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Protein

Vacuolar protein sorting-associated protein 72 homolog

Gene

Vps72

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Deposition-and-exchange histone chaperone specific for H2AFZ, specifically chaperones H2AFZ and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AFZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi156 – 206Sequence analysisAdd BLAST51

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 72 homolog
Alternative name(s):
Protein YL-1
Transcription factor-like 1
Gene namesi
Name:Vps72
Synonyms:Tcfl1, Yl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1202305 Vps72

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000662841 – 368Vacuolar protein sorting-associated protein 72 homologAdd BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki115Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei127PhosphoserineBy similarity1
Modified residuei129PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ62481
MaxQBiQ62481
PaxDbiQ62481
PeptideAtlasiQ62481
PRIDEiQ62481

PTM databases

iPTMnetiQ62481
PhosphoSitePlusiQ62481

Expressioni

Tissue specificityi

In all tissues examined, most abundantly in brain and thymus.

Gene expression databases

BgeeiENSMUSG00000008958 Expressed in 263 organ(s), highest expression level in tracheobronchial tree
CleanExiMM_VPS72
GenevisibleiQ62481 MM

Interactioni

Subunit structurei

Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41 and VPS72/YL1. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Also part of a multiprotein complex which contains SRCAP and which binds to H2AFZ/H2AZ. Interacts (via N-terminal domain) with H2AFZ.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204018, 3 interactors
ComplexPortaliCPX-976 SRCAP histone exchanging complex
CPX-990 NuA4 histone acetyltransferase complex
IntActiQ62481, 4 interactors
MINTiQ62481
STRINGi10090.ENSMUSP00000009102

Structurei

3D structure databases

SMRiQ62481
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi22 – 77Asp/Glu-rich (acidic)Add BLAST56
Compositional biasi256 – 259Poly-Ala4
Compositional biasi337 – 358Pro-richAdd BLAST22
Compositional biasi345 – 354Poly-Pro10

Sequence similaritiesi

Belongs to the VPS72/YL1 family.Curated

Phylogenomic databases

eggNOGiKOG2897 Eukaryota
ENOG41119RU LUCA
GeneTreeiENSGT00390000017503
HOGENOMiHOG000033695
HOVERGENiHBG083244
InParanoidiQ62481
KOiK11664
OMAiCERTFVT
OrthoDBiEOG091G0BQW
PhylomeDBiQ62481
TreeFamiTF314532

Family and domain databases

InterProiView protein in InterPro
IPR008895 Vps72/YL1
IPR013272 Vps72/YL1_C
PANTHERiPTHR13275 PTHR13275, 1 hit
PfamiView protein in Pfam
PF05764 YL1, 1 hit
PF08265 YL1_C, 1 hit
SMARTiView protein in SMART
SM00993 YL1_C, 1 hit

Sequencei

Sequence statusi: Complete.

Q62481-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLAGGRAPR KTAGNRLSGL LEAEEEDEFY QTTYGGFTEE SGDDEYQGDQ
60 70 80 90 100
SDTEDEVDSD FDIDEGDEPS SDGEAEEPRR KRRVVTKAYK EPLKSLRPRK
110 120 130 140 150
VSTPASSSQK AREEKTLLPL ELQDDGSDSR KSMRQSTAEH TRQTFLRVQE
160 170 180 190 200
RQGQSRRRKG PHCERPLTQE ELLREAKITE ELNLRSLETY ERLEADKKKQ
210 220 230 240 250
VHKKRKCPGP IITYHSVTVP LVGEPGPKEE NVDVEGLDPA PTASALAPHA
260 270 280 290 300
GTGTGAAAAT PPAHCSRTFI TFSDDATFEE WFPQGRPPKV PVREVCPVTH
310 320 330 340 350
RPALYRDPVT DIPYATARAF KIIREAYKKY ITAHGLPPTA SALGPGPPPP
360
EPLPGSGPRA LRQKIVIK
Length:368
Mass (Da):40,784
Last modified:February 21, 2006 - v2
Checksum:i1A7F0FB6456D81C3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75A → S in AAH04834 (PubMed:15489334).Curated1
Sequence conflicti247A → V in BAA07758 (PubMed:7702631).Curated1
Sequence conflicti247A → V in BAE33106 (PubMed:16141072).Curated1
Sequence conflicti260T → A in AAH04834 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D43643 mRNA Translation: BAA07758.1
AK140284 mRNA Translation: BAE24317.1
AK155191 mRNA Translation: BAE33106.1
BC004834 mRNA Translation: AAH04834.1
BC043029 mRNA Translation: AAH43029.2
CCDSiCCDS38543.1
PIRiJC4141
RefSeqiNP_033362.2, NM_009336.2
UniGeneiMm.133919

Genome annotation databases

EnsembliENSMUST00000009102; ENSMUSP00000009102; ENSMUSG00000008958
GeneIDi21427
KEGGimmu:21427
UCSCiuc008qia.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D43643 mRNA Translation: BAA07758.1
AK140284 mRNA Translation: BAE24317.1
AK155191 mRNA Translation: BAE33106.1
BC004834 mRNA Translation: AAH04834.1
BC043029 mRNA Translation: AAH43029.2
CCDSiCCDS38543.1
PIRiJC4141
RefSeqiNP_033362.2, NM_009336.2
UniGeneiMm.133919

3D structure databases

SMRiQ62481
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204018, 3 interactors
ComplexPortaliCPX-976 SRCAP histone exchanging complex
CPX-990 NuA4 histone acetyltransferase complex
IntActiQ62481, 4 interactors
MINTiQ62481
STRINGi10090.ENSMUSP00000009102

PTM databases

iPTMnetiQ62481
PhosphoSitePlusiQ62481

Proteomic databases

EPDiQ62481
MaxQBiQ62481
PaxDbiQ62481
PeptideAtlasiQ62481
PRIDEiQ62481

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000009102; ENSMUSP00000009102; ENSMUSG00000008958
GeneIDi21427
KEGGimmu:21427
UCSCiuc008qia.1 mouse

Organism-specific databases

CTDi6944
MGIiMGI:1202305 Vps72

Phylogenomic databases

eggNOGiKOG2897 Eukaryota
ENOG41119RU LUCA
GeneTreeiENSGT00390000017503
HOGENOMiHOG000033695
HOVERGENiHBG083244
InParanoidiQ62481
KOiK11664
OMAiCERTFVT
OrthoDBiEOG091G0BQW
PhylomeDBiQ62481
TreeFamiTF314532

Miscellaneous databases

ChiTaRSiVps72 mouse
PROiPR:Q62481
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000008958 Expressed in 263 organ(s), highest expression level in tracheobronchial tree
CleanExiMM_VPS72
GenevisibleiQ62481 MM

Family and domain databases

InterProiView protein in InterPro
IPR008895 Vps72/YL1
IPR013272 Vps72/YL1_C
PANTHERiPTHR13275 PTHR13275, 1 hit
PfamiView protein in Pfam
PF05764 YL1, 1 hit
PF08265 YL1_C, 1 hit
SMARTiView protein in SMART
SM00993 YL1_C, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVPS72_MOUSE
AccessioniPrimary (citable) accession number: Q62481
Secondary accession number(s): Q3U2N4, Q810A9, Q99K81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 21, 2006
Last modified: November 7, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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