ref. 3) Curated1
Sequence conflicti2201 – 2202Missing in BAB32786 (Ref. 3) Curated2
Sequence conflicti2322A → V in BAB32786 (Ref. 3) Curated1
Sequence conflicti2385P → Q in BAB32786 (Ref. 3) Curated1
Sequence conflicti2502R → K in BAB32786 (Ref. 3) Curated1
Sequence conflicti2505E → K in BAB32786 (Ref. 3) Curated1
Sequence conflicti2519D → N in BAB32786 (Ref. 3) Curated1
Sequence conflicti2554T → S in BAB32786 (Ref. 3) Curated1
Sequence conflicti2679 – 2688LVSTPAGPVN → VGEHPWWARD in BAB32786 (Ref. 3) Curated10
Sequence conflicti3010L → P in BAB32786 (Ref. 3) Curated1
Sequence conflicti3010L → P in BAC65684 (PubMed:12693553).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti348I → T2 Publications1
Natural varianti762S → F1 Publication1
Natural varianti773S → F1 Publication1
Natural varianti933S → L1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_008564618 – 640Missing in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_0138023318 – 3322PPEGE → RKPAFF in isoform 3. 1 Publication5
Alternative sequenceiVSP_0138033550 – 3552ETD → RLE in isoform 3. 1 Publication3
Alternative sequenceiVSP_0138043553 – 3644Missing in isoform 3. 1 PublicationAdd BLAST92

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BY726481 mRNA No translation available.
AF156529 mRNA Translation: AAD55931.1 Different initiation.
AB055980 mRNA Translation: BAB32786.1
Z78160 mRNA Translation: CAB01562.1 Sequence problems.
AK122402 Transcribed RNA Translation: BAC65684.3

NCBI Reference Sequences

More...
RefSeqi
NP_062737.2, NM_019763.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.299906

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
56381

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:56381

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BY726481 mRNA No translation available.
AF156529 mRNA Translation: AAD55931.1 Different initiation.
AB055980 mRNA Translation: BAB32786.1
Z78160 mRNA Translation: CAB01562.1 Sequence problems.
AK122402 Transcribed RNA Translation: BAC65684.3
RefSeqiNP_062737.2, NM_019763.2
UniGeneiMm.299906

3D structure databases

ProteinModelPortaliQ62504
SMRiQ62504
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207942, 1 interactor
CORUMiQ62504
IntActiQ62504, 4 interactors
MINTiQ62504
STRINGi10090.ENSMUSP00000101412

PTM databases

iPTMnetiQ62504
PhosphoSitePlusiQ62504

Proteomic databases

jPOSTiQ62504
PaxDbiQ62504
PeptideAtlasiQ62504
PRIDEiQ62504

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi56381
KEGGimmu:56381

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23013
MGIiMGI:1891706 Spen

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG0112 Eukaryota
ENOG410ZT33 LUCA
HOGENOMiHOG000231295
HOVERGENiHBG045583
InParanoidiQ62504
OrthoDBi367857at2759
PhylomeDBiQ62504

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Spen mouse

Protein Ontology

More...
PROi
PR:Q62504

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

CDDicd12348 RRM1_SHARP, 1 hit
cd12349 RRM2_SHARP, 1 hit
cd12350 RRM3_SHARP, 1 hit
cd12351 RRM4_SHARP, 1 hit
Gene3Di2.40.290.10, 1 hit
3.30.70.330, 4 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034172 SHARP_RRM1
IPR034173 SHARP_RRM2
IPR034174 SHARP_RRM3
IPR034175 SHARP_RRM4
IPR016194 SPOC-like_C_dom_sf
IPR012921 SPOC_C
IPR010912 SPOC_met
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
PF07744 SPOC, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 4 hits
SUPFAMiSSF100939 SSF100939, 1 hit
SSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 4 hits
PS50917 SPOC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMINT_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q62504
Secondary accession number(s): Q80TN9, Q99PS4, Q9QZW2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: January 16, 2019
This is version 166 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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