UniProtKB - Q62481 (VPS72_MOUSE)
Vacuolar protein sorting-associated protein 72 homolog
Vps72
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 156 – 206 | Sequence analysisAdd BLAST | 51 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- histone binding Source: MGI
GO - Biological processi
- histone exchange Source: UniProtKB
- regulation of transcription, DNA-templated Source: InterPro
- somatic stem cell population maintenance Source: MGI
Keywordsi
Molecular function | Chromatin regulator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Vacuolar protein sorting-associated protein 72 homologAlternative name(s): Protein YL-1 Transcription factor-like 1 |
Gene namesi | Name:Vps72 Synonyms:Tcfl1, Yl1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1202305, Vps72 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nuclear speck Source: MGI
- nucleus Source: GO_Central
Other locations
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000066284 | 1 – 368 | Vacuolar protein sorting-associated protein 72 homologAdd BLAST | 368 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 115 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 127 | PhosphoserineBy similarity | 1 | |
Modified residuei | 129 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q62481 |
MaxQBi | Q62481 |
PaxDbi | Q62481 |
PeptideAtlasi | Q62481 |
PRIDEi | Q62481 |
PTM databases
iPTMneti | Q62481 |
PhosphoSitePlusi | Q62481 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000008958, Expressed in tracheobronchial tree and 276 other tissues |
Genevisiblei | Q62481, MM |
Interactioni
Subunit structurei
Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41 and VPS72/YL1.
Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Also part of a multiprotein complex which contains SRCAP and which binds to H2AZ1/H2AZ.
Interacts (via N-terminal domain) with H2AZ1.
By similarityGO - Molecular functioni
- histone binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 204018, 3 interactors |
ComplexPortali | CPX-976, SRCAP histone exchanging complex CPX-990, NuA4 histone acetyltransferase complex |
IntActi | Q62481, 4 interactors |
MINTi | Q62481 |
STRINGi | 10090.ENSMUSP00000009102 |
Miscellaneous databases
RNActi | Q62481, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 22 – 77 | Asp/Glu-rich (acidic)Add BLAST | 56 | |
Compositional biasi | 256 – 259 | Poly-Ala | 4 | |
Compositional biasi | 337 – 358 | Pro-richAdd BLAST | 22 | |
Compositional biasi | 345 – 354 | Poly-Pro | 10 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2897, Eukaryota |
GeneTreei | ENSGT00390000017503 |
HOGENOMi | CLU_040862_0_0_1 |
InParanoidi | Q62481 |
OMAi | CERTFVT |
OrthoDBi | 1468037at2759 |
PhylomeDBi | Q62481 |
TreeFami | TF314532 |
Family and domain databases
InterProi | View protein in InterPro IPR008895, Vps72/YL1 IPR013272, Vps72/YL1_C |
PANTHERi | PTHR13275, PTHR13275, 1 hit |
Pfami | View protein in Pfam PF05764, YL1, 1 hit PF08265, YL1_C, 1 hit |
SMARTi | View protein in SMART SM00993, YL1_C, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MSLAGGRAPR KTAGNRLSGL LEAEEEDEFY QTTYGGFTEE SGDDEYQGDQ
60 70 80 90 100
SDTEDEVDSD FDIDEGDEPS SDGEAEEPRR KRRVVTKAYK EPLKSLRPRK
110 120 130 140 150
VSTPASSSQK AREEKTLLPL ELQDDGSDSR KSMRQSTAEH TRQTFLRVQE
160 170 180 190 200
RQGQSRRRKG PHCERPLTQE ELLREAKITE ELNLRSLETY ERLEADKKKQ
210 220 230 240 250
VHKKRKCPGP IITYHSVTVP LVGEPGPKEE NVDVEGLDPA PTASALAPHA
260 270 280 290 300
GTGTGAAAAT PPAHCSRTFI TFSDDATFEE WFPQGRPPKV PVREVCPVTH
310 320 330 340 350
RPALYRDPVT DIPYATARAF KIIREAYKKY ITAHGLPPTA SALGPGPPPP
360
EPLPGSGPRA LRQKIVIK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 75 | A → S in AAH04834 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 247 | A → V in BAA07758 (PubMed:7702631).Curated | 1 | |
Sequence conflicti | 247 | A → V in BAE33106 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 260 | T → A in AAH04834 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D43643 mRNA Translation: BAA07758.1 AK140284 mRNA Translation: BAE24317.1 AK155191 mRNA Translation: BAE33106.1 BC004834 mRNA Translation: AAH04834.1 BC043029 mRNA Translation: AAH43029.2 |
CCDSi | CCDS38543.1 |
PIRi | JC4141 |
RefSeqi | NP_033362.2, NM_009336.2 |
Genome annotation databases
Ensembli | ENSMUST00000009102; ENSMUSP00000009102; ENSMUSG00000008958 |
GeneIDi | 21427 |
KEGGi | mmu:21427 |
UCSCi | uc008qia.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D43643 mRNA Translation: BAA07758.1 AK140284 mRNA Translation: BAE24317.1 AK155191 mRNA Translation: BAE33106.1 BC004834 mRNA Translation: AAH04834.1 BC043029 mRNA Translation: AAH43029.2 |
CCDSi | CCDS38543.1 |
PIRi | JC4141 |
RefSeqi | NP_033362.2, NM_009336.2 |
3D structure databases
SMRi | Q62481 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 204018, 3 interactors |
ComplexPortali | CPX-976, SRCAP histone exchanging complex CPX-990, NuA4 histone acetyltransferase complex |
IntActi | Q62481, 4 interactors |
MINTi | Q62481 |
STRINGi | 10090.ENSMUSP00000009102 |
PTM databases
iPTMneti | Q62481 |
PhosphoSitePlusi | Q62481 |
Proteomic databases
EPDi | Q62481 |
MaxQBi | Q62481 |
PaxDbi | Q62481 |
PeptideAtlasi | Q62481 |
PRIDEi | Q62481 |
Protocols and materials databases
Antibodypediai | 20319, 177 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000009102; ENSMUSP00000009102; ENSMUSG00000008958 |
GeneIDi | 21427 |
KEGGi | mmu:21427 |
UCSCi | uc008qia.1, mouse |
Organism-specific databases
CTDi | 6944 |
MGIi | MGI:1202305, Vps72 |
Phylogenomic databases
eggNOGi | KOG2897, Eukaryota |
GeneTreei | ENSGT00390000017503 |
HOGENOMi | CLU_040862_0_0_1 |
InParanoidi | Q62481 |
OMAi | CERTFVT |
OrthoDBi | 1468037at2759 |
PhylomeDBi | Q62481 |
TreeFami | TF314532 |
Miscellaneous databases
BioGRID-ORCSi | 21427, 9 hits in 18 CRISPR screens |
ChiTaRSi | Vps72, mouse |
PROi | PR:Q62481 |
RNActi | Q62481, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000008958, Expressed in tracheobronchial tree and 276 other tissues |
Genevisiblei | Q62481, MM |
Family and domain databases
InterProi | View protein in InterPro IPR008895, Vps72/YL1 IPR013272, Vps72/YL1_C |
PANTHERi | PTHR13275, PTHR13275, 1 hit |
Pfami | View protein in Pfam PF05764, YL1, 1 hit PF08265, YL1_C, 1 hit |
SMARTi | View protein in SMART SM00993, YL1_C, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VPS72_MOUSE | |
Accessioni | Q62481Primary (citable) accession number: Q62481 Secondary accession number(s): Q3U2N4, Q810A9, Q99K81 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | February 21, 2006 | |
Last modified: | December 2, 2020 | |
This is version 144 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families