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Protein

Integrin alpha-2

Gene

Itga2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Integrin alpha-2/beta-1 is a collagen receptor, being responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. It is also a receptor for laminins, collagen C-propeptides and E-cadherin. Mice homozygous for a null mutation in the alpha-2 die very early in embryogenesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi496 – 504Sequence analysis9
Calcium bindingi560 – 568Sequence analysis9
Calcium bindingi624 – 632Sequence analysis9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion
LigandCalcium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-216083 Integrin cell surface interactions
R-MMU-3000157 Laminin interactions
R-MMU-3000170 Syndecan interactions
R-MMU-3000178 ECM proteoglycans
R-MMU-8874081 MET activates PTK2 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-2
Alternative name(s):
CD49 antigen-like family member B
Collagen receptor
Platelet membrane glycoprotein Ia
Short name:
GPIa
VLA-2 subunit alpha
CD_antigen: CD49b
Gene namesi
Name:Itga2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:96600 Itga2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 1129ExtracellularSequence analysisAdd BLAST1103
Transmembranei1130 – 1151HelicalSequence analysisAdd BLAST22
Topological domaini1152 – 1178CytoplasmicSequence analysisAdd BLAST27

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
ChainiPRO_000001623427 – 1178Integrin alpha-2Add BLAST1152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi80 ↔ 89By similarity
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi429N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi457N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi472N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi677 ↔ 734By similarity
Glycosylationi696N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi786 ↔ 792By similarity
Disulfide bondi862 ↔ 873By similarity
Disulfide bondi1016 ↔ 1047By similarity
Disulfide bondi1052 ↔ 1057By similarity
Glycosylationi1054N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1071N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1078N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ62469
PaxDbiQ62469
PeptideAtlasiQ62469
PRIDEiQ62469

PTM databases

iPTMnetiQ62469
PhosphoSitePlusiQ62469

Expressioni

Gene expression databases

BgeeiENSMUSG00000015533 Expressed in 63 organ(s), highest expression level in heart
CleanExiMM_ITGA2
ExpressionAtlasiQ62469 baseline and differential
GenevisibleiQ62469 MM

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5 and RAB21.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200814, 2 interactors
ComplexPortaliCPX-3115 Integrin alpha2-beta1 complex
IntActiQ62469, 1 interactor
MINTiQ62469
STRINGi10090.ENSMUSP00000053891

Structurei

3D structure databases

ProteinModelPortaliQ62469
SMRiQ62469
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati31 – 89FG-GAP 1PROSITE-ProRule annotationAdd BLAST59
Repeati98 – 158FG-GAP 2PROSITE-ProRule annotationAdd BLAST61
Domaini185 – 362VWFAPROSITE-ProRule annotationAdd BLAST178
Repeati363 – 417FG-GAP 3PROSITE-ProRule annotationAdd BLAST55
Repeati420 – 472FG-GAP 4PROSITE-ProRule annotationAdd BLAST53
Repeati474 – 536FG-GAP 5PROSITE-ProRule annotationAdd BLAST63
Repeati537 – 595FG-GAP 6PROSITE-ProRule annotationAdd BLAST59
Repeati601 – 661FG-GAP 7PROSITE-ProRule annotationAdd BLAST61

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi480 – 482Cell attachment siteSequence analysis3
Motifi1154 – 1158GFFKR motif5

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3637 Eukaryota
ENOG410XPVZ LUCA
GeneTreeiENSGT00930000150854
HOGENOMiHOG000059610
HOVERGENiHBG006185
InParanoidiQ62469
KOiK06481
OMAiCSNVTCW
OrthoDBiEOG091G00TK
TreeFamiTF105391

Family and domain databases

Gene3Di2.130.10.130, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 1 hit
PF00357 Integrin_alpha, 1 hit
PF08441 Integrin_alpha2, 1 hit
PF00092 VWA, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit
PS50234 VWFA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q62469-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGPGQAGGAL LLRLLMLVQG ILNCLAYNVG LPGAKIFSGP SSEQFGYSVQ
60 70 80 90 100
QLTNPQGNWL LVGSPWSGFP ENRMGDVYKC PVDLPTATCE KLNLQNSASI
110 120 130 140 150
SNVTEIKTNM SLGLTLTRNP GTGGFLTCGP LWAHQCGNQY YATGICSDVS
160 170 180 190 200
PDFQFLTSFS PAVQACPSLV DVVVVCDESN SIYPWEAVKN FLVKFVTGLD
210 220 230 240 250
IGPKKTQVAL IQYANEPRII FNLNDFETKE DMVQATSETR QHGGDLTNTF
260 270 280 290 300
RAIEFARDYA YSQTSGGRPG ATKVMVVVTD GESHDGSKLK TVIQQCNDDE
310 320 330 340 350
ILRFGIAVLG YLNRNALDTK NLIKEIKAIA STPTERYFFN VADEAALLEK
360 370 380 390 400
AGTLGEQIFS IEGTVQGGDN FQMEMAQVGF SADYAPQNDI LMLGAVGAFD
410 420 430 440 450
WSGTLVQETS HKPVIFPKQA FDQVLQDRNH SSFLGYSVAA ISTEDGVHFV
460 470 480 490 500
AGAPRANYTG QIVLYSVNKQ GNVTVIQSHR GDQIGSYFGS VLCSVDVDKD
510 520 530 540 550
TITDVLLVGA PTYMNDLKKE EGKVYLFTIT KGILNQHQFL EGPEGTGNAR
560 570 580 590 600
FGSAIAALSD INMDGFNDVI VGSPVENENS GAVYIYNGHQ GTIRTKYSQK
610 620 630 640 650
ILGSNGAFRR HLQFFGRSLD GYGDLNGDSI TDVSIGALGQ VIQLWSQSIA
660 670 680 690 700
DVAIEALFTP DKITLLNKDA KITLKLCFRA EFRPAGQNNQ VAILFNMTLD
710 720 730 740 750
ADGHSSRVTS RGVFRENSER FLQKNMVVNE VQKCSEHHIS IQKPSDVVNP
760 770 780 790 800
LDLRVDISLE NPGTSPALEA YSETVKVFSI PFYKECGSDG ICISDLILDV
810 820 830 840 850
QQLPAIQTQS FIVSNQNKRL TFSVILKNRG ESAYNTVVLA EFSENLFFAS
860 870 880 890 900
FSMPVDGTEV TCEVGSSQKS VTCDVGYPAL KSEQQVTFTI NFDFNLQNLQ
910 920 930 940 950
NQAAINFQAF SESQETNKAD NSVSLTIPLL YDAELHLTRS TNINFYEISS
960 970 980 990 1000
DENAPSVIKS VEDIGPKFIF SLKVTAGSAP VSMALVTIHI PQYTKEKNPL
1010 1020 1030 1040 1050
LYLTGIQTDQ AGDISCTAEI NPLKLPHTAP SVSFKNENFR HTKELDCRTT
1060 1070 1080 1090 1100
SCSNITCWLK DLHMKAEYFI NVTTRVWNRT FAASTFQTVQ LTAAAEIDTH
1110 1120 1130 1140 1150
NPQLFVIEEN AVTIPLMIMK PTEKAEVPTG VIIGSIIAGI LLLLAMTAGL
1160 1170
WKLGFFKRQY KKMGQNPDEM DETTELNS
Length:1,178
Mass (Da):128,955
Last modified:July 27, 2011 - v2
Checksum:i62FAEA820242A9B6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YCM1A0A286YCM1_MOUSE
Integrin alpha-2
Itga2
154Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13R → Q in CAA82877 (PubMed:8081889).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z29987 mRNA Translation: CAA82877.1
CH466568 Genomic DNA Translation: EDL18370.1
BC065139 mRNA Translation: AAH65139.1
X75427 mRNA Translation: CAA53178.1
CCDSiCCDS26787.1
PIRiS44142
RefSeqiNP_032422.2, NM_008396.2
UniGeneiMm.5007
Mm.71633

Genome annotation databases

EnsembliENSMUST00000056117; ENSMUSP00000053891; ENSMUSG00000015533
GeneIDi16398
KEGGimmu:16398
UCSCiuc007rxw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z29987 mRNA Translation: CAA82877.1
CH466568 Genomic DNA Translation: EDL18370.1
BC065139 mRNA Translation: AAH65139.1
X75427 mRNA Translation: CAA53178.1
CCDSiCCDS26787.1
PIRiS44142
RefSeqiNP_032422.2, NM_008396.2
UniGeneiMm.5007
Mm.71633

3D structure databases

ProteinModelPortaliQ62469
SMRiQ62469
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200814, 2 interactors
ComplexPortaliCPX-3115 Integrin alpha2-beta1 complex
IntActiQ62469, 1 interactor
MINTiQ62469
STRINGi10090.ENSMUSP00000053891

PTM databases

iPTMnetiQ62469
PhosphoSitePlusiQ62469

Proteomic databases

MaxQBiQ62469
PaxDbiQ62469
PeptideAtlasiQ62469
PRIDEiQ62469

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056117; ENSMUSP00000053891; ENSMUSG00000015533
GeneIDi16398
KEGGimmu:16398
UCSCiuc007rxw.1 mouse

Organism-specific databases

CTDi3673
MGIiMGI:96600 Itga2

Phylogenomic databases

eggNOGiKOG3637 Eukaryota
ENOG410XPVZ LUCA
GeneTreeiENSGT00930000150854
HOGENOMiHOG000059610
HOVERGENiHBG006185
InParanoidiQ62469
KOiK06481
OMAiCSNVTCW
OrthoDBiEOG091G00TK
TreeFamiTF105391

Enzyme and pathway databases

ReactomeiR-MMU-216083 Integrin cell surface interactions
R-MMU-3000157 Laminin interactions
R-MMU-3000170 Syndecan interactions
R-MMU-3000178 ECM proteoglycans
R-MMU-8874081 MET activates PTK2 signaling

Miscellaneous databases

PROiPR:Q62469
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015533 Expressed in 63 organ(s), highest expression level in heart
CleanExiMM_ITGA2
ExpressionAtlasiQ62469 baseline and differential
GenevisibleiQ62469 MM

Family and domain databases

Gene3Di2.130.10.130, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 1 hit
PF00357 Integrin_alpha, 1 hit
PF08441 Integrin_alpha2, 1 hit
PF00092 VWA, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit
PS50234 VWFA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiITA2_MOUSE
AccessioniPrimary (citable) accession number: Q62469
Secondary accession number(s): Q62163, Q6P1C7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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