Vps72

Functionⁱ

Deposition-and-exchange histone chaperone specific for H2AFZ, specifically chaperones H2AFZ and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AFZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	156 – 206	Sequence analysisAdd BLAST		51

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
histone binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

histone exchange Source: UniProtKB
regulation of transcription, DNA-templated Source: InterPro
somatic stem cell population maintenance
Source: MGI
Inferred from direct assayⁱ
- 19379700

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chromatin regulator, DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Vacuolar protein sorting-associated protein 72 homolog Alternative name(s): Protein YL-1 Transcription factor-like 1
Gene namesⁱ	Name:Vps72 Synonyms:Tcfl1, Yl1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 3

Organism-specific databases

MGIⁱ	MGI:1202305 Vps72

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000066284	1 – 368	Vacuolar protein sorting-associated protein 72 homologAdd BLAST		368

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	115	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	127	PhosphoserineBy similarity	1
Modified residueⁱ	129	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q62481
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q62481
PaxDbⁱ	Q62481
PeptideAtlas More...PeptideAtlasⁱ	Q62481
PRIDEⁱ	Q62481

PTM databases

iPTMnetⁱ	Q62481
PhosphoSitePlusⁱ	Q62481

Expressionⁱ

Tissue specificityⁱ

In all tissues examined, most abundantly in brain and thymus.

Gene expression databases

Bgeeⁱ	ENSMUSG00000008958 Expressed in 263 organ(s), highest expression level in tracheobronchial tree
CleanExⁱ	MM_VPS72
Genevisibleⁱ	Q62481 MM

Interactionⁱ

Subunit structureⁱ

Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41 and VPS72/YL1. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Also part of a multiprotein complex which contains SRCAP and which binds to H2AFZ/H2AZ. Interacts (via N-terminal domain) with H2AFZ.By similarity

GO - Molecular functionⁱ

histone binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	204018, 3 interactors
ComplexPortalⁱ	CPX-976 SRCAP histone exchanging complex CPX-990 NuA4 histone acetyltransferase complex
IntActⁱ	Q62481, 4 interactors
Molecular INTeraction database More...MINTⁱ	Q62481
STRINGⁱ	10090.ENSMUSP00000009102

Structureⁱ

3D structure databases

SMRⁱ	Q62481
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	22 – 77	Asp/Glu-rich (acidic)Add BLAST	56
Compositional biasⁱ	256 – 259	Poly-Ala	4
Compositional biasⁱ	337 – 358	Pro-richAdd BLAST	22
Compositional biasⁱ	345 – 354	Poly-Pro	10

Sequence similaritiesⁱ

Belongs to the VPS72/YL1 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2897 Eukaryota ENOG41119RU LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017503
HOGENOMⁱ	HOG000033695
HOVERGENⁱ	HBG083244
InParanoidⁱ	Q62481
KEGG Orthology (KO) More...KOⁱ	K11664
OMAⁱ	CERTFVT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BQW
PhylomeDBⁱ	Q62481
TreeFamⁱ	TF314532

Family and domain databases

InterProⁱ	View protein in InterPro IPR008895 Vps72/YL1 IPR013272 Vps72/YL1_C
PANTHERⁱ	PTHR13275 PTHR13275, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05764 YL1, 1 hit PF08265 YL1_C, 1 hit
SMARTⁱ	View protein in SMART SM00993 YL1_C, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q62481-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSLAGGRAPR KTAGNRLSGL LEAEEEDEFY QTTYGGFTEE SGDDEYQGDQ 
        60         70         80         90        100
SDTEDEVDSD FDIDEGDEPS SDGEAEEPRR KRRVVTKAYK EPLKSLRPRK 
       110        120        130        140        150
VSTPASSSQK AREEKTLLPL ELQDDGSDSR KSMRQSTAEH TRQTFLRVQE 
       160        170        180        190        200
RQGQSRRRKG PHCERPLTQE ELLREAKITE ELNLRSLETY ERLEADKKKQ 
       210        220        230        240        250
VHKKRKCPGP IITYHSVTVP LVGEPGPKEE NVDVEGLDPA PTASALAPHA 
       260        270        280        290        300
GTGTGAAAAT PPAHCSRTFI TFSDDATFEE WFPQGRPPKV PVREVCPVTH 
       310        320        330        340        350
RPALYRDPVT DIPYATARAF KIIREAYKKY ITAHGLPPTA SALGPGPPPP 
       360 
EPLPGSGPRA LRQKIVIK

Length:368

Mass (Da):40,784

Last modified:February 21, 2006 - v2

Checksum:ⁱ1A7F0FB6456D81C3

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	75	A → S in AAH04834 (PubMed:15489334).Curated	1
Sequence conflictⁱ	247	A → V in BAA07758 (PubMed:7702631).Curated	1
Sequence conflictⁱ	247	A → V in BAE33106 (PubMed:16141072).Curated	1
Sequence conflictⁱ	260	T → A in AAH04834 (PubMed:15489334).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D43643 mRNA Translation: BAA07758.1 AK140284 mRNA Translation: BAE24317.1 AK155191 mRNA Translation: BAE33106.1 BC004834 mRNA Translation: AAH04834.1 BC043029 mRNA Translation: AAH43029.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS38543.1
PIRⁱ	JC4141
NCBI Reference Sequences More...RefSeqⁱ	NP_033362.2, NM_009336.2
UniGeneⁱ	Mm.133919

Genome annotation databases

Ensemblⁱ	ENSMUST00000009102; ENSMUSP00000009102; ENSMUSG00000008958
GeneIDⁱ	21427
KEGGⁱ	mmu:21427
UCSC genome browser More...UCSCⁱ	uc008qia.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q62481	Vacuolar protein sorting-associated protein 72 homolog	)	HUMAN		364	UniRef90_Q15906
Vacuolar protein sorting-associated protein 72 homolog		PONAB		364
Vacuolar protein sorting-associated protein 72 homolog		BOVIN		364
Vacuolar protein sorting-associated protein 72 like protein		FUKDA		411
vacuolar protein sorting-associated protein 72 homolog isoform X1		LEPWE		376
+131

Protein	Similar proteins		Species	Score	Length	Source
Q62481	Vacuolar protein sorting-associated protein 72 homolog	)	HUMAN		364	UniRef50_Q15906
Vacuolar protein sorting-associated protein 72 homolog		PONAB		364
Vacuolar protein sorting-associated protein 72 homolog		BOVIN		364
Vacuolar protein sorting-associated protein 72 like protein		FUKDA		411
vacuolar protein sorting-associated protein 72 homolog isoform X1		LEPWE		376
+135

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D43643 mRNA Translation: BAA07758.1 AK140284 mRNA Translation: BAE24317.1 AK155191 mRNA Translation: BAE33106.1 BC004834 mRNA Translation: AAH04834.1 BC043029 mRNA Translation: AAH43029.2
CCDSⁱ	CCDS38543.1
PIRⁱ	JC4141
RefSeqⁱ	NP_033362.2, NM_009336.2
UniGeneⁱ	Mm.133919

3D structure databases

SMRⁱ	Q62481
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	204018, 3 interactors
ComplexPortalⁱ	CPX-976 SRCAP histone exchanging complex CPX-990 NuA4 histone acetyltransferase complex
IntActⁱ	Q62481, 4 interactors
MINTⁱ	Q62481
STRINGⁱ	10090.ENSMUSP00000009102

PTM databases

iPTMnetⁱ	Q62481
PhosphoSitePlusⁱ	Q62481

Proteomic databases

EPDⁱ	Q62481
MaxQBⁱ	Q62481
PaxDbⁱ	Q62481
PeptideAtlasⁱ	Q62481
PRIDEⁱ	Q62481

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000009102; ENSMUSP00000009102; ENSMUSG00000008958
GeneIDⁱ	21427
KEGGⁱ	mmu:21427
UCSCⁱ	uc008qia.1 mouse

Organism-specific databases

CTDⁱ	6944
MGIⁱ	MGI:1202305 Vps72

Phylogenomic databases

eggNOGⁱ	KOG2897 Eukaryota ENOG41119RU LUCA
GeneTreeⁱ	ENSGT00390000017503
HOGENOMⁱ	HOG000033695
HOVERGENⁱ	HBG083244
InParanoidⁱ	Q62481
KOⁱ	K11664
OMAⁱ	CERTFVT
OrthoDBⁱ	EOG091G0BQW
PhylomeDBⁱ	Q62481
TreeFamⁱ	TF314532

Miscellaneous databases

ChiTaRSⁱ	Vps72 mouse
Protein Ontology More...PROⁱ	PR:Q62481
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000008958 Expressed in 263 organ(s), highest expression level in tracheobronchial tree
CleanExⁱ	MM_VPS72
Genevisibleⁱ	Q62481 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR008895 Vps72/YL1 IPR013272 Vps72/YL1_C
PANTHERⁱ	PTHR13275 PTHR13275, 1 hit
Pfamⁱ	View protein in Pfam PF05764 YL1, 1 hit PF08265 YL1_C, 1 hit
SMARTⁱ	View protein in SMART SM00993 YL1_C, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	VPS72_MOUSE
Accessionⁱ	Q62481Primary (citable) accession number: Q62481 Secondary accession number(s): Q3U2N4, Q810A9, Q99K81
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	February 21, 2006
	Last modified:	November 7, 2018
	This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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Annotation systems

Supporting data

UniProtKB - Q62481 (VPS72_MOUSE)

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Vacuolar protein sorting-associated protein 72 homolog

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ