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UniProtKB - Q62504 (MINT_MOUSE)

Entry version 166 (16 Jan 2019)
Sequence version 2 (10 Oct 2003)
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Protein

Msx2-interacting protein

Gene

Spen

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways, such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi1 – 574Add BLAST574

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Repressor, RNA-binding
Biological processNotch signaling pathway, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Msx2-interacting protein
Alternative name(s):
SMART/HDAC1-associated repressor protein
SPEN homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Spen
Synonyms:Kiaa0929, Mint, Sharp
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1891706 Spen

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000816281 – 3644Msx2-interacting proteinAdd BLAST3644

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei99PhosphoserineBy similarity1
Modified residuei108Omega-N-methylarginineBy similarity1
Modified residuei188PhosphoserineBy similarity1
Modified residuei190PhosphoserineBy similarity1
Modified residuei310PhosphoserineBy similarity1
Modified residuei647PhosphoserineBy similarity1
Modified residuei747PhosphoserineBy similarity1
Modified residuei749PhosphoserineBy similarity1
Modified residuei758PhosphoserineBy similarity1
Modified residuei762PhosphoserineBy similarity1
Modified residuei792PhosphoserineBy similarity1
Modified residuei852PhosphoserineCombined sources1
Modified residuei855PhosphoserineCombined sources1
Modified residuei869PhosphoserineCombined sources1
Modified residuei1077PhosphoserineBy similarity1
Modified residuei1183PhosphoserineBy similarity1
Modified residuei1209PhosphoserineBy similarity1
Modified residuei1237PhosphoserineBy similarity1
Modified residuei1267PhosphoserineBy similarity1
Modified residuei1276PhosphoserineBy similarity1
Modified residuei1283PhosphoserineBy similarity1
Modified residuei1293PhosphoserineBy similarity1
Modified residuei1298PhosphoserineBy similarity1
Modified residuei1302PhosphoserineBy similarity1
Modified residuei1348PhosphoserineBy similarity1
Modified residuei1395PhosphoserineCombined sources1
Modified residuei1397PhosphoserineBy similarity1
Modified residuei1454PhosphothreonineBy similarity1
Modified residuei1456PhosphothreonineBy similarity1
Modified residuei1634PhosphothreonineBy similarity1
Modified residuei1844PhosphothreonineBy similarity1
Modified residuei1915PhosphoserineBy similarity1
Modified residuei1936PhosphoserineBy similarity1
Modified residuei1965PhosphothreonineBy similarity1
Modified residuei2128PhosphoserineBy similarity1
Modified residuei2134PhosphoserineBy similarity1
Modified residuei2171PhosphothreonineBy similarity1
Modified residuei2366PhosphoserineBy similarity1
Modified residuei2419PhosphothreonineBy similarity1
Modified residuei2450PhosphoserineBy similarity1
Modified residuei2454PhosphoserineBy similarity1
Modified residuei2458PhosphothreonineBy similarity1
Modified residuei2491PhosphoserineBy similarity1
Modified residuei2913PhosphothreonineBy similarity1
Modified residuei2925PhosphothreonineBy similarity1
Modified residuei3088Asymmetric dimethylarginineBy similarity1
Modified residuei3096Asymmetric dimethylarginineBy similarity1
Modified residuei3413PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q62504

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q62504

PeptideAtlas

More...PeptideAtlasi		Q62504

PRoteomics IDEntifications database

More...PRIDEi		Q62504

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q62504

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q62504

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in testis. Expressed at lower level in brain, lung, spleen, liver and kidney. Weakly expressed in cardiac and skeletal muscles and ovary. In spleen, it is expressed in follicular B-cells, while it is weakly expressed in marginal zone B-cells.3 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NCOR2, HDAC1, HDAC2, RBBP4, MBD3 and MTA1L1. Interacts with the nuclear receptors RAR and PPARD. Interacts with RAR in absence of ligand. Binds to the steroid receptor RNA coactivator SRA (By similarity). Interacts with MSX2. Interacts with RBPSUH; this interaction may prevent the interaction between RBPSUH and NOTCH1. Binds to HIPK3.By similarity2 Publications

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		207942, 1 interactor

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q62504

Protein interaction database and analysis system

More...IntActi		Q62504, 4 interactors

Molecular INTeraction database

More...MINTi		Q62504

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000101412

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q62504

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q62504

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 81RRM 1PROSITE-ProRule annotationAdd BLAST76
Domaini336 – 416RRM 2PROSITE-ProRule annotationAdd BLAST81
Domaini439 – 514RRM 3PROSITE-ProRule annotationAdd BLAST76
Domaini518 – 590RRM 4PROSITE-ProRule annotationAdd BLAST73
Domaini2216 – 2704RIDAdd BLAST489
Domaini3478 – 3644SPOCPROSITE-ProRule annotationAdd BLAST167

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2138 – 2462Interaction with MSX21 PublicationAdd BLAST325
Regioni2706 – 2845Interaction with RBPSUHAdd BLAST140

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili559 – 575Sequence analysisAdd BLAST17
Coiled coili822 – 850Sequence analysisAdd BLAST29
Coiled coili1185 – 1206Sequence analysisAdd BLAST22
Coiled coili1509 – 1544Sequence analysisAdd BLAST36
Coiled coili1607 – 1627Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi125 – 277Arg-richAdd BLAST153
Compositional biasi236 – 326Ser-richAdd BLAST91
Compositional biasi648 – 721Tyr-richAdd BLAST74
Compositional biasi702 – 832Arg-richAdd BLAST131
Compositional biasi2101 – 2233Ala-richAdd BLAST133
Compositional biasi2377 – 2518Pro-richAdd BLAST142
Compositional biasi2950 – 3475Pro-richAdd BLAST526

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RID domain mediates the interaction with nuclear receptors.
The SPOC domain, which mediates the interaction with NCOR2, is essential for the repressive activity.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RRM Spen family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0112 Eukaryota
ENOG410ZT33 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000231295

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG045583

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q62504

Database of Orthologous Groups

More...OrthoDBi		367857at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q62504

Family and domain databases

Conserved Domains Database

More...CDDi		cd12348 RRM1_SHARP, 1 hit
cd12349 RRM2_SHARP, 1 hit
cd12350 RRM3_SHARP, 1 hit
cd12351 RRM4_SHARP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.290.10, 1 hit
3.30.70.330, 4 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034172 SHARP_RRM1
IPR034173 SHARP_RRM2
IPR034174 SHARP_RRM3
IPR034175 SHARP_RRM4
IPR016194 SPOC-like_C_dom_sf
IPR012921 SPOC_C
IPR010912 SPOC_met

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00076 RRM_1, 3 hits
PF07744 SPOC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00360 RRM, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF100939 SSF100939, 1 hit
SSF54928 SSF54928, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50102 RRM, 4 hits
PS50917 SPOC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q62504-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVRETRHLWV GNLPENVREE KIIEHFKRYG RVESVKILPK RGSEGGVAAF 
        60         70         80         90        100
VDFVDIKSAQ KAHNSVNKMG DRDLRTDYNE PGTIPSAARG LDETVSIASR 
       110        120        130        140        150
SREVSGFRGS AGGPAYGPPP SLHAREGRYE RRLDGASDNR ERAYEHSAYG 
       160        170        180        190        200
HHERGTGAFD RTRHYDQDYY RDPRERTLQH GLYYTSRSRS PNRFDAHDPR 
       210        220        230        240        250
YEPRAREQFT LPSVVHRDIY RDDITREVRG RRPERSYQHS RSRSPHSSQS 
       260        270        280        290        300
RNQSPQRLAS QASRPTRSPS GSGSRSRSSS SDSISSSSSS SNTDSSDSSS 
       310        320        330        340        350
TASDDSPARS VQSAAVPAPT SQLLSSLEKD EPRKSFGIKV QNLPVRSIDT 
       360        370        380        390        400
SLKDGLFHEF KKFGKVTSVQ IHGASEERYG LVFFRQQEDQ EKALTASKGK 
       410        420        430        440        450
LFFGMQIEVT AWVGPETESE NEFRPLDERI DEFHPKATRT LFIGNLEKTT 
       460        470        480        490        500
TYHDLRNIFQ RFGEIVDIDI KKVNGVPQYA FLQYCDIASV CKAIKKMDGE 
       510        520        530        540        550
YLGNNRLKLG FGKSMPTNCV WLDGLSSNVS DQYLTRHFCR YGPVVKVVFD 
       560        570        580        590        600
RLKGMALVLY SEIEDAQAAV KETKGRKIGG NKIKVDFANR ESQLAFYHCM 
       610        620        630        640        650
EKSGQDMRDF YEMLTERRAG QMAQSKHEDW SADAQSPHKC REERRGSYEY 
       660        670        680        690        700
SQERTYYENV RTPGTYPEDS RRDYPARGRE FYSEWETYQG EYYDSRYYDE 
       710        720        730        740        750
PREYREYRSD PYEQDIREYS YRQRERERER ERFESDRDHE RRPIERSQSP 
       760        770        780        790        800
VHLRRPQSPG VSPAHSERLP SDSERRLYRR SSERSGSCSS VSPPRYDKLE 
       810        820        830        840        850
KARLERYTKN EKADKERTFD PERVERERRI VRKEKGEKDK AERQKRKGKA 
       860        870        880        890        900
HSPSSQPSET EQENDREQSP EKPRGSTKLS RDRADKEGPA KNRLELVPCV 
       910        920        930        940        950
VLTRVKEKEG KVIEHPPPEK LKARLGRDTT KASALDQKPQ AAQGEPAKSD 
       960        970        980        990       1000
PARGKALREK VLPSHAEVGE KEGRTKLRKH LKAEQTPELS ALDLEKLEAR 
      1010       1020       1030       1040       1050
KRRFADSGLK IEKQKPEIKK TSPETEDTRI LLKKQPDTSR DGVLLREGES 
      1060       1070       1080       1090       1100
ERKPVRKEIL KRESKKTKLE RLNSALSPKD CQDPAAVSAG SGSRPSSDVH 
      1110       1120       1130       1140       1150
AGLGELTHGS VETQETQPKK AIPSKPQPKQ LQLLENQGPE KEEVRKNYCR 
      1160       1170       1180       1190       1200
PREEPAEHRA GQEKPHGGNA EEKLGIDIDH TQSYRKQMEQ SRRKQRMEME 
      1210       1220       1230       1240       1250
IAKAEKFGSP KKDVDDYERR SLVHEVGKPP QDVTDDSPPS KKRRTDHVDF 
      1260       1270       1280       1290       1300
DICTKRERNY RSSRQISEDS ERTSCSPSVR HGSFHDDDDP RGSPRLVSVK 
      1310       1320       1330       1340       1350
GSPKGDEKGL PYPNAAVRDD PLKCNPYDSG KREQTADTAK IKLSVLNSEG 
      1360       1370       1380       1390       1400
EPSRWDPPMK QDPSRFDVSF PNSVIKRDSL RKRSVRDLEP GEVPSDSDED 
      1410       1420       1430       1440       1450
AEHRSQSPRA SSFYDSPRLS FLLRDRDQKL RERDERLASS LERNKFYSFA 
      1460       1470       1480       1490       1500
LDKTITPDTK ALLERAKSLS SSREENWSFL DWDSRFANFR NNKDKEKVDS 
      1510       1520       1530       1540       1550
APRPIPSWYM KKKKIRTDSE GKLDDKKDER REEEQERQEL FASRFLHSSI 
      1560       1570       1580       1590       1600
FEQDSKRLQH LERKSEESDF PPGRLYGRQA SEGANSTSDS VQEPVVLFHS 
      1610       1620       1630       1640       1650
RFMELTRMQQ KEKEKDQKPK EAEKQEEPET HPKTPEPAAE TKEPEPKAPV 
      1660       1670       1680       1690       1700
SAGLPAVTIT VVTPEPASSA PEKAEEAAEA PSPAGEKPAE PAPVSEETKL 
      1710       1720       1730       1740       1750
VSEPVSVPVE QPRQSDVPPG EDSRDSQDSA ALAPSAPQES AATDAVPCVN 
      1760       1770       1780       1790       1800
AEPLTPGTTV SQVESSVDPK PSSPQPLSKL TQRSEEAEEG KVEKPDTTPS 
      1810       1820       1830       1840       1850
TEPDATQNAG VASEAQPPAS EDVEANPPVA AKDRKTNKSK RSKTSVQAAA 
      1860       1870       1880       1890       1900
ASVVEKPVTR KSERIDREKL KRSSSPRGEA QKLLELKMEA EKITRTASKS 
      1910       1920       1930       1940       1950
SGGDTEHPEP SLPLSRSRRR NVRSVYATMT DHESRSPAKE PVEQPRVTRK 
      1960       1970       1980       1990       2000
RLERELQEAV VPPTTPRRGR PPKTRRRAEE DGEHERKEPA ETPRPAEGWR 
      2010       2020       2030       2040       2050
SPRSQKSAAA AGPQGKRGRN EQKVEAAAEA GAQASTREGN PKSRGEREAA 
      2060       2070       2080       2090       2100
SEPKRDRRDP STDKSGPDTF PVEVLERKPP EKTYKSKRGR ARSTRSGMDR 
      2110       2120       2130       2140       2150
AAHQRSLEMA ARAAGQAADK EAGPAAASPQ ESESPQKGSG SSPQLANNPA 
      2160       2170       2180       2190       2200
DPDREAEEES ASASTAPPEG TQLARQIELE QAVQNIAKLP EPSAAAASKG 
      2210       2220       2230       2240       2250
TATATATAAS EEPAPEHGHK PAHQASETEL AAAIGSIISD ASGEPENFSA 
      2260       2270       2280       2290       2300
PPSVPPGSQT HPREGMEPGL HEAESGILET GTATESSAPQ VSALDPPEGS 
      2310       2320       2330       2340       2350
ADTKETRGNS GDSVQEAKGS KAEVTPPRKD KGRQKTTRRR KRNANKKVVA 
      2360       2370       2380       2390       2400
ITETRASEAE QTQSESPAAE EATAATPEAP QEEKPSEKPP SPPAECTFDP 
      2410       2420       2430       2440       2450
SKTPPAESLS QENSAAEKTP CKAPVLPALP PLSQPALMDD GPQARFKVHS 
      2460       2470       2480       2490       2500
IIESDPVTPP SDSGIPPPTI PLVTIAKLPP PVIPGGVPHQ SPPPKVTEWI 
      2510       2520       2530       2540       2550
TRQEEPRAQS TPSPALPPDT KASDMDTSSS TLRKILMDPK YVSATGVTST 
      2560       2570       2580       2590       2600
SVTTAIAEPV SAPCLQEAPA PPCDPKHPPL EGVSAAAVPN ADTQASEVPV 
      2610       2620       2630       2640       2650
AADKEKVAPV IAPKITSVIS RMPVSIDLEN SQKITLAKPA PQTLTGLVSA 
      2660       2670       2680       2690       2700
LTGLVNVSLV PVNALKGPVK GSVATLKGLV STPAGPVNLL KGPVNVLTGP 
      2710       2720       2730       2740       2750
VNVLTTPVSA TVGTVNAAPG PVTAACGVTA TTGTAAVTGA VTAPAAKGKQ 
      2760       2770       2780       2790       2800
RASSNENSRF HPGSMSVIDD RPADTGSGAG LRVNTSEGVV LLSYSGQKTE 
      2810       2820       2830       2840       2850
GPQRISAKIS QIPPASAMDI EFQQSVSKSQ VKADSITPTQ SAPKGPQTPS 
      2860       2870       2880       2890       2900
AFANVAAHST LVLTAQTYNA SPVISSVKTD RPSLEKPEPI HLSVSTPVTQ 
      2910       2920       2930       2940       2950
GGTVKVLTQG INTPPVLVHN QLVLTPSIVT TNKKLADPVT LKIETKVLQP 
      2960       2970       2980       2990       3000
ANLGPTLTPH HPPALPSKLP AEVNHVPSGP STPADRTIAH LATPKPDTHS 
      3010       3020       3030       3040       3050
PRPTGPTPGL FPRPCHPSST TSTALSTNAT VMLAAGIPVP QFISSIHPEQ 
      3060       3070       3080       3090       3100
SVIMPPHSIT QTVSLGHLSQ GEVRMSTPTL PSITYSIRPE TLHSPRAPLQ 
      3110       3120       3130       3140       3150
PQQIEARAPQ RVGTPQPATT GVPALATQHP PEEEVHYHLP VARAAAPVQS 
      3160       3170       3180       3190       3200
EVLVMQSEYR LHPYTVPRDV RIMVHPHVTA VSEQPRATEG VVKVPPANKA 
      3210       3220       3230       3240       3250
PQQLVKEAVK TSDAKAVPAP APVPVPVPVP TPAPPPHGEA RILTVTPSSQ 
      3260       3270       3280       3290       3300
LQGLPLTPPV VVTHGVQIVH SSGELFQEYR YGDVRTYHAP AQQLTHTQFP 
      3310       3320       3330       3340       3350
VASSISLASR TKTSAQVPPE GEPLQSTQSA QPAPSTQATQ PIPPAPPCQP 
      3360       3370       3380       3390       3400
SQLSQPAQPP SGKIPQVSQE AKGTQTGGVE QTRLPAIPTN RPSEPHAQLQ 
      3410       3420       3430       3440       3450
RAPVETAQPA HPSPVSVSMK PDLPSPLSSQ AAPKQPLFVP ANSGPSTPPG 
      3460       3470       3480       3490       3500
LALPHAEVQP APKQESSPHG TPQRPVDMVQ LLKKYPIVWQ GLLALKNDTA 
      3510       3520       3530       3540       3550
AVQLHFVSGN NVLAHRSLPL SEGGPPLRIA QRMRLEASQL EGVARRMTVE 
      3560       3570       3580       3590       3600
TDYCLLLALP CGRDQEDVVS QTESLKAAFI TYLQAKQAAG IINVPNPGSN 
      3610       3620       3630       3640 
QPAYVLQIFP PCEFSESHLS RLAPDLLASI SNISPHLMIV IASV
Length:3,644
Mass (Da):398,754
Last modified:October 10, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9C7EC49A81A7DA4A
GO
Isoform 2 (identifier: Q62504-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     618-640: Missing.

Note: No experimental confirmation available.
Show »
Length:3,621
Mass (Da):396,203
Checksum:i878136C0D8CF0D22
GO
Isoform 3 (identifier: Q62504-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3318-3322: PPEGE → RKPAFF
     3550-3552: ETD → RLE
     3553-3644: Missing.

Note: No experimental confirmation available.
Show »
Length:3,553
Mass (Da):389,153
Checksum:i5915CA253DD7270B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2ADB0A2ADB0_MOUSE
Msx2-interacting protein
Spen
3,643Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2ADB1A2ADB1_MOUSE
Msx2-interacting protein
Spen
3,620Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD55931 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB01562 differs from that shown. Reason: Frameshift at positions 446 and 561.Curated
The sequence CAB01562 differs from that shown. Reason: Erroneous termination at position 394. Translated as Leu.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti366V → E in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti394L → B in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti409V → E in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti413V → E in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti430I → K in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti454 – 462DLRNIFQRF → EPSETSFSAL in CAB01562 (PubMed:9119401).Curated9
Sequence conflicti511F → L in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti527S → P in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti537H → N in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti566A → V in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti569A → V in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti573 – 577TKGRK → DQGQE in CAB01562 (PubMed:9119401).Curated5
Sequence conflicti754R → G in BAB32786 (Ref. 3) Curated1
Sequence conflicti1524D → A in BAB32786 (Ref. 3) Curated1
Sequence conflicti1560H → Y in BAB32786 (Ref. 3) Curated1
Sequence conflicti1570F → L in BAB32786 (Ref. 3) Curated1
Sequence conflicti1574R → G in BAB32786 (Ref. 3) Curated1
Sequence conflicti1609Q → R in BAB32786 (Ref. 3) Curated1
Sequence conflicti1659I → V in BAB32786 (Ref. 3) Curated1
Sequence conflicti1669S → F in BAB32786 (Ref. 3) Curated1
Sequence conflicti1705V → A in BAB32786 (Ref. 3) Curated1
Sequence conflicti1815A → V in BAB32786 (Ref. 3) Curated1
Sequence conflicti2097G → A in BAB32786 (Ref. 3) Curated1
Sequence conflicti2201 – 2202Missing in BAB32786 (Ref. 3) Curated2
Sequence conflicti2322A → V in BAB32786 (Ref. 3) Curated1
Sequence conflicti2385P → Q in BAB32786 (Ref. 3) Curated1
Sequence conflicti2502R → K in BAB32786 (Ref. 3) Curated1
Sequence conflicti2505E → K in BAB32786 (Ref. 3) Curated1
Sequence conflicti2519D → N in BAB32786 (Ref. 3) Curated1
Sequence conflicti2554T → S in BAB32786 (Ref. 3) Curated1
Sequence conflicti2679 – 2688LVSTPAGPVN → VGEHPWWARD in BAB32786 (Ref. 3) Curated10
Sequence conflicti3010L → P in BAB32786 (Ref. 3) Curated1
Sequence conflicti3010L → P in BAC65684 (PubMed:12693553).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti348I → T2 Publications1
Natural varianti762S → F1 Publication1
Natural varianti773S → F1 Publication1
Natural varianti933S → L1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_008564618 – 640Missing in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_0138023318 – 3322PPEGE → RKPAFF in isoform 3. 1 Publication5
Alternative sequenceiVSP_0138033550 – 3552ETD → RLE in isoform 3. 1 Publication3
Alternative sequenceiVSP_0138043553 – 3644Missing in isoform 3. 1 PublicationAdd BLAST92

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BY726481 mRNA No translation available.
AF156529 mRNA Translation: AAD55931.1 Different initiation.
AB055980 mRNA Translation: BAB32786.1
Z78160 mRNA Translation: CAB01562.1 Sequence problems.
AK122402 Transcribed RNA Translation: BAC65684.3

NCBI Reference Sequences

More...RefSeqi		NP_062737.2, NM_019763.2

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Mm.299906

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		56381

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:56381

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BY726481 mRNA No translation available.
AF156529 mRNA Translation: AAD55931.1 Different initiation.
AB055980 mRNA Translation: BAB32786.1
Z78160 mRNA Translation: CAB01562.1 Sequence problems.
AK122402 Transcribed RNA Translation: BAC65684.3
RefSeqiNP_062737.2, NM_019763.2
UniGeneiMm.299906

3D structure databases

ProteinModelPortaliQ62504
SMRiQ62504
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207942, 1 interactor
CORUMiQ62504
IntActiQ62504, 4 interactors
MINTiQ62504
STRINGi10090.ENSMUSP00000101412

PTM databases

iPTMnetiQ62504
PhosphoSitePlusiQ62504

Proteomic databases

jPOSTiQ62504
PaxDbiQ62504
PeptideAtlasiQ62504
PRIDEiQ62504

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi56381
KEGGimmu:56381

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23013
MGIiMGI:1891706 Spen

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiKOG0112 Eukaryota
ENOG410ZT33 LUCA
HOGENOMiHOG000231295
HOVERGENiHBG045583
InParanoidiQ62504
OrthoDBi367857at2759
PhylomeDBiQ62504

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Spen mouse

Protein Ontology

More...PROi		PR:Q62504

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Family and domain databases

CDDicd12348 RRM1_SHARP, 1 hit
cd12349 RRM2_SHARP, 1 hit
cd12350 RRM3_SHARP, 1 hit
cd12351 RRM4_SHARP, 1 hit
Gene3Di2.40.290.10, 1 hit
3.30.70.330, 4 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034172 SHARP_RRM1
IPR034173 SHARP_RRM2
IPR034174 SHARP_RRM3
IPR034175 SHARP_RRM4
IPR016194 SPOC-like_C_dom_sf
IPR012921 SPOC_C
IPR010912 SPOC_met
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
PF07744 SPOC, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 4 hits
SUPFAMiSSF100939 SSF100939, 1 hit
SSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 4 hits
PS50917 SPOC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMINT_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q62504
Secondary accession number(s): Q80TN9, Q99PS4, Q9QZW2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: January 16, 2019
This is version 166 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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